KEGG   ORTHOLOGY: K00505
Entry
K00505                      KO                                     
Symbol
TYR
Name
tyrosinase [EC:1.14.18.1]
Pathway
map00350  Tyrosine metabolism
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04916  Melanogenesis
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Reaction
R00731  L-tyrosine:oxygen oxidoreductase
R02078  L-tyrosine,L-dopa:oxygen oxidoreductase
R02363  hydroquinone:oxygen oxidoreductase
R02383  monophenol,L-dopa:oxygen oxidoreductase
R04693  monophenol,L-dopa:oxygen oxidoreductase
R04884  5,6-dihydroxyindole:oxygen oxidoreductase
Disease
H00168  Oculocutaneous albinism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00505  TYR; tyrosinase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00505  TYR; tyrosinase
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K00505  TYR; tyrosinase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.1  tyrosinase
     K00505  TYR; tyrosinase
Other DBs
GO: 0004503
Genes
HSA: 7299(TYR)
PTR: 451473(TYR)
PPS: 100989128(TYR)
GGO: 101148846(TYR)
PON: 100453479(TYR)
PPYG: 129007943(TYR)
NLE: 100594055 115838630
HMH: 116477395(TYR)
SSYN: 129483935(TYR)
MCC: 705792(TYR)
MCF: 102141480(TYR)
MTHB: 126934746
MNI: 105468895(TYR)
CSAB: 103248194(TYR)
CATY: 105592966(TYR)
PANU: 101020866(TYR)
TGE: 112606374(TYR)
MLEU: 105543124(TYR)
RRO: 104657434(TYR)
RBB: 108539149(TYR)
TFN: 117080742(TYR)
PTEH: 111540685(TYR)
CANG: 105509297(TYR)
CJC: 100399713(TYR)
SBQ: 101043674(TYR)
CIMI: 108296777
ANAN: 105711938(TYR)
CSYR: 103255375(TYR)
MMUR: 105865099(TYR)
LCAT: 123642237(TYR)
PCOQ: 105808221(TYR)
OGA: 100962911(TYR)
MMU: 22173(Tyr)
MCAL: 110298406(Tyr)
MPAH: 110327286(Tyr)
RNO: 308800(Tyr)
MCOC: 116100639(Tyr)
ANU: 117711951(Tyr)
MUN: 110565894(Tyr)
CGE: 100752294
MAUA: 101840761(Tyr)
PROB: 127227250(Tyr)
PLEU: 114682739(Tyr)
MORG: 121453201(Tyr)
MFOT: 126491512
AAMP: 119803035(Tyr)
NGI: 103743041(Tyr)
HGL: 101696609(Tyr)
CPOC: 100713552(Tyr)
DORD: 105983956(Tyr)
DSP: 122116277(Tyr)
PLOP: 125361622(Tyr)
NCAR: 124960121
MMMA: 107160413(Tyr)
OCU: 100008753(TYR)
OPI: 101520677(TYR)
TUP: 102485831(TYR)
GVR: 103600166(TYR)
CFA: 403405(TYR)
CLUD: 112641956(TYR)
VVP: 112932288(TYR)
VLG: 121476446(TYR)
NPO: 129506715(TYR)
AML: 100475022(TYR)
UMR: 103675370(TYR)
UAH: 113269420(TYR)
UAR: 123792343(TYR)
ELK: 111154441
LLV: 125078919
MPUF: 101683509(TYR)
MNP: 132012084(TYR)
MLK: 131839453(TYR)
NVS: 122912503(TYR)
ORO: 101363864(TYR)
EJU: 114199718(TYR)
ZCA: 113914930(TYR)
MLX: 118013459(TYR)
NSU: 110570998(TYR)
LWW: 102742435(TYR)
FCA: 751100(TYR)
PYU: 121039397(TYR)
PCOO: 112866043(TYR)
PBG: 122483228(TYR)
PVIV: 125146819(TYR)
LRUF: 124504571
PTG: 102957473(TYR)
PPAD: 109267329(TYR)
PUC: 125929456
AJU: 106967790
HHV: 120246243(TYR)
BTA: 280951(TYR)
BOM: 102272000(TYR)
BIU: 109554196(TYR)
BBUB: 102408280(TYR)
BBIS: 104993808(TYR)
CHX: 102182281(TYR)
OAS: 780502(TYR)
BTAX: 128069103(TYR)
ODA: 120874821(TYR)
CCAD: 122431382(TYR)
MREE: 136168964(TYR)
MBEZ: 129548563(TYR)
SSC: 407745(TYR)
CFR: 102509800(TYR)
CBAI: 105083516(TYR)
CDK: 105088592(TYR)
VPC: 102543612(TYR)
BACU: 103016545(TYR)
BMUS: 118899345(TYR)
OOR: 101280655(TYR)
DLE: 111184818(TYR)
PCAD: 102989004(TYR)
PSIU: 116757930(TYR)
NASI: 112410924(TYR)
ECB: 100060227(TYR)
EPZ: 103547855(TYR)
EAI: 106822679(TYR)
MYB: 102260258(TYR)
MYD: 102762530(TYR)
MMYO: 118662722(TYR)
MLF: 102430118(TYR)
MDT: 132240690(TYR)
PKL: 118713257(TYR)
EFUS: 103296990(TYR)
MNA: 107532399(TYR)
DRO: 112316020(TYR)
SHON: 118984758(TYR)
AJM: 119043575(TYR)
PDIC: 114500350(TYR)
PHAS: 123805508(TYR)
MMF: 118628030(TYR)
PPAM: 129072658(TYR)
HAI: 109374039(TYR)
RFQ: 117030409(TYR)
PALE: 102894376(TYR)
PGIG: 120590532(TYR)
PVP: 105294192(TYR)
RAY: 107514939(TYR)
MJV: 108390598(TYR)
TOD: 119254714(TYR)
SARA: 101538402(TYR)
SETR: 126019139(TYR)
LAV: 100676924(TYR)
TMU: 101358815
ETF: 101660164(TYR)
DNM: 101436149(TYR)
MDO: 100010166(TYR)
GAS: 123238815(TYR)
SHR: 100928294(TYR)
AFZ: 127555166
PCW: 110213345(TYR)
TVP: 118838649(TYR)
PBRV: 138148355(TYR)
OAA: 100080574(TYR)
GGA: 373971(TYR)
PCOC: 116241921(TYR)
MGP: 100538462(TYR)
CJO: 107308457(TYR)
TPAI: 128074250(TYR)
LMUT: 125691153(TYR)
NMEL: 110390794(TYR)
APLA: 101791683(TYR)
ACYG: 106034185(TYR)
CATA: 118245940(TYR)
AFUL: 116501296(TYR)
TGU: 100225893(TYR)
LSR: 110478390(TYR)
SCAN: 103827249(TYR)
PMOA: 120506781(TYR)
OTC: 121340987(TYR)
PRUF: 121362296(TYR)
GFR: 102035437(TYR)
FAB: 101814779(TYR)
OMA: 130255126(TYR)
PHI: 102104800(TYR)
PMAJ: 107199861(TYR)
CCAE: 111924932(TYR)
CCW: 104690323(TYR)
CBRC: 103616715(TYR)
ETL: 114063514(TYR)
ZAB: 102073575(TYR)
ZLE: 135459902(TYR)
ACHL: 103798447
SVG: 106853986(TYR)
MMEA: 130577944(TYR)
HRT: 120748820(TYR)
SATI: 136374071(TYR)
FPG: 101915664(TYR)
FCH: 102054260(TYR)
CCRI: 104166714(TYR)
NNT: 104405533(TYR)
SHAB: 115603879(TYR)
ACUN: 113480760(TYR)
TALA: 104361858(TYR)
ACHC: 115353600(TYR)
HALD: 104317037(TYR)
HLE: 104838488(TYR)
AGEN: 126048436
GCL: 127028421
CSTI: 104561248(TYR)
LDI: 104344032(TYR)
MNB: 103779458(TYR)
DPUB: 104301160(TYR)
PPUS: 135173518(TYR)
AVIT: 104268688(TYR)
BRHI: 104496235(TYR)
EGZ: 104128835(TYR)
NNI: 104017355(TYR)
PCRI: 104025917(TYR)
PCAO: 104050100(TYR)
PADL: 103926027(TYR)
AFOR: 103904764(TYR)
FGA: 104069806(TYR)
GSTE: 104263230(TYR)
CLV: 102093703(TYR)
MUI: 104539276(TYR)
PGUU: 104465724(TYR)
PLET: 104627842(TYR)
EHS: 104503590(TYR)
CMAC: 104473847(TYR)
CUCA: 104064099(TYR)
TEO: 104370913(TYR)
BREG: 104632917(TYR)
OHA: 104327638(TYR)
ACAR: 104522941(TYR)
CPEA: 104393152(TYR)
CVF: 104283043(TYR)
RTD: 128904187(TYR)
AAM: 106495505(TYR)
AROW: 112973714(TYR)
NPD: 112951483(TYR)
TGT: 104579092(TYR)
DNE: 112988550(TYR)
SCAM: 104153274(TYR)
ASN: 102385049(TYR)
AMJ: 102560883(TYR)
CPOO: 109306793(TYR)
GGN: 109303235(TYR)
PSS: 102454532(TYR)
CMY: 102935011(TYR)
CCAY: 125632955(TYR)
DCC: 119843677(TYR)
CPIC: 101935010(TYR)
TST: 117871862(TYR)
CABI: 116818084(TYR)
MRV: 120383812(TYR)
ACS: 100552257(tyr)
ASAO: 132772243(TYR)
PVT: 110088582(TYR)
SUND: 121926332(TYR)
PBI: 103060005(TYR) 103063605
PMUR: 107286363(TYR)
CTIG: 120307809(TYR)
TSR: 106547651(TYR)
PGUT: 117660003(TYR)
APRI: 131199856(TYR)
PTEX: 113440467(TYR)
NSS: 113420140(TYR)
VKO: 123029400(TYR)
PMUA: 114595291(TYR)
PRAF: 128412528(TYR)
ZVI: 118085685(TYR)
HCG: 128349049(TYR)
GJA: 107119489(TYR)
STOW: 125431508(TYR)
EMC: 129326090(TYR)
MUO: 115467853(TYR)
GSH: 117362868(TYR)
DRE: 30207(tyr)
SRX: 107731812 107737432(tyr)
SGH: 107558837(tyr)
CGIB: 128029069
PTET: 122358820(tyr)
LROH: 127177360(tyr)
OMC: 131554175(tyr)
PPRM: 120470727(tyr)
RKG: 130101119(tyr)
MAMB: 125248595(tyr)
CIDE: 127496052
CERY: 137004332(tyr)
TROS: 130564732(tyr)
TDW: 130428409(tyr)
MANU: 129438659(tyr)
IPU: 100304491 108277956(tyr)
IFU: 128620020 128621333(tyr)
SMEO: 124393257 124394828(tyr)
TFD: 113637826(tyr) 113659178
TVC: 132857969(tyr) 132863019
TRN: 134332925 134334725(tyr)
AMEX: 103040843(tyr) 103041136
CMAO: 118800559(tyr) 118824597
EEE: 113578741(tyr) 113581657
TRU: 101064772(tyr) 101080145
LCO: 104920119(tyr)
NCC: 104963013(tyr)
TBEN: 117470246(tyr) 117490431
CGOB: 115017793(tyr) 115018879
PGEO: 117457806(tyr) 117458840
GACU: 117534898(tyr) 117535274
EMAC: 134871964 134880315(tyr)
SLUC: 116037037 116048241(tyr)
ECRA: 117942457(tyr) 117954992
ESP: 116687073(tyr) 116700242
PFLV: 114552647(tyr) 114566690
GAT: 120822041 120828666(tyr)
PPUG: 119213809(tyr) 119215419
AFB: 129091276(tyr) 129113883
CLUM: 117741431(tyr) 117742834
PSWI: 130189390 130211087(tyr)
