KEGG   ORTHOLOGY: K04685
Entry
K04685                      KO                                     
Symbol
CDKN2B, P15, INK4B
Name
cyclin-dependent kinase inhibitor 2B
Pathway
map04068  FoxO signaling pathway
map04110  Cell cycle
map04218  Cellular senescence
map04350  TGF-beta signaling pathway
map04934  Cushing syndrome
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
map05226  Gastric cancer
Disease
H00015  Malignant pleural mesothelioma
H00036  Osteosarcoma
H00409  Type 2 diabetes mellitus
H01463  Mycosis fungoides
H01556  Meningioma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   04068 FoxO signaling pathway
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   04218 Cellular senescence
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   05203 Viral carcinogenesis
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
  09162 Cancer: specific types
   05226 Gastric cancer
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   05222 Small cell lung cancer
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
Other DBs
GO: 0004861
Genes
HSA: 1030(CDKN2B)
PTR: 473204(CDKN2B)
PPS: 100976219(CDKN2B)
GGO: 101146090(CDKN2B)
PON: 100459175(CDKN2B)
NLE: 100593298(CDKN2B)
MCC: 709209(CDKN2B)
MCF: 101866825(CDKN2B)
CSAB: 103219356(CDKN2B)
CATY: 105591313(CDKN2B)
PANU: 101014127(CDKN2B)
TGE: 112607789(CDKN2B)
RRO: 104654271(CDKN2B)
RBB: 108537064(CDKN2B)
TFN: 117098659(CDKN2B)
PTEH: 111537212(CDKN2B)
CJC: 100392363(CDKN2B)
SBQ: 101030939(CDKN2B)
CSYR: 103259933(CDKN2B)
MMUR: 105874193(CDKN2B)
LCAT: 123646043(CDKN2B)
OGA: 100955700(CDKN2B)
MMU: 12579(Cdkn2b)
MCAL: 110292822
MPAH: 110323643
RNO: 25164(Cdkn2b)
MCOC: 116096225(Cdkn2b)
MUN: 110554385
CGE: 113833995
MAUA: 101825579(Cdkn2b)
PLEU: 114698354
AAMP: 119817430
NGI: 103730664(Cdkn2b)
HGL: 101701062
CPOC: 100732246
CCAN: 109701109
DORD: 105988954
DSP: 122118978(Cdkn2b)
NCAR: 124964289
OCU: 100351874(CDKN2B)
OPI: 101527626(CDKN2B)
TUP: 102495801 102500294(CDKN2B)
CFA: 481563(CDKN2B)
CLUD: 112649891(CDKN2B)
VVP: 112911637(CDKN2B)
VLG: 121495864
AML: 100473431
UAH: 113260574(CDKN2B)
UAR: 123781261
ELK: 111159872
LLV: 125083921
MPUF: 101672835(CDKN2B)
EJU: 114218207(CDKN2B)
ZCA: 113934560(CDKN2B)
MLX: 118018063
FCA: 101087014(CDKN2B)
PYU: 121034524
PBG: 122475138
AJU: 106986385(CDKN2B)
HHV: 120223236(CDKN2B)
BTA: 527124(CDKN2B)
BIU: 109562837(CDKN2B)
BBUB: 102406954(CDKN2B)
CHX: 102172895(CDKN2B)
OAS: 101107164(CDKN2B)
ODA: 120862151(CDKN2B)
CCAD: 122452872(CDKN2B)
SSC: 397227(CDKN2B)
CFR: 102517211 116663067(CDKN2B)
CBAI: 105071281(CDKN2B)
CDK: 105092868(CDKN2B)
VPC: 102543341
BACU: 103011925(CDKN2B)
LVE: 103089606(CDKN2B)
OOR: 101276528(CDKN2B) 105748701
DLE: 111163122(CDKN2B)
PCAD: 102979656(CDKN2B)
PSIU: 116755636(CDKN2B)
ECB: 100034122(CDKN2B)
EPZ: 103543581(CDKN2B)
EAI: 106824765(CDKN2B)
MYB: 102260903(CDKN2B)
MMYO: 118667590(CDKN2B)
MLF: 102442800(CDKN2B)
