KEGG   ORTHOLOGY: K04035
Entry
K04035                      KO                                     
Symbol
E1.14.13.81, acsF, chlE
Name
magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase [EC:1.14.13.81]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K04035  E1.14.13.81, acsF, chlE; magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.81  magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
     K04035  E1.14.13.81, acsF, chlE; magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
Other DBs
RN: R06265 R06266 R06267 R10068
COG: COG1032
GO: 0048529
Genes
AJM: 119061104
ATH: AT3G56940(CRD1)
ALY: 9312457
CRB: 17887096
CSAT: 104712356 104781590 104791984
EUS: EUTSA_v10006009mg
BRP: 103830076 103841596
BNA: 106368040 106405693 106445907 111208747
BOE: 106299791 106312794
RSZ: 108817888 108862743
THJ: 104803235 104824384
CPAP: 110811309
CIT: 102612985
CIC: CICLE_v10011842mg
PVY: 116138854
MINC: 123225599
TCC: 18598690
GRA: 105786192
GHI: 107922564 107922571
GAB: 108460633
DZI: 111294139 111311164
EGR: 104443639
GMX: 100527925 100805393
GSJ: 114400696 114406571
PVU: PHAVU_001G108700g
VRA: 106753941
VAR: 108329545
VUN: 114173988
CCAJ: 109802482
APRC: 113860587
MTR: MTR_7g088340
CAM: 101494559
LJA: Lj1g3v4058630.1(Lj1g3v4058630.1)
ADU: 107494229
AIP: 107604718
AHF: 112696804 112754670
LANG: 109337037 109357310 109358322
FVE: 101306835
RCN: 112193460
PPER: 18770050
PMUM: 103339106
PAVI: 110763662
PDUL: 117634068
MDM: 114822994
PXB: 103938877 103938880
ZJU: 107423584
MNT: 21410579
CSV: 101219179
CMO: 103502893
BHJ: 120073932
MCHA: 111021778
CMAX: 111466024 111478142
CMOS: 111432321 111453398
CPEP: 111781371 111803339
RCU: 8289525
JCU: 105648924
HBR: 110655527
MESC: 110623376
POP: 7458885 7495664
PEU: 105136883 105137316
PALZ: 118033159 118052967
JRE: 108995356
QSU: 112034337
QLO: 115952758
TWL: 119998506 120013452
VVI: 100241461
VRI: 117919975
SLY: 101257518
SPEN: 107002129
SOT: 102600334(at103)
CANN: 107844048
NTA: 107777980 107786828
NSY: 104227011
NTO: 104089135
NAU: 109242165
INI: 109161721(PNIL34)
ITR: 116001283
SIND: 105155783 105162815
OEU: 111369306 111399586
EGT: 105976616
SSPL: 121749452 121752943 121795794 121799459
HAN: 110884853
ECAD: 122609572
LSV: 111879482
CCAV: 112518108
DCR: 108219528 108223184
CSIN: 114272420
BVG: 104889639
SOE: 110780654
CQI: 110711517 110714855
NNU: 104593560
MING: 122084975
TSS: 122641146
PSOM: 113309376 113322506
NCOL: 116259868 116264152
OSA: 4326901
DOSA: Os01t0279100-01(Os01g0279100)
OBR: 102712668
BDI: 100828682
ATS: 109776579
TDC: 119268022 119275877
TAES: 100037649 123061131 123078196
SBI: 8074544
ZMA: 103634652 103650025
SITA: 101773118
SVS: 117859246
PVIR: 120706558
PHAI: 112894302
PDA: 103698135
EGU: 105036097
MUS: 103978869 103999618
DCT: 110113521
PEQ: 110028095
AOF: 109848727
ATR: 18426189
SMO: SELMODRAFT_267431 SELMODRAFT_89989
PPP: 112284193 112288601
CRE: CHLRE_07g346050v5 CHLRE_12g510050v5
