| Entry |
|
| Name |
cardiolipin synthase (CMP-forming)
|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
|
| Sysname |
CDP-diacylglycerol:phosphatidylglycerol diacylglycerolphosphotransferase (CMP-forming)
|
| Reaction(IUBMB) |
a CDP-diacylglycerol + a phosphatidylglycerol = a cardiolipin + CMP [RN: R02030]
|
| Reaction(KEGG) |
|
| Substrate |
CDP-diacylglycerol [CPD: C00269];
phosphatidylglycerol [CPD: C00344]
|
| Product |
|
| Comment |
The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin. It requires divalent cations for activity.
|
| History |
EC 2.7.8.41 created 2014
|
| Pathway |
| ec00564 | Glycerophospholipid metabolism |
|
| Orthology |
| K08744 | cardiolipin synthase (CMP-forming) |
|
| Genes |
| MNP: | 132008132 132021739(CRLS1) |
| MDT: | 132230614 132239369(CRLS1) |
| PKL: | 118705782 118708295(CRLS1) |
| DNM: | 101424550(CRLS1) 101447986 |
| AFUL: | 116488218(CRLS1) 116499914 |
| PMUA: | 114593653(CRLS1) 114604220 |
| PRAF: | 128410046(CRLS1) 128421039 |
| SANH: | 107663140 107678734 |
| CAUA: | 113060815 113071783 113117753 |
| CGIB: | 127975788 128031412 |
| MASI: | 127410729 127455233 |
| SMEO: | 124389636 124390214(crls1) |
| CCLU: | 121544814(crls1) 121559872 |
| DSI: | Dsimw501_GD18179(Dsim_GD18179) |
| ADAR: | 125955908 125959235 |
| AALB: | 109403482 109433655 115268707 115269334 |
| PORN: | 139755734 139761046 |
| CEL: | CELE_F23H11.9(crls-1) |
| CBR: | CBG_15172(Cbr-crls-1) |
| CSAT: | 104707641 104716429 104737339 |
| HSYR: | 120119952 120151709 |
| AHF: | 112705667 112722935 112723257 |
| QSA: | O6P43_011899 O6P43_031229 |
| MSYL: | 126586209 126624260 |
| PCOX: | 137727107 137729706 |
| CSAA: | 142620490 142636710 |
| SMIL: | 130985764 131022201 |
| PTAB: | 142523216 142532956 |
| CARB: | 113709519 113709520 |
| PSOM: | 113318823 113331323 113353767 |
| TAES: | 123062286 123071048 123079419 |
| PVIR: | 120675841 120708329 |
| ACAK: | 137937716 137943157 |
| SMO: | SELMODRAFT_405738 SELMODRAFT_415497 |
| CGR: | 2889256(GVI51_I03509) |
| NCS: | NCAS_0E03780(NCAS0E03780) |
| NDI: | NDAI_0A02850(NDAI0A02850) |
| TPF: | TPHA_0A03050(TPHA0A03050) |
| TBL: | TBLA_0E02000(TBLA0E02000) |
| TDL: | TDEL_0C02300(TDEL0C02300) |
| KAF: | KAFR_0L01350(KAFR0L01350) |
| KNG: | KNAG_0B02760(KNAG0B02760) |
| LBG: | 92208157(LODBEIA_P29610) |
| CAL: | CAALFM_C100100CA(CaO19.6100) |
| CTEN: | 18247400(PSN45_004656) |
