KEGG ORTHOLOGY: K10790

ORTHOLOGY: K10790

Entry

K10790                      KO

Symbol

TREX1

Name

three prime repair exonuclease 1 [EC:3.1.11.2]

Pathway

map04623

Cytosolic DNA-sensing pathway

Disease

H00080

Systemic lupus erythematosus

H00290

Aicardi-Goutieres syndrome

H00291

Familial chilblain lupus (FCL)

H01000

Retinal vasculopathy with cerebral leukodystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    K10790  TREX1; three prime repair exonuclease 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K10790  TREX1; three prime repair exonuclease 1
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.11.2  exodeoxyribonuclease III
     K10790  TREX1; three prime repair exonuclease 1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  Other factors with a suspected DNA repair function
   Nucleases
    K10790  TREX1; three prime repair exonuclease 1

Other DBs

GO:

0008296

Genes

HSA:	11277(TREX1)

PTR:	742742(TREX1)

PPS:	100982424(TREX1)

GGO:	134758051(TREX1)

PON:	100452811(TREX1)

PPYG:

129033363(TREX1)

NLE:	100591582(TREX1)

HMH:	116473508(TREX1)

SSYN:

129482435(TREX1)

MCC:	100429168(TREX1)

MCF:	102145869(TREX1)

MTHB:

126948679

MNI:	105480405(TREX1)

CSAB:

103227588(TREX1)

CATY:

105573654(TREX1)

PANU:

101012435(TREX1)

TGE:	112619271(TREX1)

MLEU:

105540388(TREX1)

RRO:	104667839(TREX1)

RBB:	108527023(TREX1)

TFN:	117080891(TREX1)

PTEH:

111555401(TREX1)

CANG:

105509736(TREX1)

CJC:	100385398(TREX1)

SBQ:	101042042(TREX1)

CIMI:

108293527(TREX1)

ANAN:

105727658(TREX1)

CSYR:

103260620(TREX1)

MMUR:

105874926(TREX1)

LCAT:

123623316(TREX1)

PCOQ:

105813568(TREX1)

OGA:	100946464(TREX1)

MMU:	22040(Trex1)

MCAL:

110302196(Trex1)

MPAH:

110328195(Trex1)

RNO:	100049583(Trex1)

MCOC:

116073753(Trex1)

ANU:	117725083(Trex1)

MUN:	110565637(Trex1)

CGE:	100761854(Trex1)

MAUA:

101826627(Trex1)

PROB:

127236258(Trex1)

PLEU:

114705191(Trex1)

MORG:

121464202(Trex1)

MFOT:

126499801

AAMP:

119809656(Trex1)

NGI:	103750224(Trex1)

HGL:	101715376(Trex1)

CCAN:

109695273(Trex1)

DORD:

105996254(Trex1)

DSP:	122095726(Trex1)

PLOP:

125342444(Trex1)

NCAR:

124993394

MMMA:

107143520(Trex1)

OCU:

100355546

OPI:	101533161(TREX1)

TUP:	102468212(TREX1)

GVR:	103584915 103591609

CFA:	102155466(TREX1)

CLUD:

112665745(TREX1)

VVP:	112912073(TREX1)

VLG:	121494837(TREX1)

NPO:	129521712(TREX1)

AML:	100476000(TREX1)

UMR:	103674850(TREX1)

UAH:	113256837(TREX1)

UAR:	123779875(TREX1)

ELK:

111144266

LLV:

125080770

MPUF:

101672464(TREX1)

MNP:	132011283(TREX1)

MLK:	131823890(TREX1)

NVS:	122909458(TREX1)

ORO:	101372274(TREX1)

EJU:	114224956(TREX1)

ZCA:	113916710(TREX1)

MLX:	118005845(TREX1)

NSU:	110577651(TREX1)

LWW:	102730932(TREX1)

FCA:	101098935(TREX1)

PYU:	121011159(TREX1)

PCOO:

112852914(TREX1)

PBG:	122487227(TREX1)

PVIV:

125155380(TREX1)

LRUF:

124525170

PTG:	102964735(TREX1)

PPAD:

109247764(TREX1)

PUC:

125930670

AJU:

106979179

HHV:	120229277(TREX1)

BTA:	282099(TREX1)

BOM:	102271118(TREX1)

BIU:	109576261(TREX1)

BBUB:

102408023(TREX1)

BBIS:

104997243(TREX1)

CHX:	102189528(TREX1)

OAS:	101119766(TREX1)

BTAX:

128050426(TREX1)

CSUM:

138087531(TREX1)

ODA:	120868258(TREX1)

CCAD:

122424524(TREX1)

MREE:

136166864(TREX1)

MBEZ:

129547802(TREX1)

SSC:	100155669(TREX1)

CFR:	102522505(TREX1)

CBAI:

105080290(TREX1)

CDK:	105087958(TREX1)

VPC:	102542251(TREX1)

BACU:

103013392(TREX1)

