KEGG ORTHOLOGY: K13164

ORTHOLOGY: K13164

Entry

K13164                      KO

Symbol

MSL2

Name

male-specific lethal 2

Disease

H02837

Karayol-Borroto-Haghshenas neurodevelopmental syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome
    K13164  MSL2; male-specific lethal 2
   03036 Chromosome and associated proteins
    K13164  MSL2; male-specific lethal 2
Spliceosome [BR:ko03041]
Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   hnRNP proteins
    K13164  MSL2; male-specific lethal 2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HAT complexes
    MSL complex
     K13164  MSL2; male-specific lethal 2

Genes

HSA:	55167(MSL2)

PTR:	470933(MSL2)

PPS:	100980453(MSL2)

GGO:	101135974(MSL2)

PON:	100453652(MSL2)

PPYG:

129032784(MSL2)

NLE:	100600826(MSL2)

HMH:	116461763(MSL2)

SSYN:

129491272(MSL2)

MCC:	717049(MSL2)

MCF:	102145992(MSL2)

MTHB:

126948145

MNI:	105469911(MSL2)

CSAB:

103241628(MSL2)

CATY:

105586410(MSL2)

PANU:

101020869(MSL2)

TGE:	112619657(MSL2)

MLEU:

105553869(MSL2)

RRO:	104663565(MSL2)

RBB:	108531419(MSL2)

TFN:	117084151(MSL2)

PTEH:

111523338(MSL2)

CANG:

105523362(MSL2)

CJC:	100398191(MSL2)

SBQ:	101045266(MSL2)

CIMI:

108284344(MSL2)

ANAN:

105716499(MSL2)

CSYR:

103250836 103267728(MSL2)

MMUR:

105884067(MSL2)

LCAT:

123629351(MSL2)

PCOQ:

105826624(MSL2)

OGA:	100961734(MSL2)

MMU:	77853(Msl2)

MCAL:

110302167(Msl2)

MPAH:

110315376 110327735(Msl2)

RNO:	315959(Msl2)

MCOC:

116072022(Msl2)

ANU:	117693495(Msl2)

ASYL:

127688660(Msl2)

MUN:	110565801(Msl2)

CGE:	100760221(Msl2)

MAUA:

101828451(Msl2)

PROB:

127214743 127214806 127217639 127237846(Msl2)

PLEU:

114693541(Msl2)

MORG:

121464275(Msl2)

MFOT:

126499897

AAMP:

119809149(Msl2)

NGI:	103740964(Msl2)

HGL:	101698122(Msl2)

CPOC:

100729291(Msl2)

CCAN:

109683939(Msl2)

DORD:

105999615(Msl2)

DSP:	122099867(Msl2)

PLOP:

125342665(Msl2)

NCAR:

124993344

MMMA:

107143374(Msl2)

ITI:	101975694(Msl2)

OCU:

100348585

OPI:	101530381(MSL2)

TUP:	102501715(MSL2)

GVR:	103599914(MSL2)

CFA:	485673(MSL2)

CLUD:

112661060(MSL2)

VVP:	112932511(MSL2)

VLG:	121478733(MSL2)

NPO:	129507230(MSL2)

AML:	100472284(MSL2)

UMR:	103678875(MSL2)

UAH:	113253965(MSL2)

UAR:	123788402(MSL2)

ELK:

111155162

LLV:

125104080

MPUF:

101670661(MSL2)

MNP:	132011815(MSL2)

MLK:	131824570(MSL2)

NVS:	122908921(MSL2)

ORO:	101374394(MSL2)

EJU:	114205546(MSL2)

ZCA:	113918627(MSL2)

MLX:	118004078(MSL2)

NSU:	110570731(MSL2)

LWW:	102750866(MSL2)

FCA:	101083106(MSL2)

PYU:	121033711(MSL2)

PCOO:

112850394(MSL2)

PBG:	122491962(MSL2)

PVIV:

125175361(MSL2)

LRUF:

124526953

LGF:	123611526(MSL2)

AJU:

106987490

PTG:	102965032(MSL2)

PPAD:

109259591(MSL2)

PUC:

125921316

PLEZ:

122230020(MSL2)

HHV:	120248229(MSL2)

BTA:	525740(MSL2)

BOM:	102281675(MSL2)

BIU:	109560105(MSL2)

BBUB:

102399194(MSL2)

BBIS:

105001823(MSL2)

CHX:	102191464(MSL2)

