KEGG ORTHOLOGY: K10384

ORTHOLOGY: K10384

Entry

K10384                      KO

Symbol

FLG

Name

filaggrin

Pathway

map04382

Cornified envelope formation

Disease

H00735

Ichthyosis vulgaris

H00737

Peeling skin syndrome

H01358

Atopic dermatitis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    K10384  FLG; filaggrin
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K10384  FLG; filaggrin
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    K10384  FLG; filaggrin

Genes

HSA:	2312(FLG) 388698(FLG2)

PTR:	104002779(FLG)

PPS:	100994382(FLG)

GGO:	101147994(FLG) 115930780(FLG2)

PON:	100437584(FLG)

PPYG:

129032188(FLG) 129040337(FLG2)

NLE:	100598645(FLG2) 105740655(FLG)

HMH:

116469409

SSYN:

134734289(FLG) 134734290(FLG2)

MCC:	712658(FLG) 717480(FLG2)

MCF:	102138001(FLG) 141409340(FLG2)

MTHB:

126932924 126935340

MNI:	105498246(FLG2)

CSAB:

103225875(FLG2)

CATY:

105590252(FLG2)

PANU:

101021311 103875983(FLG)

TGE:	112618914(FLG2)

MLEU:

105534785(FLG2)

RRO:	104653924(FLG) 104682000(FLG2)

TFN:	117074126(FLG2) 117074133 117074827(FLG)

PTEH:

111543933(FLG2)

CANG:

105508943

CJC:	128930148(FLG)

SBQ:

101032389

CIMI:

108297423(FLG2)

ANAN:

135272310(FLG)

CSYR:

103255172(FLG2)

MMUR:

105873077

LCAT:

123634778(FLG)

ERUF:

138390365(FLG)

PCOQ:

105821746

MMU:	14246(Flg) 229574(Flg2)

MCAL:

110291868(Flg2)

MPAH:

110320836(Flg2)

RNO:	24641(Flg)

ANU:	117707371 117707373(Flg)

ASYL:

127683636(Flg2)

MUN:	110540779(Flg) 110540780

MAUA:

101832479 121142150(Flg2)

PROB:

127232942

PLEU:

114683139(Flg2) 119088254

MORG:

MFOT:

AAMP:

NGI:

CCAN:

109680788(Flg2)

DORD:

105984741

PLOP:

125360198(Flg)

NCAR:

124989625

MMMA:

107156614(Hrnr)

OCU:	100351762 127493657

OCZ:	121168765(FLG) 121168864

TUP:	102489006(FLG2)

GVR:	103594114(FLG2)

CFA:	102157111(FLG)

CLUD:

112663934(FLG) 125752760

VVP:	112907983(FLG2)

VLG:	121491813(FLG)

NPO:	129501493(FLG)

AML:

100480898

UMR:	103667593 103667594

UAH:	123000357 125282892(FLG)

UAR:	123787755 123787756

ELK:

111161989

LLV:	125097318 125097319 125098761

MPUF:

101675605 101694141

MNP:	132002131(FLG2)

MLK:	131810568 131810569(FLG)

NVS:	122899200(FLG)

ORO:	101379211(FLG2) 101383289

EJU:

114197296

MLX:	118000379(FLG2)

MANO:

123860245 135364037

LWW:

102751175

FCA:	101086079 101086332 123379090

PCOO:

112865401(FLG2)

PBG:

122481196

PVIV:

125159441

LRUF:

124514245 124514246

LGF:	123596856(FLG)

AJU:	106989441 128313987

PTG:	102970728(FLG2)

PPAD:

109256978

PUC:

125913328

PLEZ:

122225966(FLG) 122225968(FLG2)

BOM:

102285335

BIU:	109557011(FLG2)

BBUB:

102394723

CHX:	102187909 108634870

OAS:

101120628

BTAX:

128045426(FLG2)

CSUM:

138098069(FLG2)

ODA:	120855460 120859530

CCAD:

122434928

MREE:

136176439(FLG2)

OVR:

110140013

MBEZ:

129541352

SSC:

100513083

CFR:	102513193(FLG)

CBAI:

105068263(FLG2)

CDK:

VPC:

OOR:

DDP:

EAI:

MYD:	102770629(FLG2)

MDT:

132221057

MYUM:

138996092

EFUS:

114233571

MNA:	107540767 107540769(FLG2)

DRO:	112316037(FLG) 112316044(FLG2)

PDIC:

118498116

PHAS:

123804593(FLG2)

MMF:	118637676(FLG) 118637677

PPAM:

129062118(FLG)

PALE:

102885959

RAY:	118612933 118612934(FLG)

TOD:	119236859 119236860(FLG)

SARA:

101551250

SFUM:

130023637(FLG)

LAV:	100669840(FLG2) 104845867

MDO:	103106047(FLG)

SHR:

AFZ:

PBRV:

Reference

PMID:21531719

Authors

Hsu CY, Henry J, Raymond AA, Mechin MC, Pendaries V, Nassar D, Hansmann B, Balica S, Burlet-Schiltz O, Schmitt AM, Takahara H, Paul C, Serre G, Simon M

Title

Deimination of human filaggrin-2 promotes its proteolysis by calpain 1.

Journal

J Biol Chem 286:23222-33 (2011)
DOI:10.1074/jbc.M110.197400

Sequence

[hsa:388698]

Reference

PMID:2740331

Authors

McKinley-Grant LJ, Idler WW, Bernstein IA, Parry DA, Cannizzaro L, Croce CM, Huebner K, Lessin SR, Steinert PM

Title

Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.

Journal

Proc Natl Acad Sci U S A 86:4848-52 (1989)
DOI:10.1073/pnas.86.13.4848

Sequence

[hsa:2312]

LinkDB

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