BMUS:

118903194(TREX1)

LVE:	103087946(TREX1)

OOR:	101285141(TREX1)

DLE:	111174434(TREX1)

PCAD:

102980491(TREX1)

PSIU:

116761870(TREX1)

NASI:

112403754(TREX1)

ECB:	100063767(TREX1)

EPZ:	103556025(TREX1)

EAI:	106821772(TREX1)

MYD:	102761907(TREX1)

MMYO:

118668516(TREX1)

MDT:	132215890(TREX1)

PKL:	118715703(TREX1)

EFUS:

103300803(TREX1)

MNA:	107529424(TREX1)

DRO:	112309591(TREX1)

SHON:

118989516(TREX1)

AJM:	119036566(TREX1)

PDIC:

114501798(TREX1)

MMF:	118633053(TREX1)

PPAM:

129087562(TREX1)

HAI:	109377922(TREX1)

RFQ:	117037225(TREX1)

PALE:

102883126(TREX1)

PGIG:

120582312(TREX1)

PVP:	105302360(TREX1)

RAY:	107513315(TREX1)

MJV:	108402651(TREX1)

TOD:	119259576(TREX1)

SARA:

101550009(TREX1)

SETR:

126014110(TREX1)

LAV:	100675657(TREX1)

TMU:

101348902

ETF:	101639315(TREX1)

DNM:	101437213(TREX1)

MDO:	100023478(TREX1)

GAS:	123255730(TREX1)

SHR:	105749561(TREX1)

PCW:	110217070(TREX1)

TVP:	118831633(TREX1)

PBRV:

138163153(TREX1)

OAA:	100078153(TREX1)

AAM:	106486659(TREX1)

ACS:	100561159(trex1)

ASAO:

132769204(TREX1)

PVT:

110080645

SUND:

121920344(TREX1)

PMUA:

114591610(TREX1)

PRAF:

128408226(TREX1)

ZVI:

118081570

HCG:

128345601

GJA:	107115530(TREX1)

STOW:

125428955

EMC:	129328965(TREX1)

MUO:	115472094(TREX1)

GSH:

117351329

BFO:	118428519 118429258

CIN:	104266336 108949427

SCLV:

120325883 120333709 120339051 120339212

SPU:

755651

APLC:

110984809

SKO:	100371579 100374425 102801394

DME:	Dmel_CG3165(CG3165)

DER:	113564235 6541864

DSE:

6613180

DSI:	Dsimw501_GD23197(Dsim_GD23197)

DYA:	Dyak_GE18196

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17603

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:	105223716 125778455

RZE:

AOQ:

TDA:

MDE:

SCAC:

106082054 106086324 106088477

LCQ:

111687289

LSQ:	119602318 119602319

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003945 CpipJ_CPIJ012074

CPII:

BCOO:

LLL:

OBO:

NPT:

NFB:

NLO:

NVG:	124298101 124299228

TCA:

SOY:

AGRG:

CSET:

AGB:

LDC:	111507507 111509056

DVV:

APLN:

PPYR:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:	124540316 124540317

MCIX:

123665592 123665603 123665742

PMAC:

106715110

PPOT:

106103112 106108232

PXU:	106128331 106128651

BPHI:

PRAP:

PBX:

PNAP:

ZCE:	119836969 119837053

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113493735 113505154 113505206

SLIU:

111350997 111357937 111359081

OFU:	114356077 114357456

ATRA:

106138001 106142133

GMW:	113511313 113523252

PGW:	126376663 126376672

LGLY:

125231680 125235884 125237836

CSTB:

DCI:

CLEC:

NLU:

PHU:	Phum_PHUM581960

TPAL:

ZNE:

BROR:

IEL:

DPX:	DAPPUDRAFT_105157 DAPPUDRAFT_105158 DAPPUDRAFT_312568 DAPPUDRAFT_312570 DAPPUDRAFT_327373

DMK:	116920063 123471194

PVM:

HAME:

PTRU:

ESN:

MNZ:

MRJ:

DSV:	119437146 119440204

RSAN:

RMP:

VDE:

VJA:

CSCU:

111612878 111612880 111625910 111633322

CVS:	136987137 136987152 136987180

PTEP:

107437315 107457102

ABRU:

129968814 129969597

SDM:

118185971

LOA:	LOAG_04618

TSP:

Tsp_03749

LGI:	LOTGIDRAFT_227290

BGT:

HRJ:

HASI:

MYI:

MMER:

RPHI:

OBI:

SMM:	Smp_146310

SHX:	MS3_00006820(TREX1_1)

OVI:	T265_08224

EGL:

NVE:

EPA:

ATEN:

Reference

PMID:10391904

Authors

Mazur DJ, Perrino FW

Title

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.

Journal

J Biol Chem 274:19655-60 (1999)
DOI:10.1074/jbc.274.28.19655

Sequence

[hsa:11277] [mmu:22040]

LinkDB

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