KEGG   ORTHOLOGY: K00022
Entry
K00022                      KO                                     

Symbol
HADH
Name
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
Pathway
map00062  Fatty acid elongation
map00071  Fatty acid degradation
map00280  Valine, leucine and isoleucine degradation
map00281  Geraniol degradation
map00310  Lysine degradation
map00380  Tryptophan metabolism
map00650  Butanoate metabolism
map00930  Caprolactam degradation
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01212  Fatty acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Disease
H00525  Disorders of mitochondrial fatty-acid oxidation
H01267  Familial hyperinsulinemic hypoglycemia
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00071 Fatty acid degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00310 Lysine degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00380 Tryptophan metabolism
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09109 Metabolism of terpenoids and polyketides
   00281 Geraniol degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
Other DBs
RN: R01778 R01975 R04203 R04737 R04739 R04741 R04743 R04745 R04748 R05066 R06941 R08094
GO: 0003857
Genes
HSA: 3033(HADH)
PTR: 461424(HADH)
PPS: 100995262(HADH)
GGO: 101139662(HADH)
PON: 100447416(HADH)
NLE: 100592501(HADH)
MCC: 696181(HADH)
MCF: 101865482(HADH)
CSAB: 103236085(HADH)
CATY: 105571410(HADH)
PANU: 101018316(HADH)
RRO: 104670046(HADH)
RBB: 108515890(HADH)
TFN: 117085761(HADH)
PTEH: 111547879(HADH)
CJC: 100400121(HADH)
SBQ: 101048002(HADH)
MMUR: 105872330(HADH)
MMU: 15107(Hadh)
MCAL: 110290812(Hadh)
MPAH: 110320141(Hadh)
RNO: 113965(Hadh)
MCOC: 116093793(Hadh)
MUN: 110553441(Hadh)
CGE: 100761491(Hadh)
PLEU: 114682849(Hadh)
NGI: 103742549(Hadh)
HGL: 101712136(Hadh)
CCAN: 109684305(Hadh)
OCU: 100352945(HADH)
OPI: 101535877(HADH)
TUP: 102474187(HADH)
CFA: 478506(HADH)
VVP: 112934205(HADH)
VLG: 121493114(HADH)
AML: 100466232(HADH)
UMR: 103661727(HADH)
UAH: 113255543(HADH)
ORO: 101371823(HADH)
ELK: 111154677
MPUF: 101690625(HADH)
EJU: 114222683(HADH)
MLX: 118027078(HADH)
FCA: 101088327(HADH)
PYU: 121031465(HADH)
PBG: 122477675(HADH)
PTG: 102972274(HADH)
PPAD: 109247833(HADH)
AJU: 106983658(HADH)
HHV: 120236162(HADH)
BTA: 532785(HADH)
BOM: 102267786(HADH)
BIU: 109560267(HADH)
BBUB: 102410510(HADH)
CHX: 102171856(HADH)
OAS: 101122862(HADH)
ODA: 120861742(HADH) 120862679
CCAD: 122422156(HADH)
SSC: 397604(HADH)
CFR: 102510383(HADH)
CBAI: 105067990(HADH)
CDK: 105105288(HADH)
BACU: 103020566(HADH)
LVE: 103069724(HADH)
OOR: 101288394(HADH)
DLE: 111171489(HADH)
PCAD: 102996325(HADH)
ECB: 100072956(HADH)
EPZ: 103557034(HADH)
EAI: 106829815(HADH)
MYB: 102256814(HADH)
MYD: 102768229(HADH)
MMYO: 118673159(HADH)
MNA: 107538297(HADH)
