KEGG   ORTHOLOGY: K12648
Entry
K12648                      KO                                     
Symbol
MAVS, IPS1
Name
mitochondrial antiviral-signaling protein
Pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   04622 RIG-I-like receptor signaling pathway
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   04623 Cytosolic DNA-sensing pathway
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05160 Hepatitis C
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05171 Coronavirus disease - COVID-19
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05164 Influenza A
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05162 Measles
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05168 Herpes simplex virus 1 infection
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
   05169 Epstein-Barr virus infection
    K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
Genes
HSA: 57506(MAVS)
PTR: 470026(MAVS)
PPS: 100979730(MAVS)
GGO: 101129182(MAVS)
PON: 100432985(MAVS)
NLE: 100597283(MAVS)
MCC: 717616(MAVS)
MCF: 102132372(MAVS)
CSAB: 103247611(MAVS)
CATY: 105582130(MAVS)
PANU: 101008300(MAVS)
TGE: 112632848(MAVS)
RRO: 104674592(MAVS)
RBB: 108533499(MAVS)
TFN: 117068514(MAVS)
PTEH: 111548059(MAVS)
CJC: 100410549(MAVS)
SBQ: 101035231(MAVS)
CSYR: 103268983(MAVS)
MMUR: 105866005(MAVS)
LCAT: 123622556(MAVS)
OGA: 100945143(MAVS)
MMU: 228607(Mavs)
MCAL: 110307081(Mavs)
MPAH: 110318507(Mavs)
RNO: 311430(Mavs)
MCOC: 116090959(Mavs)
MUN: 110559626(Mavs)
CGE: 100764931(Mavs)
MAUA: 101826955(Mavs)
PLEU: 114699515(Mavs)
MORG: 121460460(Mavs)
AAMP: 119814914(Mavs)
NGI: 103743123(Mavs)
HGL: 101703437(Mavs)
CPOC: 100712673(Mavs)
CCAN: 109691285(Mavs)
DORD: 105981763(Mavs)
DSP: 122120262(Mavs)
NCAR: 124976774
OCU: 100356540(MAVS)
OPI: 101533668(MAVS)
TUP: 102475194(MAVS)
CFA: 485789(MAVS)
CLUD: 112673652(MAVS)
VVP: 112930079(MAVS)
VLG: 121478053(MAVS)
AML: 100482674(MAVS)
UMR: 103674396(MAVS)
UAH: 113258384(MAVS)
UAR: 123799351(MAVS)
ELK: 111141602
LLV: 125108204
MPUF: 101681780(MAVS)
ORO: 101367736(MAVS)
EJU: 114220599(MAVS)
ZCA: 113938749(MAVS)
MLX: 118011281(MAVS)
FCA: 101085709(MAVS)
PYU: 121012443(MAVS)
PBG: 122496522(MAVS)
PTG: 102963414(MAVS)
PPAD: 109274754(MAVS)
AJU: 106980168(MAVS)
HHV: 120225772(MAVS)
BTA: 618508(MAVS)
BOM: 102277675(MAVS)
BIU: 109567183(MAVS)
BBUB: 102409463(MAVS)
CHX: 102178286(MAVS)
OAS: 101119838(MAVS)
ODA: 120868905(MAVS)
CCAD: 122448857(MAVS)
SSC: 100037290(MAVS)
CFR: 102509188(MAVS)
CBAI: 105083024(MAVS)
CDK: 105096015(MAVS)
VPC: 102539671(MAVS)
BACU: 103013047(MAVS)
LVE: 103078463(MAVS)
OOR: 101284556(MAVS)
DLE: 111184404(MAVS)
PCAD: 102978512(AP5S1)
PSIU: 116740220(MAVS)
ECB: 100066212(MAVS)
EPZ: 103559810(MAVS)
EAI: 106847679(MAVS)
MYB: 102249156(MAVS)
MYD: 102767843(MAVS)
MMYO: 118663001(MAVS)
MLF: 102440412(MAVS)
MNA: 107536394(MAVS)
PKL: 118707494(MAVS)
HAI: 109383826(MAVS)
DRO: 112303983(MAVS)
SHON: 118990900(MAVS)
AJM: 119051154(MAVS)
PDIC: 114507072(MAVS)
PHAS: 123814801(MAVS)
MMF: 118618558(MAVS)
RFQ: 117016019(MAVS)
PALE: 102892463(MAVS)
PGIG: 120603434(MAVS)
PVP: 105298539(MAVS)
RAY: 107505762(MAVS)
MJV: 108393859(MAVS)
TOD: 119235264(MAVS)
SARA: 101542406(MAVS)
LAV: 100664089(MAVS)
TMU: 101358775
DNM: 101422140
MDO: 103094760(MAVS)
GAS: 123256022(MAVS)
SHR: 100926796(MAVS)
PCW: 110218357(MAVS)
OAA: 103169896
GGA: 422936(MAVS)
PCOC: 116225681(MAVS)