VCN: VOLCADRAFT_80084 VOLCADRAFT_81575
MNG: MNEG_2725
CSL: COCSUDRAFT_35563
CVR: CHLNCDRAFT_144710 CHLNCDRAFT_48731
APRO: F751_5195
OLU: OSTLU_47501
OTA: OT_ostta15g02680
BPG: Bathy08g00340
MIS: MICPUN_107081
MPP: MICPUCDRAFT_49742
CME: CymeCp123(ycf59)
PDQ: CL55_00013320
RAC: RA876_06085
LIM: L103DPR2_00993
LIH: L63ED372_00649
HYR: BSY239_1293(acsF)
METP: C1M51_03515(acsF)
RGE: RGE_33550(acsF)
RBN: RBXJA2T_09517
RDP: RD2015_1005
METR: BSY238_2458(acsF)
BEB: AEM42_07535
RPOD: E0E05_11850(acsF)
AGC: BSY240_3656(acsF)
ABAW: D5400_04995(acsF)
PDES: FE840_002385(acsF)
BRA: BRADO1649(acsF)
BBT: BBta_6407(acsF)
BRS: S23_19480(acsF)
AOL: S58_58890
BRO: BRAD285_5752(acsF)
BRQ: CIT40_23790(acsF)
BGZ: XH91_02790(acsF)
BBET: F8237_24825(acsF)
RPA: RPA1552
RPB: RPB_3971
RPC: RPC_1323
RPD: RPD_3726
RPE: RPE_1357
RPT: Rpal_1740
RPX: Rpdx1_3968
BOS: BSY19_4045(acsF)
MEA: Mex_1p5263(acsF)
MDI: METDI5863(acsF)
MEX: Mext_4806
MCH: Mchl_5273
MPO: Mpop_5351
MZA: B2G69_06015
MRD: Mrad2831_1838
MET: M446_3728
MOR: MOC_2242(acsF)
META: Y590_24560
MAQU: Maq22A_c01730
MPHY: MCBMB27_01460
MEE: DA075_04100(acsF)
METD: C0214_26300(acsF)
METX: A3862_21735
METS: DK389_01020(acsF)
METI: DK427_17970(acsF)
MMES: MMSR116_22300(acsF)
MTEA: DK419_05060(acsF)
MIND: mvi_09270(acsF)
MOG: MMB17_13905(acsF)
MSL: Msil_2032
BBAR: RHAL1_00849(acsF)
MROS: EHO51_17220(acsF)
CMET: K6K41_01590(acsF)
AUB: LXB15_06330(acsF)
BSB: Bresu_3074
BRL: BZG35_15590
RUT: FIU92_10090
JAN: Jann_0151(acsF)
RDE: RD1_0129(acsF)
RLI: RLO149_p940810(acsF)
RPON: G3256_19035(acsF)
DSH: Dshi_3544(acsF)
RED: roselon_01108
SUAM: BOO69_19140
TOM: BWR18_20125
RMM: ROSMUCSMR3_00891
ROK: RAK1035_3761
RID: RIdsm_01769
ROM: EI983_05500(acsF)
ROH: FIU89_14155
THAA: CFI11_23890(acsF)
MARU: FIU81_16415
ROT: FIV09_18205
MALU: KU6B_16560(acsF)
RSP: RSP_0294
RSH: Rsph17029_1938
RSQ: Rsph17025_1000
RSK: RSKD131_1621
CAZT: LV780_04345(acsF)
RBL: B6K69_03530
PTP: RCA23_c29820(acsF)
RSU: NHU_00221(acsF)
RHM: B5V46_02505
RHC: RGUI_1977
LVS: LOKVESSMR4R_03614
RBG: BG454_02870(acsF)
GEH: HYN69_05365(acsF)
TAW: EI545_18785(acsF)
POZ: I0K15_16950(acsF)
FAQ: G5B39_10045(acsF)
HBC: AEM38_14670
NOT: C7W88_00610(acsF)
NGF: FRF71_09275(acsF)
NOG: GKE62_08565(acsF)
SPHI: TS85_22955
SSAN: NX02_18395
SCHY: GVO57_11575(acsF)
CIJ: WG74_05165
BLAS: BSY18_2698(acsF)
BFW: B5J99_04440
PALG: HFP57_06820(acsF)
PARJ: J4G78_07405(acsF)
SAND: H3309_10305(acsF)
POQ: KZX46_18655(acsF)
ALH: G6N82_11565(acsF)
ELQ: Ga0102493_111813
ERK: CD351_14000(acsF)
ERF: FIU90_13955
PNS: A9D12_01410
PORL: BG023_112695
PHZ: CHX26_14625(acsF)
POT: E2E27_07210(acsF)
AMV: ACMV_19060(acsF)
NCB: C0V82_18105(acsF)
SKT: IGS68_17055(acsF)
SMUC: JL100_008990(acsF)
SROE: JL101_015225(acsF)
RCE: RC1_2105(acsF)
ELIO: KO353_02845(acsF)
SYN: sll1214 sll1874(AT103)
SYZ: MYO_116600(at103) MYO_150
SYY: SYNGTS_0005(sll1214) SYNGTS_1645(chlAII)
SYT: SYNGTI_0005(sll1214) SYNGTI_1645(chlAII)
SYS: SYNPCCN_0005(sll1214) SYNPCCN_1644(chlAII)