MNA: 107541193(CDKN2B)
PKL: 118716636(CDKN2B) 118716727
HAI: 109374676(CDKN2B)
DRO: 112302879(CDKN2B)
SHON: 118984060(CDKN2B)
AJM: 119065838(CDKN2B)
PDIC: 114506849(CDKN2B)
PHAS: 123819579(CDKN2B)
MMF: 118630258
RFQ: 117032140(CDKN2B)
PALE: 102893142(CDKN2B)
PGIG: 120617116(CDKN2B)
PVP: 105298440(CDKN2B) 105311216
RAY: 107506721(CDKN2B)
MJV: 108386438(CDKN2B)
SARA: 101538844(CDKN2B)
LAV: 100664726(CDKN2B)
TMU: 101351137
DNM: 101422825(CDKN2B)
MDO: 100021947(CDKN2B)
PCW: 110201194
OAA: 114807863
GGA: 395076(CDKN2B)
PCOC: 116236213
CJO: 107306707(CDKN2B)
NMEL: 110389663
TGU: 100218902
SCAN: 115485128
PMOA: 120513622(CDKN2B)
PMAJ: 107198353
MRV: 120407585(CDKN2B) 120407586
ACS: 100562668(cdkn2b)
PBI: 103066227
TSR: 106544529
PMUA: 114588114
ZVI: 118075361
STOW: 125437260 125437261(CDKN2B)
XLA: 108706939(cdkn2b.S) 779240(cdkn2b.L)
XTR: 448767(cdkn2b)
NPR: 108801558
RTEM: 120945069
BBUF: 120991543
BGAR: 122932528
CCAR: 109098476
PPRM: 120494947(cdkn2a/b)
MAMB: 125272442(cdkn2a/b)
IPU: 108263810(cdkn2a/b)
PHYP: 113524623
SMEO: 124399489(cdkn2a/b)
TFD: 113646500(cdkn2a/b)
AMEX: 111189396
EEE: 113568101
TRU: 101062640
LCO: 104926969
NCC: 104965090
CGOB: 115010295
PLEP: 121942416(cdkn2a/b)
SLUC: 116034259(cdkn2a/b)
ECRA: 117958042(cdkn2a/b)
PFLV: 114567514
GAT: 120825585(cdkn2a/b)
PPUG: 119217634(cdkn2a/b)
MSAM: 119898939(cdkn2a/b)
CUD: 121508682(cdkn2a/b)
ALAT: 119021282(cdkn2a/b)
MZE: 101471656
ONL: 100707378
OAU: 116330037(cdkn2a/b)
OLA: 110014168(cdkn2b)
OML: 112157283(cdkn2a/b)
XMA: 102224758(cdkn2b)
XCO: 114144722(cdkn2b)
XHE: 116719341(cdkn2b)
PRET: 103466455(cdkn2b)
PFOR: 103148476
PLAI: 106949622
PMEI: 106919335
GAF: 122830098(cdkn2a/b)
CVG: 107095864(cdkn2b)
CTUL: 119796275(cdkn2a/b)
GMU: 124868114(cdkn2a/b)
NFU: 107375282(cdkn2b)
ALIM: 106517050(cdkn2b)
AOCE: 111582895
MCEP: 125004481(cdkn2a/b)
POV: 109638248
SSEN: 122770538(cdkn2a/b)
HHIP: 117765838(cdkn2a/b)
HSP: 118123919(cdkn2a/b)
LCF: 108896541
SDU: 111236603
SLAL: 111670409
XGL: 120800516(cdkn2a/b)
HCQ: 109511366
MALB: 109961337
BSPL: 114854505(cdkn2a/b)
SASA: 100196147(cdn2b) 106610370(CDN2B)
OTW: 112238791(cdkn2a/b)
OMY: 100653430(cdn2b) 118936745
OGO: 124019047(cdkn2a/b)
ONE: 115115324
SALP: 112078010
SNH: 120034979(cdkn2a/b)
ELS: 105021059
PKI: 111859259
AANG: 118226896(cdkn2a/b)
LOC: 102686533(cdkn2b) 102689462
PSPA: 121296220(cdkn2a/b) 121298958
LCM: 102356560(CDKN2B)
CMK: 103182848(cdkn2a/b)
HAME: 121853332
 » show all
Reference
  Authors
Canepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF
  Title
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.
  Journal
IUBMB Life 59:419-26 (2007)
DOI:10.1080/15216540701488358
Reference
PMID:8078588
  Authors
Hannon GJ, Beach D
  Title
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.
  Journal
Nature 371:257-61 (1994)
DOI:10.1038/371257a0
  Sequence
[hsa:1030]
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