OAS:	101113815(MSL2)

BTAX:

128047376(MSL2)

CSUM:

138080285(MSL2)

ODA:	120857541(MSL2)

CCAD:

122445298(MSL2)

MREE:

136173384(MSL2)

OVR:	110134581(MSL2)

MBEZ:

129547533(MSL2)

SSC:	100155763(MSL2)

CFR:	102512440(MSL2)

CBAI:

105063243(MSL2)

CDK:	105085281(MSL2)

VPC:	102534641(MSL2)

BACU:

102998302(MSL2)

BMUS:

118894542(MSL2)

LVE:	103086269(MSL2)

OOR:	101280119(MSL2) 125964577

LALB:

132515447 132520923(MSL2)

DLE:	111179212(MSL2)

PCAD:

102984728(MSL2)

PSIU:

116753399(MSL2)

NASI:

112400477(MSL2)

ECB:	100065902(MSL2)

EPZ:	103561448(MSL2)

EAI:	106823192(MSL2)

MYB:	102241526(MSL2)

MYD:	102752827(MSL2)

MMYO:

118668148(MSL2)

MLF:	102433313(MSL2)

MDT:	132215535(MSL2)

MYUM:

139022377(MSL2)

PKL:	118715312(MSL2)

EFUS:

103296329(MSL2)

MNA:	107546092(MSL2)

DRO:	112309603(MSL2)

SHON:

118997545(MSL2)

AJM:	119048263(MSL2)

PDIC:

114502102(MSL2)

PHAS:

123830523(MSL2)

MMF:	118633153(MSL2)

PPAM:

129088188(MSL2)

HAI:	109389235(MSL2)

RFQ:	117037115(MSL2)

PALE:

102884138(MSL2)

PGIG:

120582113(MSL2)

PVP:	105300823(MSL2)

RAY:	107508496(MSL2)

MJV:	108406418(MSL2)

TOD:	119257743(MSL2)

SARA:

101547028(MSL2) 105943324

SFUM:

130030358(MSL2)

SETR:

126012141(MSL2)

LAV:	100668206(MSL2)

TMU:

101354351

ETF:	101658712(MSL2)

DNM:	101425976(MSL2)

MDO:	100023720(MSL2)

GAS:	123242327(MSL2)

SHR:	100922891(MSL2)

AFZ:

127554226

PCW:	110208201(MSL2)

TVP:	118838465(MSL2)

PBRV:

138142853(MSL2)

OAA:	100089495(MSL2)

TACU:

119932305(MSL2)

GGA:	429119(MSL2)

PCOC:

116231038(MSL2)

MGP:	100550400(MSL2)

CJO:	107317852(MSL2)

TPAI:

128082772(MSL2)

LMUT:

125697328(MSL2)

NMEL:

110397766(MSL2)

APLA:

101789959(MSL2)

ACYG:

106039223(MSL2)

CATA:

118247256(MSL2)

AFUL:

116492305(MSL2)

TGU:	100223394(MSL2)

LSR:	110474067(MSL2)

SCAN:

103815473(MSL2)

PMOA:

120496436(MSL2)

OTC:	121342106(MSL2)

PRUF:

121364031(MSL2)

ATRC:

139594843(MSL2)

GFR:	102032283(MSL2)

FAB:	101820876(MSL2)

OMA:	130256991(MSL2)

PHI:	102113516(MSL2)

PMAJ:

107208973(MSL2)

CCAE:

111933688(MSL2)

CCW:	104696689(MSL2)

CBRC:

103612390(MSL2)

ACOE:

138114618(MSL2)

ETL:	114054823(MSL2)

ZAB:	102062429(MSL2)

ZLE:	135451718(MSL2)

ACHL:

103812200(MSL2)

SVG:	106849698(MSL2)

MMEA:

130581490(MSL2)

HRT:	120757335(MSL2)

SATI:

136365600(MSL2)

CCIC:

134047863(MSL2)

FPG:	101915638(MSL2)

FCH:	102049596(MSL2)

CCRI:

104157133(MSL2)

NNT:	104401430(MSL2)

SHAB:

115611370(MSL2)

ACUN:

113483739(MSL2)

TALA:

104356826(MSL2)

ACHC:

115347502(MSL2)

HALD:

104319861(MSL2)

HLE:	104827856(MSL2)

AGEN:

126039717

HHAR:

128149162(MSL2)

GCL:

127020326

CSTI:

104561081(MSL2)

LDI:	104350028(MSL2)

MNB:	103768443(MSL2)

DPUB:

104309983(MSL2)

AVIT:

104278533(MSL2)

BRHI:

104497329(MSL2)

EGZ:	104131261(MSL2)

NNI:	104010617(MSL2)

PCRI:

104028260(MSL2)

PCAO:

104052083(MSL2)

PADL:

103916925(MSL2)

AFOR:

103903696(MSL2)

FGA:	104080102(MSL2)

GSTE:

104261655(MSL2)

CBOY:

140654419(MSL2)

CLV:	102092890(MSL2)

MUI:	104535850(MSL2)

PLET:

104627137(MSL2)

EHS:	104514795(MSL2)

CMAC:

104479887(MSL2)

CUCA:

104066364(MSL2)

TEO:	104383633(MSL2)

BREG:

104635959(MSL2)

OHA:	104335083(MSL2)

ACAR:

104532289(MSL2)

CPEA:

104385094(MSL2)

CVF:	104288544(MSL2)

RTD:	128911556(MSL2)

CRID:

134517963(MSL2)

AAM:	106485694(MSL2)

AROW:

112970789(MSL2)

NPD:	112953489(MSL2)

TGT:	104571543(MSL2)

DNE:	112983466(MSL2)

SCAM:

104154200(MSL2)

ASN:	102379724(MSL2)

AMJ:	102575555(MSL2)

CPOO:

109315264(MSL2)

GGN:	109288272(MSL2)

PSS:	102450634(MSL2)

CMY:	102937542(MSL2)

CCAY:

125642618(MSL2)

DCC:	119861791(MSL2)

CPIC:

101945342(MSL2)

TST:	117882847(MSL2)

CABI:

116833379(MSL2)

MRV:	120372614(MSL2)

ACS:	100565492(msl2)

ASAO:

132770777(MSL2)

PVT:	110075847(MSL2)

SUND:

121925775(MSL2)

PBI:	103055931(MSL2)

PMUR:

107290042(MSL2)

CTIG:

120313905(MSL2)

TSR:	106538396(MSL2)

PGUT:

117678508(MSL2)

APRI:

131201471(MSL2)

PTEX:

113436758(MSL2)

NSS:	113425141(MSL2)

VKO:	123025817(MSL2)

PMUA:

114597680(MSL2)

PRAF:

128414441(MSL2)

ZVI:	118093385(MSL2)

HCG:	128352474(MSL2)

GJA:	107123595(MSL2)

STOW:

125437971(MSL2)

EMC:	129332375(MSL2)

XLA:	100381082(msl2.L) 108718218(msl2.S)

XTR:	100125142(msl2)

NPR:	108790034(MSL2)

RTEM:

120936405(MSL2)

BBUF:

120989675 120997522(MSL2)

BGAR:

122934126(MSL2)

PWL:	138265640(MSL2)

MUO:	115478765(MSL2)

GSH:	117366512(MSL2)

DRE:	564400(msl2a) 797201(msl2b)

SRX:	107709889 107709890 107721926 107722612 107725878

SANH:

107663653 107680240 107685436 107688489

SGH:	107550607 107584967 107586758 107590248 107590249

CCAR:

109047910 109047912(msl2a) 109049153 122135380

CAUA:

113042402 113045917 113066154 113095079 113116475

CGIB:

127946523 127950564 128012911 128028931

PTET:

122326905(msl2a) 122329582(msl2b)

LROH:

127153570(msl2a) 127156042(msl2b)

OMC:	131533293(msl2b) 131553579(msl2a)

PPRM:

120482836(msl2a) 120488407(msl2b)

RKG:	130070908(msl2a) 130083999(msl2b)

MAMB:

125250752(msl2a) 125258531(msl2b)

CIDE:

127499169 127506008

CERY:

137002748(msl2a) 137013853(msl2b)

MASI:

127431619 127434495 127441521 127442563

TROS:

130547154(msl2b) 130554721(msl2a)

TDW:	130413174(msl2b) 130415738(msl2a)

MANU:

129425511(msl2b) 129442243(msl2a)

PDAB:

135740256(msl2b) 135766845(msl2a)

IPU:	108261835(msl2b)

IFU:	128599562(msl2b)

PHYP:

113541048(msl2)

SMEO:

124375639(msl2b)

TFD:	113660343(msl2b)

TVC:	132840072(msl2b)