SYQ: SYNPCCP_0005(sll1214) SYNPCCP_1644(chlAII)
SYJ: D082_08250(AT103) D082_11950(ycf59)
SYO: C7I86_00025(acsF) C7I86_08535(acsF)
SYC: syc2188_d(ycf59)
SYU: M744_06900
SYF: Synpcc7942_1907
SYD: Syncc9605_1310
SYE: Syncc9902_1165
SYG: sync_1304(acsF)
SYR: SynRCC307_1476(acsF)
SYX: SynWH7803_1102(acsF)
SYP: SYNPCC7002_A0707(acsF) SYNPCC7002_A1992(acsF)
CYA: CYA_2703(acsF)
CYB: CYB_1254(acsF)
SYNE: Syn6312_2481
SYNP: Syn7502_00420 Syn7502_03308
SYNK: KR100_08475
SYNR: KR49_02360
SYND: KR52_09945
SYH: Syncc8109_1357
SYNW: SynWH8103_01332(acsF)
SYV: AWQ23_03685 AWQ23_09990
SYL: AWQ21_03545 AWQ21_08625
SYNC: CB0101_00325(acsF) CB0101_01670(acsF)
DSL: Dacsa_1976 Dacsa_3627
SYW: SYNW1198(PNIL34)
CGC: Cyagr_0706 Cyagr_1039
CYI: CBM981_0231(acsF) CBM981_1951(acsF)
PMA: Pro_0992(acsF)
PMM: PMM0844(PNIL34)
PMT: PMT_2196
PMN: PMN2A_0227
PMI: PMT9312_0956
PMB: A9601_10251(pniL34)
PMC: P9515_09201(pnilL34)
PMF: P9303_29201(pniL34)
PMG: P9301_10241(pniL34)
PMH: P9215_10571(pniL34)
PMJ: P9211_09191(pniIL34)
PME: NATL1_08941(pnil34)
PRC: EW14_1059
PRM: EW15_0910
CMP: Cha6605_2406
AMR: AM1_0465(acsF) AM1_2295(acsF)
TVN: NIES2134_111220(ycf59) NIES2134_116400
SLW: BRW62_05965
TEL: tlr1426(ycf59) tlr1722
THN: NK55_02575(acsF1) NK55_05260(acsF2)
THEC: FFX45_07110(acsF) FFX45_08845(acsF)
LEP: Lepto7376_1355 Lepto7376_4048
LEN: LEP3755_29800
LET: O77CONTIG1_03690
LBO: LBWT_34030 LBWT_42950
KOV: K9N68_02375(acsF) K9N68_36290(acsF)
LSC: KIK02_06920(acsF) KIK02_21825(acsF)
LSK: J5X98_15830(acsF) J5X98_19820(acsF)
HHG: XM38_022230(acsF3)
PSEU: Pse7367_3159
PSER: ABRG53_0108(acsF) ABRG53_3949(acsF)
THEU: HPC62_08165(acsF)
GLP: Glo7428_0168
GEN: GM3709_1534 GM3709_1815
GEE: GM3708_585 GM3708_779
CHON: NIES4102_11510 NIES4102_38690
MAR: MAE_39240 MAE_46620
MPK: VL20_3790 VL20_5937
MIQ: B5D77_05165
MVZ: myaer102_13940 myaer102_20250
CAN: Cyan10605_1422 Cyan10605_2707
CSN: Cyast_0064 Cyast_2869
CYL: AA637_00120(acsF) AA637_14735(acsF-2)
HAO: PCC7418_1706 PCC7418_3522
ENN: FRE64_04905(acsF) FRE64_09065(acsF)
CYU: UCYN_08810 UCYN_11800
CYT: cce_2967 cce_4412
CWA: CwatDRAFT_3460 CwatDRAFT_6122
CYP: PCC8801_2261 PCC8801_3705
CYH: Cyan8802_2312 Cyan8802_3758
CYC: PCC7424_2605 PCC7424_3134
CYJ: Cyan7822_4263 Cyan7822_5395
CYN: Cyan7425_4340 Cyan7425_4781
TER: Tery_0728
ARP: NIES39_B00770(acsF)
PAGH: NIES204_10470
OXY: HCG48_01810(acsF) HCG48_10825(acsF)
MVAG: D0A34_17970(acsF)
LFS: HFV01_07170(acsF)
MIC: Mic7113_1589 Mic7113_5321
GEI: GEI7407_1972 GEI7407_2883
OAC: Oscil6304_5538 Oscil6304_5882
ONI: Osc7112_1426 Osc7112_2921
MPRO: BJP34_03660
PHOR: JWS08_05890(acsF) JWS08_18920(acsF)
CEP: Cri9333_1679
GVI: gll3625(ycf59)
GLJ: GKIL_2292(acsF)
GML: ISF26_02875(acsF)
ANA: all1880 alr1358 alr3300
NPU: Npun_F1653 Npun_F6446
NOS: Nos7107_1361 Nos7107_5431
NOP: Nos7524_0896 Nos7524_3425 Nos7524_3949
NON: NOS3756_16090 NOS3756_44890
NFL: COO91_01779 COO91_03121
NOE: CLI64_10670(acsF) CLI64_21635(acsF) CLI64_28005(acsF)