HAI: 109379463(HADH)
DRO: 112296341(HADH)
SHON: 118977123(HADH)
AJM: 119061439(HADH)
MMF: 118615840(HADH)
PALE: 102886680(HADH)
PGIG: 120591171(HADH)
RAY: 107511528(HADH)
MJV: 108405594(HADH)
TOD: 119243646(HADH)
LAV: 100658675(HADH)
TMU: 101344876
MDO: 100010946(HADH)
SHR: 100933168(HADH)
PCW: 110218606(HADH)
OAA: 100080904(HADH)
GGA: 420290(HADH)
PCOC: 116237980(HADH)
MGP: 100542994(HADH)
CJO: 107313259(HADH)
NMEL: 110398347(HADH)
APLA: 101795779(HADH)
ACYG: 106038615(HADH)
TGU: 100231239(HADH)
LSR: 110468006(HADH)
SCAN: 103826257(HADH)
PMOA: 120502825(HADH)
OTC: 121348416(HADH)
PRUF: 121360226(HADH)
GFR: 102035108(HADH)
FAB: 101807376(HADH)
PHI: 102109282(HADH)
PMAJ: 107203268(HADH)
CCAE: 111928333(HADH)
CCW: 104697292(HADH)
ETL: 114057905(HADH)
FPG: 101918111(HADH)
FCH: 102050479(HADH)
CLV: 102084813(HADH)
EGZ: 104135502(HADH)
NNI: 104021316(HADH)
ACUN: 113479674(HADH)
PADL: 103919565(HADH)
AAM: 106491832(HADH)
AROW: 112972205(HADH)
NPD: 112957319(HADH)
DNE: 112987872(HADH)
ASN: 102386854(HADH)
AMJ: 102561189(HADH)
CPOO: 109309401(HADH)
GGN: 109300931(HADH)
PSS: 102443484(HADH)
CMY: 102929959(HADH)
CPIC: 101953292(HADH)
TST: 117878224(HADH)
CABI: 116837672(HADH)
ACS: 100556994(hadh)
PVT: 110080465(HADH)
PBI: 103064897(HADH)
PMUR: 107282826(HADH)
TSR: 106543017(HADH)
PGUT: 117679922(HADH)
PMUA: 114604109(HADH)
ZVI: 118083337(HADH)
GJA: 107123147(HADH)
XLA: 380594(hadh.L)
XTR: 496484(hadh)
NPR: 108785417(HADH)
DRE: 445121(hadh)
SRX: 107729339 107756993(hadh)
SANH: 107675781(hadh) 107684325
SGH: 107583243(hadh) 107594428
CCAR: 109046450
CAUA: 113044021 113044057
IPU: 100528694(hadh)
PHYP: 113546051(hadh)
AMEX: 103033308(hadh)
EEE: 113591283(hadh)
TRU: 101064489(hadh)
TNG: GSTEN00033452G001
LCO: 104927263(hadh)
NCC: 104953566(hadh)
CGOB: 115010035 115010260(hadh)
ELY: 117255691(hadh) 117264646 117264647
PLEP: 121960578 121960579 121963506 121964982
SLUC: 116034314(hadh)
ECRA: 117957919(hadh)
PFLV: 114568568(hadh)
GAT: 120825745(hadh)
PPUG: 119217779(hadh)
MSAM: 119898918(hadh) 119899029
CUD: 121507842(hadh)
MZE: 101465947(hadh)
ONL: 100704813(hadh)
OAU: 116330081(hadh)
OLA: 101166688(hadh)
OML: 112157397(hadh)
XMA: 102226893(hadh)
XCO: 114145464(hadh)
XHE: 116720694(hadh)
PRET: 103472731(hadh)
CVG: 107094619(hadh)
CTUL: 119779062(hadh)
NFU: 107375321(hadh)
KMR: 108235435(hadh)
ALIM: 106517065(hadh)
AOCE: 111570983 111578596
CSEM: 103384097 103384099
POV: 109638243(hadh)
LCF: 108888245(hadh)
SDU: 111236647(hadh)
SLAL: 111671175(hadh)
XGL: 120800218(hadh)
HCQ: 109511078(hadh)
BPEC: 110165377(hadh)
MALB: 109955489(hadh)
SASA: 106610339(hadh)
OTW: 112239253(hadh)
OMY: 110497327 110497328
SALP: 112071963(hadh)
SNH: 120034900 120034902
ELS: 105020990(hadh)
SFM: 108924594 108924596
PKI: 111837334(hadh)
AANG: 118227603(hadh)
