KEGG   DISEASE: Meningioma
Entry
H01556                      Disease                                
Name
Meningioma
Description
Meningiomas are the second-most common central nervous system tumor in adults. These tumors arise from arachnoid cells of the meninges, the covering layer of the brain. The majority of meningiomas tend to be benign, localized, and non-invasive. However, some meningiomas tend to be more aggressive with tendencies toward invasion of the surrounding brain, high propensity for recurrence, and in rare cases extracranial metastasis. Hereditary factors and ionizing radiation play an important role in the initiation of at least some meningiomas. Inactivation of the NF2 tumor suppressor gene is likely responsible for the initiation of more than half of all meningiomas and may cause a mesenchymal-like cytomorphology. Recently, novel mutations have been discovered in non-NF2 meningiomas. The somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of eye, brain, and central nervous system
   H01556  Meningioma
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Neoplasms of brain or central nervous system
   2A01  Primary neoplasms of meninges
    H01556  Meningioma
Related
pathway
hsa05200  Pathways in cancer
Gene
NF2 [HSA:4771] [KO:K16684]
SMARCB1 [HSA:6598] [KO:K11648]
SMARCE1 [HSA:6605] [KO:K11651]
SUFU [HSA:51684] [KO:K06229]
PTEN [HSA:5728] [KO:K01110]
CDKN2A [HSA:1029] [KO:K06621]
CDKN2B [HSA:1030] [KO:K04685]
TRAF7 [HSA:84231] [KO:K10646]
AKT1 [HSA:207] [KO:K04456]
KLF4 [HSA:9314] [KO:K17846]
SMO [HSA:6608] [KO:K06226]
MN1 [HSA:4330] [KO:K22543]
PDGFB [HSA:5155] [KO:K17386]
Carcinogen
Ionising radiation
Other DBs
ICD-11: 2A01.00
ICD-10: D32.9
MeSH: D008579
OMIM: 607174
Reference
PMID:25857641 (GENE)
  Authors
Smith MJ
  Title
Germline and somatic mutations in meningiomas.
  Journal
Cancer Genet 208:107-14 (2015)
DOI:10.1016/j.cancergen.2015.02.003
Reference
  Authors
Miller R Jr, DeCandio ML, Dixon-Mah Y, Giglio P, Vandergrift WA 3rd, Banik NL, Patel SJ, Varma AK, Das A
  Title
Molecular Targets and Treatment of Meningioma.
  Journal
J Neurol Neurosurg 1:1000101 (2014)
Reference
  Authors
Choy W, Kim W, Nagasawa D, Stramotas S, Yew A, Gopen Q, Parsa AT, Yang I
  Title
The molecular genetics and tumor pathogenesis of meningiomas and the future directions of meningioma treatments.
  Journal
Neurosurg Focus 30:E6 (2011)
DOI:10.3171/2011.2.FOCUS1116
Reference
  Authors
Shibuya M
  Title
Pathology and molecular genetics of meningioma: recent advances.
  Journal
Neurol Med Chir (Tokyo) 55:14-27 (2015)
DOI:10.2176/nmc.ra.2014-0233
Reference
  Authors
Riemenschneider MJ, Perry A, Reifenberger G
  Title
Histological classification and molecular genetics of meningiomas.
  Journal
Lancet Neurol 5:1045-54 (2006)
DOI:10.1016/S1474-4422(06)70625-1
Reference
  Authors
Simon M, Bostrom JP, Hartmann C
  Title
Molecular genetics of meningiomas: from basic research to potential clinical applications.
  Journal
Neurosurgery 60:787-98; discussion 787-98 (2007)
DOI:10.1227/01.NEU.0000255421.78431.AE
Reference
PMID:7731706 (MN1)
  Authors
Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA, et al.
  Title
Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.
  Journal
Oncogene 10:1521-8 (1995)
Reference
PMID:2212004 (PDGFB)
  Authors
Smidt M, Kirsch I, Ratner L
  Title
Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas.
  Journal
J Clin Invest 86:1151-7 (1990)
DOI:10.1172/JCI114820
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