CANA: 137790492(tyr) 137803064
CVE: 137876404 137877541(tyr)
MSAM: 119883400(tyr) 119895337
CUD: 121518828 121524120(tyr)
ALAT: 119006367(tyr) 119030940
ASTR: 137596608(tyr) 137606556
ONL: 100700374 100707700(tyr)
OAU: 116322990(tyr) 116331461
OLA: 100049427(tyr) 101171514
OML: 112139508 112150029(tyr)
CSAI: 133441684(tyr) 133459415
XMA: 102216777 102222951(tyr)
XCO: 114153091 114161843(tyr)
XHE: 116708061(tyr) 116728342
PRET: 103474486(tyr) 103475522
PFOR: 103140502 103146266(tyr)
PLAI: 106950591 106958863(tyr)
PMEI: 106914104 106918015(tyr)
GAF: 122833005(tyr) 122844839
PPRL: 129359260(tyr) 129368489
CVG: 107087918 107091929(tyr)
CTUL: 119771817(tyr) 119783464
GMU: 124876592 124884508(tyr)
NFU: 107380455(tyr) 107386962
KMR: 108236980 108244618(tyr)
ALIM: 106514125 106517255(tyr)
NWH: 119411088(tyr) 119420008
MCEP: 125014064(tyr) 125021303
CSEM: 103378543(tyr) 103395402
POV: 109634605(tyr) 109635738
SSEN: 122773016(tyr) 122779548
HHIP: 117772813(tyr) 117773990
HSP: 118106457(tyr) 118122668
PPLT: 128440257(tyr)
SMAU: 118299879(tyr) 118301560
HCQ: 109509733 109525374(tyr)
SSCV: 125972234(tyr) 125982324
SBIA: 133491776 133504590(tyr)
PEE: 133404965(tyr) 133416504
PTAO: 133467407 133482359(tyr)
BPEC: 110158560 110174305(tyr)
MALB: 109959313 109971605(tyr)
BSPL: 114868616(tyr) 114868934
OTW: 112232177 112267296(tyr)
OMY: 100135825 100135828(tyr)
ELS: 105024066(tyr) 105026640
SFM: 108923732 108932465(tyr)
LOC: 102687207(tyr)
PSPA: 121302601(tyr)
PSEX: 120519559
LCM: 102365572(TYR)
CMK: 103185187(tyr)
RTP: 109921379(tyr)
CPLA: 122550589(tyr)
LERI: 129698248(tyr)
PMRN: 116953350(TYR)
LRJ: 133351432(TYR)
SCLV: 120342909
DME: Dmel_CG42639(PPO1) Dmel_CG42640(PPO3)
DSE: 6609708
DSI: Dsimw501_GD11733(Dsim_GD11733) Dsimw501_GD25430(Dsim_GD25430)
DAN: 6496059
DSR: 110177925
DPO: 4804100
DPE: 6589981
DMN: 108160538
DWI: 6643368
DGR: 6560300
DAZ: 108616230
DNV: 108654794
DHE: 111597672
DVI: 6626051
CCAT: 101460986
RZE: 108366181
GFS: 119639699
ECOE: 129949398
HIS: 119646185
AFUN: 125772415
CNS: 116351145
PPAP: 129801388
DSM: 124412090
NPT: 124224816
NFB: 124187883
NLO: 107224379
NVG: 124301309
CSEC: 111863773
FCD: 110850352
PVM: 113827912
PMOO: 119583423
HAZT: 108679769
TUT: 107369608
CSCU: 111641656
PTEP: 107444762
SDM: 118205071
CEL: CELE_C34G6.2(tyr-4)
CBR: CBG_04025(Cbr-tyr-4)
BMY: BM_BM3483(Bm3483)
PCAN: 112576568
GAE: 121390964
HRJ: 124268408
CANU: 128187051
OED: 125682877
MMER: 123535176
RPHI: 132742487
MAEA: 128244825
OSN: 115219783
LLON: 135487855
NTE: NEUTE1DRAFT103253(NEUTE1DRAFT_103253) NEUTE1DRAFT117718(NEUTE1DRAFT_117718) NEUTE1DRAFT118745(NEUTE1DRAFT_118745) NEUTE1DRAFT124197(NEUTE1DRAFT_124197) NEUTE1DRAFT125579(NEUTE1DRAFT_125579) NEUTE1DRAFT93419(NEUTE1DRAFT_93419)
SMP: 10802107(SMAC4_09195) 10805042(SMAC4_04920) 10808536(SMAC4_04270) 10808577(SMAC4_04313) 10808704(SMAC4_06010) 10809071(SMAC4_00012) 10810251(SMAC4_01459) 10810296(SMAC4_01505) 10810380(SMAC4_01592)
TATV: 25776692(TrAtP1_012215) 25777593(TrAtP1_007661) 25780128(TrAtP1_010231)
TASP: 36609524(TrAFT101_010490) 36612211(TrAFT101_009492) 36615182(TrAFT101_007774) 36616461(TrAFT101_009487)
MAW: 19247028(J3458_000472) 19247267(J3458_022097) 19247976(J3458_005087) 19250027(J3458_015295) 19252269(J3458_021163) 90964211(J3458_021199)
MBRN: 26238408(ustQ_0) 26239659(TYR) 26242521(tyr1_1) 26243569(tyr1_2) 26246866(ustQ_1) 26247267(orsC_1) 26247667(orsC_0)
PLJ: 28883541(PLICBS_000498) 28892626(PLICBS_006597)
CDET: 87936518(CDEST_00015) 87938025(CDEST_01522) 87938242(CDEST_01739) 87939604(CDEST_03101) 87939610(CDEST_03107) 87939836(CDEST_03333) 87942221(CDEST_05718) 87943905(CDEST_07402) 87944196(CDEST_07693) 87944479(CDEST_07976) 87944521(CDEST_08018) 87944815(CDEST_08312) 87947207(CDEST_10707) 87947348(CDEST_10848) 87947666(CDEST_11166) 87948520(CDEST_12020) 87948574(CDEST_12074) 87949534(CDEST_13034) 87949803(CDEST_13303) 87951267(CDEST_14767)
CPW: 9692343(D8B26_006956) 9692851(D8B26_007850) 9693535(D8B26_008230)
ABE: ARB_00532
TVE: TRV_00392
PTRR: 6338404(PtrM4_021610) 6339083(PtrM4_018500) 6339505(PtrM4_021070) 6340539(PtrM4_058880) 6340608(PtrM4_058520) 6341599(PtrM4_069970) 6343058(PtrM4_117720) 6346288(PtrM4_136270) 6347183(PtrM4_033720) 6347581(PtrM4_124720) 6349122(PtrM4_130770) 90957305(PtrM4_124910) 90958249(PtrM4_152690)
ABP: AGABI1DRAFT114468(AGABI1DRAFT_114468) AGABI1DRAFT114491(AGABI1DRAFT_114491) AGABI1DRAFT114493(AGABI1DRAFT_114493) AGABI1DRAFT116717(AGABI1DRAFT_116717) AGABI1DRAFT62737(AGABI1DRAFT_62737) AGABI1DRAFT85838(AGABI1DRAFT_85838)
ABV: AGABI2DRAFT135027(AGABI2DRAFT_135027) AGABI2DRAFT191507(AGABI2DRAFT_191507) AGABI2DRAFT191532(AGABI2DRAFT_191532) AGABI2DRAFT194055(AGABI2DRAFT_194055) AGABI2DRAFT239416(AGABI2DRAFT_239416)
SCM: SCHCO_02601704(SCHCODRAFT_02601704)
EBB: F652_1501
LEM: LEN_2997(melC2)
PPUN: PP4_19320
PFO: Pfl01_3461(melC2)
PFC: PflA506_4965(melC2)
PFB: VO64_2552
PCHP: C4K32_2614
PSIL: PMA3_28020
SDE: Sde_0316
HCH: HCH_03392
RSY: RSUY_22190(melC2_1) RSUY_29370(melC2_2)
BPS: BPSS1731
BPSE: BDL_5087(melO)
BPSM: BBQ_4408(melO)
BPSU: BBN_5187(melO)
BPSD: BBX_4253(melO)
BPK: BBK_4451(melO)
BPSH: DR55_3536(melO)
BPSA: BBU_4293(melO)
BPSO: X996_5813(melO)
BUT: X994_5374(melO)
BTQ: BTQ_3941(melO)
BTJ: BTJ_4973(melO)
BTZ: BTL_3442(melO)
BTD: BTI_3837
BTV: BTHA_4444(melO)
BTHE: BTN_5428(melO)
BTHM: BTRA_5703(melO)
BTHA: DR62_5606
BTHL: BG87_3396(melO)
BOK: DM82_4935(melC2) DM82_5976(melO)
BOC: BG90_4662(melO) BG90_5660(melC2)
BCON: NL30_37765
BUB: BW23_4486(melO) BW23_6019
BSTG: WT74_18825
BUL: BW21_5830
BPH: Bphy_4746
CABA: SBC2_28520
DAC: Daci_1610
NEU: NE1241
MHUA: MCHK_11960
SMX: SM11_pC0105(mepA1) SM11_pC0156(mepA2)
AVI: Avi_2427
RHN: AMJ98_PC00117(melA)
REZ: AMJ99_PB00114(melA)
AOL: S58_42440
BARH: WN72_11285
RPB: RPB_2167
NWI: Nwi_0968
MET: M446_5336
MSC: BN69_0277
LABT: FIU93_19085(melC2)
SIL: SPO1405
MALG: MALG_04738
RSU: NHU_02308
SCL: sce8942
BCA: BCE_A0211
BMQ: BMQ_3385
BMD: BMD_3389
BMH: BMWSH_1797(melC1)
BMEG: BG04_300(melC2)
BEO: BEH_25025
MBOK: MBOE_44510
CEF: CE1756
CFAC: CFAEC_07835(melC2)
SCO: SCO2700(melC2)
SMA: SAVERM_1137(melC2) SAVERM_5362(melC2-2)
SGR: SGR_2447(melC2-2) SGR_527(melC2-1)
SGB: WQO_32205
SFI: SFUL_6847
SCB: SCAB_59241(melC2) SCAB_85681(melC2B)
SHY: SHJG_4198
SFA: Sfla_5963
SDV: BN159_5596(melC2) BN159_7561 BN159_8269(melC2)
STRP: F750_0607
SLV: SLIV_24170(melC2)
SAMB: SAM23877_2730(melC)
SPRI: SPRI_2876
SRW: TUE45_00932(melC2_1) TUE45_03314(melC2_2)
SLE: sle_45350(sle_45350)
SRN: A4G23_03056(melC2)
STRD: NI25_25425
SLAU: SLA_4839
SLX: SLAV_04435(melC1) SLAV_04520(melC2) SLAV_32845(melC3) SLAV_35305(melC4)
SFK: KY5_2844c
SGE: DWG14_05427(melC2_1) DWG14_07892(melC2_2)
SRJ: SRO_4762
SNF: JYK04_07745(melC2_2) JYK04_07760(melC2_3)
SHUN: DWB77_04340(melC2_1) DWB77_06688(melC2_2)
SCYG: S1361_03250(melC1) S1361_14845(melC2)
SAUH: SU9_033190
SXT: KPP03845_106703(melC2_1) KPP03845_106718(melC2_2)
SMIB: SMIR_39840
FAL: FRAAL0531
SESP: BN6_45030(melC2)
ALO: CRK59534
ACTU: Actkin_04030(melC2)
ASE: ACPL_5017(griF)
ACTS: ACWT_4887
RXY: Rxyl_1947
AMR: AM1_B0356
NSH: GXM_05756
CTHE: Chro_3115
LUI: llg_31770
GAW: V144x_27600(griF)
FTJ: FTUN_5759
SACI: Sinac_0162
SUS: Acid_5081
ABAC: LuPra_00956 LuPra_02564(melC2)
FLN: FLA_2632
DFE: Dfer_1836
CBAL: M667_12305
CBAT: M666_12215
KOS: KORDIASMS9_02290(melC2)
TAA: NMY3_00348(griF) NMY3_03193(melC2)
 » show all
Reference
PMID:1903356
  Authors
Giebel LB, Strunk KM, Spritz RA
  Title
Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment.