| ASAU: | 88175839(PUMCH_004779) |
| YLI: | 2908748(YALI2_E01036g) |
| NTE: | NEUTE1DRAFT122183(NEUTE1DRAFT_122183) |
| SMP: | 10808121(SMAC4_02286) |
| RTHE: | 98121844(VTJ83DRAFT_1080) |
| TATV: | 25783101(TrAtP1_009878) |
| TASP: | 36618737(TrAFT101_011306) |
| MAW: | 19246202(J3458_003756) |
| UVI: | 66067110(UV8b_06333) |
| PLJ: | 28886994(PLICBS_002302) |
| DCON: | 63715691(DCS_03048) |
| CDET: | 87937357(CDEST_00854) |
| BFU: | BCIN_03g07430(Bccrd1) |
| PPSF: | 300788122(PFLUO_LOCUS2501) |
| CPW: | 9696624(D8B26_000718) |
| PTRR: | 6340400(PtrM4_014790) |
| ADAC: | 96088865(ACET3X_008543) |
| CDEC: | 89992648(IAS62_005879) |
| CTEG: | 91992994(I308_106139) |
| CBAS: | 91986019(I312_105975) |
| CDEP: | 91088571(L203_104361) |
| KMG: | 30167672(I203_106773) |
| KNE: | 92178536(IAR55_001277) |
| KDJ: | 28965075(I303_101367) |
| KBI: | 30207665(I302_104561) |
| KPIN: | 30176262(I206_100078) |
| KSH: | 87953433(IL334_001302) |
| KER: | 91106567(V865_007766) |
| KSN: | 43591170(CI109_102108) |
| KEP: | 91092003(L201_001331) |
| CCAC: | CcaHIS019_0605830(CcaverHIS019_0605830) |
| PPL: | POSPLDRAFT_26909 POSPLDRAFT_27949 |
| ABP: | AGABI1DRAFT114250(AGABI1DRAFT_114250) |
| ABV: | AGABI2DRAFT191269(AGABI2DRAFT_191269) |
| SCM: | SCHCO_02619624(SCHCODRAFT_02619624) |
| EHI: | EHI_035400(17.t00024) |
| MANP: | EHN06_08160 EHN06_08205 |
| MICC: | AUP74_00920(pgsA_1) |
| LLG: | 44548918_02523(pgsA2) |
| LJR: | NCTC11533_02673(pgsA2) |
| LCJ: | NCTC11976_00344(pgsA2) |
| LWA: | SAMEA4504053_3305(pgsA2) |
| LSS: | NCTC12082_01859(pgsA2) |
| LADL: | NCTC12735_01591(pgsA2) |
| TNI: | TVNIR_3397(pgsA_[C]) |
| URU: | DSM104443_02372(pgsA) |
| UPL: | DSM104440_02115(pgsA) |
| PACA: | ID47_03140 ID47_03915 |
| GAGG: | Gromo_00192 Gromo_00427 |
| NRH: | T8J41_17935 T8J41_19815(pgsA) |
| AMIH: | CO731_04170(pgsA_1) |
| LAS: | CLIBASIA_02435(pgsA) |
| VGO: | GJW-30_1_01771(pgsA) GJW-30_1_03495(pgsA2) |
| RHZ: | RHPLAN_14650 RHPLAN_44540 |
| MAQU: | Maq22A_c26275(pgsA) |
| HDT: | HYPDE_28443 HYPDE_37773 |
| HMC: | HYPMC_2991(pgsA) HYPMC_4116 |
| HNI: | W911_06570 W911_06765 |
| FIL: | BN1229_v1_0075(pgsA) BN1229_v1_3935 |
| FIY: | BN1229_v1_0077(pgsA) BN1229_v1_3922 |
| METG: | HT051_06030(pgsA) HT051_07210 |
| MROS: | EHO51_04345 EHO51_06605(pgsA) |
| PLEO: | OHA_1_00211(pgsA2) OHA_1_02346(pgsA) |
| TSO: | IZ6_08640(pgsA) IZ6_16040 |
| BRN: | D1F64_11820 D1F64_17250(pgsA) |
