KEGG ORTHOLOGY: K06267

ORTHOLOGY: K06267

Entry

K06267                      KO

Symbol

HMMR, RHAMM, CD168

Name

hyaluronan-mediated motility receptor

Pathway

map04512

ECM-receptor interaction

Disease

H00031

Breast cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06267  HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06267  HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor
   00536 Glycosaminoglycan binding proteins
    K06267  HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor
CD molecules [BR:ko04090]
Proteins
  K06267  CD168, HMMR; hyaluronan-mediated motility receptor (RHAMM)
Glycosaminoglycan binding proteins [BR:ko00536]
Hyaluronan
  Cell surface receptors
   K06267  HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor

Genes

HSA:	3161(HMMR)

PTR:	737973(HMMR)

PPS:	100995365(HMMR)

GGO:	101124717(HMMR)

PON:	100446821(HMMR)

PPYG:

129036356(HMMR)

NLE:	100589397(HMMR)

HMH:	116471811(HMMR)

SSYN:

129486056(HMMR)

MCC:	697991(HMMR)

MCF:	102145946(HMMR)

MTHB:

126955938

MNI:	105480814(HMMR)

CSAB:

103244927(HMMR)

CATY:

105581609(HMMR)

PANU:

101007912(HMMR)

TGE:	112625790(HMMR)

MLEU:

105552181(HMMR)

RRO:	104665497(HMMR)

RBB:	108540043(HMMR)

TFN:	117065508(HMMR)

PTEH:

111547193(HMMR)

CANG:

105515805(HMMR)

CJC:	100406414(HMMR)

SBQ:	101041455(HMMR)

CIMI:

108308585(HMMR)

ANAN:

105723201(HMMR)

CSYR:

103276199(HMMR)

MMUR:

105864841(HMMR)

LCAT:

123637990(HMMR)

ERUF:

138393146(HMMR)

PCOQ:

105810073(HMMR)

OGA:	100949385(HMMR)

MMU:	15366(Hmmr)

MCAL:

110304249(Hmmr)

MPAH:

110331903(Hmmr)

RNO:	25460(Hmmr)

MCOC:

116077824(Hmmr)

ANU:	117711319(Hmmr)

ASYL:

127694964(Hmmr)

MUN:	110540037(Hmmr)

CGE:	100772538(Hmmr)

MAUA:

101840914(Hmmr)

PROB:

127219418(Hmmr)

PLEU:

114689849(Hmmr)

PMAV:

102916137(Hmmr)

MORG:

121463885(Hmmr)

MFOT:

126499437

AAMP:

119813030(Hmmr)

CNL:	130877458(Hmmr)

NGI:	103747750(Hmmr)

HGL:	101717355(Hmmr)

CPOC:

100734920(Hmmr)

CCAN:

109699092(Hmmr)

DORD:

105994959(Hmmr)

DSP:	122125007(Hmmr)

DMER:

138808009(Hmmr)

PLOP:

125341854(Hmmr)

NCAR:

124987288 124994752

MMMA:

107147971(Hmmr)

ITI:	101968427(Hmmr)

OCU:

100353907

OPI:	101529697(HMMR)

OCZ:	121159441(HMMR)

TUP:	102483003(HMMR)

GVR:	103590807(HMMR)

CFA:	100855768 611838(HMMR)

CLUD:

112651721(HMMR) 112678430

VVP:	112926533(HMMR)

VLG:	121486735(HMMR)

NPO:	129509425(HMMR)

AML:	100482380(HMMR)

UMR:	103664513(HMMR)

UAH:	113264055(HMMR)

UAR:	123788569(HMMR)

ELK:

111141008

LLV:

125099705

MPUF:

101689156(HMMR)

MNP:	132028392(HMMR)

MLK:	131831873(HMMR)

NVS:	122893180(HMMR)

ORO:	101364635(HMMR)

EJU:	114211990(HMMR) 114215190

ZCA:	113913578 113929551(HMMR)

