KEGG ORTHOLOGY: K06624

ORTHOLOGY: K06624

Entry

K06624                      KO

Symbol

CDKN1B, P27, KIP1

Name

cyclin-dependent kinase inhibitor 1B

Pathway

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04110

Cell cycle

map04151

PI3K-Akt signaling pathway

map04933

AGE-RAGE signaling pathway in diabetic complications

map04934

Cushing syndrome

map05162

Measles

map05165

Human papillomavirus infection

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05203

Viral carcinogenesis

map05206

MicroRNAs in cancer

map05215

Prostate cancer

map05220

Chronic myeloid leukemia

map05222

Small cell lung cancer

map05226

Gastric cancer

Disease

H00018

Gastric cancer

H00024

Prostate cancer

H00247

Multiple endocrine neoplasia syndrome

H01102

Pituitary adenomas

H01431

Cushing syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04066 HIF-1 signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04068 FoxO signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04151 PI3K-Akt signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05202 Transcriptional misregulation in cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05206 MicroRNAs in cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05203 Viral carcinogenesis
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09162 Cancer: specific types
   05226 Gastric cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05220 Chronic myeloid leukemia
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05215 Prostate cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05222 Small cell lung cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09172 Infectious disease: viral
   05162 Measles
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05169 Epstein-Barr virus infection
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05165 Human papillomavirus infection
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04934 Cushing syndrome
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B

Other DBs

GO:

0004861

Genes

HSA:	1027(CDKN1B)

PTR:	466947(CDKN1B)

PPS:	100985362(CDKN1B)

GGO:	101147653(CDKN1B)

PON:	100449905(CDKN1B)

PPYG:

129010319(CDKN1B)

NLE:	100589956(CDKN1B)

HMH:	116472702(CDKN1B)

SSYN:

129483341(CDKN1B)

MCC:	697188(CDKN1B)

MCF:	102117954(CDKN1B)

MTHB:

126930782

MNI:	105482108(CDKN1B)

CSAB:

103218647(CDKN1B)

CATY:

105585139(CDKN1B)

PANU:

101001461(CDKN1B)

TGE:	112634261(CDKN1B)

MLEU:

105549206(CDKN1B)

RRO:	104668343(CDKN1B)

RBB:	108530341(CDKN1B)

TFN:	117090495(CDKN1B)

PTEH:

111552085(CDKN1B)

CANG:

105520264(CDKN1B)

CJC:	100387508(CDKN1B)

SBQ:	101030975(CDKN1B)

CIMI:

108304025(CDKN1B)

ANAN:

105713873(CDKN1B)

CSYR:

103264812(CDKN1B)

MMUR:

105876702(CDKN1B)

LCAT:

123639989(CDKN1B)

PCOQ:

105819524(CDKN1B)

OGA:	100964179(CDKN1B)

MMU:	12576(Cdkn1b)

MCAL:

110296846(Cdkn1b)

MPAH:

110316560(Cdkn1b)

RNO:	83571(Cdkn1b)

MCOC:

116099702(Cdkn1b)

ANU:	117715314(Cdkn1b)

MUN:	110551008(Cdkn1b)

CGE:	100689401(Cdkn1b)

MAUA:

101844027(Cdkn1b)

PROB:

127212978(Cdkn1b)

PLEU:

114710338(Cdkn1b)

MORG:

121441659(Cdkn1b)

MFOT:

126489198

AAMP:

119807071(Cdkn1b)

NGI:	103737662(Cdkn1b)

HGL:	101698721(Cdkn1b)

CPOC:

100729359(Cdkn1b)

CCAN:

109701269(Cdkn1b)

DORD:

105992216(Cdkn1b)

DSP:	122101247(Cdkn1b)

PLOP:

125342836(Cdkn1b)

NCAR:

124983239

MMMA:

107152676(Cdkn1b)

OCU:

100009037

OPI:	101522654(CDKN1B)

TUP:	102501235(CDKN1B)

GVR:	103592695(CDKN1B)

CFA:	403429(CDKN1B)

CLUD:

112665406(CDKN1B)

VVP:	112917274(CDKN1B)

