KEGG   ORTHOLOGY: K00022
Entry
K00022                      KO                                     

Symbol
HADH
Name
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
Pathway
map00062  Fatty acid elongation
map00071  Fatty acid degradation
map00280  Valine, leucine and isoleucine degradation
map00281  Geraniol degradation
map00310  Lysine degradation
map00380  Tryptophan metabolism
map00650  Butanoate metabolism
map00930  Caprolactam degradation
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01212  Fatty acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Disease
H00525  Disorders of mitochondrial fatty-acid oxidation
H01267  Familial hyperinsulinemic hypoglycemia
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00071 Fatty acid degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00310 Lysine degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00380 Tryptophan metabolism
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09109 Metabolism of terpenoids and polyketides
   00281 Geraniol degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
Other DBs
RN: R01778 R01975 R04203 R04737 R04739 R04741 R04743 R04745 R04748 R05066 R06941 R08094
GO: 0003857
Genes
HSA: 3033(HADH)
PTR: 461424(HADH)
PPS: 100995262(HADH)
GGO: 101139662(HADH)
PON: 100447416(HADH)
NLE: 100592501(HADH)
MCC: 696181(HADH)
MCF: 101865482(HADH)
CSAB: 103236085(HADH)
CATY: 105571410(HADH)
PANU: 101018316(HADH)
RRO: 104670046(HADH)
RBB: 108515890(HADH)
TFN: 117085761(HADH)
PTEH: 111547879(HADH)
CJC: 100400121(HADH)
SBQ: 101048002(HADH)
MMUR: 105872330(HADH)
MMU: 15107(Hadh)
MCAL: 110290812(Hadh)
MPAH: 110320141(Hadh)
RNO: 113965(Hadh)
MCOC: 116093793(Hadh)
MUN: 110553441(Hadh)
CGE: 100761491(Hadh)
PLEU: 114682849(Hadh)
NGI: 103742549(Hadh)
HGL: 101712136(Hadh)
CCAN: 109684305(Hadh)
OCU: 100352945(HADH)
OPI: 101535877(HADH)
TUP: 102474187(HADH)
CFA: 478506(HADH)
VVP: 112934205(HADH)
VLG: 121493114(HADH)
AML: 100466232(HADH)
UMR: 103661727(HADH)
UAH: 113255543(HADH)
ORO: 101371823(HADH)
ELK: 111154677
MPUF: 101690625(HADH)
EJU: 114222683(HADH)
MLX: 118027078(HADH)
FCA: 101088327(HADH)
PYU: 121031465(HADH)
PBG: 122477675(HADH)
PTG: 102972274(HADH)
PPAD: 109247833(HADH)
AJU: 106983658(HADH)
HHV: 120236162(HADH)
BTA: 532785(HADH)
BOM: 102267786(HADH)
BIU: 109560267(HADH)
BBUB: 102410510(HADH)
CHX: 102171856(HADH)
OAS: 101122862(HADH)
ODA: 120861742(HADH) 120862679
CCAD: 122422156(HADH)
SSC: 397604(HADH)
CFR: 102510383(HADH)
CBAI: 105067990(HADH)
CDK: 105105288(HADH)
BACU: 103020566(HADH)
LVE: 103069724(HADH)
OOR: 101288394(HADH)
DLE: 111171489(HADH)
PCAD: 102996325(HADH)
ECB: 100072956(HADH)
EPZ: 103557034(HADH)
EAI: 106829815(HADH)
MYB: 102256814(HADH)
MYD: 102768229(HADH)
MMYO: 118673159(HADH)