LOC: 102686410(hadh)
PSPA: 121321782(hadh)
ARUT: 117409124 117421538
LCM: 102353593(HADH)
CMK: 103182114(hadh)
RTP: 109931148(hadh)
BFO: 118410867
BBEL: 109474151
CIN: 100187496
SCLV: 120336673 120344086 120347463
SPU: 582126
APLC: 110986845
SKO: 100374558 102802639
ACOZ: 120959440 120959441
AARA: 120900043 120900044
AAG: 5576217
AALB: 109422205 115260380
CQU: CpipJ_CPIJ006478 CpipJ_CPIJ006479 CpipJ_CPIJ016777 CpipJ_CPIJ016778
CPII: 120416727 120416728
TCA: 661810
DPA: 109544547
ATD: 109600322 109608602
AGB: 108903976
LDC: 111509478 111517440
NVL: 108563366
APLN: 108735525 108735530
PPYR: 116177691 116177692
OTU: 111426685
BMOR: 100862760(3HCD) 732951
BMAN: 114250158 114251439
MSEX: 115444176 115444201
DPL: KGM_213171 KGM_213213
BANY: 112044069 112044079
PMAC: 106713161 106713163
PPOT: 106105168 106105169
PXU: 106125613 106125614
PRAP: 110999114 110999115
ZCE: 119840115 119840116
HAW: 110380255 110380259
TNL: 113503789 113503790
PXY: 105384951 105384952 105396360 105396361
API: 100169569(Hadh)
DNX: 107169133
AGS: 114130161
RMD: 113553196
BTAB: 109035749
DCI: 103515549
CLEC: 106668531 106669340
HHAL: 106677832 106684334 106684335
NLU: 111051364
PHU: Phum_PHUM268940
FOC: 113217276
ZNE: 110831040
CSEC: 111869028 111869118
FCD: 110846012 110853638 110862569
DPX: DAPPUDRAFT_57769
DMK: 116920848
PVM: 113810046
HAME: 121874871
HAZT: 108667107 108670888 108683551
EAF: 111705078 111715616
ISC: IscW_ISCW014460
DSV: 119436570
RSAN: 119377897 119388915 119400118
RMP: 119161536
VDE: 111248612
VJA: 111271387
TUT: 107363024 107363252
DPTE: 113794498 113794509
CSCU: 111633100
PTEP: 107445456
SDM: 118194392
CEL: CELE_B0272.3 CELE_F01G10.2(ech-8) CELE_F01G10.3(ech-9) CELE_F54C8.1(F54C8.1) CELE_R09B5.6(hacd-1)
CBR: CBG03387(Cbr-ech-8) CBG03388(Cbr-ech-9) CBG06566(Cbr-hacd-1) CBG10094 CBG16139
BMY: BM_BM1730(Bm1730)
LOA: LOAG_06485
NAI: NECAME_08274
TSP: Tsp_06158
HRO: HELRODRAFT_185875
LGI: LOTGIDRAFT_203490
PCAN: 112569773
BGT: 106057696 106060215
GAE: 121378589
CRG: 105348652
MYI: 110451237
PMAX: 117331315
OBI: 106868457
OSN: 115209747
LAK: 106150701 106158000
OVI: T265_13984
EGL: EGR_03347
NVE: 5518441
EPA: 110240159
ATEN: 116286492
ADF: 107338199
AMIL: 114963753
PDAM: 113677957
SPIS: 111346544
HMG: 100198712
AQU: 100637276
QSU: 112036853
FGR: FGSG_00090
FPU: FPSE_08132
FVR: FVEG_12628
FOX: FOXG_15310
MAJ: MAA_08842
PLJ: VFPFJ_10847
ELA: UCREL1_1123
PSCO: LY89DRAFT_730720
ANI: AN7238.2
AOR: AO090009000113
ANG: ANI_1_1658104(An12g03260) ANI_1_70184(An19g00140)
AFV: AFLA_007657 AFLA_011248
PCS: Pc19g00460
ZTR: MYCGRDRAFT_65829
PFJ: MYCFIDRAFT_134610
CNE: CNC03600 CNH00460 CNI02410
CNB: CNBC3610 CNBH2290 CNBL0440
CGI: CGB_C5470W CGB_H3430C CGB_L0200C
TMS: TREMEDRAFT_24464
TASA: A1Q1_00338 A1Q1_03023 A1Q1_06701
WSE: WALSEDRAFT_61189