| PSTG: | E8M01_00055 E8M01_34810 |
| TMO: | TMO_1838 TMO_c0131(pgsA) |
| THET: | F1847_06005(pgsA) F1847_09020 |
| TAV: | G4V39_03525 G4V39_04335 |
| TMAI: | FVE67_03415 FVE67_04935 |
| OBG: | Verru16b_02571(pgsA) |
| LCRE: | Pla8534_41340(pgsA_1) |
| ALUS: | STSP2_03330(pgsA2_2) |
| LKB: | LPTSP3_g13450(pgsA_1) |
| TPX: | Turpa_2077 Turpa_3868 |
| MCOS: | GM418_20080 GM418_23010 GM418_23645 |
| MGOS: | DIU38_008655 DIU38_030310 |
| KOS: | KORDIASMS9_02119(pgsA) |
| PROC: | Ptc2401_00519(pgsA_2) |
| RMG: | Rhom172_0692 Rhom172_2372 |
| PFLO: | G3M65_01210 G3M65_05580 |
| DTH: | DICTH_0990 DICTH_1746 |
| PBK: | Back11_52270(pgsA_2) |
| PKP: | SK3146_03665(pgsA_1) |
| COHN: | KCTCHS21_55960(pgsA) |
| PABS: | JIR001_30200(pgsA_2) |
| EFU: | HMPREF0351_10392(pgsA) |
| MARR: | BKP56_06425 BKP56_08615 |
| CCB: | Clocel_1089 Clocel_2030 |
| CLT: | CM240_2235 CM240_2669 |
| CCK: | Ccar_09690 Ccar_24705 |
| CCOH: | SAMEA4530647_2460(pgsA_2) |
| CRW: | CROST_000010(pgsA_1) CROST_038020 |
| CFB: | CLFE_003000(pgsA_1) CLFE_009800 |
| CAUN: | CLAUR_029960(pgsA_2) CLAUR_037250 |
| HHW: | NCTC503_02715(pgsA2) |
| EHA: | Ethha_1017 Ethha_1298 |
| CAML: | H6X83_01975 H6X83_10535 |
| SMAN: | C12CBH8_21520(pgsA_2) |
| VFA: | MM35RIKEN_08140(pgsA) |
| VCOP: | MM50RIKEN_14640(pgsA_2) |
| CFEM: | HCR03_12205 HCR03_17445 |
| BPEN: | NQ488_05420 NQ488_14445 |
| CCOM: | I6K69_06410 I6K69_12210 |
| BPRO: | PMF13cell1_03668(pgsA1) PMF13cell1_05160(pgsA_2) |
| CSCI: | HDCHBGLK_00060(pgsA_1) |
| DLO: | K5I24_10205 K5I24_15390 |
| CBAR: | PATL70BA_0341 PATL70BA_2285 |
| GFE: | Gferi_03535 Gferi_04350 |
| TPET: | TPHSE_05890(pgsA_1) |
| HALS: | D7D81_12585 D7D81_12650 |
| CAD: | Curi_c05170(pgsA1) Curi_c08180(pgsA2) |
| SPOA: | EQM13_00660 EQM13_06700(pgsA) |
| FIT: | Fi14EGH31_06120(pgsA_2) Fi14EGH31_12850(pgsA_3) |
| CDIA: | CaldiYA01_10600(pgsA) |
| AAXA: | NCTC10138_01657(pgsA_2) |
| MALA: | NCTC10135_00590(pgsA) |
| PCAT: | Pcatena_07910(pgsA) |
| DDT: | AAY81_05640 AAY81_09575 |
| RTS: | CE91St31_16780(pgsA2) |
| MBO: | BQ2027_MB1853(pgsA2) |
| MAVM: | MAA44156_01519(pgsA) |
| MMAN: | MMAN_11660(pgsA2_2) |
| MMAE: | MMARE11_26200(pgsA2) |
| MPSE: | MPSD_27760(pgsA1_2) |
| MSHO: | MSHO_40260(pgsA2_1) |
| MFJ: | MFLOJ_06490(pgsA2_1) |
| MSTO: | MSTO_07750(pgsA2_1) |
| MSAK: | MSAS_06980(pgsA2_1) |
| MBAI: | MB901379_02496(pgsA) |
| MSHJ: | MSHI_13730(pgsA1_1) |
