KEGG ORTHOLOGY: K12648

ORTHOLOGY: K12648

Entry

K12648                      KO

Symbol

MAVS, IPS1

Name

mitochondrial antiviral-signaling protein

Pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05171

Coronavirus disease - COVID-19

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   04622 RIG-I-like receptor signaling pathway
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   04623 Cytosolic DNA-sensing pathway
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05160 Hepatitis C
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05171 Coronavirus disease - COVID-19
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05164 Influenza A
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05162 Measles
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05168 Herpes simplex virus 1 infection
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05169 Epstein-Barr virus infection
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein

Genes

HSA:	57506(MAVS)

PTR:	470026(MAVS)

PPS:	100979730(MAVS)

GGO:	101129182(MAVS)

PON:	100432985(MAVS)

PPYG:

129021916(MAVS)

NLE:	100597283(MAVS)

HMH:	116461432(MAVS)

SSYN:

129474708(MAVS)

MCC:	717616(MAVS)

MCF:	102132372(MAVS)

MTHB:

126929120

MNI:	105481575(MAVS)

CSAB:

103247611(MAVS)

CATY:

105582130(MAVS)

PANU:

101008300(MAVS)

TGE:	112632848(MAVS)

MLEU:

105535879(MAVS)

RRO:	104674592(MAVS)

RBB:	108533499(MAVS)

TFN:	117068514(MAVS)

PTEH:

111548059(MAVS)

CANG:

105512800(MAVS)

CJC:	100410549(MAVS)

SBQ:	101035231(MAVS)

CIMI:

108286781(MAVS)

ANAN:

105719332(MAVS)

CSYR:

103268983(MAVS)

MMUR:

105866005(MAVS)

LCAT:

123622556(MAVS)

PCOQ:

105806202(MAVS)

OGA:	100945143(MAVS)

MMU:	228607(Mavs)

MCAL:

110307081(Mavs)

MPAH:

110318507(Mavs)

RNO:	311430(Mavs)

MCOC:

116090959(Mavs)

ANU:	117704174(Mavs)

MUN:	110559626(Mavs)

CGE:	100764931(Mavs)

MAUA:

101826955(Mavs)

PROB:

127221418(Mavs)

PLEU:

114699515(Mavs)

MORG:

121460460(Mavs)

MFOT:

126495486

AAMP:

119814914(Mavs)

NGI:	103743123(Mavs)

HGL:	101703437(Mavs)

CPOC:

100712673(Mavs)

CCAN:

109691285(Mavs)

DORD:

105981763(Mavs)

DSP:	122120262(Mavs)

PLOP:

125353299(Mavs)

NCAR:

124976774

MMMA:

107139692(Mavs)

OCU:

100356540

OPI:	101533668(MAVS)

TUP:	102475194(MAVS)

GVR:	103604445(MAVS)

CFA:	485789(MAVS)

CLUD:

112673652(MAVS)

VVP:	112930079(MAVS)

VLG:	121478053(MAVS)

NPO:	129522891(AP5S1)

AML:	100482674(MAVS)

UMR:	103674396(MAVS)

UAH:	113258384(MAVS)

UAR:	123799351(MAVS)

ELK:

111141602

LLV:

125108204

MPUF:

101681780(MAVS)

MNP:	132008179 132021755

MLK:	131807997(MAVS)

NVS:	122916229(MAVS)

ORO:	101367736(MAVS)

EJU:	114220599(MAVS)

ZCA:	113938749(MAVS)

MLX:	118011281(MAVS)

NSU:	110579411(MAVS)

LWW:	102727031(MAVS)

FCA:	101085709(MAVS)

PYU:	121012443(MAVS)

PCOO:

112869235(MAVS)

PBG:	122496522(MAVS)

PVIV:

125162013(MAVS)

LRUF:

124503382

PTG:	102963414(MAVS)

PPAD:

109274754(MAVS)

PUC:

125936139

AJU:

106980168

HHV:	120225772(MAVS)

BTA:	618508(MAVS)

BOM:	102277675(MAVS)

BIU:	109567183(MAVS)

BBUB:

102409463(MAVS)

BBIS:

104986050(MAVS)

CHX:	102178286(MAVS)

OAS:	101119838(MAVS)

BTAX:

128057999(MAVS)

ODA:	120868905(MAVS)

CCAD:

122448857(MAVS)

MBEZ:

129560195(MAVS)

SSC:	100037290(MAVS)

CFR:	102509188(MAVS)

CBAI:

105083024(MAVS)

CDK:	105096015(MAVS)

VPC:	102539671(MAVS)

BACU:

103013047(MAVS)

BMUS:

118881552(MAVS)