MLX:	118016405(HMMR) 118020459

MANO:

123845488 123862121(HMMR)

NSU:	110585410(HMMR) 110589528

LWW:	102729048 102737354 115940782

FCA:	101087202(HMMR)

PYU:	121010439(HMMR)

PCOO:

112860414(HMMR)

PBG:	122492833(HMMR)

PVIV:

125168835(HMMR)

LRUF:

124520478

LGF:	123611087(HMMR)

AJU:

106970383

PTG:	102969134(HMMR)

PPAD:

109267445(HMMR)

PUC:

125934452

PLEZ:

122224954(HMMR)

HHV:	120224064(HMMR)

CCRU:

144230086(HMMR)

BTA:	281227(HMMR)

BOM:	102268494 102269510

BIU:

109562276

BBUB:

102402856(HMMR)

BKE:	129637744(HMMR)

BBIS:

105005372(HMMR)

CHX:	102185463(HMMR)

OAS:

443128

BTAX:

128051455

CSUM:

138085381(HMMR)

ODA:	120863334(HMMR)

CCAD:

122439593(HMMR)

MREE:

136156347(HMMR)

OVR:	110142418(HMMR)

MBEZ:

129559371(HMMR)

SSC:	100515063(HMMR)

CFR:	102508113(HMMR)

CBAI:

105082690(HMMR)

CDK:	105097695(HMMR)

VPC:	102538959(HMMR)

BACU:

103008599(HMMR)

BMUS:

118893206(HMMR)

LVE:	103081850(HMMR)

OOR:	101269634(HMMR)

LALB:

132518568(HMMR)

GMF:	115844284(HMMR)

DDP:	132421968(HMMR)

DLE:	111185455(HMMR)

PCAD:

102990222(HMMR)

PSIU:

116751293(HMMR)

PPHC:

136120009(HMMR)

NASI:

112405100(HMMR)

ECB:	100070798(HMMR)

EPZ:	103563563(HMMR)

EAI:	106832161(HMMR)

MYB:	102248944(HMMR)

MYD:	102774403(HMMR)

MMYO:

118658973(HMMR)

MLF:	102432241(HMMR)

MDT:	132235935(HMMR)

MYUM:

139010252(HMMR)

PKL:	118710651(HMMR)

EFUS:

103291626(HMMR)

MNA:	107537881(HMMR)

DRO:	112319628(HMMR)

SHON:

118982832(HMMR)

AJM:	119065806(HMMR)

PDIC:

114510049(HMMR)

PHAS:

123807176(HMMR)

MMF:	118615957(HMMR)

PPAM:

129066496(HMMR) 129076053

HAI:	109375537(HMMR)

RFQ:	117017116(HMMR)

PALE:

102891903(HMMR)

PGIG:

120614427(HMMR)

PVP:	105289946(HMMR)

RAY:	107521907(HMMR)

MJV:	108401273(HMMR)

TOD:	119236876(HMMR)

SARA:

101548406(HMMR)

SFUM:

130041085(HMMR)

SETR:

126011894(HMMR)

LAV:	100654275(HMMR)

TMU:

101340428

ETF:	101643976(HMMR)

DNM:	101417944(HMMR)

MDO:	100030672(HMMR)

GAS:	123235556(HMMR)

SHR:	100915464(HMMR)

AFZ:

127550166

PCW:	110212393(HMMR)

TVP:	118843443(HMMR)

PBRV:

138172688(HMMR)

MLAO:

141506058(HMMR)

OAA:	100079090(HMMR)

TACU:

119950476(HMMR)

GGA:	416163(HMMR)

PCOC:

116231997(HMMR)

MGP:	100541832(HMMR)

CJO:	107320253(HMMR)

TPAI:

128081476(HMMR)

LMUT:

125700108(HMMR)

NMEL:

110405180(HMMR)

APLA:

101800083(HMMR)

AACU:

137864150(HMMR)

OJA:	118173564(HMMR)

ACYG:

