| Entry |
|
| Symbol |
guaA, GMPS
|
| Name |
GMP synthase (glutamine-hydrolysing) [EC: 6.3.5.2]
|
| Pathway |
| map00983 | Drug metabolism - other enzymes |
|
| Module |
| M00050 | Guanine ribonucleotide biosynthesis, IMP => GDP,GTP |
|
| Reaction |
| R01230 | xanthosine-5'-phosphate:ammonia ligase (AMP-forming) |
| R01231 | xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) |
| R08244 | 6-thioxanthine 5'-monophosphate:L-glutamine amido-ligase (AMP-forming) |
|
| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K01951 guaA, GMPS; GMP synthase (glutamine-hydrolysing)
09111 Xenobiotics biodegradation and metabolism
00983 Drug metabolism - other enzymes
K01951 guaA, GMPS; GMP synthase (glutamine-hydrolysing)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors
K01951 guaA, GMPS; GMP synthase (glutamine-hydrolysing)
Enzymes [BR:ko01000]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.2 GMP synthase (glutamine-hydrolysing)
K01951 guaA, GMPS; GMP synthase (glutamine-hydrolysing)
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
Family C26: gamma-glutamyl hydrolase family
K01951 guaA, GMPS; GMP synthase (glutamine-hydrolysing)
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| Other DBs |
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| Genes |
» show all
|
| Reference |
|
| Authors |
Hirst M, Haliday E, Nakamura J, Lou L |
| Title |
Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. |
| Journal |
J Biol Chem 269:23830-7 (1994) |
| Sequence |
|
| Reference |
|
| Authors |
Zalkin H, Argos P, Narayana SV, Tiedeman AA, Smith JM |
| Title |
Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase. |
| Journal |
J Biol Chem 260:3350-4 (1985) |
| Sequence |
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| LinkDB |
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