LVE:	103078463(MAVS)

OOR:	101284556(MAVS)

DLE:	111184404(MAVS)

PCAD:

102978512(AP5S1)

PSIU:

116740220(MAVS)

NASI:

112398436(MAVS)

ECB:	100066212(MAVS)

EPZ:	103559810(MAVS)

EAI:	106847679(MAVS)

MYB:	102249156(MAVS)

MYD:	102767843(MAVS)

MMYO:

118663001(MAVS)

MLF:	102440412(MAVS)

MDT:	132239400(MAVS)

PKL:	118707494(MAVS)

EFUS:

103285642(MAVS)

MNA:	107536394(MAVS)

DRO:	112303983(MAVS)

SHON:

118990900(MAVS)

AJM:	119051154(MAVS)

PDIC:

114507072(MAVS)

PHAS:

123814801(MAVS)

MMF:	118618558(MAVS)

PPAM:

129070825(MAVS)

HAI:	109383826(MAVS)

RFQ:	117016019(MAVS)

PALE:

102892463(MAVS)

PGIG:

120603434(MAVS)

PVP:	105298539(MAVS)

RAY:	107505762(MAVS)

MJV:	108393859(MAVS)

TOD:	119235264(MAVS)

SARA:

101542406(MAVS)

SETR:

126017349(MAVS)

LAV:	100664089(MAVS)

TMU:

101358775

ETF:	101663462(MAVS)

DNM:

101422140

MDO:	103094760(MAVS)

GAS:	123256022(MAVS)

SHR:	100926796(MAVS)

AFZ:

127547414

PCW:	110218357(MAVS)

TVP:	118841554(MAVS)

OAA:

103169896

GGA:	422936(MAVS)

PCOC:

116225681(MAVS)

MGP:	100540843(MAVS)

CJO:	107314118(MAVS)

TPAI:

128080359(MAVS)

LMUT:

125692728(MAVS)

NMEL:

110397561(MAVS)

APLA:

101794527(MAVS)

ACYG:

106036708(MAVS)

CATA:

118248489(MAVS)

AFUL:

116488818(MAVS)

TGU:	100218625(MAVS)

LSR:	110473320(MAVS)

SCAN:

103823098(MAVS)

PMOA:

120509501(MAVS)

OTC:	121335108(MAVS)

PRUF:

121364703(MAVS)

GFR:	102037502(MAVS)

FAB:	101816643(MAVS)

OMA:	130252064(MAVS)

PHI:	102104929(MAVS)

PMAJ:

107203612(MAVS)

CCAE:

111929114(MAVS)

CCW:	104690829(MAVS)

CBRC:

103621121(MAVS)

ETL:	114067785(MAVS)

ZAB:	102070315(MAVS)

ZLE:	135447159(MAVS)

ACHL:

103812217(MAVS)

SVG:

106853166

MMEA:

130575428(MAVS)

HRT:	120753208(MAVS)

SATI:

136360299(MAVS)

FPG:	101913471(MAVS)

FCH:	102057725(MAVS)

CCRI:

104166543(MAVS)

NNT:	104409820(MAVS)

SHAB:

115610309(MAVS)

ACUN:

113479367(MAVS)

TALA:

104363085(MAVS)

ACHC:

115344346(MAVS)

HALD:

104325917

HLE:	104840074(MAVS)

AGEN:

126034148

GCL:

127015750

CSTI:

104556834

LDI:	104345418(MAVS)

DPUB:

104306819(MAVS)

AVIT:

104274478(MAVS)

EGZ:	104126939(MAVS)

NNI:	104018557(MAVS)

PCRI:

104030182

PADL:

103923522

AFOR:

103908334(MAVS)

FGA:

104075421

GSTE:

104260278

CLV:	102086411(MAVS)

MUI:	104537675(MAVS)

PGUU:

104470015

PLET:

104625931

EHS:	104502448(MAVS)

CUCA:

104064525

TEO:	104373556(MAVS)

BREG:

104643426(MAVS)

CPEA:

104386167(MAVS)

CVF:	104284246(MAVS)

RTD:	128909975(MAVS)

AAM:	106484546(MAVS)

AROW:

112969435(MAVS)

NPD:

112955527

DNE:	112996370(MAVS)

SCAM:

104148594

ASN:	106722801(MAVS)

AMJ:	106737409(MAVS)

CPOO:

109322300(MAVS)

GGN:	109304002(MAVS)

PSS:	102443724(MAVS)

CMY:	102936151(MAVS)

CCAY:

125635109(MAVS)

DCC:	119854309(MAVS)

CPIC:

101940360(MAVS)

TST:	117878312(MAVS)