WIC: J056_002981
UMA: UMAG_01099
PFP: PFL1_02306
MGL: MGL_2947
MRT: MRET_3548
MSYM: MSY001_0418
PGR: PGTG_17222
MLR: MELLADRAFT_72978
MBR: MONBRDRAFT_34126
CPV: cgd3_330
CHO: Chro.30048
PTM: GSPATT00031585001
PTI: PHATRDRAFT_39681(HAD2)
FCY: FRACYDRAFT_270026(HADH1)
TPS: THAPSDRAFT_11182
AAF: AURANDRAFT_60274 AURANDRAFT_60388
PIF: PITG_08061
PSOJ: PHYSODRAFT_565338
SPAR: SPRG_01616
TBR: Tb927.2.4130
TCR: 509717.90 510105.240
LMA: LMJF_36_1140
LIF: LINJ_36_1200
LDO: LDBPK_361200
LMI: LMXM_36_1140
LBZ: LBRM_35_1270
LPAN: LPMP_351170
SACZ: AOT14_01810
ATN: FM020_09920
MOI: MOVS_08050
MOS: AXE82_09430
BOJ: CBF45_10195
KGY: EHF36_10590
DPY: BA022_03905
GLC: JQN73_16875
DML: Dmul_39300(hbd6)
RAS: RAS_09580
OAN: Oant_4803
AALA: IGS74_00470
BRD: JL11_10700
BVY: NCTC9239_02589(paaH)
PALW: PSAL_018210(hbd_1)
NRE: BES08_30980
SPHK: SKP52_22325
SPHI: TS85_20930
SSAN: NX02_02550 NX02_09670
SCLO: SCLO_2000770
SPYG: YGS_C2P0328 YGS_C2P0736
RMUC: FOB66_00580
NCB: C0V82_22830
TMO: TMO_c0211
BIF: N288_05050
BCIR: C2I06_01275
BCK: BCO26_0595
BAG: Bcoa_0582
BCOA: BF29_3106
BKO: CKF48_08520
GGH: GHH_c03770
GEL: IB49_12160
LSP: Bsph_0516
LGY: T479_18950
LFU: HR49_04950
LYS: LBYS11_18480
LYB: C3943_21520
LYZ: DCE79_07655
LPAK: GDS87_19580
BMUR: ABE28_002795
PPSR: I6J18_11175
AQT: FN924_18040
BTHV: CQJ30_02175
PRD: F7984_04495
SEDD: ERJ70_16040
BOU: I5818_01225
SSCZ: RN70_00480
SFF: FOB90_07545
MCL: MCCL_0058
PPRT: ET464_04535
SACA: FFV09_22200
AAC: Aaci_1250
AAD: TC41_1172
TAB: CIG75_09570
SIV: SSIL_2032
SSIL: SOLI23_08565
SOB: CSE16_06045
PANA: BBH88_17160
PMAR: B0X71_03905
KUR: ASO14_181
RST: ATY39_06490
PLAY: DNR44_016460
PABS: JIR001_23780
SAG: SAG1673
SAN: gbs1717
SGC: A964_1577(paaH)
SAGL: GBS222_1399
SAGM: BSA_17310
SAGI: MSA_17980
SAGR: SAIL_17270
SAGP: V193_07475
SAGC: DN94_07475
SAGT: GBSCOH1_1524
SAGE: EN72_09040
SAGG: EN73_08195
SAGN: W903_1664
SPSU: NCTC13786_01518(paaH)
SPOC: NCTC10925_01637(paaH)
LJE: BUE77_06845
LRU: HMPREF0538_21246
LRT: LRI_1856
LOR: AYI71_00225
LVA: LV515_07955
LFN: LF145_06510
LPON: LP475_00440
LNG: BSQ50_10215
LFV: LF543_05005
LBH: Lbuc_0069 Lbuc_2291
LBN: LBUCD034_0049(hbd1) LBUCD034_0128 LBUCD034_2391(hbd3)
LPAR: FAM21731_00990 FAM21731_01107 FAM21731_01947
LKF: DNL43_04560 DNL43_05280
LHIL: G8J22_02723
LKO: ABN16_01830
LHO: LOOC260_119260
LOL: LACOL_1403
LPD: AYR62_01865 AYR62_03065 AYR62_13845
LGN: ABM34_00430
LHB: D1010_16185
LPSE: FGL85_11125
WCB: AO080_11835
WJO: FOL01_0209
WPA: CO680_05650 CO680_07355
WHE: EFA59_00970
WVR: IE337_00175
CLS: CXIVA_09410(FadB)
EEL: EUBELI_01653
MDV: C5Q96_05340
APR: Apre_1169 Apre_1176
AVG: I6H45_00040
AOB: I6H46_03060
FRO: AALO17_03620
FIT: Fi14EGH31_21620
BULL: JOS54_05065
EBM: SG0102_21390
MYV: G155_00535
MFT: XA26_01080
MCHT: MCHIJ_08190 MCHIJ_23550