  Journal
Genomics 9:435-45 (1991)
DOI:10.1016/0888-7543(91)90409-8
  Sequence
[hsa:7299]
LinkDB

KEGG   ENZYME: 1.14.18.1
Entry
EC 1.14.18.1                Enzyme                                 
Name
tyrosinase;
monophenol monooxygenase;
phenolase;
monophenol oxidase;
cresolase;
monophenolase;
tyrosine-dopa oxidase;
monophenol monooxidase;
monophenol dihydroxyphenylalanine:oxygen oxidoreductase;
N-acetyl-6-hydroxytryptophan oxidase;
monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase;
o-diphenol:O2 oxidoreductase;
phenol oxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
L-tyrosine,L-dopa:oxygen oxidoreductase
Reaction(IUBMB)
(1) L-tyrosine + O2 = dopaquinone + H2O (overall reaction);
(1a) L-tyrosine + 1/2 O2 = L-dopa [RN:R00031];
(1b) L-dopa + 1/2 O2 = dopaquinone + H2O;
(2) 2 L-dopa + O2 = 2 dopaquinone + 2 H2O [RN:R00045]
Reaction(KEGG)
Substrate
L-tyrosine [CPD:C00082];
O2 [CPD:C00007];
L-dopa [CPD:C00355]
Product
dopaquinone [CPD:C00822];
H2O [CPD:C00001];
L-dopa [CPD:C00355]
Comment
A type III copper protein found in a broad variety of bacteria, fungi, plants, insects, crustaceans, and mammals, which is involved in the synthesis of betalains and melanin. The enzyme, which is activated upon binding molecular oxygen, can catalyse both a monophenolase reaction cycle (reaction 1) or a diphenolase reaction cycle (reaction 2). During the monophenolase cycle, one of the bound oxygen atoms is transferred to a monophenol (such as L-tyrosine), generating an o-diphenol intermediate, which is subsequently oxidized to an o-quinone and released, along with a water molecule. The enzyme remains in an inactive deoxy state, and is restored to the active oxy state by the binding of a new oxygen molecule. During the diphenolase cycle the enzyme binds an external diphenol molecule (such as L-dopa) and oxidizes it to an o-quinone that is released along with a water molecule, leaving the enzyme in the intermediate met state. The enzyme then binds a second diphenol molecule and repeats the process, ending in a deoxy state [7]. The second reaction is identical to that catalysed by the related enzyme catechol oxidase (EC 1.10.3.1). However, the latter can not catalyse the hydroxylation or monooxygenation of monophenols.
History
EC 1.14.18.1 created 1972, modified 1976, modified 1980 (EC 1.14.17.2 created 1972, incorporated 1984), modified 2012
Pathway
ec00350  Tyrosine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00505  tyrosinase
Genes
HSA7299(TYR)
PTR451473(TYR)
PPS100989128(TYR)
GGO101148846(TYR)
PON100453479(TYR)
PPYG129007943(TYR)
NLE100594055 115838630
HMH116477395(TYR)
SSYN129483935(TYR)
MCC705792(TYR)
MCF102141480(TYR)
MTHB126934746
MNI105468895(TYR)
CSAB103248194(TYR)
CATY105592966(TYR)
PANU101020866(TYR)
TGE112606374(TYR)
MLEU105543124(TYR)
RRO104657434(TYR)
RBB108539149(TYR)
TFN117080742(TYR)
PTEH111540685(TYR)
CANG105509297(TYR)
CJC100399713(TYR)
SBQ101043674(TYR)
CIMI108296777
ANAN105711938(TYR)
CSYR103255375(TYR)
MMUR105865099(TYR)
LCAT123642237(TYR)
PCOQ105808221(TYR)
OGA100962911(TYR)
MMU22173(Tyr)
MCAL110298406(Tyr)
MPAH110327286(Tyr)
RNO308800(Tyr)
MCOC116100639(Tyr)
ANU117711951(Tyr)
MUN110565894(Tyr)
CGE100752294
MAUA101840761(Tyr)
PROB127227250(Tyr)
PLEU114682739(Tyr)
MORG121453201(Tyr)
MFOT126491512
AAMP119803035(Tyr)
NGI103743041(Tyr)
HGL101696609(Tyr)
CPOC100713552(Tyr)
DORD105983956(Tyr)
DSP122116277(Tyr)
PLOP125361622(Tyr)
NCAR124960121
MMMA107160413(Tyr)
OCU100008753(TYR)
OPI101520677(TYR)
TUP102485831(TYR)
GVR103600166(TYR)
CFA403405(TYR)
CLUD112641956(TYR)
VVP112932288(TYR)
VLG121476446(TYR)
NPO129506715(TYR)
AML100475022(TYR)
UMR103675370(TYR)
UAH113269420(TYR)
UAR123792343(TYR)
ELK111154441
LLV125078919
MPUF101683509(TYR)
MNP132012084(TYR)
MLK131839453(TYR)
NVS122912503(TYR)
ORO101363864(TYR)
EJU114199718(TYR)
ZCA113914930(TYR)
MLX118013459(TYR)
NSU110570998(TYR)
LWW102742435(TYR)
FCA751100(TYR)
PYU121039397(TYR)
PCOO112866043(TYR)
PBG122483228(TYR)
PVIV125146819(TYR)
LRUF124504571
PTG102957473(TYR)
PPAD109267329(TYR)
PUC125929456
AJU106967790
HHV120246243(TYR)
BTA280951(TYR)
BOM102272000(TYR)
BIU109554196(TYR)
BBUB102408280(TYR)
BBIS104993808(TYR)
CHX102182281(TYR)
OAS780502(TYR)
BTAX128069103(TYR)
ODA120874821(TYR)
CCAD122431382(TYR)
MREE136168964(TYR)
MBEZ129548563(TYR)
SSC407745(TYR)
CFR102509800(TYR)
CBAI105083516(TYR)
CDK105088592(TYR)
VPC102543612(TYR)
BACU103016545(TYR)
BMUS118899345(TYR)
LVE103083618 103090680
OOR101280655(TYR)
DLE111184818(TYR)
PCAD102989004(TYR)
PSIU116757930(TYR)
NASI112410924(TYR)
ECB100060227(TYR)
EPZ103547855(TYR)
EAI106822679(TYR)
MYB102260258(TYR)
MYD102762530(TYR)
MMYO118662722(TYR)
MLF102430118(TYR)
MDT132240690(TYR)
PKL118713257(TYR)
EFUS103296990(TYR)
MNA107532399(TYR)
DRO112316020(TYR)
SHON118984758(TYR)
AJM119043575(TYR)
PDIC114500350(TYR)
PHAS123805508(TYR)
MMF118628030(TYR)
PPAM129072658(TYR)
HAI109374039(TYR)
RFQ117030409(TYR)
PALE102894376(TYR)
PGIG120590532(TYR)
PVP105294192(TYR)
RAY107514939(TYR)
MJV108390598(TYR)
TOD119254714(TYR)
SARA101538402(TYR)
SETR126019139(TYR)
LAV100676924(TYR)
TMU101358815
ETF101660164(TYR)
DNM101436149(TYR)
MDO100010166(TYR)
GAS123238815(TYR)
SHR100928294(TYR)
AFZ127555166
PCW110213345(TYR)
TVP118838649(TYR)
PBRV138148355(TYR)
OAA100080574(TYR)
GGA373971(TYR)
PCOC116241921(TYR)
MGP100538462(TYR)
CJO107308457(TYR)
TPAI128074250(TYR)
LMUT125691153(TYR)
NMEL110390794(TYR)
APLA101791683(TYR)
ACYG106034185(TYR)
CATA118245940(TYR)
AFUL116501296(TYR)
TGU100225893(TYR)
LSR110478390(TYR)
SCAN103827249(TYR)
PMOA120506781(TYR)
OTC121340987(TYR)
PRUF121362296(TYR)
GFR102035437(TYR)
FAB101814779(TYR)
OMA130255126(TYR)
PHI102104800(TYR)
PMAJ107199861(TYR)
CCAE111924932(TYR)
CCW104690323(TYR)
CBRC103616715(TYR)
ETL114063514(TYR)
ZAB102073575(TYR)
ZLE135459902(TYR)
ACHL103798447
SVG106853986(TYR)
MMEA130577944(TYR)
HRT120748820(TYR)
SATI136374071(TYR)
FPG101915664(TYR)
FCH102054260(TYR)
CCRI104166714(TYR)
NNT104405533(TYR)
SHAB115603879(TYR)
ACUN113480760(TYR)
TALA104361858(TYR)
ACHC115353600(TYR)
HALD104317037(TYR)
HLE104838488(TYR)
AGEN126048436
GCL127028421
CSTI104561248(TYR)
LDI104344032(TYR)
MNB103779458(TYR)
DPUB104301160(TYR)
PPUS135173518(TYR)
AVIT104268688(TYR)
BRHI104496235(TYR)
EGZ104128835(TYR)
NNI104017355(TYR)
PCRI104025917(TYR)
PCAO104050100(TYR)
PADL103926027(TYR)
AFOR103904764(TYR)
FGA104069806(TYR)
GSTE104263230(TYR)
CLV102093703(TYR)
MUI104539276(TYR)
PGUU104465724(TYR)
PLET104627842(TYR)
EHS104503590(TYR)
CMAC104473847(TYR)
CUCA104064099(TYR)
TEO104370913(TYR)
BREG104632917(TYR)
OHA104327638(TYR)
ACAR104522941(TYR)
CPEA104393152(TYR)
CVF104283043(TYR)
RTD128904187(TYR)
AAM106495505(TYR)
AROW112973714(TYR)
NPD112951483(TYR)
TGT104579092(TYR)
DNE112988550(TYR)
SCAM104153274(TYR)
ASN102385049(TYR)
AMJ102560883(TYR)
CPOO109306793(TYR)
GGN109303235(TYR)
PSS102454532(TYR)
CMY102935011(TYR)
CCAY125632955(TYR)
DCC119843677(TYR)
CPIC101935010(TYR)
TST117871862(TYR)
CABI116818084(TYR)
MRV120383812(TYR)
ACS100552257(tyr)
ASAO132772243(TYR)
PVT110088582(TYR)
SUND121926332(TYR)
PBI103060005(TYR) 103063605
PMUR107286363(TYR)
CTIG120307809(TYR)
TSR106547651(TYR)
PGUT117660003(TYR)
APRI131199856(TYR)
PTEX113440467(TYR)
NSS113420140(TYR)