106034419(HMMR)

CATA:

118256755(HMMR)

AFUL:

116495028(HMMR)

TGU:	100229538(HMMR)

LSR:	110481033(HMMR)

SCAN:

103817461(HMMR)

PMOA:

120498565(HMMR)

OTC:	121332289(HMMR)

PRUF:

121364602(HMMR)

ATRC:

139597627(HMMR)

GFR:	102034880(HMMR)

FAB:	101820950(HMMR)

OMA:	130258868(HMMR)

PHI:	102110453(HMMR)

PMAJ:

107210743(HMMR)

CCAE:

111935749(HMMR)

CCW:	104693565(HMMR)

CBRC:

103624891(HMMR)

ACOE:

138117882(HMMR)

ETL:	114067237(HMMR)

ZAB:	102071287(HMMR)

ZLE:	135453595(HMMR)

ACHL:

103806712(HMMR)

SVG:	106853872(HMMR)

MMEA:

130579414(HMMR)

HRT:	120759190(HMMR)

SATI:

136367396(HMMR)

CCIC:

134049585(HMMR)

FPG:	101911314(HMMR)

FCH:	102050882(HMMR)

CCRI:

104165564(HMMR)

NNT:	104411120(HMMR)

SHAB:

115615546(HMMR)

ACUN:

113485154(HMMR)

SURA:

141949519(HMMR)

TALA:

104356971(HMMR)

ACHC:

115334383(HMMR)

HALD:

104319945(HMMR)

HLE:	104839026(HMMR)

AGEN:

126050786

HHAR:

128134475(HMMR)

BBUT:

142044355(HMMR)

GCL:

127021900

CSTI:

104551728(HMMR)

LDI:	104341365(HMMR)

MNB:	103777019(HMMR)

DPUB:

104301880(HMMR)

PPUS:

135185197(HMMR)

AVIT:

104268494(HMMR)

BRHI:

104498752(HMMR)

EGZ:	104133611(HMMR)

NNI:	104016543(HMMR)

PCRI:

104034699(HMMR)

PCAO:

104040340(HMMR)

PARX:

142061272(HMMR)

PADL:

103912265(HMMR)

AFOR:

103904287(HMMR)

FGA:	104082193(HMMR)

CBOR:

142088625(HMMR)

GSTE:

104252202(HMMR)

CBOY:

140656950(HMMR)

MAME:

142413615(HMMR)

CLV:	102084711(HMMR)

CNIC:

135993925(HMMR)

MUI:	104546088(HMMR)

PGUU:

104459744(HMMR)

PLET:

104615480(HMMR)

EHS:	104504583(HMMR)

CMAC:

104474749(HMMR)

CUCA:

104062926(HMMR)

TEO:	104377063(HMMR)

BREG:

104630959(HMMR)

GAME:

129212694(HMMR)

OHA:	104331668 104332009 104338725

ACAR:

104519453(HMMR)

CPEA:

104392622(HMMR)

CVF:	104281763(HMMR)

RTD:	128916066(HMMR)

CRID:

134521894(HMMR)

LMIC:

141749652(HMMR)

AAM:	106493626(HMMR)

AROW:

112973005(HMMR)

NPD:	112954522(HMMR)

TGT:	104567034(HMMR)

DNE:	112993716(HMMR)

SCAM:

104154076(HMMR)

ASN:	102384646(HMMR)

AMJ:	102562518(HMMR)

CPOO:

109309967(HMMR)

GGN:	109290106(HMMR)

PSS:	102459268(HMMR)

CIZ:	142021058(HMMR)

CMY:	102947719(HMMR)

CCAY:

125641827(HMMR)

LKP:	140915729(HMMR)

NDS:	141992061(HMMR)

DCC:	119860603(HMMR)

CPIC:

101941487(HMMR)

TST:	117882139(HMMR)

CABI:

116822283(HMMR)

MRV:	120369941(HMMR)

ACS:	100557070(hmmr)

ASAO:

132768772(HMMR)

PVT:	110086743(HMMR)

SUND:

121924367(HMMR)

PBI:	103055232(HMMR)

PMUR:

107293583(HMMR)

CTIG:

120308136(HMMR)

TSR:	106544889(HMMR)

PGUT:

117658138(HMMR)

PCAE:

139310243(HMMR)

APRI:

131191962(HMMR)

PTEX:

113433654(HMMR)

NSS:	113421658 113421665

VKO:	123035522(HMMR)

PMUA:

114590854(HMMR)

PRAF:

128407733(HMMR)

ZVI:	118080020(HMMR)

HCG:	128345347(HMMR)

GJA:	107122417(HMMR)

STOW:

125429396(HMMR)

EMC:	129328322(HMMR)

XLA:	493576(hmmr.L)

XTR:	779567(hmmr)

NPR:	108799454(HMMR)

RTEM:

120932396(HMMR)

ACAT:

141132445(HMMR)

PADS:

140323547(HMMR)

BBUF:

121009168(HMMR)

BGAR:

122922772

DTC:	141087939(HMMR)

PWL:	138245627(HMMR)

MUO:	115476943(HMMR)

GSH:	117357332(HMMR)

DRE:	322012(hmmR)

SRX:	107707212 107751923

SANH:

107666600 107670188

SGH:	107561281 107600153

CCAR:

109094426(hmmr)

CAUA:

113057721 113073487 113114192

CGIB:

127971916 128027308

PTET:

122357273(hmmr)

LROH:

127176078(hmmr)

GRF:	141288521(hmmr)

OMC:	131553856(hmmr)

PPRM:

120461102(hmmr)

RKG:	130075601(hmmr)

MAMB:

125259206(hmmr)

CIDE:

127525699

CERY:

137008082(hmmr)

MASI:

127413358 127418378

TROS:

130563789(hmmr)

TDW:	130437971(hmmr)

MANU:

129422663(hmmr)

PDAB:

135748412(hmmr)

IPU:

108269157

IFU:	128611256(hmmr)

PHYP:

113528686

SMEO:

124386590(hmmr)

TFD:	113635839(hmmr)

TVC:	132855621(hmmr)

CGAR:

128531268(hmmr)

NGRA:

132890724(hmmr)

TRN:	134318831(hmmr)

AMEX:

103028028(hmmr)

CMAO:

118806419(hmmr)

EEE:

113581439

CHAR:

105902860

SPIL:

134069141(hmmr)

ASAD:

121694150(hmmr)

TRU:	497121(hmmr)

TFS:	130531730(hmmr)

LCO:

104923892

NCC:	104957137 104957141

TBEN:

117475264(hmmr)

CGOB:

115014204

PGEO:

117453325(hmmr)

GACU:

117545251(hmmr)

EMAC:

134860339(hmmr)

ELY:	117260591(hmmr)

EFO:	125894922(hmmr)

PLEP:

121947930(hmmr)

SLUC:

116052072(hmmr)

ECRA:

117952119(hmmr)

ESP:	116697156(hmmr)

PFLV:

114562562

GAT:	120818464(hmmr)

PPUG:

119210448(hmmr)

AFB:	129090037(hmmr)

CLUM:

117737532(hmmr)

PSWI:

130210034(hmmr)

CANA:

137798898(hmmr)

CVE:	137875866(hmmr)

MSAM:

119889047(hmmr)

SCHU:

122880878(hmmr)

EARM:

139291429(hmmr)

CUD:	121515898(hmmr)

SPUL:

138598270(hmmr)

LMIX:

132982453(hmmr)

HTC:	141793999(hmmr)

ALAT:

119007965(hmmr)

ASTR:

137602646(hmmr)

PKLU:

139207015(hmmr)

MZE:	101468833(hmmr)

ONL:	100704342(hmmr)

OAU:	116315162(hmmr)

OLA:	101165072(hmmr)

OML:	112153521(hmmr)

CSAI:

133447226(hmmr)

XMA:	102229042(hmmr)

XCO:	114139620(hmmr)

XHE:	116714920(hmmr)

PRET:

103470900(hmmr)

PFOR:

103155893(hmmr)

PLAI:

106941836(hmmr)

PMEI:

106928220(hmmr)

GAF:	122837575(hmmr)

PPRL:

129362910(hmmr)

CVG:

107086335

CTUL:

119771972(hmmr)

GMU:	124859816(hmmr)

NFU:	107383788(hmmr)

KMR:	108237937(hmmr)

ALIM:

106529799

NWH:	119408286(hmmr)

AOCE:

111588051(hmmr)

EJA:	138211197(hmmr)

BFRE:

138619991(hmmr)

MCEP:

125008715(hmmR)

CSEM:

103391411

POV:	109628493(hmmr)

SSEN:

122778899(hmmr)

SSOE:

131472932(hmmr)

HHIP:

117769613(hmmr)

HSP:	118112764(hmmr)

PPLT:

128445922(hmmr)

SMAU:

118319745(hmmr)

LCF:	108882781(hmmr)

SDU:

111226646

SLAL:

111664632

XGL:	120785498(hmmr)

HCQ:	109524472(hmmr)

SSCV:

125993952(hmmr)

SBIA:

133509105(hmmr)

PEE:	133407893(hmmr)

PTAO:

133485004(hmmr)

BPEC:

110162353(hmmr)

ENY:	140354664(hmmr)

MALB:

109956471

BSPL:

114864217(hmmr)

SJO:	128362894(hmmr)

SSCO:

133985953(hmmr)

TTY:	137189109(hmmr)

GMH:

115552430

SASA:

106604349 106612053(hmmr)

STRU:

115168428 115190164

OTW:	112255911(hmmr)

OMY:	110487767 110504634(hmmr)

OGO:	123993635 124011320

ONE:	115129193 115130960

OKI:	109907349 109910028

OKE:	118363238 118381403

OMM:	135526645 135545561(hmmr)

OCLA:

139365864 139390642

SALP:

111965979 111967209

SNH:	120047925 120062413

SFON:

129827481(hmmr) 129858400

CCLU:

121533196(hmmr)

ELS:

105007077

OEP:	134032636(hmmr)

SFM:	108936793(hmmr)

PKI:

111848923

AANG:

118222230

AROT:

135249739

CCOG:

133124434(hmmr)

LOC:	102688576(hmmr)

PSPA:

121296887 121324677

ARUT:

117431436

CMK:	103188214(hmmr)

CPLA:

122556481(hmmr)

CPUN:

140491914(hmmr)

HOC:	132823278(hmmr)

SCAU:

119965420(hmmr)

LERI:

129701595(hmmr)

HAKA:

140739098(hmmr)

BBEL:

109477500

CIN:	493183(rhamm)

SCLV:

CLEP:

SPU:

LPIC:

PFLL:

TCA:

TMOL:

RFG:

ATD:

CSET:

HAXR:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:	111419041 111427691

HHAL:

TPAL:

CSEC:

IEL:

DMK:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

LSM:

RMP:

VDE:

VJA:

PCAN:

112559665 112559795 112577445

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

RPHI:

MAEA:

LAK:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HSY:

RES:

AQU:

Reference

PMID:8890751

Authors

Wang C, Entwistle J, Hou G, Li Q, Turley EA

Title

The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.

Journal

Gene 174:299-306 (1996)
DOI:10.1016/0378-1119(96)00080-7

Sequence

[hsa:3161]

Reference

PMID:26825774

Authors

Kouvidi K, Berdiaki A, Tzardi M, Karousou E, Passi A, Nikitovic D, Tzanakakis GN

Title

Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a beta-catenin/c-myc signaling axis.

Journal

Biochim Biophys Acta 1860:814-24 (2016)
DOI:10.1016/j.bbagen.2016.01.019

LinkDB

DBGET integrated database retrieval system