NSH: GXM_02364 GXM_06469
NED: HUN01_03560(acsF) HUN01_10900(acsF)
AVA: Ava_4776 Ava_4958
NAZ: Aazo_2963 Aazo_3391
ANB: ANA_C10475(acsF) ANA_C11197(acsF)
ACY: Anacy_0238 Anacy_3447 Anacy_5348
AWA: AA650_00580 AA650_05545
ANN: EH233_00590(acsF) EH233_12300(acsF)
CSG: Cylst_1264 Cylst_3224
RSIN: B6N60_00143 B6N60_03087 B6N60_05088
CALO: Cal7507_4415
CALT: Cal6303_0508 Cal6303_0540 Cal6303_3632
CALH: IJ00_00755 IJ00_01475
RIV: Riv7116_2518 Riv7116_3605
FIS: FIS3754_05810 FIS3754_12410
NSP: BMF81_00211(acsF) BMF81_04265(acsF_2)
DOU: BMF77_02276 BMF77_02422
DFS: HGD76_05435(acsF) HGD76_06245(acsF)
CCUR: IAR63_09695(acsF)
AFLO: HEQ12_04350(acsF) HEQ12_08955(acsF)
TOQ: HCG51_06915(acsF) HCG51_14440(acsF) HCG51_32660(acsF)
NCN: BZZ01_00630 BZZ01_14365
CTHE: Chro_1308
PLP: Ple7327_2340 Ple7327_3805
SCS: Sta7437_4309
STAN: STA3757_30850 STA3757_37100
CER: RGRSB_0189
RRS: RoseRS_1905
RCA: Rcas_1541
CAU: Caur_2590
CHL: Chy400_2799
CAG: Cagg_1285
CTM: Cabther_A1379
CVL: J8C06_02545(acsF)
CHLO: J8C02_06675(acsF)
GPH: GEMMAAP_06425
GGR: HKW67_08865(acsF)
 » show all
Reference
PMID:14673103
  Authors
Tottey S, Block MA, Allen M, Westergren T, Albrieux C, Scheller HV, Merchant S, Jensen PE
  Title
Arabidopsis CHL27, located in both envelope and thylakoid membranes, is required for the synthesis of protochlorophyllide.
  Journal
Proc Natl Acad Sci U S A 100:16119-24 (2003)
DOI:10.1073/pnas.2136793100
  Sequence
[ath:AT3G56940]
LinkDB

KEGG   ENZYME: 1.14.13.81
Entry
EC 1.14.13.81               Enzyme                                 
Name
magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase;
Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)
Reaction(IUBMB)
magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = 3,8-divinyl protochlorophyllide a + 3 NADP+ + 5 H2O (overall reaction) [RN:R10068];
(1a) magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O [RN:R06265];
(1b) 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O [RN:R06266];
(1c) 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 = 3,8-divinyl protochlorophyllide a + NADP+ + 2 H2O [RN:R06267]
Reaction(KEGG)
R06265 R06266 R06267 R10068
Substrate
magnesium-protoporphyrin IX 13-monomethyl ester [CPD:C04536];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007];
131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester;
131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester
Product
3,8-divinyl protochlorophyllide a [CPD:C11831];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester;
131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester
Comment
Requires Fe(II) for activity. The enzyme participates in the biosynthesis of chlorophyllide a in aerobic organisms. The same transformation is achieved in anaerobic organisms by EC 1.21.98.3, anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase. Some facultative phototrophic bacteria, such as Rubrivivax gelatinosus, possess both enzymes.