VKO123029400(TYR)
PMUA114595291(TYR)
PRAF128412528(TYR)
ZVI118085685(TYR)
HCG128349049(TYR)
GJA107119489(TYR)
STOW125431508(TYR)
EMC129326090(TYR)
XLA100158309 108704650 108708762 108710021 108719638 108719639 121395206
XTR100125152(tyr) 100486242 100492641
NPR108792805 108792810 108794763(TYR) 108801245 108803423 108804169
RTEM120920386 120920756 120920840 120921028 120921029 120928838 120928968(TYR) 120941784 120941786
BBUF120981433 120981998 120981999 120982591 120982592 120982593 120982594 120992318 120994196(TYR) 120996662 120996663 121002078 121002080
BGAR122921761 122921791 122921836 122921846 122921943 122921986 122922023 122922217 122923300(TYR) 122931738 122931739 122932707
MUO115467853(TYR)
GSH117362868(TYR)
DRE30207(tyr)
SRX107731812 107737432(tyr)
SANH107669900 107670098
SGH107558837(tyr)
CCAR109077077 109082593
CAUA113058766 113100299 113114712
CGIB128029069
PTET122358820(tyr)
LROH127177360(tyr)
OMC131554175(tyr)
PPRM120470727(tyr)
RKG130101119(tyr)
MAMB125248595(tyr)
CIDE127496052
CERY137004332(tyr)
MASI127422597 127429874
TROS130564732(tyr)
TDW130428409(tyr)
MANU129438659(tyr)
IPU100304491 108277956(tyr)
IFU128620020 128621333(tyr)
PHYP113543610 113544601
SMEO124393257 124394828(tyr)
TFD113637826(tyr) 113659178
TVC132857969(tyr) 132863019
TRN134332925 134334725(tyr)
AMEX103040843(tyr) 103041136
CMAO118800559(tyr) 118824597
EEE113578741(tyr) 113581657
TRU101064772(tyr) 101080145
TFS130521098 130535552(tyr) 130537493
TNGGSTEN00010318G001 GSTEN00018906G001
LCO104920119(tyr)
NCC104963013(tyr)
TBEN117470246(tyr) 117490431
CGOB115017793(tyr) 115018879
PGEO117457806(tyr) 117458840
GACU117534898(tyr) 117535274
EMAC134871964 134880315(tyr)
ELY117253957 117260186(tyr) 117272046
EFO125888825(tyr) 125898293 125899546
PLEP121943428(tyr) 121943933 121952100
SLUC116037037 116048241(tyr)
ECRA117942457(tyr) 117954992
ESP116687073(tyr) 116700242
PFLV114552647(tyr) 114566690
GAT120822041 120828666(tyr)
PPUG119213809(tyr) 119215419
AFB129091276(tyr) 129113883
CLUM117741431(tyr) 117742834
PSWI130189390 130211087(tyr)
CANA137790492(tyr) 137803064
CVE137876404 137877541(tyr)
MSAM119883400(tyr) 119895337
SCHU122878052 122879443(tyr) 122888177
CUD121518828 121524120(tyr)
ALAT119006367(tyr) 119030940
ASTR137596608(tyr) 137606556
MZE101476383 101480088
ONL100700374 100707700(tyr)
OAU116322990(tyr) 116331461
OLA100049427(tyr) 101171514
OML112139508 112150029(tyr)
CSAI133441684(tyr) 133459415
XMA102216777 102222951(tyr)
XCO114153091 114161843(tyr)
XHE116708061(tyr) 116728342
PRET103474486(tyr) 103475522
PFOR103140502 103146266(tyr)
PLAI106950591 106958863(tyr)
PMEI106914104 106918015(tyr)
GAF122833005(tyr) 122844839
PPRL129359260(tyr) 129368489
CVG107087918 107091929(tyr)
CTUL119771817(tyr) 119783464
GMU124876592 124884508(tyr)
NFU107380455(tyr) 107386962
KMR108236980 108244618(tyr)
ALIM106514125 106517255(tyr)
NWH119411088(tyr) 119420008
AOCE111565888 111572659(tyr) 111573059
MCEP125014064(tyr) 125021303
CSEM103378543(tyr) 103395402
POV109634605(tyr) 109635738
SSEN122773016(tyr) 122779548
HHIP117772813(tyr) 117773990
HSP118106457(tyr) 118122668
PPLT128440257(tyr)
SMAU118299879(tyr) 118301560
LCF108886621 108888021 108893275
SDU111217124 111220162 111224123(tyr) 111238342
SLAL111651624 111655308(tyr) 111664331 111668310
XGL120792070(tyr) 120794477 120802701
HCQ109509733 109525374(tyr)
SSCV125972234(tyr) 125982324
SBIA133491776 133504590(tyr)
PEE133404965(tyr) 133416504
PTAO133467407 133482359(tyr)
BPEC110158560 110174305(tyr)
MALB109959313 109971605(tyr)
BSPL114868616(tyr) 114868934
SJO128358013 128360949(tyr) 128371889
SASA100136546 106569882 106588324
STRU115173621 115176221 115206586
OTW112232177 112267296(tyr)
OMY100135825 100135828(tyr)
OGO124005778(tyr) 124013126 124044371
ONE115117118 115128456
OKI109908450 109909722
OKE118381912(tyr) 118398111 118399383
SALP111955187 112073729
SNH120022663 120027332 120028905(tyr)
CCLU121567810 121572854 121585699
ELS105024066(tyr) 105026640
SFM108923732 108932465(tyr)
PKI111833935 111854373
AANG118209325(tyr) 118232067 118235116
LOC102687207(tyr)
PSPA121302601(tyr)
ARUT117404921 117405438 117406512 117414286 117965811
PSEX120519559
LCM102365572(TYR)
CMK103185187(tyr)
RTP109921379(tyr)
CPLA122550589(tyr)
HOC132814808 132814809 132814810 132816707(tyr)
LERI129698248(tyr)
PMRN116953350(TYR)
LRJ133351432(TYR)
BFO118403552 118403555 118403626 118405245 118406129 118406482 118410197 118414777 118417650 118420461 118421210 118432227
BBEL109465224 109465439 109465936 109466145 109473472 109476713
CIN100179878 100182881 100183064
SCLV120342909
SKO100368593 100368747 100376573 100376875
DMEDmel_CG42639(PPO1) Dmel_CG42640(PPO3)
DER6546722 6547312
DSE6609708
DSIDsimw501_GD11733(Dsim_GD11733) Dsimw501_GD25430(Dsim_GD25430)
DYADyak_GE10651 Dyak_GE13951 Dyak_GE14257
DAN6496059
DSR110177925
DPO4804100
DPE6589981
DMN108160538
DWI6643368
DGR6560300
DMODmoj_GI19287
DAZ108616230
DNV108654794
DHE111597672
DVI6626051
CCAT101460986
BOD106627200 106627223
BDR105227781 105227782
RZE108366181
AOQ129245195 129245436
TDA119674737 119683236
MDE101900449 131804257
SCAC106088616 106088618
LCQ111686529 111687025
LSQ119602309 119602310 119602311
GFS119639699
ECOE129949398
CLON129610838 129610839
HIS119646185
AGA1269042 1275792 1275799 1276915
ACOZ120947481 120947482 120947981 120951745
AARA120895449 120897988 120897990
AMER121592419 121592420 121592421 121593435
ASTE118509466 118511824 118511833
AFUN125772415
AMOU128301355 128302199 128304807
AALI118464146 118465171
AAG5566258 5566259 5574118 5575359 5575366 5578062
AALB109408587 109408601 109423853 109423856 109431713 109431716 115260125 115267476 115267500 115267501 115269621 115270199 115270200 115270202
ASUA134211140 134211486 134211487 134211488 134215173 134215447
CQUCpipJ_CPIJ005078 CpipJ_CPIJ005187 CpipJ_CPIJ009877 CpipJ_CPIJ009878 CpipJ_CPIJ016563 CpipJ_CPIJ016564
CPII120412910 120413405 120413408 120413414 120413423 120417857
CNS116351145
BCOO119066132 119075318 119081277 119083655
LLL129792737 129792738
PPAP129801388
DSM124412090
NPT124224816
NFB124187883
NLO107224379
NVG124301309
CSEC111863773
FCD110850352
PVM113827912
PJA122244459 122244460 122245324 122251425 122256095 122264827 122264830
PCHN125031336 125045898 125045899 125046082 125046086 125046091 125046093 125046164 125046223 125046228 125046232 125046233 125046236 125046240 125046244 125046247
PMOO119583423
HAME121862863 121862864 121862865 121862866 121862867 121877318 121877332 121877417 121877419 121877420 121877421 121877422 121879283 121879296 121880036 121880042 121880057 121880137
PCLA123746131 123746134 123746135 123760021 123760023 123760024 123760025 123760026 123760027 123763667 123763670 123773414 123773415 123773416 123773417 123773418 123773420 123773421 123773422 123773423
CQD128685078 128692748 128692754 128692760 128693499 128694368 128694464 128694465 128694466 128694467 128694468 128694471 128694472 128694473 128694474
PTRU123505735 123510903 123510904 123513867 123516769 123516775 123519961 123519962 123519963 123519964 123519966 123519969 123519970
ESN126981081 126981089 126981097 126981104 126981111 126981139 126988766 126988767 126988768 126988770 126988771 126988772 126988773 126988774 126988775 127001575 127005376