MNA: 107538297(HADH)
HAI: 109379463(HADH)
DRO: 112296341(HADH)
SHON: 118977123(HADH)
AJM: 119061439(HADH)
MMF: 118615840(HADH)
PALE: 102886680(HADH)
PGIG: 120591171(HADH)
RAY: 107511528(HADH)
MJV: 108405594(HADH)
TOD: 119243646(HADH)
LAV: 100658675(HADH)
TMU: 101344876
MDO: 100010946(HADH)
SHR: 100933168(HADH)
PCW: 110218606(HADH)
OAA: 100080904(HADH)
GGA: 420290(HADH)
PCOC: 116237980(HADH)
MGP: 100542994(HADH)
CJO: 107313259(HADH)
NMEL: 110398347(HADH)
APLA: 101795779(HADH)
ACYG: 106038615(HADH)
TGU: 100231239(HADH)
LSR: 110468006(HADH)
SCAN: 103826257(HADH)
PMOA: 120502825(HADH)
OTC: 121348416(HADH)
PRUF: 121360226(HADH)
GFR: 102035108(HADH)
FAB: 101807376(HADH)
PHI: 102109282(HADH)
PMAJ: 107203268(HADH)
CCAE: 111928333(HADH)
CCW: 104697292(HADH)
ETL: 114057905(HADH)
FPG: 101918111(HADH)
FCH: 102050479(HADH)
CLV: 102084813(HADH)
EGZ: 104135502(HADH)
NNI: 104021316(HADH)
ACUN: 113479674(HADH)
PADL: 103919565(HADH)
AAM: 106491832(HADH)
AROW: 112972205(HADH)
NPD: 112957319(HADH)
DNE: 112987872(HADH)
ASN: 102386854(HADH)
AMJ: 102561189(HADH)
CPOO: 109309401(HADH)
GGN: 109300931(HADH)
PSS: 102443484(HADH)
CMY: 102929959(HADH)
CPIC: 101953292(HADH)
TST: 117878224(HADH)
CABI: 116837672(HADH)
ACS: 100556994(hadh)
PVT: 110080465(HADH)
PBI: 103064897(HADH)
PMUR: 107282826(HADH)
TSR: 106543017(HADH)
PGUT: 117679922(HADH)
PMUA: 114604109(HADH)
ZVI: 118083337(HADH)
GJA: 107123147(HADH)
XLA: 380594(hadh.L)
XTR: 496484(hadh)
NPR: 108785417(HADH)
DRE: 445121(hadh)
SRX: 107729339 107756993(hadh)
SANH: 107675781(hadh) 107684325
SGH: 107583243(hadh) 107594428
CCAR: 109046450
IPU: 100528694(hadh)
PHYP: 113546051(hadh)
AMEX: 103033308(hadh)
EEE: 113591283(hadh)
TRU: 101064489(hadh)
LCO: 104927263(hadh)
NCC: 104953566(hadh)
CGOB: 115010035 115010260(hadh)
SLUC: 116034314(hadh)
ECRA: 117957919(hadh)
PFLV: 114568568(hadh)
GAT: 120825745(hadh)
PPUG: 119217779(hadh)
MSAM: 119898918(hadh) 119899029
CUD: 121507842(hadh)
MZE: 101465947(hadh)
ONL: 100704813(hadh)
OAU: 116330081(hadh)
OLA: 101166688(hadh)
OML: 112157397(hadh)
XMA: 102226893(hadh)
XCO: 114145464(hadh)
XHE: 116720694(hadh)
PRET: 103472731(hadh)
CVG: 107094619(hadh)
CTUL: 119779062(hadh)
NFU: 107375321(hadh)
KMR: 108235435(hadh)
ALIM: 106517065(hadh)
POV: 109638243(hadh)
LCF: 108888245(hadh)
SDU: 111236647(hadh)
SLAL: 111671175(hadh)
XGL: 120800218(hadh)
HCQ: 109511078(hadh)
BPEC: 110165377(hadh)
MALB: 109955489(hadh)
SASA: 106610339(hadh)
OTW: 112239253(hadh)
SALP: 112071963(hadh)
ELS: 105020990(hadh)
PKI: 111837334(hadh)
AANG: 118227603(hadh)
LOC: 102686410(hadh)
PSPA: 121321782(hadh)
LCM: 102353593(HADH)
CMK: 103182114(hadh)
RTP: 109931148(hadh)
BFO: 118410867
BBEL: 109474151
CIN: 100187496
SPU: 582126
APLC: 110986845
AAG: 5576217
TCA: 661810
DPA: 109544547
