KEGG   DRUG: Givinostat hydrochloride
Entry
D12743                      Drug                                   
Name
Givinostat hydrochloride (USAN);
Givinostat hydrochloride hydrate;
Duvyzat (TN)
Product
DUVYZAT (Italfarmaco SPA)
Formula
C24H27N3O4. HCl. H2O
Exact mass
475.1874
Mol weight
475.96
Structure
Class
Antineoplastic
 DG03133  Histone deacetylase inhibitor
Remark
ATC code: M09AX14
Chemical structure group: DG03284
Product (DG03284): D12743<US>
Efficacy
Antineoplastic, Nervous system disease treatment, Histone deacetylase inhibitor
  Disease
Duchenne muscular dystrophy [DS:H01963]
Comment
Treatment of Duchenne muscular dystrophy and polycythemia vera.
Target
HDAC [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933 79885] [KO:K06067 K11404 K11406 K11407 K11408 K11405 K11409 K18671 K11418]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M09 OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
   M09A OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
    M09AX Other drugs for disorders of the musculo-skeletal system
     M09AX14 Givinostat
      D12743  Givinostat hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Givinostat
   D12743  Givinostat hydrochloride (USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG03133  Histone deacetylase inhibitor
   DG03284  Givinostat
    D12743  Givinostat hydrochloride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Histone deacetylase
    HDAC
     D12743  Givinostat hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12743
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12743
Drug groups [BR:br08330]
 Antineoplastic
  DG03133  Histone deacetylase inhibitor
   DG03284  Givinostat
Other DBs
CAS: 732302-99-7
PubChem: 497621156
ChEBI: 231335
LinkDB
KCF data

ATOM        33
            1   C8y C    14.9790  -13.5091
            2   C8y C    14.9790  -14.9090
            3   C8x C    16.1689  -15.6089
            4   C8y C    17.4988  -14.9090
            5   C8x C    17.4988  -13.5091
            6   C8x C    16.1689  -12.8091
            7   C8x C    13.7891  -12.8091
            8   C8y C    12.5291  -13.5091
            9   C8x C    12.5291  -14.9090
            10  C8x C    13.7891  -15.6089
            11  C1b C    11.3392  -12.8091
            12  N1c N    10.1493  -13.5091
            13  C1b C     8.9594  -12.8091
            14  C1b C    10.1493  -14.9090
            15  C1a C     8.9594  -15.6089
            16  C1a C     7.7695  -13.5091
            17  C1b C    18.6887  -15.6089
            18  O7a O    19.8786  -14.9090
            19  C7a C    21.0685  -15.6089
            20  N1b N    22.2585  -14.9090
            21  O6a O    21.0685  -17.0088
            22  C8y C    23.4484  -15.6089
            23  C8x C    23.4484  -17.0088
            24  C8x C    24.7083  -17.7088
            25  C8y C    25.8982  -17.0088
            26  C8x C    25.8982  -15.6089
            27  C8x C    24.7083  -14.9090
            28  C5a C    27.0881  -17.7088
            29  N1b N    28.2781  -17.0088
            30  O5a O    27.0881  -19.1087
            31  O1b O    29.4680  -17.7088
            32  X   Cl   26.8800  -12.5300
            33  O0  O    30.4500  -12.4600
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    8  11 1
            13   11  12 1
            14   12  13 1
            15   12  14 1
            16   14  15 1
            17   13  16 1
            18    4  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23   20  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1
            30   25  28 1
            31   28  29 1
            32   28  30 2
            33   29  31 1

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