KEGG   ORTHOLOGY: K05050
Entry
K05050                      KO                                     
Symbol
CXCR2, IL8RB, CD182
Name
C-X-C chemokine receptor type 2
Pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04144  Endocytosis
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05163  Human cytomegalovirus infection
Disease
H00097  WHIM syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
 09160 Human Diseases
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
   04050 Cytokine receptors
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
   04090 CD molecules
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Chemokine
   CXC Chemokine
    K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
Cytokine receptors [BR:ko04050]
 Chemokine receptors
  CXC Chemokine
   K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
CD molecules [BR:ko04090]
 Proteins
  K05050  CD182, CXCR2; chemokine (C-X-C motif) receptor 2
Other DBs
GO: 0004918
Genes
HSA: 3579(CXCR2)
PTR: 470644(CXCR2)
PPS: 100978269(CXCR2)
GGO: 101151143
PON: 100461066(CXCR2)
NLE: 100596676
MCC: 700407(CXCR2)
MCF: 102139639(CXCR2)
CSAB: 103217855(CXCR2)
CATY: 105587076
PANU: 101017180(CXCR2) 103876540
TGE: 112636087(CXCR2)
RRO: 104660011
RBB: 108541855(CXCR2)
TFN: 117094540
PTEH: 111548370(CXCR2)
CJC: 100415726(CXCR2)
SBQ: 101038106(CXCR2)
MMU: 12765(Cxcr2)
MCAL: 110305112
MPAH: 110322649(Cxcr2)
RNO: 29385(Cxcr2)
MCOC: 116089224(Cxcr2)
CGE: 100755640(Cxcr2)
PLEU: 114709324
NGI: 103727708(Cxcr2)
HGL: 101712581(Cxcr2)
CPOC: 100379569(Cxcr2)
DORD: 106001970(Cxcr2)
DSP: 122107411
NCAR: 124980526
OCU: 100328627(CXCR2)
OPI: 101532421(CXCR2)
TUP: 102484805(CXCR2)
CFA: 478905(CXCR2)
VVP: 112922564
VLG: 121480684
AML: 100466219 100470409(CXCR2)
UAH: 113250472(CXCR2)
UAR: 123779464
ELK: 111145052
LLV: 125096351
MPUF: 101678099 101679399(CXCR2)
ORO: 101368927(CXCR2)
ZCA: 113920300(CXCR2)
MLX: 118012056
FCA: 101085396(CXCR2)
PYU: 121031051(CXCR2)
PBG: 122481755(CXCR2)
PTG: 102952080(CXCR2)
PPAD: 109265081(CXCR2)
AJU: 106970115
HHV: 120232444(CXCR2)
BTA: 782719(CXCR2)
BOM: 102269514(CXCR2)
BIU: 109570475(CXCR2)
BBUB: 102398743(CXCR2)
CHX: 102188811(CXCR2)
OAS: 101110214(CXCR2)
ODA: 120854388
CCAD: 122426699
SSC: 100124654(CXCR2)
CFR: 106729878(CXCR2)
CBAI: 105064000
CDK: 105096069(CXCR2) 105096070
BACU: 103020356(CXCR2)
LVE: 103068692(CXCR2)
OOR: 101272299
DLE: 111171816(CXCR2)
PCAD: 102995856(CXCR2)
PSIU: 116757057
ECB: 100055552(CXCR2)
EPZ: 103564145(CXCR2)
EAI: 106838436
MYB: 102246524(CXCR2)
MYD: 102753405(CXCR2)
MMYO: 118661768(CXCR2)
MLF: 102417769(CXCR2)
MNA: 107524751(CXCR2)
PKL: 118709904(CXCR2)
HAI: 109380534
DRO: 112307954
SHON: 118975369(CXCR2) 118975407
AJM: 119039529
PDIC: 114494636(CXCR2)
MMF: 118625201
RFQ: 117025484
PGIG: 120587642
PVP: 105291074(CXCR2)
MJV: 108389224
TOD: 119254840
SARA: 101555581
LAV: 100665573
TMU: 101342494
DNM: 101441256
MDO: 100012302(CXCR2)
GAS: 123240137(CXCR2) 123240138(CXCR1)
SHR: 100922206
PCW: 110219494(CXCR2)
OAA: 100083635
GGA: 430652(CXCR1)
PCOC: 116227328
MGP: 100540439
CJO: 107316955
NMEL: 110400551
APLA: 101805430
ACYG: 106045913
AFUL: 116490999
TGU: 101233427
LSR: 110468379
SCAN: 103814344(CXCR2)
PMOA: 120511517
OTC: 121337526
PRUF: 121356547
GFR: 102034929
FAB: 101815012
PHI: 102101581
PMAJ: 107207279
CCAE: 111932197
CCW: 104693981
ETL: 114055437(CXCR2)
ZAB: 102063186
FPG: 101922140
FCH: 102053362
CLV: 102098998
EGZ: 104127599
NNI: 104010076
ACUN: 113482287
TALA: 104364160
PADL: 103914253
ACHC: 115343350
AAM: 106499143
AROW: 112971998
NPD: 112951499
DNE: 112997270
ASN: 102388805(CXCR1)
AMJ: 102574892(CXCR2)
CPOO: 109323230
GGN: 109301467
PSS: 102452532
CMY: 102935676
CPIC: 101954115
TST: 117885086
CABI: 116815802
MRV: 120374289
ACS: 100554601
SUND: 121919133
PBI: 103048542
STOW: 125426985
XLA: 108701265(cxcr1.L) 398309(cxcr1.S)
XTR: 101732165(cxcr2)
NPR: 108783862
RTEM: 120944238
DRE: 796724(cxcr2) 797181
PPRM: 120487020(cxcr2) 120487304
MAMB: 125270714 125270716(cxcr2)
IPU: 108266439(cxcr2) 108266440
SMEO: 124382943 124383052(cxcr2)
TFD: 113653103 113653161(cxcr2)
SLUC: 116044187 116044311(cxcr2)
CUD: 121522305 121522891(cxcr2)
GMU: 124871005 124871034(cxcr2)
KMR: 108238526(cxcr2) 108244287
CSEM: 103392444
POV: 109631370(cxcr2) 109646027
CMK: 103190409
BGT: 106070619
 » show all
Reference
PMID:1891716
  Authors
Murphy PM, Tiffany HL
  Title
Cloning of complementary DNA encoding a functional human interleukin-8 receptor.
  Journal
Science 253:1280-3 (1991)
DOI:10.1126/science.1891716
  Sequence
[hsa:3579]
Reference
  Authors
Reutershan J, Morris MA, Burcin TL, Smith DF, Chang D, Saprito MS, Ley K
  Title
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung.
  Journal
J Clin Invest 116:695-702 (2006)
DOI:10.1172/JCI27009
  Sequence
[mmu:12765]
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