History
EC 1.14.13.81 created 2003, modified 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04035  magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
Genes
AJM: 119061104
ATH: AT3G56940(CRD1)
ALY: 9312457
CRB: 17887096
CSAT: 104712356 104781590 104791984
EUS: EUTSA_v10006009mg
BRP: 103830076 103841596
BNA: 106368040 106405693 106445907 111208747
BOE: 106299791 106312794
RSZ: 108817888 108862743
THJ: 104803235 104824384
CPAP: 110811309
CIT: 102612985
CIC: CICLE_v10011842mg
PVY: 116138854
MINC: 123225599
TCC: 18598690
GRA: 105786192
GHI: 107922564 107922571
GAB: 108460633
DZI: 111294139 111311164
EGR: 104443639
GMX: 100527925 100805393
GSJ: 114400696 114406571
PVU: PHAVU_001G108700g
VRA: 106753941
VAR: 108329545
VUN: 114173988
CCAJ: 109802482
APRC: 113860587
MTR: MTR_7g088340
CAM: 101494559
LJA: Lj1g3v4058630.1(Lj1g3v4058630.1)
ADU: 107494229
AIP: 107604718
AHF: 112696804 112754670
LANG: 109337037 109357310 109358322
FVE: 101306835
RCN: 112193460
PPER: 18770050
PMUM: 103339106
PAVI: 110763662
PDUL: 117634068
MDM: 114822994
PXB: 103938877 103938880
ZJU: 107423584
MNT: 21410579
CSV: 101219179
CMO: 103502893
BHJ: 120073932
MCHA: 111021778
CMAX: 111466024 111478142
CMOS: 111432321 111453398
CPEP: 111781371 111803339
RCU: 8289525
JCU: 105648924
HBR: 110655527
MESC: 110623376
POP: 7458885 7495664
PEU: 105136883 105137316
PALZ: 118033159 118052967
JRE: 108995356
QSU: 112034337
QLO: 115952758
TWL: 119998506 120013452
VVI: 100241461
VRI: 117919975
SLY: 101257518
SPEN: 107002129
SOT: 102600334(at103)
CANN: 107844048
NTA: 107777980 107786828
NSY: 104227011
NTO: 104089135
NAU: 109242165
INI: 109161721(PNIL34)
ITR: 116001283
SIND: 105155783 105162815
OEU: 111369306 111399586
EGT: 105976616
SSPL: 121749452 121752943 121795794 121799459
HAN: 110884853
ECAD: 122609572
LSV: 111879482
CCAV: 112518108
DCR: 108219528 108223184
CSIN: 114272420
BVG: 104889639
SOE: 110780654
CQI: 110711517 110714855
NNU: 104593560
MING: 122084975
TSS: 122641146
PSOM: 113309376 113322506
NCOL: 116259868 116264152
OSA: 4326901
DOSA: Os01t0279100-01(Os01g0279100)
OBR: 102712668
BDI: 100828682
ATS: 109776579
TDC: 119268022 119275877
TAES: 100037649 123061131 123078196
SBI: 8074544
ZMA: 103634652 103650025
SITA: 101773118
SVS: 117859246
PVIR: 120706558
PHAI: 112894302
PDA: 103698135
EGU: 105036097
MUS: 103978869 103999618
DCT: 110113521
PEQ: 110028095
AOF: 109848727
ATR: 18426189
SMO: SELMODRAFT_267431 SELMODRAFT_89989
PPP: 112284193 112288601
CRE: CHLRE_07g346050v5 CHLRE_12g510050v5
VCN: VOLCADRAFT_80084 VOLCADRAFT_81575
MNG: MNEG_2725
CSL: COCSUDRAFT_35563
CVR: CHLNCDRAFT_144710 CHLNCDRAFT_48731
APRO: F751_5195
OLU: OSTLU_47501
OTA: OT_ostta15g02680
BPG: Bathy08g00340
MIS: MICPUN_107081
MPP: MICPUCDRAFT_49742
CME: CymeCp123(ycf59)
PDQ: CL55_00013320
RAC: RA876_06085
LIM: L103DPR2_00993
LIH: L63ED372_00649
HYR: BSY239_1293(acsF)
METP: C1M51_03515(acsF)
RGE: RGE_33550(acsF)
RBN: RBXJA2T_09517
RDP: RD2015_1005