HAZT108679769
TUT107369608
CSCU111641656
PTEP107444762
UDV129216085 129231827 129233050
SDM118205071
LPOL106459573 106466062
CELCELE_C34G6.2(tyr-4)
CBRCBG_04025(Cbr-tyr-4)
CRQGCK72_001023
NAINECAME_02535
BMYBM_BM3483(Bm3483)
LOALOAG_01721 LOAG_01722
PCAN112576568
GAE121390964
HRJ124268408
CRG105320011 105329244
CANU128187051
CVN111137395 111137397
OED125682877
MYI110440429 110453410
PMAX117337450 117338000
MMER123535176
RPHI132742487
MAEA128244825
OBI106867101 106875468
OSN115219783
LJP135462975 135462978 135463034
SMMSmp_013540 Smp_050270
SHXMS3_00005233
OVIT265_06081 T265_07191 T265_08937
LLON135487855
EPA110236302 110240416 110247811 110249873
ATEN116287291 116297103 116298694 116298734 116305009 116305999
ADF107334638 107353911 107356803
AMIL114967052 114972254
PDAM113670632 113677267 113679449 113682212 113682213 113682241 113682242
SPIS111323206 111327271 111329757 111332088 111339209 111347611
DGT114521715 114523285 114525179 114528374 114528375 114540274
XEN124434147 124434150 124434367 124446883 124452199 124456338
HSY130639731 130639757 130642685 130642711 130650855
NCRNCU00776(T) NCU05762 NCU08615 NCU09199 NCU10031 NCU10865 NCU11382
NTENEUTE1DRAFT103253(NEUTE1DRAFT_103253) NEUTE1DRAFT117718(NEUTE1DRAFT_117718) NEUTE1DRAFT118745(NEUTE1DRAFT_118745) NEUTE1DRAFT124197(NEUTE1DRAFT_124197) NEUTE1DRAFT125579(NEUTE1DRAFT_125579) NEUTE1DRAFT93419(NEUTE1DRAFT_93419)
SMP10802107(SMAC4_09195) 10805042(SMAC4_04920) 10808536(SMAC4_04270) 10808577(SMAC4_04313) 10808704(SMAC4_06010) 10809071(SMAC4_00012) 10810251(SMAC4_01459) 10810296(SMAC4_01505) 10810380(SMAC4_01592)
PANPODANS72p219 PODANSg09832 PODANSg10078 PODANSg1860 PODANSg2196 PODANSg2296 PODANSg2513 PODANSg2609 PODANSg315 PODANSg3516 PODANSg4057 PODANSg4293 PODANSg6905 PODANSg7297
PBELQC761_105740 QC761_108060 QC761_115850 QC761_118030 QC761_121700 QC761_300460 QC761_300971 QC761_506690 QC761_507480 QC761_510090 QC761_510410 QC761_602370 QC761_603730 QC761_610120 QC761_610400 QC761_700690
PPSDQC762_0075280 QC762_105740 QC762_108060 QC762_115850 QC762_118030 QC762_121700 QC762_300460 QC762_300971 QC762_506690 QC762_507480 QC762_510090 QC762_510410 QC762_602370 QC762_603730 QC762_610120 QC762_610400 QC762_700690
PPSPQC763_0039550 QC763_105740 QC763_108060 QC763_115850 QC763_118030 QC763_121700 QC763_300460 QC763_300971 QC763_506690 QC763_507480 QC763_510090 QC763_510410 QC763_602370 QC763_603730 QC763_610120 QC763_610400 QC763_700690
PPSAQC764_105740 QC764_108060 QC764_115850 QC764_118030 QC764_121700 QC764_300460 QC764_300971 QC764_506690 QC764_507480 QC764_510090 QC764_510410 QC764_602370 QC764_603730 QC764_610120 QC764_610400 QC764_700690
TTTTHITE_124715 THITE_125575 THITE_2037172 THITE_2040058 THITE_2046868 THITE_2056637 THITE_2088815 THITE_2118068 THITE_2131928 THITE_62739
MTMMYCTH_2029356 MYCTH_2063591 MYCTH_2066939 MYCTH_2117807 MYCTH_2297253 MYCTH_44230 MYCTH_53288 MYCTH_60685 MYCTH_71063 MYCTH_76199
CTHRCTHT_0006300 CTHT_0018720 CTHT_0047000 CTHT_0054510 CTHT_0072520
MGRMGG_01571 MGG_02508 MGG_03962 MGG_05862 MGG_05914 MGG_06169 MGG_07419 MGG_07585 MGG_08455 MGG_09614 MGG_10561 MGG_10585 MGG_11274 MGG_11545 MGG_13937 MGG_14157 MGG_14598
PPEIPpBr36_00685 PpBr36_01090 PpBr36_02328 PpBr36_02591 PpBr36_02685 PpBr36_02731 PpBr36_03009 PpBr36_04432 PpBr36_05465 PpBr36_05572 PpBr36_10017 PpBr36_10043 PpBr36_10084 PpBr36_10675 PpBr36_10726
PGRIPgNI_00043 PgNI_00061 PgNI_01695 PgNI_02134 PgNI_02259 PgNI_02311 PgNI_02460 PgNI_02818 PgNI_03926 PgNI_05427 PgNI_06966 PgNI_08727 PgNI_11020 PgNI_11047 PgNI_11104 PgNI_12502
TMNUCRPA7_237 UCRPA7_2909 UCRPA7_3211 UCRPA7_3344 UCRPA7_371 UCRPA7_4229 UCRPA7_5596 UCRPA7_6194 UCRPA7_7423
SSCKSPSK_03114 SPSK_03125 SPSK_06106 SPSK_06304 SPSK_06317 SPSK_06500
FGRFGSG_01988 FGSG_03348 FGSG_03531 FGSG_03801 FGSG_04510 FGSG_04869 FGSG_05628 FGSG_08007 FGSG_09522 FGSG_11106 FGSG_11420 FGSG_11450 FGSG_11517 FGSG_11528
FPUFPSE_02368 FPSE_03294 FPSE_03345 FPSE_03736 FPSE_04043 FPSE_04474 FPSE_04575 FPSE_04679 FPSE_05743 FPSE_06220 FPSE_09325 FPSE_11583 FPSE_12166
FPOAFPOAC1_000058 FPOAC1_002118 FPOAC1_004095 FPOAC1_005287 FPOAC1_005720 FPOAC1_005917 FPOAC1_006217 FPOAC1_006996 FPOAC1_007384 FPOAC1_007676 FPOAC1_008055 FPOAC1_009825 FPOAC1_012139
FVNFVRRES_00179 FVRRES_02361 FVRRES_04518 FVRRES_04753 FVRRES_06293 FVRRES_06526 FVRRES_06819 FVRRES_07631 FVRRES_08050 FVRRES_08148 FVRRES_08618 FVRRES_10474 FVRRES_10873 FVRRES_10899 FVRRES_13213 FVRRES_13785
FVRFVEG_01614 FVEG_03534 FVEG_03589 FVEG_04071 FVEG_06859 FVEG_07441 FVEG_07596 FVEG_07657 FVEG_08309 FVEG_09948 FVEG_10660 FVEG_11137 FVEG_11735 FVEG_12404 FVEG_12513 FVEG_12936 FVEG_13776
FOXFOXG_04315 FOXG_04561 FOXG_05674 FOXG_06218 FOXG_07401 FOXG_09259 FOXG_13704 FOXG_16885 FOXG_16980 FOXG_18401 FOXG_20392
NHENECHADRAFT_47204 NECHADRAFT_66755 NECHADRAFT_75769 NECHADRAFT_77359 NECHADRAFT_83487 NECHADRAFT_85924 NECHADRAFT_87703 NECHADRAFT_98192
FFCNCS54_00192800 NCS54_00297000 NCS54_00358600 NCS54_00637300 NCS54_01027200 NCS54_01252300 NCS54_01412000 NCS54_01437900
FKRNCS57_00191000 NCS57_00292200 NCS57_00364100 NCS57_00676300 NCS57_01020500 NCS57_01257400 NCS57_01393600 NCS57_01420700 NCS57_01447700
FMUJ7337_003603 J7337_004077 J7337_007845 J7337_007985 J7337_009520 J7337_010136 J7337_010329 J7337_010558 J7337_011983 J7337_012195 J7337_013242 J7337_013697
TRETRIREDRAFT_45445 TRIREDRAFT_50793
TRRM419DRAFT_142431 M419DRAFT_96450
TATV25776692(TrAtP1_012215) 25777593(TrAtP1_007661) 25780128(TrAtP1_010231)
TASP36609524(TrAFT101_010490) 36612211(TrAFT101_009492) 36615182(TrAFT101_007774) 36616461(TrAFT101_009487)
MAW19247028(J3458_000472) 19247267(J3458_022097) 19247976(J3458_005087) 19250027(J3458_015295) 19252269(J3458_021163) 90964211(J3458_021199)
MAJMAA_02091 MAA_07723 MAA_08523 MAA_08534 MAA_08673 MAA_09216 MAA_10022 MAA_10530 MAA_10801
MBRN26238408(ustQ_0) 26239659(TYR) 26242521(tyr1_1) 26243569(tyr1_2) 26246866(ustQ_1) 26247267(orsC_1) 26247667(orsC_0)
PCHMVFPPC_00193 VFPPC_12090
CMTCCM_02058 CCM_07390 CCM_08750 CCM_09562
AMUSLMH87_003120 LMH87_004738 LMH87_005347 LMH87_009957
PLJ28883541(PLICBS_000498) 28892626(PLICBS_006597)
PTKZJDV02_004516 JDV02_007774 JDV02_009614 JDV02_010762
VALVDBG_01849 VDBG_02571 VDBG_05486 VDBG_07262 VDBG_08159 VDBG_09565 VDBG_10207
VDAVDAG_03034 VDAG_04798 VDAG_05971 VDAG_07137 VDAG_09765 VDAG_10051 VDAG_10407
CFJCFIO01_00121 CFIO01_00408 CFIO01_00576 CFIO01_00750 CFIO01_01072 CFIO01_01415 CFIO01_02736 CFIO01_03356 CFIO01_03581 CFIO01_03721 CFIO01_03730 CFIO01_03763 CFIO01_05091 CFIO01_05143 CFIO01_05264 CFIO01_05576 CFIO01_05578 CFIO01_05880 CFIO01_06632 CFIO01_07362 CFIO01_07616 CFIO01_08986 CFIO01_10726 CFIO01_10964 CFIO01_11228 CFIO01_11905 CFIO01_12464
CLUPCLUP02_02097 CLUP02_04310 CLUP02_04575 CLUP02_05823 CLUP02_06789 CLUP02_07485 CLUP02_08488 CLUP02_12699 CLUP02_12701 CLUP02_13192 CLUP02_14108 CLUP02_15690 CLUP02_16424 CLUP02_17169 CLUP02_17264 CLUP02_17940
CHIGCH63R_00879 CH63R_00885 CH63R_01093 CH63R_01806 CH63R_03193 CH63R_03403 CH63R_05148 CH63R_05546 CH63R_05602 CH63R_07020 CH63R_07299 CH63R_07609 CH63R_10826 CH63R_12386 CH63R_13047 CH63R_13626 CH63R_13766 CH63R_14094 CH63R_14356 CH63R_14563