VLG:	121480271(CDKN1B)

NPO:	129517176(CDKN1B)

AML:	100467824(CDKN1B)

UMR:	103677760(CDKN1B)

UAH:	113257870(CDKN1B)

UAR:	123781751(CDKN1B)

ELK:	111142072 111142115

LLV:

125106593

MPUF:

101688289(CDKN1B)

MNP:	132019499(CDKN1B)

MLK:	131839026(CDKN1B)

NVS:	122891702(CDKN1B)

ORO:	101362774(CDKN1B)

EJU:	114221704(CDKN1B)

ZCA:	113922890(CDKN1B)

MLX:	118025649(CDKN1B)

NSU:	110580846(CDKN1B)

LWW:	102749650(CDKN1B)

FCA:	493958(CDKN1B)

PYU:	121038909(CDKN1B)

PCOO:

112867392(CDKN1B)

PBG:	122473385(CDKN1B)

PVIV:

125170074(CDKN1B)

LRUF:

124500999

PTG:	102965656(CDKN1B)

PPAD:

109268629(CDKN1B)

PUC:

125918841

AJU:

106965649

HHV:	120236900(CDKN1B)

BTA:	512613(CDKN1B)

BOM:	102276245(CDKN1B)

BIU:	109559641(CDKN1B)

BBUB:

102406138(CDKN1B)

BBIS:

105002174(CDKN1B)

CHX:	102175277(CDKN1B)

OAS:	100127219(CDKN1B)

BTAX:

128047650(CDKN1B)

ODA:	120858866(CDKN1B)

CCAD:

122423697(CDKN1B)

MBEZ:

129536837(CDKN1B)

SSC:	397584(CDKN1B)

CFR:	102518884(CDKN1B)

CBAI:

105062235(CDKN1B)

CDK:	105094245(CDKN1B)

VPC:	102534959(CDKN1B)

BACU:

103001464(CDKN1B)

BMUS:

118902318(CDKN1B)

LVE:	103070701(CDKN1B)

OOR:	101287264(CDKN1B)

DLE:	111176781(CDKN1B)

PCAD:

102981902(CDKN1B)

PSIU:

116760537(CDKN1B)

NASI:

112391736(CDKN1B)

ECB:	111773925(CDKN1B)

EPZ:	103552733(CDKN1B)

EAI:	106826745(CDKN1B)

MYB:	102252017(CDKN1B)

MYD:	102767192(CDKN1B)

MMYO:

118650327(CDKN1B)

MLF:	102429961(CDKN1B)

MDT:	132227307(CDKN1B)

PKL:	118729119(CDKN1B)

EFUS:

103285100(CDKN1B)

MNA:	107525363(CDKN1B)

DRO:	112318485(CDKN1B)

SHON:

118978371(CDKN1B)

AJM:	119042826(CDKN1B)

PDIC:

114512889(CDKN1B)

PHAS:

123812935(CDKN1B)

MMF:	118624260(CDKN1B)

PPAM:

129085013(CDKN1B)

HAI:	109383166(CDKN1B)

RFQ:	117029064(CDKN1B)

PALE:

102880085(CDKN1B)

PGIG:

120613734(CDKN1B)

PVP:	105302792(CDKN1B)

RAY:	107516566(CDKN1B)

MJV:	108391616(CDKN1B)

TOD:	119247697(CDKN1B)

SARA:

101544887(CDKN1B)

SETR:

126022439(CDKN1B)

LAV:	100674125(CDKN1B)

TMU:

101360273

ETF:	101641071(CDKN1B)

DNM:	101424995(CDKN1B)

MDO:	100014923(CDKN1B)

GAS:	123248489(CDKN1B)

SHR:	100928055(CDKN1B)

AFZ:

127539369

PCW:	110218707(CDKN1B)

TVP:	118850228(CDKN1B)

OAA:	100090228(CDKN1B)

GGA:	374106(CDKN1B)

PCOC:

116235199(CDKN1B)

MGP:	100545308(CDKN1B)

CJO:	107317865(CDKN1B)

TPAI:

128084455(CDKN1B)

