Homo sapiens (human): 8841
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Entry
8841 CDS
T01001
Symbol
HDAC3, HD3, KDAC3, RPD3, RPD3-2
Name
(RefSeq) histone deacetylase 3
KO
K11404
histone deacetylase 3 [EC:
3.5.1.98
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04613
Neutrophil extracellular trap formation
hsa04919
Thyroid hormone signaling pathway
hsa05034
Alcoholism
hsa05203
Viral carcinogenesis
Drug target
Abexinostat (
DG01402
):
D10060
D10084
Belinostat:
D08870
<US>
Bocodepsin (
DG03260
):
D12551
D12552
Entinostat:
D09338
Fimepinostat:
D11319
Givinostat (
DG03284
):
D12742
D12743
<US>
Mocetinostat (
DG01404
):
D09357
D09641
Nanatinostat:
D11442
Panobinostat (
DG01403
):
D10019
D10319
Quisinostat (
DG01407
):
D10321
D10322
Remetinostat:
D10977
Romidepsin:
D06637
<JP/US>
Tinostamustine:
D11182
Tucidinostat:
D10993
<JP>
Vorinostat:
D06320
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
8841 (HDAC3)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
8841 (HDAC3)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
8841 (HDAC3)
09165 Substance dependence
05034 Alcoholism
8841 (HDAC3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
8841 (HDAC3)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.98 histone deacetylase
8841 (HDAC3)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDACs (histone deacetylases)
Class I HDACs
8841 (HDAC3)
HDAC complexes
SMART complex
8841 (HDAC3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Hist_deacetyl
Motif
Other DBs
NCBI-GeneID:
8841
NCBI-ProteinID:
NP_003874
OMIM:
605166
HGNC:
4854
Ensembl:
ENSG00000171720
UniProt:
O15379
Structure
PDB
LinkDB
All DBs
Position
5:complement(141620881..141636849)
Genome browser
AA seq
428 aa
AA seq
DB search
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
NT seq
1287 nt
NT seq
+upstream
nt +downstream
nt
atggccaagaccgtggcctatttctacgaccccgacgtgggcaacttccactacggagct
ggacaccctatgaagccccatcgcctggcattgacccatagcctggtcctgcattacggt
ctctataagaagatgatcgtcttcaagccataccaggcctcccaacatgacatgtgccgc
ttccactccgaggactacattgacttcctgcagagagtcagccccaccaatatgcaaggc
ttcaccaagagtcttaatgccttcaacgtaggcgatgactgcccagtgtttcccgggctc
tttgagttctgctcgcgttacacaggcgcatctctgcaaggagcaacccagctgaacaac
aagatctgtgatattgccattaactgggctggtggtctgcaccatgccaagaagtttgag
gcctctggcttctgctatgtcaacgacattgtgattggcatcctggagctgctcaagtac
caccctcgggtgctctacattgacattgacatccaccatggtgacggggttcaagaagct
ttctacctcactgaccgggtcatgacggtgtccttccacaaatacggaaattacttcttc
cctggcacaggtgacatgtatgaagtcggggcagagagtggccgctactactgtctgaac
gtgcccctgcgggatggcattgatgaccagagttacaagcaccttttccagccggttatc
aaccaggtagtggacttctaccaacccacgtgcattgtgctccagtgtggagctgactct
ctgggctgtgatcgattgggctgctttaacctcagcatccgagggcatggggaatgcgtt
gaatatgtcaagagcttcaatatccctctactcgtgctgggtggtggtggttatactgtc
cgaaatgttgcccgctgctggacatatgagacatcgctgctggtagaagaggccattagt
gaggagcttccctatagtgaatacttcgagtactttgccccagacttcacacttcatcca
gatgtcagcacccgcatcgagaatcagaactcacgccagtatctggaccagatccgccag
acaatctttgaaaacctgaagatgctgaaccatgcacctagtgtccagattcatgacgtg
cctgcagacctcctgacctatgacaggactgatgaggctgatgcagaggagaggggtcct
gaggagaactatagcaggccagaggcacccaatgagttctatgatggagaccatgacaat
gacaaggaaagcgatgtggagatttaa
DBGET
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