KEGG   ORTHOLOGY: K10384
Entry
K10384                      KO                                     
Symbol
FLG
Name
filaggrin
Disease
H00735  Ichthyosis vulgaris
H00737  Peeling skin syndrome
H01358  Atopic dermatitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K10384  FLG; filaggrin
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    K10384  FLG; filaggrin
Genes
HSA: 2312(FLG) 388698(FLG2)
PTR: 104002779(FLG)
PPS: 100994382(FLG)
GGO: 101147994(FLG) 115930780(FLG2)
PON: 100437584(FLG)
PPYG: 129032188(FLG) 129040337(FLG2)
NLE: 100598645(FLG2) 105740655(FLG)
HMH: 116469409
SSYN: 134734289(FLG) 134734290(FLG2)
MCC: 712658(FLG) 717480(FLG2)
MCF: 102138001(FLG)
MTHB: 126932924 126935340
MNI: 105498246(FLG2)
CSAB: 103225875(FLG2)
CATY: 105590252(FLG2)
PANU: 103875983(FLG)
TGE: 112618853(HRNR) 112618914(FLG2)
MLEU: 105534785(FLG2)
RRO: 104653924(FLG) 104682000(FLG2)
TFN: 117074126(FLG2) 117074133 117074827(FLG)
PTEH: 111543933(FLG2)
CANG: 105508943
SBQ: 101032389
ANAN: 135272310(FLG)
CSYR: 103267622(HRNR)
MMUR: 105873077
LCAT: 123634778(FLG)
MMU: 14246(Flg) 229574(Flg2)
MCAL: 110291868(Flg2)
MPAH: 110320836(Flg2)
ASYL: 127683636(Flg2)
PLEU: 114683139(Flg2) 114687245 119088254
MORG: 121437764
NGI: 103734075
CCAN: 109680788(Flg2)
DORD: 105984741
PLOP: 125360198(Flg)
NCAR: 124989625 124989633
MMMA: 107156614(Hrnr)
OCU: 100351762
TUP: 102489006(FLG2)
CFA: 102157111(FLG)
CLUD: 112663934(FLG)
VVP: 112907983(FLG2)
NPO: 129501493(FLG)
AML: 100480898
UMR: 103667593 103667594
UAH: 123000357
UAR: 123787755 123787756 123787757(HRNR)
ELK: 111161989
LLV: 125097319 125098761
MPUF: 101675605 101694141
MLK: 131810569(FLG)
NVS: 122899200(FLG)
ORO: 101379211(FLG2) 101383289
EJU: 114197296
LWW: 102751175
FCA: 101086079 101086332
PCOO: 112865401(FLG2)
LRUF: 124514246
LGF: 123596856(FLG)
AJU: 128313987
PTG: 102970728(FLG2)
PPAD: 109256978
PUC: 125913328
PLEZ: 122225966(FLG) 122225968(FLG2)
BIU: 109557011(FLG2)
BBUB: 102394723
CHX: 102187909 108634870
OAS: 101120628
BTAX: 128045426(FLG2)
CSUM: 138098069(FLG2)
ODA: 120855460 120859530
MREE: 136176439(FLG2)
OVR: 110140013
MBEZ: 129541352
SSC: 100513083
CFR: 102513193(FLG)
CDK: 105093910
EPZ: 103547913
EAI: 106848365
MYD: 102770629(FLG2)
MDT: 132221057
MYUM: 138996092
EFUS: 114233571
MNA: 107540767 107540769(FLG2)
DRO: 112316037(FLG) 112316044(FLG2)
AJM: 119042077(FLG2)
MMF: 118637676(FLG) 118637677
PPAM: 129062118(FLG)
PALE: 102885959
TOD: 119236860(FLG)
SFUM: 130023637(FLG)
LAV: 104845867
MDO: 103106047(FLG)
TVP: 118857496
 » show all
Reference
PMID:21531719
  Authors
Hsu CY, Henry J, Raymond AA, Mechin MC, Pendaries V, Nassar D, Hansmann B, Balica S, Burlet-Schiltz O, Schmitt AM, Takahara H, Paul C, Serre G, Simon M
  Title
Deimination of human filaggrin-2 promotes its proteolysis by calpain 1.
  Journal
J Biol Chem 286:23222-33 (2011)
DOI:10.1074/jbc.M110.197400
  Sequence
[hsa:388698]
Reference
PMID:2740331
  Authors
McKinley-Grant LJ, Idler WW, Bernstein IA, Parry DA, Cannizzaro L, Croce CM, Huebner K, Lessin SR, Steinert PM
  Title
Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.
  Journal
Proc Natl Acad Sci U S A 86:4848-52 (1989)
DOI:10.1073/pnas.86.13.4848
  Sequence
[hsa:2312]
LinkDB

DBGET integrated database retrieval system