LMUT:

125686198(CDKN1B)

NMEL:

110390809(CDKN1B)

APLA:

101791694(CDKN1B)

ACYG:

106031051(CDKN1B)

CATA:

118250192(CDKN1B)

AFUL:

116501761(CDKN1B)

TGU:	100190046(CDKN1B)

LSR:	110472989(CDKN1B)

SCAN:

103819664(CDKN1B)

PMOA:

120501595(CDKN1B)

OTC:	121332839(CDKN1B)

GFR:	102045566(CDKN1B)

FAB:	101811953(CDKN1B)

OMA:	130248242(CDKN1B)

PHI:	102099407(CDKN1B)

PMAJ:

107204220(CDKN1B)

CCAE:

111942051(CDKN1B)

CCW:	120411944(CDKN1B)

CBRC:

103613082(CDKN1B)

ETL:	114071520 114072483 114073090

ZAB:	102062405(CDKN1B)

ZLE:	135460246(CDKN1B)

ACHL:

103802142(CDKN1B)

SVG:	106855792(CDKN1B)

MMEA:

130577821(CDKN1B)

HRT:	120752389(CDKN1B)

SATI:

136361542(CDKN1B)

FPG:	101922239(CDKN1B)

FCH:	102051672(CDKN1B)

CCRI:

104156816(CDKN1B)

SHAB:

115605064(CDKN1B)

TALA:

116962100(CDKN1B)

ACHC:

115352528(CDKN1B)

HLE:	104836626(CDKN1B)

AGEN:

126048008

GCL:

127027566

CSTI:

104560613(CDKN1B)

LDI:	104346494(CDKN1B)

MNB:	103771174(CDKN1B)

DPUB:

104304515(CDKN1B)

BRHI:

104490779

EGZ:	104124225(CDKN1B)

NNI:	104012648(CDKN1B)

PADL:

103913629 103917238

AFOR:

103906560(CDKN1B)

CLV:	102092237(CDKN1B)

EHS:	104515754(CDKN1B)

CUCA:

104066610(CDKN1B)

CPEA:

104395095(CDKN1B)

RTD:

128918286

AAM:	106488961(CDKN1B)

AROW:

112976482(CDKN1B)

NPD:	112942349(CDKN1B)

TGT:	104568069(CDKN1B)

DNE:	112991554(CDKN1B)

SCAM:

104146602(CDKN1B)

AMJ:	102571564(CDKN1B)

CPOO:

109316306(CDKN1B)

GGN:	109296440(CDKN1B)

PSS:	102452459(CDKN1B)

CCAY:

125624079(CDKN1B)

CPIC:

101954164(CDKN1B)

TST:	117884245(CDKN1B)

CABI:

116838033(CDKN1B)

MRV:	120406118(CDKN1B)

ACS:	100565024(cdkn1c) 100565071(cdkn1b)

ASAO:

132776446(CDKN1B)

PVT:

110074986

SUND:

121918739

PMUR:

107286956(CDKN1B)

CTIG:

120313063(CDKN1B)

TSR:	106547400(CDKN1B)

PGUT:

117678890(CDKN1B)

APRI:

131202340(CDKN1B)

PTEX:

113437237(CDKN1B)

NSS:	113419730(CDKN1B)

VKO:	123017207(CDKN1B)

PMUA:

114596839(CDKN1B)

PRAF:

128413507(CDKN1B)

ZVI:	118096485(CDKN1B)

HCG:	128328511(CDKN1B)

STOW:

125443691(CDKN1B)

EMC:	129344207(CDKN1B)

XLA:	108710741 492306(cdkn1b.S)

XTR:	101732126(cdkn1b)

BBUF:

121004079

BGAR:

122928509(CDKN1B)

MUO:	115477564(CDKN1B)

GSH:	117364323(CDKN1B)

DRE:	368329(cdkn1bb) 402862(cdkn1ba)

SRX:	107725668 107732982 107745109 107745559

SANH:

107664845 107668652 107701191

SGH:	107549588 107553888 107558598 107590325

CCAR:

109051418 109067664 109077180 109085097 109085104

CAUA:

113042948 113043021 113048132 113063086 113063328 113066613 113074399

CGIB:

127947230 127956965 127974495 128014511

PTET:

122330755(cdkn1bb) 122342688(cdkn1ba)

LROH:

127156930(cdkn1bb) 127164397(cdkn1ba)

OMC:	131534452(cdkn1bb) 131538274(cdkn1ba)

PPRM:

120460370(cdkn1bb) 120476998(cdkn1ba)

RKG:	130072257(cdkn1ba) 130078145(cdkn1bb)

MAMB:

125244706(cdkn1ba) 125247478(cdkn1bb)

CIDE:

127506699 127511559

CERY:

137015007(cdkn1bb) 137024465(cdkn1ba)

MASI:

127435016 127436078 127436376 127437133

TROS:

130547811(cdkn1ba) 130551575(cdkn1bb)

TDW:	130414173(cdkn1bb) 130420307(cdkn1ba)

MANU:

129432161(cdkn1ba) 129434073(cdkn1bb)

IPU:	100528292(cdkn1bb) 108280031(cdkn1ba)

IFU:	128618199(cdkn1bb) 128623322(cdkn1ba)

PHYP:

113531770(cdkn1b)

SMEO:

124392633(cdkn1bb) 124401849(cdkn1ba)

TFD:	113639220(cdkn1bb) 113645891(cdkn1ba)

TVC:	132857143(cdkn1bb) 132859121(cdkn1ba)

TRN:	134321446(cdkn1bb) 134324426(cdkn1ba)

AMEX:

103025923(cdkn1bb) 103030485(cdkn1ba)

CMAO:

118811853(cdkn1bb) 118812475(cdkn1ba)

EEE:	113572522 113583571

CHAR:

105913428(cdkn1bb) 122132134(cdkn1ba)

TRU:	101071664(cdkn1b) 105417782

TFS:	130518883 130536725(cdkn1bb)

LCO:	104921009(cdkn1b) 104933552

NCC:	104955518(cdkn1b) 104955766

TBEN:

117483302 117497461(cdkn1bb)

CGOB:

115010264(cdkn1b) 115028457

PGEO:

117439078(cdkn1ba) 117447937(cdkn1bb)

GACU:

117547802(cdkn1bb) 117558302

EMAC:

134879117(cdkn1ba) 134880505(cdkn1bb)

ELY:	117248920(cdkn1ba) 117262362(cdkn1bb)

EFO:	125882862(cdkn1ba) 125887499(cdkn1bb)

PLEP:

121950598(cdkn1bb) 121961347(cdkn1ba)

SLUC:

116038763(cdkn1bb) 116039819

ECRA:

117938422 117948489(cdkn1bb)

ESP:	116672831 116693641(cdkn1b)

PFLV:

114550190 114560212(cdkn1b)

GAT:	120809056(cdkn1bb) 120812631

PPUG:

119196337(cdkn1bb) 119211423

AFB:	129108101(cdkn1bb) 129112606

CLUM:

117732133(cdkn1bb)

PSWI:

130195164(cdkn1bb) 130200549(cdkn1ba)

MSAM:

119894302(cdkn1bb) 119917913(cdkn1ba)

SCHU:

122875381(cdkn1bb)

CUD:	121505732(cdkn1ba) 121515649(cdkn1bb)

ALAT:

119023781(cdkn1bb) 119032317(cdkn1ba)

MZE:	101466273 101468035(cdkn1b)

ONL:	100709597(cdkn1b) 102083324

OAU:	116328734(cdkn1ba) 116332098(cdkn1bb)

OLA:	101166473(cdkn1b)

OML:	112151979(cdkn1bb) 118598090(cdkn1ba)

CSAI:

133443830(cdkn1bb)

XMA:	102221028 102235773

XCO:	114155712 114161104

XHE:	116736718 116737383

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122826720(cdkn1ba) 122835664(cdkn1bb)

PPRL:

129364493(cdkn1bb) 129376240

CVG:	107097852(cdkn1b) 107099560

CTUL:

119776226(cdkn1ba) 119780381(cdkn1bb)