METR: BSY238_2458(acsF)
BEB: AEM42_07535
RPOD: E0E05_11850(acsF)
AGC: BSY240_3656(acsF)
ABAW: D5400_04995(acsF)
PDES: FE840_002385(acsF)
BRA: BRADO1649(acsF)
BBT: BBta_6407(acsF)
BRS: S23_19480(acsF)
AOL: S58_58890
BRO: BRAD285_5752(acsF)
BRQ: CIT40_23790(acsF)
BGZ: XH91_02790(acsF)
BBET: F8237_24825(acsF)
RPA: RPA1552
RPB: RPB_3971
RPC: RPC_1323
RPD: RPD_3726
RPE: RPE_1357
RPT: Rpal_1740
RPX: Rpdx1_3968
BOS: BSY19_4045(acsF)
MEA: Mex_1p5263(acsF)
MDI: METDI5863(acsF)
MEX: Mext_4806
MCH: Mchl_5273
MPO: Mpop_5351
MZA: B2G69_06015
MRD: Mrad2831_1838
MET: M446_3728
MOR: MOC_2242(acsF)
META: Y590_24560
MAQU: Maq22A_c01730
MPHY: MCBMB27_01460
MEE: DA075_04100(acsF)
METD: C0214_26300(acsF)
METX: A3862_21735
METS: DK389_01020(acsF)
METI: DK427_17970(acsF)
MMES: MMSR116_22300(acsF)
MTEA: DK419_05060(acsF)
MIND: mvi_09270(acsF)
MOG: MMB17_13905(acsF)
MSL: Msil_2032
BBAR: RHAL1_00849(acsF)
MROS: EHO51_17220(acsF)
CMET: K6K41_01590(acsF)
AUB: LXB15_06330(acsF)
BSB: Bresu_3074
BRL: BZG35_15590
RUT: FIU92_10090
JAN: Jann_0151(acsF)
RDE: RD1_0129(acsF)
RLI: RLO149_p940810(acsF)
RPON: G3256_19035(acsF)
DSH: Dshi_3544(acsF)
RED: roselon_01108
SUAM: BOO69_19140
TOM: BWR18_20125
RMM: ROSMUCSMR3_00891
ROK: RAK1035_3761
RID: RIdsm_01769
ROM: EI983_05500(acsF)
ROH: FIU89_14155
THAA: CFI11_23890(acsF)
MARU: FIU81_16415
ROT: FIV09_18205
MALU: KU6B_16560(acsF)
RSP: RSP_0294
RSH: Rsph17029_1938
RSQ: Rsph17025_1000
RSK: RSKD131_1621
CAZT: LV780_04345(acsF)
RBL: B6K69_03530
PTP: RCA23_c29820(acsF)
RSU: NHU_00221(acsF)
RHM: B5V46_02505
RHC: RGUI_1977
LVS: LOKVESSMR4R_03614
RBG: BG454_02870(acsF)
GEH: HYN69_05365(acsF)
TAW: EI545_18785(acsF)
POZ: I0K15_16950(acsF)
FAQ: G5B39_10045(acsF)
HBC: AEM38_14670
NOT: C7W88_00610(acsF)
NGF: FRF71_09275(acsF)
NOG: GKE62_08565(acsF)
SPHI: TS85_22955
SSAN: NX02_18395
SCHY: GVO57_11575(acsF)
CIJ: WG74_05165
BLAS: BSY18_2698(acsF)
BFW: B5J99_04440
PALG: HFP57_06820(acsF)
PARJ: J4G78_07405(acsF)
SAND: H3309_10305(acsF)
POQ: KZX46_18655(acsF)
ALH: G6N82_11565(acsF)
ELQ: Ga0102493_111813
ERK: CD351_14000(acsF)
ERF: FIU90_13955
PNS: A9D12_01410
PORL: BG023_112695
PHZ: CHX26_14625(acsF)
POT: E2E27_07210(acsF)
AMV: ACMV_19060(acsF)
NCB: C0V82_18105(acsF)
SKT: IGS68_17055(acsF)
SMUC: JL100_008990(acsF)
SROE: JL101_015225(acsF)
RCE: RC1_2105(acsF)
ELIO: KO353_02845(acsF)
SYN: sll1214 sll1874(AT103)
SYZ: MYO_116600(at103) MYO_150
SYY: SYNGTS_0005(sll1214) SYNGTS_1645(chlAII)
SYT: SYNGTI_0005(sll1214) SYNGTI_1645(chlAII)
SYS: SYNPCCN_0005(sll1214) SYNPCCN_1644(chlAII)
SYQ: SYNPCCP_0005(sll1214) SYNPCCP_1644(chlAII)
SYJ: D082_08250(AT103) D082_11950(ycf59)
SYO: C7I86_00025(acsF) C7I86_08535(acsF)
SYC: syc2188_d(ycf59)
SYU: M744_06900
SYF: Synpcc7942_1907
SYD: Syncc9605_1310
SYE: Syncc9902_1165
SYG: sync_1304(acsF)
SYR: SynRCC307_1476(acsF)
SYX: SynWH7803_1102(acsF)
SYP: SYNPCC7002_A0707(acsF) SYNPCC7002_A1992(acsF)
CYA: CYA_2703(acsF)
CYB: CYB_1254(acsF)
SYNE: Syn6312_2481
SYNP: Syn7502_00420 Syn7502_03308