MGP: 100540843(MAVS)
CJO: 107314118(MAVS)
NMEL: 110397561(MAVS)
APLA: 101794527(MAVS)
ACYG: 106036708(MAVS)
AFUL: 116488818(MAVS)
TGU: 100218625(MAVS)
LSR: 110473320(MAVS)
SCAN: 103823098(MAVS)
PMOA: 120509501(MAVS)
OTC: 121335108(MAVS)
PRUF: 121364703(MAVS)
GFR: 102037502(MAVS)
FAB: 101816643(MAVS)
PHI: 102104929(MAVS)
PMAJ: 107203612(MAVS)
CCAE: 111929114(MAVS)
CCW: 104690829(MAVS)
CBRC: 103621121(MAVS)
ETL: 114067785(MAVS)
ZAB: 102070315(MAVS)
ACHL: 103812217(MAVS)
FPG: 101913471(MAVS)
FCH: 102057725(MAVS)
CLV: 102086411(MAVS)
EGZ: 104126939(MAVS)
NNI: 104018557(MAVS)
PLET: 104625931
PCRI: 104030182
ACUN: 113479367(MAVS)
TALA: 104363085(MAVS)
PADL: 103923522
ACHC: 115344346(MAVS)
HALD: 104325917
CCRI: 104166543(MAVS)
CSTI: 104556834
EHS: 104502448(MAVS)
MUI: 104537675(MAVS)
FGA: 104075421
GSTE: 104260278
LDI: 104345418(MAVS)
AAM: 106484546(MAVS)
AROW: 112969435(MAVS)
NPD: 112955527
DNE: 112996370(MAVS)
ASN: 106722801(MAVS)
AMJ: 106737409(MAVS)
CPOO: 109322300(MAVS)
GGN: 109304002(MAVS)
PSS: 102443724(MAVS)
CMY: 102936151(MAVS)
CPIC: 101940360(MAVS)
TST: 117878312(MAVS)
CABI: 116816734(MAVS)
MRV: 120407059(MAVS)
PVT: 110085979(MAVS)
SUND: 121930466(MAVS)
PBI: 103057375(MAVS)
PGUT: 117656958(MAVS)
VKO: 123022552(MAVS)
PMUA: 114604226(MAVS)
ZVI: 118079069(MAVS)
GJA: 107117585(MAVS)
STOW: 125440238(MAVS)
XLA: 108697133
XTR: 100485829(mavs)
RTEM: 120924520
BBUF: 120990473(MAVS)
BGAR: 122923976(MAVS)
DRE: 562867(mavs)
PPRM: 120479873(mavs)
MAMB: 125276587(mavs)
IPU: 108263240(mavs)
PHYP: 113544585(mavs)
SMEO: 124402470(mavs)
TFD: 113639834(mavs)
AMEX: 103043870(mavs)
LCO: 104939758(mavs)
NCC: 104949067(mavs)
CGOB: 115027800
ECRA: 117935773
GAT: 120832442(mavs)
PPUG: 119227267(mavs)
MSAM: 119909963(mavs)
CUD: 121526793(mavs)
ALAT: 119004944(mavs)
MZE: 101485745(mavs)
ONL: 100710322(mavs)
OAU: 116322073(mavs)
OLA: 101167666(mavs)
OML: 112143451(mavs)
XMA: 102221226(mavs)
XCO: 114134791(mavs)
XHE: 116708603(mavs)
PRET: 103458182(mavs)
PFOR: 103150075(mavs)
PLAI: 106956676(mavs)
PMEI: 106919345(mavs)
GAF: 122846112(mavs)
CVG: 107103405
CTUL: 119779720(mavs)
GMU: 124855861(mavs)
NFU: 107391890
KMR: 108246086(mavs)
ALIM: 106524279(mavs)
NWH: 119429301(mavs)
AOCE: 111583331
POV: 109636497
HHIP: 117755910(mavs)
HSP: 118116539(mavs)
LCF: 108876599(mavs)
SDU: 111226054(mavs)
SLAL: 111672858(mavs)
XGL: 120795827(mavs)
HCQ: 109528133(mavs)
BPEC: 110157332(mavs)
MALB: 109962482(mavs)
BSPL: 114848314(mavs)
OTW: 112236223
OMY: 100499614(mavs)
SALP: 112074575
SNH: 120060108
SFM: 108918897(mavs)
AANG: 118228256
LOC: 107076971
LCM: 102358794
CMK: 103181499(mavs)
GAE: 121366972
CRG: 105337492
PMAX: 117340036
 » show all
Reference
  Authors
Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S
  Title
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
  Journal
Nat Immunol 6:981-8 (2005)
DOI:10.1038/ni1243
  Sequence
[hsa:57506]
Reference
  Authors
Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB
  Title
VISA is an adapter protein required for virus-triggered IFN-beta signaling.
  Journal
Mol Cell 19:727-40 (2005)
DOI:10.1016/j.molcel.2005.08.014
  Sequence
[hsa:57506]
Reference
  Authors
Seth RB, Sun L, Ea CK, Chen ZJ
  Title
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
  Journal
Cell 122:669-82 (2005)
DOI:10.1016/j.cell.2005.08.012
  Sequence
[hsa:57506]
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