CDET87936518(CDEST_00015) 87938025(CDEST_01522) 87938242(CDEST_01739) 87939604(CDEST_03101) 87939610(CDEST_03107) 87939836(CDEST_03333) 87942221(CDEST_05718) 87943905(CDEST_07402) 87944196(CDEST_07693) 87944479(CDEST_07976) 87944521(CDEST_08018) 87944815(CDEST_08312) 87947207(CDEST_10707) 87947348(CDEST_10848) 87947666(CDEST_11166) 87948520(CDEST_12020) 87948574(CDEST_12074) 87949534(CDEST_13034) 87949803(CDEST_13303) 87951267(CDEST_14767)
SAPOSAPIO_CDS0763 SAPIO_CDS0817 SAPIO_CDS10283 SAPIO_CDS10337 SAPIO_CDS1849 SAPIO_CDS2486 SAPIO_CDS4183 SAPIO_CDS4560 SAPIO_CDS4594 SAPIO_CDS5307 SAPIO_CDS5719 SAPIO_CDS5814 SAPIO_CDS6610 SAPIO_CDS6711
ELAUCREL1_10730 UCREL1_11048 UCREL1_11569 UCREL1_2086 UCREL1_4052 UCREL1_4692 UCREL1_4892 UCREL1_5309 UCREL1_6142 UCREL1_9156 UCREL1_9820
PFYPFICI_00306 PFICI_00735 PFICI_00910 PFICI_01304 PFICI_01382 PFICI_01616 PFICI_01627 PFICI_01793 PFICI_02433 PFICI_02434 PFICI_02467 PFICI_02608 PFICI_03069 PFICI_03179 PFICI_03197 PFICI_03209 PFICI_03416 PFICI_03705 PFICI_03761 PFICI_03798 PFICI_04036 PFICI_04774 PFICI_05651 PFICI_05780 PFICI_06059 PFICI_06134 PFICI_06895 PFICI_07585 PFICI_08399 PFICI_09482 PFICI_09806 PFICI_09835 PFICI_10646 PFICI_10811 PFICI_11301 PFICI_11659 PFICI_11715 PFICI_12414 PFICI_12415 PFICI_12515 PFICI_12711 PFICI_13172 PFICI_14066 PFICI_14194 PFICI_14411 PFICI_14680 PFICI_14681 PFICI_14867 PFICI_14984
SSLSS1G_01576 SS1G_04725 SS1G_13364 SS1G_14461
BFUBCIN_01g08630 BCIN_02g02120 BCIN_03g00690 BCIN_03g07730 BCIN_06g00420 BCIN_11g02170 BCIN_13g02250 BCIN_14g05570 BCIN_15g03960 BCIN_15g05090 BCIN_16g01460
MBEMBM_00428 MBM_00926 MBM_01261 MBM_01908 MBM_04238 MBM_05368 MBM_06721 MBM_07856 MBM_08430 MBM_09162 MBM_09776
PSCOLY89DRAFT_143304 LY89DRAFT_395176 LY89DRAFT_50069 LY89DRAFT_576321 LY89DRAFT_577417 LY89DRAFT_579440 LY89DRAFT_595981 LY89DRAFT_637354 LY89DRAFT_642764 LY89DRAFT_686719 LY89DRAFT_693452 LY89DRAFT_697902 LY89DRAFT_708542 LY89DRAFT_708689 LY89DRAFT_731629 LY89DRAFT_736605 LY89DRAFT_760926 LY89DRAFT_771157
GLZGLAREA_01250 GLAREA_02296 GLAREA_02544 GLAREA_04289 GLAREA_04332 GLAREA_05981 GLAREA_06285 GLAREA_07225 GLAREA_07417 GLAREA_07673 GLAREA_09792 GLAREA_09918 GLAREA_10602 GLAREA_11779 GLAREA_12180 GLAREA_12218 GLAREA_12491
ANIANIA_00231(ivoB) ANIA_01318 ANIA_02799 ANIA_05311 ANIA_09388
AFMAFUA_1G17430 AFUA_3G01070 AFUA_4G13780
ACTACLA_008160 ACLA_052770 ACLA_059670 ACLA_063650
NFINFIA_001930 NFIA_007900 NFIA_045560 NFIA_102590
AORAO090001000117 AO090001000383 AO090010000557 AO090012000590 AO090023000424 AO090026000145 AO090038000061 AO090113000032 AO090701000859
ANGAn01g09220 An03g00280 An09g02980 An09g05130 An12g01670 An15g07670
AFVAFLA_002308 AFLA_005378 AFLA_006159 AFLA_006771 AFLA_008456 AFLA_008724 AFLA_009744 AFLA_012315 AFLA_014040
ALUCAKAW2_10018A AKAW2_20977A AKAW2_40349S AKAW2_40531A AKAW2_50055A AKAW2_60029S
ACHEACHE_21217S ACHE_40106S ACHE_41013A ACHE_50006S
APUUAPUU_10110S APUU_11902A APUU_50273S APUU_70009A APUU_70291A
PCSN7525_004501 N7525_006341 N7525_009930 N7525_010038
PDPPDIP_10310
POUPOX_b03313 POX_b03419 POX_f07688
TMFEYB26_000106 EYB26_005676 EYB26_006536
TRGTRUGW13939_00681 TRUGW13939_02323 TRUGW13939_06655 TRUGW13939_09856 TRUGW13939_09870 TRUGW13939_10638
CIMCIMG_07314 CIMG_07583 CIMG_09471
CPW9692343(D8B26_006956) 9692851(D8B26_007850) 9693535(D8B26_008230)
UREUREG_01037 UREG_04223 UREG_04846 UREG_07700 UREG_07862
ABEARB_00532
TVETRV_00392
PBLPAAG_00580 PAAG_00699 PAAG_01024 PAAG_06439 PAAG_06600 PAAG_08820
PBNPADG_01055 PADG_01336 PADG_03805 PADG_04135 PADG_04213 PADG_11373
AJEHCAG_00691 HCAG_03668 HCAG_04262 HCAG_04336 HCAG_05196 HCAG_06499 HCAG_07859
BGHBDBG_01177 BDBG_01880 BDBG_01962 BDBG_02780 BDBG_03625 BDBG_07330
PNOSNOG_01119 SNOG_03559 SNOG_04173 SNOG_04287 SNOG_04568 SNOG_06516 SNOG_08483 SNOG_09849 SNOG_12217 SNOG_12540 SNOG_13474 SNOG_13698 SNOG_14370 SNOG_15093
PTEPTT_00821 PTT_04675 PTT_06952 PTT_07434 PTT_08919 PTT_13389 PTT_13955 PTT_14992 PTT_17698 PTT_18525 PTT_19801
PTRR6338404(PtrM4_021610) 6339083(PtrM4_018500) 6339505(PtrM4_021070) 6340539(PtrM4_058880) 6340608(PtrM4_058520) 6341599(PtrM4_069970) 6343058(PtrM4_117720) 6346288(PtrM4_136270) 6347183(PtrM4_033720) 6347581(PtrM4_124720) 6349122(PtrM4_130770) 90957305(PtrM4_124910) 90958249(PtrM4_152690)
BZECOCCADRAFT_102316 COCCADRAFT_103009 COCCADRAFT_105909 COCCADRAFT_109170 COCCADRAFT_32562 COCCADRAFT_33898 COCCADRAFT_38698 COCCADRAFT_40308 COCCADRAFT_40958 COCCADRAFT_4379 COCCADRAFT_8081 COCCADRAFT_83302 COCCADRAFT_99049
BSCCOCSADRAFT_107681 COCSADRAFT_182139 COCSADRAFT_190822 COCSADRAFT_193604 COCSADRAFT_195337 COCSADRAFT_195395 COCSADRAFT_196077 COCSADRAFT_33785 COCSADRAFT_355670 COCSADRAFT_358132 COCSADRAFT_79172 COCSADRAFT_79558
BORCOCMIDRAFT_105359 COCMIDRAFT_105593 COCMIDRAFT_27821 COCMIDRAFT_29404 COCMIDRAFT_38149 COCMIDRAFT_38490 COCMIDRAFT_38979 COCMIDRAFT_39888 COCMIDRAFT_81583 COCMIDRAFT_82953 COCMIDRAFT_85451 COCMIDRAFT_98124
AALTCC77DRAFT_1007936 CC77DRAFT_1012626 CC77DRAFT_1029770 CC77DRAFT_1031012 CC77DRAFT_1032431 CC77DRAFT_1032694 CC77DRAFT_1037436 CC77DRAFT_1040043 CC77DRAFT_1057474 CC77DRAFT_1060154 CC77DRAFT_1062991 CC77DRAFT_108295 CC77DRAFT_1099203 CC77DRAFT_17420 CC77DRAFT_28637 CC77DRAFT_333754 CC77DRAFT_935643 CC77DRAFT_935744 CC77DRAFT_946375 CC77DRAFT_978718 CC77DRAFT_980510 CC77DRAFT_992059
ARABEKO05_0000579 EKO05_0000924 EKO05_0001895 EKO05_0003178 EKO05_0004493 EKO05_0005564 EKO05_0005591 EKO05_0005755 EKO05_0007990 EKO05_0009017 EKO05_0009804 EKO05_0010128 EKO05_0010571 EKO05_0010776
ZTRMYCGRDRAFT_104299(TYR) MYCGRDRAFT_111476 MYCGRDRAFT_11769 MYCGRDRAFT_39869 MYCGRDRAFT_42698 MYCGRDRAFT_43919 MYCGRDRAFT_51282 MYCGRDRAFT_70129 MYCGRDRAFT_75965 MYCGRDRAFT_77890 MYCGRDRAFT_84703 MYCGRDRAFT_86183 MYCGRDRAFT_94308
PFJMYCFIDRAFT_110418 MYCFIDRAFT_120322 MYCFIDRAFT_128367 MYCFIDRAFT_137987 MYCFIDRAFT_163142 MYCFIDRAFT_210572 MYCFIDRAFT_211783 MYCFIDRAFT_57308 MYCFIDRAFT_60660 MYCFIDRAFT_61304 MYCFIDRAFT_62451
FFUCLAFUR5_02372 CLAFUR5_03570 CLAFUR5_07573 CLAFUR5_08075 CLAFUR5_09414 CLAFUR5_10589 CLAFUR5_10659 CLAFUR5_10868 CLAFUR5_12040 CLAFUR5_12946 CLAFUR5_13723 CLAFUR5_14224 CLAFUR5_14545
CBETCB0940_02220 CB0940_03657 CB0940_03732 CB0940_04199 CB0940_05011 CB0940_05259 CB0940_05543 CB0940_06070 CB0940_06199 CB0940_07852 CB0940_10374 CB0940_10398 CB0940_10441 CB0940_10613
BCOMBAUCODRAFT_109268 BAUCODRAFT_139295 BAUCODRAFT_29922 BAUCODRAFT_36350 BAUCODRAFT_68232
NPAUCRNP2_1491 UCRNP2_2531 UCRNP2_2887 UCRNP2_3166 UCRNP2_4253 UCRNP2_5576 UCRNP2_762 UCRNP2_763 UCRNP2_8263 UCRNP2_8733
TMLGSTUM_00004221001 GSTUM_00008539001 GSTUM_00008562001
TVSTRAVEDRAFT_113592 TRAVEDRAFT_114906 TRAVEDRAFT_19801
DSQDICSQDRAFT_102354 DICSQDRAFT_166418 DICSQDRAFT_51081
PCOPHACADRAFT_259085 PHACADRAFT_262375
SHSSTEHIDRAFT_125229 STEHIDRAFT_134497 STEHIDRAFT_149781 STEHIDRAFT_149909 STEHIDRAFT_167058 STEHIDRAFT_60059 STEHIDRAFT_85636
HIRHETIRDRAFT_326548 HETIRDRAFT_384428 HETIRDRAFT_456224
PSQPUNSTDRAFT_127383 PUNSTDRAFT_74793 PUNSTDRAFT_98486
ADLAURDEDRAFT_120413 AURDEDRAFT_130706 AURDEDRAFT_158568 AURDEDRAFT_162433 AURDEDRAFT_172710 AURDEDRAFT_179545 AURDEDRAFT_179828 AURDEDRAFT_181360
FMEFOMMEDRAFT_136217 FOMMEDRAFT_92287
GTRGLOTRDRAFT_92245 GLOTRDRAFT_92246