SYNK: KR100_08475
SYNR: KR49_02360
SYND: KR52_09945
SYH: Syncc8109_1357
SYNW: SynWH8103_01332(acsF)
SYV: AWQ23_03685 AWQ23_09990
SYL: AWQ21_03545 AWQ21_08625
SYNC: CB0101_00325(acsF) CB0101_01670(acsF)
DSL: Dacsa_1976 Dacsa_3627
SYW: SYNW1198(PNIL34)
CGC: Cyagr_0706 Cyagr_1039
CYI: CBM981_0231(acsF) CBM981_1951(acsF)
PMA: Pro_0992(acsF)
PMM: PMM0844(PNIL34)
PMT: PMT_2196
PMN: PMN2A_0227
PMI: PMT9312_0956
PMB: A9601_10251(pniL34)
PMC: P9515_09201(pnilL34)
PMF: P9303_29201(pniL34)
PMG: P9301_10241(pniL34)
PMH: P9215_10571(pniL34)
PMJ: P9211_09191(pniIL34)
PME: NATL1_08941(pnil34)
PRC: EW14_1059
PRM: EW15_0910
CMP: Cha6605_2406
AMR: AM1_0465(acsF) AM1_2295(acsF)
TVN: NIES2134_111220(ycf59) NIES2134_116400
SLW: BRW62_05965
TEL: tlr1426(ycf59) tlr1722
THN: NK55_02575(acsF1) NK55_05260(acsF2)
THEC: FFX45_07110(acsF) FFX45_08845(acsF)
LEP: Lepto7376_1355 Lepto7376_4048
LEN: LEP3755_29800
LET: O77CONTIG1_03690
LBO: LBWT_34030 LBWT_42950
KOV: K9N68_02375(acsF) K9N68_36290(acsF)
LSC: KIK02_06920(acsF) KIK02_21825(acsF)
LSK: J5X98_15830(acsF) J5X98_19820(acsF)
HHG: XM38_022230(acsF3)
PSEU: Pse7367_3159
PSER: ABRG53_0108(acsF) ABRG53_3949(acsF)
THEU: HPC62_08165(acsF)
GLP: Glo7428_0168
GEN: GM3709_1534 GM3709_1815
GEE: GM3708_585 GM3708_779
CHON: NIES4102_11510 NIES4102_38690
MAR: MAE_39240 MAE_46620
MPK: VL20_3790 VL20_5937
MIQ: B5D77_05165
MVZ: myaer102_13940 myaer102_20250
CAN: Cyan10605_1422 Cyan10605_2707
CSN: Cyast_0064 Cyast_2869
CYL: AA637_00120(acsF) AA637_14735(acsF-2)
HAO: PCC7418_1706 PCC7418_3522
ENN: FRE64_04905(acsF) FRE64_09065(acsF)
CYU: UCYN_08810 UCYN_11800
CYT: cce_2967 cce_4412
CWA: CwatDRAFT_3460 CwatDRAFT_6122
CYP: PCC8801_2261 PCC8801_3705
CYH: Cyan8802_2312 Cyan8802_3758
CYC: PCC7424_2605 PCC7424_3134
CYJ: Cyan7822_4263 Cyan7822_5395
CYN: Cyan7425_4340 Cyan7425_4781
TER: Tery_0728
ARP: NIES39_B00770(acsF)
PAGH: NIES204_10470
OXY: HCG48_01810(acsF) HCG48_10825(acsF)
MVAG: D0A34_17970(acsF)
LFS: HFV01_07170(acsF)
MIC: Mic7113_1589 Mic7113_5321
GEI: GEI7407_1972 GEI7407_2883
OAC: Oscil6304_5538 Oscil6304_5882
ONI: Osc7112_1426 Osc7112_2921
MPRO: BJP34_03660
PHOR: JWS08_05890(acsF) JWS08_18920(acsF)
CEP: Cri9333_1679
GVI: gll3625(ycf59)
GLJ: GKIL_2292(acsF)
GML: ISF26_02875(acsF)
ANA: all1880 alr1358 alr3300
NPU: Npun_F1653 Npun_F6446
NOS: Nos7107_1361 Nos7107_5431
NOP: Nos7524_0896 Nos7524_3425 Nos7524_3949
NON: NOS3756_16090 NOS3756_44890
NFL: COO91_01779 COO91_03121
NOE: CLI64_10670(acsF) CLI64_21635(acsF) CLI64_28005(acsF)
NSH: GXM_02364 GXM_06469
NED: HUN01_03560(acsF) HUN01_10900(acsF)
AVA: Ava_4776 Ava_4958
NAZ: Aazo_2963 Aazo_3391
ANB: ANA_C10475(acsF) ANA_C11197(acsF)
ACY: Anacy_0238 Anacy_3447 Anacy_5348
AWA: AA650_00580 AA650_05545
ANN: EH233_00590(acsF) EH233_12300(acsF)
CSG: Cylst_1264 Cylst_3224
RSIN: B6N60_00143 B6N60_03087 B6N60_05088
CALO: Cal7507_4415
CALT: Cal6303_0508 Cal6303_0540 Cal6303_3632
CALH: IJ00_00755 IJ00_01475
RIV: Riv7116_2518 Riv7116_3605
