Homo sapiens (human): 55869
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Entry
55869 CDS
T01001
Symbol
HDAC8, CDA07, CDLS5, HD8, HDACL1, KDAC8, MRXS6, RPD3, WTS
Name
(RefSeq) histone deacetylase 8
KO
K11405
histone deacetylase 8 [EC:
3.5.1.98
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04110
Cell cycle
hsa04613
Neutrophil extracellular trap formation
hsa05034
Alcoholism
hsa05203
Viral carcinogenesis
Network
nt06512
Chromosome cohesion and segregation
Element
N01483
Cohesin acetylation
Disease
H00631
Cornelia de Lange syndrome
Drug target
Abexinostat (
DG01402
):
D10060
D10084
Belinostat:
D08870
<US>
Bocodepsin (
DG03260
):
D12551
D12552
Entinostat:
D09338
Fimepinostat:
D11319
Givinostat (
DG03284
):
D12742
D12743
<US>
Mocetinostat (
DG01404
):
D09357
D09641
Nanatinostat:
D11442
Panobinostat (
DG01403
):
D10019
D10319
Quisinostat (
DG01407
):
D10321
D10322
Remetinostat:
D10977
Resminostat:
D13021
Romidepsin:
D06637
<JP/US>
Vorinostat:
D06320
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
55869 (HDAC8)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
55869 (HDAC8)
09165 Substance dependence
05034 Alcoholism
55869 (HDAC8)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
55869 (HDAC8)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.98 histone deacetylase
55869 (HDAC8)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDACs (histone deacetylases)
Class I HDACs
55869 (HDAC8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Hist_deacetyl
BFN_dom
Motif
Other DBs
NCBI-GeneID:
55869
NCBI-ProteinID:
NP_060956
OMIM:
300269
HGNC:
13315
Ensembl:
ENSG00000147099
UniProt:
Q9BY41
Structure
PDB
PDBj
LinkDB
All DBs
Position
X:complement(72329516..72572843)
Genome browser
AA seq
377 aa
AA seq
DB search
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
NT seq
1134 nt
NT seq
+upstream
nt +downstream
nt
atggaggagccggaggaaccggcggacagtgggcagtcgctggtcccggtttatatctat
agtcccgagtatgtcagtatgtgtgactccctggccaagatccccaaacgggccagtatg
gtgcattctttgattgaagcatatgcactgcataagcagatgaggatagttaagcctaaa
gtggcctccatggaggagatggccaccttccacactgatgcttatctgcagcatctccag
aaggtcagccaagagggcgatgatgatcatccggactccatagaatatgggctaggttat
gactgcccagccactgaagggatatttgactatgcagcagctataggaggggctacgatc
acagctgcccaatgcctgattgacggaatgtgcaaagtagcaattaactggtctggaggg
tggcatcatgcaaagaaagatgaagcatctggtttttgttatctcaatgatgctgtcctg
ggaatattacgattgcgacggaaatttgagcgtattctctacgtggatttggatctgcac
catggagatggtgtagaagacgcattcagtttcacctccaaagtcatgaccgtgtccctg
cacaaattctccccaggatttttcccaggaacaggtgacgtgtctgatgttggcctaggg
aagggacggtactacagtgtaaatgtgcccattcaggatggcatacaagatgaaaaatat
taccagatctgtgaaagtgtactaaaggaagtataccaagcctttaatcccaaagcagtg
gtcttacagctgggagctgacacaatagctggggatcccatgtgctcctttaacatgact
ccagtgggaattggcaagtgtcttaagtacatccttcaatggcagttggcaacactcatt
ttgggaggaggaggctataaccttgccaacacggctcgatgctggacatacttgaccggg
gtcatcctagggaaaacactatcctctgagatcccagatcatgagtttttcacagcatat
ggtcctgattatgtgctggaaatcacgccaagctgccggccagaccgcaatgagccccac
cgaatccaacaaatcctcaactacatcaaagggaatctgaagcatgtggtctag
DBGET
integrated database retrieval system
