Homo sapiens (human): 1027
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Entry
1027 CDS
T01001
Symbol
CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Name
(RefSeq) cyclin dependent kinase inhibitor 1B
KO
K06624
cyclin-dependent kinase inhibitor 1B
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04012
ErbB signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04151
PI3K-Akt signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04934
Cushing syndrome
hsa05162
Measles
hsa05165
Human papillomavirus infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05203
Viral carcinogenesis
hsa05206
MicroRNAs in cancer
hsa05215
Prostate cancer
hsa05220
Chronic myeloid leukemia
hsa05222
Small cell lung cancer
hsa05226
Gastric cancer
Network
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06230
Cell cycle (cancer)
nt06240
Transcription (cancer)
nt06261
Gastric cancer
nt06267
Small cell lung cancer
nt06272
Prostate cancer
nt06360
Cushing syndrome
Element
N00091
p27-Cell cycle G1/S
N00092
Amplified MYC to p27-cell cycle G1/S
N00093
Loss of CDKN1B to p27-cell cycle G1/S
N00119
MLL-AF4 fusion to transcriptional activation
N00254
CDKN1B-reduced expression to p27-cell cycle G1/S
N00264
EBV EBNA3C to p27-Cell cycle G1/S
N00290
Mutation-inactivated MEN1 to transcription
N00316
Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00359
HPV E7 to p27-cell cycle G1/S
N00362
HPV E5 to p21-cell cycle G1/S
Disease
H00018
Gastric cancer
H00024
Prostate cancer
H00247
Multiple endocrine neoplasia syndrome
H01102
Pituitary adenomas
H01431
Cushing syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
1027 (CDKN1B)
04068 FoxO signaling pathway
1027 (CDKN1B)
04151 PI3K-Akt signaling pathway
1027 (CDKN1B)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1027 (CDKN1B)
05202 Transcriptional misregulation in cancer
1027 (CDKN1B)
05206 MicroRNAs in cancer
1027 (CDKN1B)
05203 Viral carcinogenesis
1027 (CDKN1B)
09162 Cancer: specific types
05226 Gastric cancer
1027 (CDKN1B)
05220 Chronic myeloid leukemia
1027 (CDKN1B)
05215 Prostate cancer
1027 (CDKN1B)
05222 Small cell lung cancer
1027 (CDKN1B)
09172 Infectious disease: viral
05162 Measles
1027 (CDKN1B)
05169 Epstein-Barr virus infection
1027 (CDKN1B)
05165 Human papillomavirus infection
1027 (CDKN1B)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
1027 (CDKN1B)
04934 Cushing syndrome
1027 (CDKN1B)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
1027 (CDKN1B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
CDI
Multi-haem_cyto
Motif
Other DBs
NCBI-GeneID:
1027
NCBI-ProteinID:
NP_004055
OMIM:
600778
HGNC:
1785
Ensembl:
ENSG00000111276
UniProt:
P46527
Q6I9V6
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:12717368..12722369
Genome browser
AA seq
198 aa
AA seq
DB search
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKW
NFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIG
APANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPN
AGSVEQTPKKPGLRRRQT
NT seq
597 nt
NT seq
+upstream
nt +downstream
nt
atgtcaaacgtgcgagtgtctaacgggagccctagcctggagcggatggacgccaggcag
gcggagcaccccaagccctcggcctgcaggaacctcttcggcccggtggaccacgaagag
ttaacccgggacttggagaagcactgcagagacatggaagaggcgagccagcgcaagtgg
aatttcgattttcagaatcacaaacccctagagggcaagtacgagtggcaagaggtggag
aagggcagcttgcccgagttctactacagacccccgcggccccccaaaggtgcctgcaag
gtgccggcgcaggagagccaggatgtcagcgggagccgcccggcggcgcctttaattggg
gctccggctaactctgaggacacgcatttggtggacccaaagactgatccgtcggacagc
cagacggggttagcggagcaatgcgcaggaataaggaagcgacctgcaaccgacgattct
tctactcaaaacaaaagagccaacagaacagaagaaaatgtttcagacggttccccaaat
gccggttctgtggagcagacgcccaagaagcctggcctcagaagacgtcaaacgtaa
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