CABI:

116816734(MAVS)

MRV:	120407059(MAVS)

PVT:	110085979(MAVS)

SUND:

121930466(MAVS)

PBI:	103057375(MAVS)

PGUT:

117656958(MAVS)

PTEX:

113448301(MAVS)

VKO:	123022552(MAVS)

PMUA:

114604226(MAVS)

ZVI:	118079069(MAVS)

GJA:	107117585(MAVS)

STOW:

125440238(MAVS)

XLA:

108697133

XTR:	100485829(mavs)

RTEM:

120924520

BBUF:

120990473(MAVS)

BGAR:

122923976(MAVS)

DRE:	562867(mavs)

SRX:	107708482 107733776

SANH:

107678546 107690146

SGH:	107567854 107582532

CCAR:

109054991 109104080

CAUA:

113057046 113078056 113112907

CGIB:

127970410 128026376

PTET:

122356296(mavs)

LROH:

127175603(mavs)

OMC:	131552594(mavs)

PPRM:

120479873(mavs)

RKG:	130083058(mavs)

MAMB:

125276587(mavs)

CIDE:

127524650

CERY:

137019958(mavs)

TDW:	130431776 130432136(mavs)

MANU:

129416828(mavs)

IPU:

108263240

PHYP:

113544585(mavs)

SMEO:

124402470(mavs)

TFD:	113639834(mavs)

AMEX:

103043870(mavs)

EEE:	113568964 113585807

TFS:	130539717(mavs)

TNG:	GSTEN00019955G001

LCO:	104939758(mavs)

NCC:	104949067(mavs)

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

134881248(mavs)

ELY:	117266710 117266733

EFO:	125900850 125900857(mavs)

PLEP:

121953286 121953287 121953289

SLUC:

116057503 116057504

ECRA:

117935773

ESP:	116686108 116686116

PFLV:

114546615 114546616

GAT:	120832442(mavs)

PPUG:

119227267(mavs)

AFB:	129103431(mavs)

CLUM:

117725307(mavs)

PSWI:

130201936(mavs)

MSAM:

119909963(mavs)

CUD:	121526793(mavs)

ALAT:

119004944(mavs)

MZE:	101485745(mavs)

ONL:	100710322(mavs)

OAU:	116322073(mavs)

OLA:	101167666(mavs)

OML:	112143451(mavs)

CSAI:

133462842(mavs)

XMA:	102221226(mavs)

XCO:	114134791(mavs)

XHE:	116708603(mavs)

PRET:

103458182(mavs)

PFOR:

103150075(mavs)

PLAI:

106956676(mavs)

PMEI:

106919345(mavs)

GAF:	122846112(mavs)

PPRL:

129377360(mavs)

CVG:

107103405

CTUL:

119779720(mavs)

GMU:	124855861(mavs)

NFU:

107391890

KMR:	108246086(mavs)

ALIM:

106524279(mavs)

NWH:	119429301(mavs)

AOCE:

111583331

POV:

109636497

SSEN:

122782543 122782802

HHIP:

117755910(mavs)

HSP:	118116539(mavs)

PPLT:

128451109(mavs)

SMAU:

118285813(mavs)

LCF:

108876599

SDU:	111226054(mavs)

SLAL:

111672858(mavs)

XGL:	120795827(mavs)

HCQ:	109528133(mavs)

PEE:	133412572(mavs)

PTAO:

133488098(mavs)

BPEC:

110157332(mavs)

MALB:

109962482(mavs)

BSPL:

114848314(mavs)

SASA:

100316613 106611470

STRU:

115173045

OTW:

112236223

OMY:	100499614(mavs)

OGO:	124001999 124047010

ONE:	115123146 115125924

OKI:

OKE:

SALP:

SNH:

SFM:	108918897(mavs)

PKI:	111835564 111835566

AANG:

LOC:

PSPA:

ARUT:

LCM:

CRG:

PMAX:

Reference

PMID:16127453

Authors

Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S

Title

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.

Journal

Nat Immunol 6:981-8 (2005)
DOI:10.1038/ni1243

Sequence

[hsa:57506]

Reference

PMID:16153868

Authors

Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB

Title

VISA is an adapter protein required for virus-triggered IFN-beta signaling.

Journal

Mol Cell 19:727-40 (2005)
DOI:10.1016/j.molcel.2005.08.014

Sequence

[hsa:57506]

Reference

PMID:16125763

Authors

Seth RB, Sun L, Ea CK, Chen ZJ

Title

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.

Journal

Cell 122:669-82 (2005)
DOI:10.1016/j.cell.2005.08.012

Sequence

[hsa:57506]

LinkDB

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