GMU:	124861208(cdkn1bb) 124883195(cdkn1ba)

NFU:	107384056 107388428(cdkn1b)

KMR:	108240964 108246606(cdkn1bb)

ALIM:

106525565 106528189

NWH:	119415856(cdkn1bb) 119427956(cdkn1ba)

AOCE:

111573186 111577772(cdkn1b)

MCEP:

125015288(cdkn1bb)

CSEM:

103380321(cdkn1b) 103382902

POV:	109624669(cdkn1b) 109632735

SSEN:

122766808(cdpf1) 122776047(cdkn1bb)

HHIP:

117756987(cdkn1ba) 117762828(cdkn1bb)

HSP:	118101858(cdkn1ba) 118109406(cdkn1bb)

PPLT:

128428448(cdkn1ba) 128444694(cdkn1bb)

SMAU:

118290624 118314970(cdkn1bb)

LCF:	108883075(cdkn1bb) 108890602(cdkn1ba)

SDU:	111224759 111229694(cdkn1b)

SLAL:

111650370(cdkn1b) 111651967

XGL:	120792674(cdkn1bb) 120797278

HCQ:	109523748 109529876(cdkn1b)

SSCV:

125970910

SBIA:

133502622(cdkn1bb)

PEE:	133397425 133403243(cdkn1bb)

PTAO:

133472215(cdkn1ba) 133478046(cdkn1bb)

BPEC:

110164974 110169421(cdkn1b)

MALB:

109960936 109974134(cdkn1b)

BSPL:

114857106(cdkn1bb) 114861503(cdkn1ba)

SJO:	128353391(cdkn1ba) 128359124(cdkn1bb)

SASA:

106560990(cdkn1b) 106575072(CDN1B) 106584490(CDN1B) 106609100

STRU:

115180610 115192669 115196967(cdkn1b) 115198635

OTW:	112214453 112216753 112218171 112240696

OMY:	110490138(cdkn1ba) 110500295 110521395(cdkn1bb)

OGO:	123995625(cdkn1ba) 124014035 124038476

ONE:	115106841 115133262 115134429(cdkn1b)

OKI:	109864404 109867294(cdkn1b) 109896833

OKE:	118359264 118366090 118373652 118396522

SALP:

111951405 111962224(cdkn1b) 112069693

SNH:	120032073(cdkn1ba) 120049833 120066154

CCLU:

121531728 121540605 121554832 121581240

ELS:	105018460(cdkn1b) 105020266

SFM:	108931519 108935889

PKI:	111833308(cdkn1b) 111858596

AANG:

118219144 118232306

LOC:	102688046(cdkn1b)

PSPA:

121318617 121319555

ARUT:

117414998 117419491(cdkn1bb)

PSEX:

120539654(cdkn1bb)

LCM:	102355060(CDKN1B)

CMK:	103179336(cdkn1bb)

RTP:	109931217(cdkn1bb)

CPLA:

122548044(cdkn1bb)

HOC:	132824703(cdkn1bb)

LERI:

129706064(cdkn1bb)

BFO:

BBEL:

CIN:

SCLV:

APLC:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

MPHA:

AEC:

ACEP:

VEM:

DQU:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

API:

DNX:	107166459 107166550

AGS:

114127596

CSEC:

111870931

DPX:	DAPPUDRAFT_331277

DMK:

116929959

PVM:	113803050 113827313

PPOI:

CSCU:

PTEP:

GAE:

HRJ:

MYI:

PMAX:

MMER:

DPOL:

LAK:

ATEN:

ADF:

AMIL:

PDAM:

DGT:

XEN:	124452733 124456542

HMG:	100197618 105844255

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Reference

PMID:8033212

Authors

Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J

Title

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.

Journal

Cell 78:59-66 (1994)
DOI:10.1016/0092-8674(94)90572-X

Sequence

[hsa:1027]

Reference

PMID:19887899

Authors

Lee J, Kim SS

Title

The function of p27 KIP1 during tumor development.

Journal

Exp Mol Med 41:765-71 (2009)
DOI:10.3858/emm.2009.41.11.102

Sequence

[hsa:1027]

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