| MKY: | IWGMT90018_30240(pgsA1_1) |
| MPHL: | MPHLCCUG_02349(pgsA_1) |
| MTHN: | 4412656_02239(pgsA) |
| MAUU: | NCTC10437_03035(pgsA_3) |
| MFLV: | NCTC10271_02562(pgsA2_1) |
| MSAL: | DSM43276_02117(pgsA2_1) |
| MTER: | 4434518_01868(pgsA2) |
| NFR: | ERS450000_01613(pgsA2_2) |
| NAD: | NCTC11293_03723(pgsA2_1) |
| RHU: | A3Q40_01819(pgsA1_2) |
| RRT: | 4535765_02738(pgsA_2) |
| RCR: | NCTC10994_00350(pgsA_1) |
| GOM: | D7316_01257(pgsA1_2) |
| SAMB: | SAM23877_1447(pgsA) |
| SRW: | TUE45_01785(pgsA2_1) |
| SLE: | sle_57090(sle_57090) |
| SRN: | A4G23_00636(pgsA2_1) |
| SSPB: | CP982_08165 CP982_23120 |
| SXT: | KPP03845_101583(pgsA1) |
| SHAU: | K9S39_30470 K9S39_37655 |
| STYI: | C9F11_07195(pgsA1) C9F11_22620(pgsA3) |
| LEIZ: | IT072_03460 IT072_12565 |
| AMAU: | DSM26151_12810(pgsA2) |
| MALK: | MalAC0309_1270(pgsA) |
| PSEV: | USB125703_02031(pgsA1) |
| AAGI: | NCTC2676_1_00905(pgsA_1) |
| ARTM: | MN0502_11530(pgsA_1) |
| CGRN: | 4412665_01261(pgsA_2) |
| TLA: | TLA_TLA_00104(pgsA1) |
| PROP: | QQ658_06955 QQ658_12160 |
| NAQU: | ENKNEFLB_02265(pgsA1) |
| NRO: | K8W59_08100 K8W59_14700 |
| NBI: | SHK19_07995 SHK19_11040 |
| AER: | AERYTH_08595 AERYTH_16900 |
| AWS: | ACN3XK_29165 ACN3XK_30130 |
| MMAR: | MODMU_2675 MODMU_4979 |
| AMYZ: | HUW46_08983(pgsA1_2) |
| STP: | Strop_2387 Strop_2928 |
| MTEM: | GCE86_08780 GCE86_11395 |
| PFLA: | Pflav_035640(pgsA_2) |
| ASER: | Asera_46290(pgsA_2) |
| BFK: | QN062_01675 QN062_03895 |
| DPB: | BABL1_gene_945(pgsA2) |
| CGW: | UR58_C0001G0495(pgsA) |
» show all
|
| Reference |
|
| Authors |
Schlame M, Hostetler KY |
| Title |
Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement. |
| Journal |
J Biol Chem 266:22398-403 (1991) |
| Reference |
|
| Authors |
Nowicki M, Muller F, Frentzen M |
| Title |
Cardiolipin synthase of Arabidopsis thaliana. |
| Journal |
|
| Sequence |
|
| Reference |
|
| Authors |
Houtkooper RH, Akbari H, van Lenthe H, Kulik W, Wanders RJ, Frentzen M, Vaz FM |
| Title |
Identification and characterization of human cardiolipin synthase. |
| Journal |
|
| Sequence |
|
| Reference |
|
| Authors |
Sandoval-Calderon M, Geiger O, Guan Z, Barona-Gomez F, Sohlenkamp C |
| Title |
A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria. |
| Journal |
|
| Sequence |
|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.8.41 |
| ExPASy - ENZYME nomenclature database: | 2.7.8.41 |
|
| LinkDB |
|