AGB: 108903976
NVL: 108563366
OTU: 111426685
BMOR: 100862760(3HCD) 732951
API: 100169569(Hadh)
DNX: 107169133
AGS: 114130161
RMD: 113553196
BTAB: 109035749
DCI: 103515549
NLU: 111051364
FOC: 113217276
ZNE: 110831040
DMK: 116920848
PVM: 113810046
HAME: 121874871
DSV: 119436570
RMP: 119161536
VDE: 111248612
VJA: 111271387
CSCU: 111633100
PTEP: 107445456
SDM: 118194392
CBR: CBG03387(Cbr-ech-8) CBG03388(Cbr-ech-9) CBG06566(Cbr-hacd-1) CBG10094 CBG16139
BMY: BM_BM1730(Bm1730)
TSP: Tsp_06158
PCAN: 112569773
GAE: 121378589
CRG: 105348652
MYI: 110451237
PMAX: 117331315
OBI: 106868457
OSN: 115209747
EGL: EGR_03347
NVE: 5518441
EPA: 110240159
ATEN: 116286492
ADF: 107338199
AMIL: 114963753
PDAM: 113677957
SPIS: 111346544
HMG: 100198712
AQU: 100637276
QSU: 112036853
MAJ: MAA_08842
ANI: AN7238.2
ANG: ANI_1_1658104(An12g03260) ANI_1_70184(An19g00140)
MGL: MGL_2947
MRT: MRET_3548
CPV: cgd3_330
PTI: PHATRDRAFT_39681(HAD2)
FCY: FRACYDRAFT_270026(HADH1)
SPAR: SPRG_01616
DML: Dmul_39300(hbd6)
RAS: RAS_09580
OAN: Oant_4803
BVY: NCTC9239_02589(paaH)
PALW: PSAL_018210(hbd_1)
SPHI: TS85_20930
TMO: TMO_c0211
BAG: Bcoa_0582
BCOA: BF29_3106
LSP: Bsph_0516
SSCZ: RN70_00480
MCL: MCCL_0058
AAC: Aaci_1250
AAD: TC41_1172
SIV: SSIL_2032
KUR: ASO14_181
SAG: SAG1673
SAN: gbs1717
SGC: A964_1577(paaH)
SAGM: BSA_17310
SAGI: MSA_17980
SAGR: SAIL_17270
SAGP: V193_07475
SAGC: DN94_07475
SAGE: EN72_09040
SAGG: EN73_08195
SAGN: W903_1664
SPSU: NCTC13786_01518(paaH)
SPOC: NCTC10925_01637(paaH)
LRT: LRI_1856
CLS: CXIVA_09410(FadB)
MALV: MALV_34090
MAUB: MAUB_30040
CVA: CVAR_1037(fadB4)
CGY: CGLY_10395(fadB2)
CCJ: UL81_10630(fadB4) UL81_10975(fadB2)
CEE: CENDO_05160(mmgB3)
CPRE: Csp1_17760(hbd)
NFR: ERS450000_00058(paaH_1)
NAD: NCTC11293_05196(paaH_2)
RER: RER_56680(hbd)
REY: O5Y_27070
RHB: NY08_2071
RFA: A3L23_00405(hbd_1)
RHS: A3Q41_03003(hbd_2)
CMI: CMM_0206
BAST: BAST_1609
APV: Apar_0174
OLS: Olsu_0283
PCAT: Pcatena_03730(mmgB)
SMIZ: 4412673_03592(fadB_2)
EAO: BD94_0876
ELB: VO54_01782(mmgB_2)
CGLE: NCTC11432_02002(fadB2)
CTAK: 4412677_00646(paaH_1)
CJG: NCTC13459_00990(fadB2)
MARN: LN42_03005
MST: Msp_0718
MRU: mru_0990(hbd)
MSI: Msm_0965
MEB: Abm4_1160(hbd)
MEYE: TL18_07665
MOL: YLM1_0538
 » show all
Reference
PMID:8687463
  Authors
Vredendaal PJ, van den Berg IE, Malingre HE, Stroobants AK, Olde Weghuis DE, Berger R
  Title
Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.
  Journal
Biochem Biophys Res Commun 223:718-23 (1996)
DOI:10.1006/bbrc.1996.0961
  Sequence
[hsa:3033]
Reference
  Authors
Yang SY, He XY, Schulz H
  Title
3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease.
  Journal
FEBS J 272:4874-83 (2005)
DOI:10.1111/j.1742-4658.2005.04911.x
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