RSXRhiXN_01179 RhiXN_01663 RhiXN_02269 RhiXN_02296 RhiXN_02337 RhiXN_05404 RhiXN_05782 RhiXN_06103 RhiXN_07540 RhiXN_07541 RhiXN_07864 RhiXN_09964 RhiXN_09966 RhiXN_09976 RhiXN_10066 RhiXN_10070 RhiXN_10078 RhiXN_11415 RhiXN_11533 RhiXN_11534 RhiXN_12287
LBCLACBIDRAFT_185727(R3) LACBIDRAFT_252993(R2) LACBIDRAFT_295069(R1)
CCICC1G_00591 CC1G_00628 CC1G_00642 CC1G_02471 CC1G_02744 CC1G_02758 CC1G_05029 CC1G_05599 CC1G_05636 CC1G_06016 CC1G_06017 CC1G_08048 CC1G_09596 CC1G_09997 CC1G_10006 CC1G_10470 CC1G_10864 CC1G_14163
ABPAGABI1DRAFT114468(AGABI1DRAFT_114468) AGABI1DRAFT114491(AGABI1DRAFT_114491) AGABI1DRAFT114493(AGABI1DRAFT_114493) AGABI1DRAFT116717(AGABI1DRAFT_116717) AGABI1DRAFT62737(AGABI1DRAFT_62737) AGABI1DRAFT85838(AGABI1DRAFT_85838)
ABVAGABI2DRAFT135027(AGABI2DRAFT_135027) AGABI2DRAFT191507(AGABI2DRAFT_191507) AGABI2DRAFT191532(AGABI2DRAFT_191532) AGABI2DRAFT194055(AGABI2DRAFT_194055) AGABI2DRAFT239416(AGABI2DRAFT_239416)
PCUBJR316_0009949
MPRMPER_00316 MPER_06625 MPER_10173 MPER_11172
MRRMoror_13743 Moror_14222 Moror_14459 Moror_16390 Moror_2848 Moror_4191 Moror_5289 Moror_5295
MOREE1B28_003052 E1B28_003053 E1B28_006242 E1B28_008888 E1B28_012975 E1B28_012985 E1B28_013014
SCMSCHCO_02601704(SCHCODRAFT_02601704)
CPUTCONPUDRAFT_159604
SLASERLADRAFT_417600 SERLADRAFT_435855 SERLADRAFT_462697
WSEWALSEDRAFT_31846 WALSEDRAFT_33078 WALSEDRAFT_33098 WALSEDRAFT_51377
WICJ056_000778 J056_004791 J056_004816
UMAUMAG_01130
PFPPFL1_02365
SGRAEX895_003755 EX895_006074
PGRPGTG_11024 PGTG_13399 PGTG_17780 PGTG_17781 PGTG_21816
PTRCPtA15_18A124 PtA15_18A155 PtA15_18A379 PtA15_6A106
PSTRPst134EA_003354 Pst134EA_026778 Pst134EA_026779 Pst134EA_026780 Pst134EA_026810 Pst134EA_027080 Pst134EA_027082 Pst134EA_031680
MLRMELLADRAFT_40700 MELLADRAFT_65069 MELLADRAFT_72825 MELLADRAFT_85700 MELLADRAFT_94290 MELLADRAFT_94291
ECUECU10_1590
EINEint_101560
EHEEHEL_101630
EROEROM_101490
NCENCER_100633
VNXVNE69_11073
FCYFRACYDRAFT_234770 FRACYDRAFT_291506(TYR1)
AAFAURANDRAFT_62829
PIFPITG_05533 PITG_09759 PITG_22861
PSOJPHYSODRAFT_254953 PHYSODRAFT_255991 PHYSODRAFT_262769 PHYSODRAFT_301135 PHYSODRAFT_332303 PHYSODRAFT_352822 PHYSODRAFT_393487 PHYSODRAFT_528364
SPARSPRG_03900 SPRG_12325 SPRG_12328 SPRG_12341 SPRG_16940 SPRG_21152
EHXEMIHUDRAFT_435727 EMIHUDRAFT_441312
EBBF652_1501
HPARAL518_13830
OPODSM2777_17095
GKNPVT67_14890
BUJBurJV3_2118
STESMG068_11050
LABLA76x_3129
LAQGLA29479_58
LCPLC55x_3156
LGULG3211_2072
LEMLEN_2997(melC2)
TAMNN4264_04995 N4264_25580
PPUNPP4_19320
PFOPfl01_3461(melC2)
PFCPflA506_4965(melC2)
PFBVO64_2552
PVRPverR02_29085
PCHEY04_12235
PCPJM49_17640
PCHPC4K32_2614
PSILPMA3_28020
PKEDLD99_17420
PGYAWU82_08750 AWU82_09940
PZEHU754_014905 HU754_027935
PMOEHV782_015130 HV782_015135 HV782_017940
PTZHU718_018670
PSHHHU773_017050
PTKEXN22_25740
PGFJ0G10_28520
PFITKJY40_18035
PKMPZ739_27625
PCUCPSH97_17540 PSH97_21785
PPAELDL65_08815
PSHSJJN09_06960 JJN09_08460
PBAMNUH87_04440 NUH87_27990
ASEII8T81_09045
ASHAG8E00_12935
PLZS4054249_13110
PALNB0W48_17090
CELLCBR65_14155
SDESde_0316
MEECPL263_08540
MPSYCEK71_19595
MISZMishRS11D_11940 MishRS11D_27280
HCHHCH_03392
MMEMarme_3962
CVICV_1618 CV_3262
CVCBKX93_07055 BKX93_21325
CHRIDK842_01180
CHRBDK843_06460
CRZD1345_11645
CHAECH06BL_23870
RSORSc0337 RSc1501
RSEF504_1861 F504_358
RPUCDC45_01730 CDC45_07720
RNCGO999_07285 GO999_14990
RSCRCFBP_11480 RCFBP_21150
RSLRPSI07_1536 RPSI07_3072
RSNRSPO_c01550(mel) RSPO_c03068
RSMCMR15_11457 CMR15_30607
RSYRSUY_22190(melC2_1) RSUY_29370(melC2_2)
RSGJK151_03685 JK151_20570
BPSBPSS1731
BPMBURPS1710b_A0806
BPLBURPS1106A_A2352
BPDBURPS668_A2490
BPSEBDL_5087(melO)
BPSMBBQ_4408(melO)
BPSUBBN_5187(melO)
BPSDBBX_4253(melO)
BPZBP1026B_II1855
BPQBPC006_II2321
BPKBBK_4451(melO)
BPSHDR55_3536(melO)
BPSABBU_4293(melO)
BPSOX996_5813(melO)
BUTX994_5374(melO)
BTEBTH_II0649
BTQBTQ_3941(melO)
BTJBTJ_4973(melO)
BTZBTL_3442(melO)
BTDBTI_3837
BTVBTHA_4444(melO)
BTHEBTN_5428(melO)
BTHMBTRA_5703(melO)
BTHADR62_5606
BTHLBG87_3396(melO)
BOKDM82_4935(melC2) DM82_5976(melO)
BOCBG90_4662(melO) BG90_5660(melC2)
BUUWS70_21370 WS70_24455 WS70_26070
BSAVWS86_25910 WS86_27555
BHGI6G56_21275
BUDAQ610_24045
BURBcep18194_C6986
BCEPAPZ15_36815
BCONNL30_37765
BUBBW23_4486(melO) BW23_6019
BSTGWT74_18825
BULBW21_5830
BURKDM992_38035
BPHBphy_4746
PHSC2L64_14670
PTSCUJ90_03110 CUJ90_05940 CUJ90_19890
CABASBC2_28520
DACDaci_1610
DTSBI380_16345
DLAI6G47_16590
COFFOZ74_03910
JAZYQ44_12220
JASFJQ89_00220
JLVG3257_11635
MASWAM586_00980
MTIMDIR46_12795
MASZC9I28_17200
MALIEYF70_16315
MUMFCL38_02120
MFLAGO485_00465
UNDUNDKW_4116
UNYUNDYM_4093
NEUNE1241
NCOAAW31_11520
NMUNmul_A0527 Nmul_A0920 Nmul_A2156
NLCEBAPG3_007900 EBAPG3_008435 EBAPG3_010310 EBAPG3_013745
NIZNNRS527_01554 NNRS527_02554
MCIMesci_2556
MOPMesop_2736
MAMMesau_02677
MESWA9K65_029890
MESPC1M53_19375
MHUAMCHK_11960
SMKSinme_5620
SMQSinmeB_5263 SinmeB_5898
SMXSM11_pC0105(mepA1) SM11_pC0156(mepA2)
SMEGC770_GR4pB025
SMDSmed_6129 Smed_6429
SFHSFHH103_03330
SKMPZL22_005469 PZL22_005523
AVFRvVAR031_20190
AVIAvi_2427
RETRHE_PD00076
RGARGR602_PB00026
RHNAMJ98_PC00117(melA)
RPHAAMC79_PC00027 AMC79_PC00097(melA)
RHXAMK02_PC00028 AMK02_PC00105(melA)
RHKKim5_PA00147(melA) Kim5_PD00094
REZAMJ99_PB00114(melA)
RJGCCGE525_30755
RRGJ3P73_31490 J3P73_34700
RLSHB780_09565
RHIZQMO80_005817
OINIAR37_02355
BJUBJ6T_51930 BJ6T_85090
BJPRN69_25295 RN69_41115
AOLS58_42440
BRCBCCGELA001_30690
BROBRAD285_3390 BRAD285_7735(melO)
BGZXH91_31910
BBETF8237_32810
BARHWN72_11285
BSEPHAP48_0000435
BBANJ4G43_027030 J4G43_047670
BGKIC762_09240
BRAZLRP30_33000
RPBRPB_2167
NWINwi_0968
NHANham_1018 Nham_2941
METM446_5336
MTEADK419_00340
MSCBN69_0277
MROSEHO51_06675
MESZLNB28_01115
BRND1F64_02265 D1F64_12490 D1F64_14240
LAPACP90_13425
LABPFJ695_12835
LABTFIU93_19085(melC2)
LAGGB0E33_25240
CMBCSW64_03300 CSW64_10860
CFHC1707_03765 C1707_11730 C1707_13170
APAHKB221_12010
SILSPO1405
RPONG3256_07580
MALGMALG_04738
SAGUCDO87_04335
RSUNHU_02308
RHMB5V46_11020
SPHFDM480_12755
SPAPH3Z74_20035
EMVHQR01_11175
ALIAZOLI_2891
AZZDEW08_16130
AOZHUE56_24420
NAOY958_25140
NCBC0V82_25060
THACCSC3H3_01670
SURSTAUR_8357
AGEAA314_02204 AA314_10041
AVMJQX13_16805 JQX13_43045
MBDMEBOL_007060
CFUSCYFUS_005445 CYFUS_008812
SCLsce8942
SAMYDB32_001184
NANNO0S08_30320
BCABCE_A0211
BCUBCAH820_B0256
BTBBMB171_P0244
BTHTH175_328p166
BWDCT694_10280
BPANNLJ82_27595
BMQBMQ_3385
BMDBMD_3389
BMHBMWSH_1797(melC1)
BMEGBG04_300(melC2)
BEOBEH_25025
PPSRI6J18_05250
ALKGMOJ78_05625
LFBC1X05_10350
MDXBTO20_18015
MFTXA26_30040
MBOKMBOE_44510
CEFCE1756
CFACCFAEC_07835(melC2)
SCOSCO2700(melC2)
SMASAVERM_1137(melC2) SAVERM_5362(melC2-2)
SGRSGR_2447(melC2-2) SGR_527(melC2-1)
SGBWQO_32205
SFISFUL_6847
SANLKZO11_24635 KZO11_36075
SCYER2B67_01595 R2B67_34505
SCBSCAB_59241(melC2) SCAB_85681(melC2B)
SSXSACTE_0308
SHYSHJG_4198
SHOSHJGH_3963
SFASfla_5963
SVESVEN_4652 SVEN_6839
SDVBN159_5596(melC2) BN159_7561 BN159_8269(melC2)
SALSSLNWT_3078 SLNWT_5696
STRPF750_0607
SCIB446_04405 B446_14305
SLVSLIV_24170(melC2)
SGUSGLAU_02720 SGLAU_12285
SVTSVTN_24175
SCWTU94_11780
SLDT261_0115 T261_8487
SLCSL103_21680
STRMM444_30700 M444_30770
SAMBSAM23877_2730(melC)
SPRISPRI_2876
SCZABE83_01635 ABE83_33420
SCXAS200_14210 AS200_28875 AS200_40770
SRWTUE45_00932(melC2_1) TUE45_03314(melC2_2)
SLEsle_45350(sle_45350)
