KEGG ORTHOLOGY: K13066

KEGG

ORTHOLOGY: K13066

Entry

K13066                      KO

Symbol

COMT

Name

caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase [EC:2.1.1.68 2.1.1.4]

Pathway

Tryptophan metabolism

Phenylpropanoid biosynthesis

Metabolic pathways

Biosynthesis of secondary metabolites

Module

Monolignol biosynthesis, phenylalanine/tyrosine => monolignol

Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin

Reaction

S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

caffeic aldehyde:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K13066  COMT; caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase
  09110 Biosynthesis of other secondary metabolites
   00940 Phenylpropanoid biosynthesis
    K13066  COMT; caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.4  acetylserotonin O-methyltransferase
     K13066  COMT; caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase
    2.1.1.68  caffeate O-methyltransferase
     K13066  COMT; caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase

Other DBs

COG:

GO:	0047763 0017096

Genes

BTAX:

ATH:	AT5G54160(OMT1)

ALY:	9302094 9302099 9303555 9303558

CRB:	17876808 17896611

CSAT:

104703789 104717445 104722135 104725937 104729294 104730586 104730602 104752845 104761441

EUS:	EUTSA_v10013896mg EUTSA_v10013897mg EUTSA_v10013908mg EUTSA_v10025520mg EUTSA_v10025522mg EUTSA_v10027501mg

BRP:	103844876 103844878 103851985 103857055 103861716 103868698

BNA:	106356003 106373206 106374490 106385406 106392944 106409594 106418605 106434499 106434512 106437143 106437536 106444684 111205367

BOE:	106296210 106304347 106314910 106318901 106326817 106332463 106336119

RSZ:	108840420 108842003 108847745 108849034 108855334 108855432 130500633 130507220

THJ:	104799941 104799942 104799943 104802099 104804741 104811887 104813820

CPAP:

PVY:	116109069 116109124 116109126 116111931 116111937 116116119 116116634 116117203 116120218 116120219 116121824 116125659 116128982 116129819 116135367

MINC:

123193589 123193590 123201620 123203759 123206967 123207172 123207173 123207175 123209138 123210223 123215322 123215323 123228814 123228972 123228974 123229057 123229059 123230013 123230022

TCC:	108661886 108663133 18507240 18587033 18589881 18589884 18592353 18599823 18599828 18601594 18605869 18605934

GRA:	105765366 105765367 105765368 105765408 105767646 105777756 105778083 105778084 105782479 105786164 105791250 105792628 105792629 105799382

GAB:	108454744 108454946 108456843 108458089 108462551 108462612 108463104 108468573 108468576 108470190 108476615 108478631 108478815 108481968 108487847

DZI:	111277023 111277024 111279472 111279932 111289581 111294125 111295573 111296804 111297033 111298242 111302720 111302721

RARG:

115726821 115726834 115727591 115730123 115734249 115739186 115742327 115742328 115743970 115744104 115745274 115745275 115745276 115745277 115748015 115748016 115755970 115757569 125312589

GMX:	100777636 100780100 100788873 100803633 100805999(IMT1) 100806525

GSJ:	114400750 114410222 114415629 114415631 114415633 114418253

PVU:	137820377 137821888 137822085 137822086 137822087 137822088 137822089 137822090 137822092 137822093

VRA:	106760166 106760167 106764425

VAR:	108322235 108322321 108331569 108332176 108337604 108347163

VUN:	114162415 114162417 114164317 114166549 114167305 114193513

VUM:	124822830 124834297 124843151 124844039

CCAJ:

109789134 109794407 109797532 109817907

APRC:

113848006 113851065 113861533 113865423 113874611

MTR:	11417290 11421675 11428411 11428747 25481245 25501422 25501425 25501426 25501428 25501432

TPRA:

123889523 123908912 123909020 123909021 123913580 123924507 123924511

CAM:	101489645 101499314 101499972

PSAT:

127074970 127081194 127117487 127117488 127117489 127132054 127132084

VVO:	131610788 131615633 131645931 131645933 131645955 131650899 131661230

LJA:	130731442 130732879 130747059 130749119

ADU:

AIP:

AHF:	112698013 112715717 112784538

LANG:

109328338 109338233 109343467 109345737 109359349 109359350

PCIN:

129288030 129288417 129303975 129304011 129304160 129313942 129313943 129314378

QSA:	O6P43_014915 O6P43_018511 O6P43_018512 O6P43_020016 O6P43_027443 O6P43_027444 O6P43_027445 O6P43_027447 O6P43_027450 O6P43_031488

FVE:	101294295 101296734 101308514

AANS:

126783326 126803893 126804089

RCN:	112173018 112174337 112177138 112177243 112178673 112184684 112186762 112187184 112195792 112199890

PPER:

18776084 18784868 18786300 18786738 18786962 18787303 18790301

PMUM:

103319810 103322531 103333559 103342357 103342358 103342359(OMT1) 103342360 103343871

PAVI:

110749562 110750598 110754534 110754543 110758861 110764012 110764013 110764014 110764015 110764024 110764059 110772009

PDUL:

117613038 117615943 117617464 117619155 117620318 117625659 117625687 117628001

MDM:	103406240 103406241 103410332 103416926 103420798 103421923 103422036 103426499 103426529 103428516 103431087 103433538 103439452 103439955 103439956 103439958 103444340 114821537

PXB:	103927980 103927981 103927983 103935025 103935026 103943352 103943506 103951568 103951571 103951572 103951578 103956347

PCOX:

137717945 137719531 137719672 137720306 137720307 137721176 137721282 137721522 137721523 137733844 137733845 137734684 137735295 137735546

ZJU:	107414981 107418645 107418646 107418657 107418658 107418659 107423786 107423795 107423799 107423818 107429761 107434023

MNT:	21386163 21396224 21399503 21402552 21402554 21402556 21406195

CSAV:

115703695 115703767 115704986 115706437 115706440 115706441 115716367 115716906 115721930 115723302 133031098 133033009 133036025

HLP:	133778173 133797404 133797405 133834373

CSV:	101204109 101205290 101214675 101214916

CMO:	103491014 103501180 103503246 107990280

BHJ:	120069086 120089696 120090274 120090551 120091798

MCHA:

111011723 111013374 111013400 111021443

CMAX:

111467633 111498431

CMOS:

111443843 111443858 111443866 111443875 111443892 111443897 111443906 111443926 111450048

CPEP:

111800838 111800840 111800841 111802251

RCU:	8262723 8270912 8270961 8270962 8282965 8285506 8288877

MEAN:

126656431 126664634 126685798 126686904 126686906 126686907

JCU:	105631282 105631656 105632993 105635946 105636072 105639044 105639046 105646425 105646969 110009243

HBR:	110633210 110634239 110634596 110634655 110635655 110637255 110646402 110650778 110651119 110660998 110663184 110666566 110666571 110667200 110667558 110668193 110668919 110668933

MESC:

110606332 110606366 110609830 110620427 110620573 110621614 110621616 110625885 110625905 110626912 110627924

POP:	112326165 7455369 7464476 7486809 7487746 7489078 7491420 7493466

PEU:	105110074 105116664 105126241 105135039 105135998 105136006 105136824 105139125

PALZ:

118037805 118040848 118041177 118041178 118042464 118043955 118043959 118063366 118063469 118063471

PNZ:	133675947 133678544 133680856 133680968 133682250 133682854 133682858 133682905 133690742 133690806 133690883 133692952 133703911

JRE:	108981438 108984504 108984894 108988282 108988354 108996985 108997950 109001928 109007527 109016296 109017756 109019627 109019628 118343751

AGLU:

133854114 133854577 133854848 133854862 133854873 133856564 133861312 133863128 133864117 133864118 133864192 133864343 133865774 133867188

QSU:	111984638 111986891 111998091 111999738 112003971 112004110 112008529 112008537 112008542 112008545 112010443 112022960 112024712 112025116 112034364 112039311

CSAA:

142614680 142614699 142618734 142618872 142619769 142622743 142630649 142631358 142631792 142634764 142638637 142638962 142638999 142641066 142644135

TWL:	119980326 119991969 119992484 119993419 119993421 119993422 120003335 120004090 120004360 120017161 120017162

VVI:	100232862 100232921 100242108 100253843 100255690 100260649 100260763 100260786 100265976 100265990 100854172 132253142

VRI:	117905577 117905995 117906164 117928551 117931761 117931763 117931793 117932682 117932824 117934093 117934121

SLY:	101247834 101251452 101258157 101261963(CTOMT1) 101262824

SPEN:

107002798 107015050 107021224 107022387 107022691 107023557 107023901

SOT:	102580081 102590869 102598963 102599285 102599938 102601059 102601955 107058365

SSTN:

125850018 125858515 125864991 125872242 125874005 125874309 125874334 125874421 125874422 125874423 125874424 125874437

SDUL:

129877139 129894354 129900050 129900634 129900817

CANN:

107845577 107862991 107873006 107874581 107874582 107875336 124893919

LBB:	132604937 132607228 132626646 132626663 132631985 132632002 132632190

NTA:	107781704 107786249 107788038 107793948 107795225(OMT) 107808034 107809583

NSY:	104210365 104213493 104220105 104220510 104232532 104247907

NTO:	104093759 104094532 104102219 104112840 104113085

NAU:	109207707 109213341 109214785 109216530 109225432 109238560

INI:	109150685 109165820 109165828 109169365 109169372 109169378 109169387 109194027

ITR:	115995564 115997239 116000356 116027462 116027469 116027475

SIND:

105155389 105155459 105155461 105156074 105160270 105166789 105166790 105166792 105166793 105171204 105176053

OEU:	111367736 111397542

EGT:	105948694 105958797 105959984 105963647 105964561 105964570 105964613 105964669

SSPL:

121755989 121781296 121792982 121793860

SMIL:

130993304 130999983 131016166

SHIS:

125197435 125209845 125212956 125217723

APAN:

127246917 127256425

HPUM:

PEBU:

140810364 140810506 140813937 140813946 140816497 140826627 140826638 140840007 140840981 140841034 140841035 140841036 140841038 140841040

ECAD:

122580299 122584671 122585007 122587186 122603167 122604332 122605064 122605407 122606653 122606654 122606655 122606657 122607521

LSV:	111885575 111885585 111903002 111903004 111903396 111920419

CCAV:

112502160 112517955 112518480 112524515

DCR:	108210405 108213212 108213412 108214102 108214103 108214345 108215346 108215347 108215577 108215829 108221040 108223084

AGRV:

141672364 141682993 141685906 141686580 141687337 141692442 141693201 141693643 141693708 141705999 141708313 141717290 141717296 141721511 141721512 141721540

CSIN:

114256533 114258943 114263502 114279920 114281109 114289828 114298482 114299270 114311917 114318633 114318652 114318654 114319246

RVL:	131297882 131300318 131300492 131306389 131306397 131312075 131324320

AEW:	130752610 130757246 130760883 130766806 130766817 130766826 130790222 130791401 130793849

DLT:	127796638 127796639 127801236 127801248

BVG:	104887972 104888149 104888150 104888557 104897755 104901566 104901641 104901795 104901881 104901967 104902057 104902142 104902234

SOE:	110778083 110780238 110784083 110784177 110784196 110785731 110785749 110797580 110797596 110797628 110801392

CQI:	110685492 110690251 110692919 110692921 110693058 110697403 110697782 110713433 110713990 110713992 110724195 110727557 110727590 110727597 110729489 110729654 110731660 110731662

ATRI:

130806644 130809948 130809949 130824825 130825451 130825452 130825453 130825454 130825773

SLAF:

141589747 141589869 141592879 141606368 141606780 141606781 141609335 141609336 141609337 141610802 141610803 141610804 141610806 141610808 141610809 141612788 141613140 141622039 141655483

MOF:	131146034 131161953

NNU:	104585771 104590656 104596816 104601399 104604834

PSOM:

113286544 113288498 113326813 113332502 113341805 113346262 113346520

OSA:	4344702(COMT)

DOSA:

OBR:

OGL:

TDC:	119270800 119279020 119280848 119305126 119305127 119306746 119319175 119324413 119334749 119336376 119341366 119361971 119361975

TAES:

123147740 123164941 123177153 123178260

TUA:	125519037 125519563

HVG:

LPER:

LRD:

SBI:

ZMA:

MFLO:

136476450 136476470

SITA:

SVS:

PVIR:

120658570 120680242 120711449

PHAI:

PAUA:

133895468 133898836

TANG:

140775963 140776416 140776605 140776636

PDA:	103696092 103706414 103716997

EGU:	105037617 105042923 105054950 105054951 105054994

MUS:	103973830 103974192 103974304 103980348 135605395 135608343 135609221 135622032 135623383 135623384 135623540 135626412

ZOF:	122000275 122032468 122032830 122034804

DCT:	110098174 110100929 110101663 110101682 110108293 110108304

PEQ:	110020850 110023022 110023954 110023969 110026827 110031091 110034484 110039323

AOF:	109820654 109821887 109822249 109837170 109837171 109838501

MSIN:

131218596 131233500 131234034 131234035 131235354 131248689 131248693 131248696 131248697 131257761 131257772 131257773 131257774 131257780

ACAK:

137933932 137948087

NCOL:

116252484 116253190 116253193 116253194 116260880 116262254 116262255 116263147

ATR:

SMO:	SELMODRAFT_450944(COMT1-1) SELMODRAFT_450945(COMT1-2)

PPP:	112288207 112289725

Reference

Authors

Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel JP

Title

Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase.

Journal

Plant Cell 14:1265-77 (2002)
DOI:10.1105/tpc.001412

Sequence

Reference

Authors

Byeon Y, Lee HY, Lee K, Back K

Title

Caffeic acid O-methyltransferase is involved in the synthesis of melatonin by methylating N-acetylserotonin in Arabidopsis.

Journal

J Pineal Res 57:219-27 (2014)
DOI:10.1111/jpi.12160

Sequence

[ath:AT5G54160]

LinkDB

DBGET integrated database retrieval system