FIS: FIS3754_05810 FIS3754_12410
NSP: BMF81_00211(acsF) BMF81_04265(acsF_2)
DOU: BMF77_02276 BMF77_02422
DFS: HGD76_05435(acsF) HGD76_06245(acsF)
CCUR: IAR63_09695(acsF)
AFLO: HEQ12_04350(acsF) HEQ12_08955(acsF)
TOQ: HCG51_06915(acsF) HCG51_14440(acsF) HCG51_32660(acsF)
NCN: BZZ01_00630 BZZ01_14365
CTHE: Chro_1308
PLP: Ple7327_2340 Ple7327_3805
SCS: Sta7437_4309
STAN: STA3757_30850 STA3757_37100
CER: RGRSB_0189
RRS: RoseRS_1905
RCA: Rcas_1541
CAU: Caur_2590
CHL: Chy400_2799
CAG: Cagg_1285
CTM: Cabther_A1379
CVL: J8C06_02545(acsF)
CHLO: J8C02_06675(acsF)
GPH: GEMMAAP_06425
GGR: HKW67_08865(acsF)
 » show all
Reference
1  [PMID:3202840]
  Authors
Walker CJ, Mansfield KE, Rezzano IN, Hanamoto CM, Smith KM, Castelfranco PA
  Title
The magnesium-protoporphyrin IX (oxidative) cyclase system. Studies on the mechanism and specificity of the reaction sequence.
  Journal
Biochem J 255:685-92 (1988)
Reference
2  [PMID:12226378]
  Authors
Bollivar DW, Beale SI.
  Title
The Chlorophyll Biosynthetic Enzyme Mg-Protoporphyrin IX Monomethyl Ester (Oxidative) Cyclase (Characterization and Partial Purification from Chlamydomonas reinhardtii and Synechocystis sp. PCC 6803).
  Journal
Plant Physiol 112:105-114 (1996)
DOI:10.1104/pp.112.1.105
Reference
3  [PMID:11790744]
  Authors
Pinta V, Picaud M, Reiss-Husson F, Astier C
  Title
Rubrivivax gelatinosus acsF (previously orf358) codes for a conserved, putative binuclear-iron-cluster-containing protein involved in aerobic oxidative cyclization of Mg-protoporphyrin IX monomethylester.
  Journal
J Bacteriol 184:746-53 (2002)
DOI:10.1128/JB.184.3.746-753.2002
Reference
4  [PMID:14673103]
  Authors
Tottey S, Block MA, Allen M, Westergren T, Albrieux C, Scheller HV, Merchant S, Jensen PE
  Title
Arabidopsis CHL27, located in both envelope and thylakoid membranes, is required for the synthesis of protochlorophyllide.
  Journal
Proc Natl Acad Sci U S A 100:16119-24 (2003)
DOI:10.1073/pnas.2136793100
  Sequence
[ath:AT3G56940]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.81
IUBMB Enzyme Nomenclature: 1.14.13.81
ExPASy - ENZYME nomenclature database: 1.14.13.81
BRENDA, the Enzyme Database: 1.14.13.81
CAS: 92353-62-3
LinkDB

KEGG   REACTION: R06265
Entry
R06265                      Reaction                               
Name
magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)
Definition
Magnesium protoporphyrin monomethyl ester + NADPH + H+ + Oxygen <=> 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O
Equation
C04536 + C00005 + C00080 + C00007 <=> C11829 + C00006 + C00001
Comment
first step of three-step reaction (see R10068, R06265+R06266+R06267)
Reaction class
RC00001  C00005_C00006
RC00741  C04536_C11829
Enzyme
1.14.13.81
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K04035  magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase [EC:1.14.13.81]
Other DBs
RHEA: 24275
LinkDB

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