MFX: MFAL_36630
MIJ: MINS_39920
MALV: MALV_34090
MAUB: MAUB_30040
CVA: CVAR_1037(fadB4)
CGY: CGLY_10395(fadB2)
CDO: CDOO_12730
CCJ: UL81_10630(fadB4) UL81_10975(fadB2)
CEE: CENDO_05160(mmgB3)
CSAN: E3227_04420 E3227_10035
CPRE: Csp1_17760(hbd)
CYZ: C3B44_06365
CLIA: C3E79_04830 C3E79_09915 C3E79_10855
NFR: ERS450000_00058(paaH_1)
NSL: BOX37_20820
NOD: FOH10_24390
NAH: F5544_39880
NAD: NCTC11293_05196(paaH_2)
NWL: NWFMUON74_58260
RER: RER_56680(hbd)
REY: O5Y_27070
REB: XU06_27330
RQI: C1M55_28915
RPY: Y013_07145
RBY: CEJ39_18055
RHB: NY08_2071
RAV: AAT18_23775
RFA: A3L23_00405(hbd_1)
RHS: A3Q41_03003(hbd_2)
RRZ: CS378_13420
RHQ: IM25_21175
RHOD: AOT96_08580
RTM: G4H71_12260
RGO: KYT97_18090
GTA: BCM27_04455
GIT: C6V83_15165
GAM: GII34_16720
DIT: C3V38_08225
DLU: A6035_02380
SCIN: CP977_00260
CMI: CMM_0206
CMH: VO01_00845
CCAP: AES38_00590
MIX: AB663_002337
MPRT: ET475_06135
MSED: E3O41_10765
RFS: C1I64_07955
CUM: NI26_12110
AGY: ATC03_16440
AGM: DCE93_12395
AGF: ET445_06035
SALA: ESZ53_06415
LYD: D7I47_00860
LYK: FLP23_11410
MANT: BHD05_09655
FRN: F1C15_08210
SUBT: KPL76_00420
AAQ: AOC05_15220
GCR: GcLGCM259_2898
RSA: RSal33209_1555
NAE: BHE16_05930
AUL: DCC27_010120
NSN: EXE58_09390
AEZ: C3E78_09545
AEF: GEV26_08925
MUZ: H4N58_05830
BAST: BAST_1609
BACT: AB656_05470
BSUE: BS3272_02225
CCU: Ccur_03690
SHI: Shel_02640
APV: Apar_0174
OLS: Olsu_0283
OLO: ADJ70_07400
PCAT: Pcatena_03730(mmgB)
ATB: J4859_06945
TRC: DYE49_00865
SPHN: BV902_22405
SMIZ: 4412673_03592(fadB_2)
SPSC: E2P86_06330
SDJ: NCTC13534_04906
SMUI: I6J00_11000
EST: DN752_09105
FUV: JR347_10575
FFA: FFWV33_17545
FSE: DI487_12365
PTQ: P700755_002669
POA: CW731_04740
OLL: CW732_06820
PSYN: E9099_03285
FBE: FF125_09045
EAO: BD94_0876
EMN: M876_02675
EEN: BBD30_02930
ELB: VO54_01782(mmgB_2)
EMG: BBD33_17015
EGO: BBD34_13335
EGM: AYC65_12985
ELZ: FCS00_06770
ELT: FGE20_01130
CHH: A0O34_00520
CHRY: CEY12_08605
CHRS: EAG08_01955
CBEN: EG339_23085
CGLE: NCTC11432_02002(fadB2)
CTAK: 4412677_00646(paaH_1)
CJG: NCTC13459_00990(fadB2)
CCAS: EIB73_05985
ESTE: HNV03_12890
OCY: OSSY52_11590
MPZ: Marpi_0526
MARN: LN42_03005
MST: Msp_0718
METB: AW729_02425
MRU: mru_0990(hbd)
MSI: Msm_0965
MEB: Abm4_1160(hbd)
MEYE: TL18_07665
MOL: YLM1_0538
 » show all
Reference
PMID:8687463
  Authors
Vredendaal PJ, van den Berg IE, Malingre HE, Stroobants AK, Olde Weghuis DE, Berger R
  Title
Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.
  Journal
Biochem Biophys Res Commun 223:718-23 (1996)
DOI:10.1006/bbrc.1996.0961
  Sequence
[hsa:3033]
Reference
  Authors
Yang SY, He XY, Schulz H
  Title
3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease.
  Journal
FEBS J 272:4874-83 (2005)
DOI:10.1111/j.1742-4658.2005.04911.x
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