SRNA4G23_03056(melC2)
SPAVSpa2297_11415
STRTA8713_10705
SCLFBB341_09235 BB341_30130
SGSAVL59_27390 AVL59_41165
STSIA4E84_02435 A4E84_14195
SALWCP975_18870 CP975_34810
SGMGCM10017557_54060
SCADDN051_25000 DN051_34610
SPHWNFX46_15090 NFX46_34410
SLSSLINC_0493 SLINC_3116 SLINC_6310
SPLULK06_010265 LK06_030665
STRDNI25_25425
SNWBBN63_33140
SSIAA7J05_16930
SVUB1H20_22510 B1H20_32960
SPUNBFF78_26985 BFF78_39110
SLAUSLA_4839
SALFSMD44_03252 SMD44_04375
SALJSMD11_0232 SMD11_2156 SMD11_4471
SLXSLAV_04435(melC1) SLAV_04520(melC2) SLAV_32845(melC3) SLAV_35305(melC4)
STROSTRMOE7_33875
SFKKY5_2844c
SNZDC008_11895 DC008_31765
SGEDWG14_05427(melC2_1) DWG14_07892(melC2_2)
SRJSRO_4762
SLKSLUN_35010
SGDELQ87_25180
SQZFQU76_00655 FQU76_22085
SCYAEJ357_16325 EJ357_44480
SASTCD934_21775
STIRDDW44_28445
SKACP970_28350
SGZC0216_13500 C0216_13560
SVNCP980_03950 CP980_04030
SNKCP967_32450
SHAWCEB94_02905 CEB94_14860
SRKFGW37_11240 FGW37_22855
SFICEIZ62_03330 EIZ62_14475
SGALCP966_12785 CP966_30965 CP966_33475
SSPODDQ41_29425
SVRCP971_32975
SPADDVK44_34870
SFYGFH48_26140 GFH48_37635
SAQUEJC51_05835 EJC51_18655
SGFHEP81_05088
SCAVCVT27_01085 CVT27_31670
SSEOD0Z67_09950
SRIMCP984_07200
SSUBCP968_03800 CP968_03850
SPHVF9278_01880 F9278_16050
SCINCP977_21875 CP977_30610
SFUGCNQ36_12290
SPACB1H29_23970
STSUB7R87_21695 B7R87_32880
SCHACP983_27830 CP983_40880
SGXH4W23_25780 H4W23_35650
SCOECP976_15760 CP976_40205
SSPBCP982_17385 CP982_21845
SNFJYK04_07745(melC2_2) JYK04_07760(melC2_3)
SPLACP981_04435
SBROGQF42_05870 GQF42_16430 GQF42_17135
STUIGCM10017668_24010 GCM10017668_66110
SCHFIPT68_03030 IPT68_13135
SHUNDWB77_04340(melC2_1) DWB77_06688(melC2_2)
SCYGS1361_03250(melC1) S1361_14845(melC2)
SFEUIM697_07615 IM697_25760
SLIAHA039_01420
SDWK7C20_01920
SVDCP969_14720
SCALI6J39_22265 I6J39_32740
SAUHSU9_033190
SFBCP974_16600
SPRACP972_12895
SPEUCGZ69_30745
SROIIAG44_26605
SXNIAG42_15550
SGJIAG43_10695 IAG43_20265
SANUK7396_00875
STRYEQG64_01365 EQG64_32940
SDDD9753_23130 D9753_33120
SACTDMT42_02855 DMT42_14210
SGOBtest1122_24460
SINEKI385_00440 KI385_07030
SLFJEQ17_30225 JEQ17_45085
SDECL3078_02250 L3078_16180
SAOVG3H79_18070 G3H79_23065
SDURM4V62_16430
SYANNRK68_31935 NRK68_31995
SAKBK1J60_28645 K1J60_43135
STAALDH80_06280 LDH80_15255
SNIGHEK616_78930
SCAEIHE65_29110 IHE65_43145
SSPNLXH13_15105
SCIRSTRCI_000415 STRCI_000925 STRCI_003044
SXTKPP03845_106703(melC2_1) KPP03845_106718(melC2_2)
SLONLGI35_24365
STUDSTRTU_006392
SGKPET44_29135 PET44_29205
SARGHKX69_22325 HKX69_32110
SJNRI060_27375 RI060_40870
SCYNN8I84_04285
SOVQZH56_14015 QZH56_23900
SFIYF0344_06005
SKGKJK29_24585 KJK29_37690
SCOAQU709_27720 QU709_43195
SROCRGF97_24395
SFPQUY26_19305 QUY26_24640
SCHGNRO40_16485
STTNBSL84_31835 BSL84_31905
SINNABB07_24575 ABB07_34930
KBUQ4V64_17745
STPBQR97_13135 QR97_38280
SRPAHEP86_05960
SMIBSMIR_39840
SCAJO1G22_27340 O1G22_37875
STRWQHG49_22645
STRLHEP84_05220
STSDHEP87_06100
SRPZHEP85_03855 HEP85_15025
SCHEQRN89_01490 QRN89_31825
SGLYP8A20_34735
KABB7C62_01160 B7C62_34100
KAUB6264_26070 B6264_26805
KCHO1G21_03285
STRIC7M71_020425
ABRYNYE86_23055 NYE86_35225
AGYATC03_08065
OEKFFI11_004770
MGGMPLG2_0023
MUZH4N58_08600
MHAIOHB01_37640
FRAFrancci3_0237
FALFRAAL0531
FREFranean1_0747
FSYFsymDg_3452
SESPBN6_45030(melC2)
SSYIEKG83_17370
KPHYAOZ06_01340
ALOCRK59534
ACTUActkin_04030(melC2)
ASEACPL_5017(griF)
ACTSACWT_4887
ASICQ0Z83_055090 Q0Z83_090170
AOUACTOB_002216
CATICS0771_56940
RXYRxyl_1947
AMRAM1_B0356
GLPGlo7428_0847 Glo7428_5015
GDUP0S91_16175
MPROBJP34_20610
NPUNpun_R1263 Npun_R2099
NFLCOO91_00787 COO91_08722
NSHGXM_05756
HBQQI031_01330
RIVRiv7116_1881 Riv7116_3373 Riv7116_4784
DHTNG743_21120
DCMNIES806_45180
SCYTSAMD_29630 SAMD_57720 SAMD_63740
SCYSNIES4073_28710 NIES4073_37790
BSENDP114_02280 DP114_18080
BOXDP113_02240 DP113_18015
CTHEChro_3115
FGIOP10G_2483
LUOHHL09_03665
LAMBKBB96_04140
LUIllg_31770
RMLFF011L_35240
GAWV144x_27600(griF)
GMSSOIL9_16870
FTJFTUN_5759
TSPHKIH39_18375
SACISinac_0162
GMAAciX8_2382
TSAAciPR4_2313 AciPR4_2528
SUSAcid_5081
ABACLuPra_00956 LuPra_02564(melC2)
SCORJ3U87_17570
CSACSIO70_23045
FLNFLA_2632
PROEH9L23_12150
MSABSNE25_01750
OLIFKG96_00970
DFEDfer_1836
HCUMUN79_26180
HCFMUN80_24030
RTIDC20_00365
FSDLXD69_16350
CAOCelal_3121
CBALM667_12305
CBATM666_12215
LACICW733_04575
LNUN7U66_00255
LULLPB138_05090
OLLCW732_12540
OAQDZC78_02650
KOSKORDIASMS9_02290(melC2)
MLILQLS71_016425
AQBD1818_16450
AQAD1815_14610
GAAHX109_13405
ASAGFGM00_04895
SPONHME9304_02823
ZSPMQE36_15120
CHRSEAG08_03890
CCAUEG346_02980
CCAOH5J24_06275
NIRNSED_00525
NKRNKOR_02315
NUEC5F50_10960
NICDSQ20_07055
TAANMY3_00348(griF) NMY3_03193(melC2)
 » show all
Reference
1
  Authors
Dawson CR, Tarpley WB.
  Title
The copper oxidases.
  Journal
In: Sumner JB, Myrback K (eds). The Enzymes. 1st ed. Vol. 2. New York: Academic Press; 1951. p. 454-498.
Reference
2  [PMID:5842066]
  Authors
Patil SS, Zucker M.
  Title
Potato phenolases. Purification and properties.
  Journal
J Biol Chem 240:3938-43 (1965)
Reference
3  [PMID:13972077]
  Authors
POMERANTZ SH.
  Title
Separation, purification, and properties of two tyrosinases from hamster melanoma.
  Journal
J Biol Chem 238:2351-7 (1963)
Reference
4
  Authors
Robb DA.
  Title
`Tyrosinase.
  Journal
In: Lontie R (ed). Copper Proteins and Copper Enzymes. Vol. 2. Boca Raton, FL: CRC Press; 1984. p. 207-240.
Reference
5  [PMID:7873577]
  Authors
Sanchez-Ferrer A, Rodriguez-Lopez JN, Garcia-Canovas F, Garcia-Carmona F
  Title
Tyrosinase: a comprehensive review of its mechanism.
  Journal
Biochim Biophys Acta 1247:1-11 (1995)
DOI:10.1016/0167-4838(94)00204-T
Reference
6  [PMID:8660589]
  Authors
Steiner U, Schliemann W, Strack D
  Title
Assay for tyrosine hydroxylation activity of tyrosinase from betalain-forming plants and cell cultures.
  Journal
Anal Biochem 238:72-5 (1996)
DOI:10.1006/abio.1996.0253
Reference
7  [PMID:21416076]
  Authors
Rolff M, Schottenheim J, Decker H, Tuczek F
  Title
Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme.
  Journal
Chem Soc Rev 40:4077-98 (2011)
DOI:10.1039/c0cs00202j
Other DBs
ExplorEnz - The Enzyme Database: 1.14.18.1
IUBMB Enzyme Nomenclature: 1.14.18.1
ExPASy - ENZYME nomenclature database: 1.14.18.1
BRENDA, the Enzyme Database: 1.14.18.1
CAS: 9002-10-2
LinkDB

KEGG   REACTION: R02078
Entry
R02078                      Reaction                               
Name
L-tyrosine,L-dopa:oxygen oxidoreductase
Definition
3,4-Dihydroxy-L-phenylalanine + L-Tyrosine + Oxygen <=> Dopaquinone + 3,4-Dihydroxy-L-phenylalanine + H2O
Equation
Reaction class
RC00046  C00082_C00355
RC00180  C00355_C00822
Enzyme
1.10.3.1        1.14.18.1
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.10  Acting on diphenols and related substances as donors
   1.10.3  With oxygen as acceptor
    1.10.3.1
     R02078  3,4-Dihydroxy-L-phenylalanine + L-Tyrosine + Oxygen <=> Dopaquinone + 3,4-Dihydroxy-L-phenylalanine + H2O
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.1
     R02078  3,4-Dihydroxy-L-phenylalanine + L-Tyrosine + Oxygen <=> Dopaquinone + 3,4-Dihydroxy-L-phenylalanine + H2O
Orthology
K00422  polyphenol oxidase [EC:1.10.3.1]
K00505  tyrosinase [EC:1.14.18.1]
LinkDB

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