CGAR:

128514076(msl2b)

NGRA:

132866996(msl2b)

TRN:	134300954(msl2b)

AMEX:

103023204(msl2b) 103029372(msl2a)

CMAO:

118798700(msl2b) 118804793(msl2a)

EEE:	113576109 113576505

CHAR:

122130327(msl2b) 122131788

SPIL:

134065944(msl2b)

TRU:	101061190 101071026

TFS:	130514027(msl2b) 130540399(msl2a)

TNG:	GSTEN00012728G001 GSTEN00015869G001 GSTEN00016552G001

LCO:	104920040 104939190

NCC:	104963109(msl2) 104963211

TBEN:

117493857(msl2a) 117497544(msl2b)

CGOB:

115025680 115027142

PGEO:

117466084(msl2b) 117468118(msl2a)

GACU:

117537888(msl2b) 117558766

EMAC:

134858176(msl2b) 134881185(msl2a)

ELY:	117248750(msl2a) 117265013(msl2b)

EFO:	125882235(msl2b) 125900614(msl2a)

PLEP:

121953860 121960811(msl2b)

SLUC:

116040020(msl2b) 116057707(msl2a)

ECRA:

117935844(msl2a) 117937523(msl2b)

ESP:	116670493 116672612

PFLV:

114546868 114549219

GAT:	120814853 120832840(msl2a)

PPUG:

119198883(msl2b) 119227888(msl2a)

AFB:	129103522 129110821

CLUM:

117749801(msl2b) 117751105(msl2a)

PSWI:

130201043(msl2a)

CANA:

137787655(msl2a) 137788504(msl2b)

CVE:	137866444(msl2a) 137871672

MSAM:

119910154(msl2a) 119912952

SCHU:

122861597(msl2a) 122866213(msl2b)

CUD:	121525815(msl2a) 121527355(msl2b)

SPUL:

138591311(msl2a) 138596286(msl2b)

LMIX:

132992973(msl2a) 132993928(msl2b)

ALAT:

119004307(msl2a) 119008321(msl2b)

ASTR:

137587584(msl2b) 137611335

MZE:	101469738 101478341

ONL:	100691257 100708050

OAU:	116318109(msl2a) 116322152(msl2b)

OLA:	101156373 101172112

OML:	112143935(msl2a) 112151524(msl2b)

CSAI:

133423469(msl2b) 133462523(msl2a)

XMA:	102224262 102232485 111606139

XCO:	114133899 114136635

XHE:	116708655 116711457

PRET:

103456722 103458421(msl2)

PFOR:

103146538 103146963

PLAI:

106940212 106947754

PMEI:

106912422 106933876

GAF:	122824416(msl2b) 122845676(msl2a)

PPRL:

129365273(msl2a) 129378921(msl2b)

CVG:	107085127(msl2) 107103204

CTUL:

119776289 119788172(msl2a)

GMU:	124855904(msl2a) 124858353(msl2b)

NFU:	107383105 107392064(msl2)

KMR:	108234659(msl2b) 108247986(msl2a)

ALIM:

106525537(msl2) 106534383

NWH:

119426956

AOCE:

111563441(msl2a) 111580148(msl2b)

EJA:	138193851 138200167(msl2a)

BFRE:

138625710(msl2b) 138627951(msl2a)

MCEP:

124995539(msl2b) 125024078(msl2a)

CSEM:

103377510 103379024

POV:	109645713 109646011

SSEN:

122769330(msl2b) 122783011(msl2a)

SSOE:

131445143(msl2a) 131458170

HHIP:

117753841(msl2b) 117755613(msl2a)

HSP:	118098521 118116454(msl2a)

PPLT:

128425669 128450684

SMAU:

118285735(msl2a) 118291522(msl2b)

LCF:	108875060 108885062

SDU:	111226218 111238291

SLAL:

111651408 111665905

XGL:	120790115 120795894(msl2a)

HCQ:	109517244 109518588

SSCV:

125980993(msl2a) 125986136(msl2b)

SBIA:

133492435(msl2b) 133513077(msl2a)

PEE:	133396335(msl2b) 133412408

PTAO:

133469991(msl2b) 133487940(msl2a)

BPEC:

110154965 110164315

ENY:	140364302 140370258

MALB:

109959426 109969631

BSPL:

114848363(msl2a) 114853375(msl2b)

SJO:	128374836(msl2a) 128382275

SSCO:

134000370(msl2a) 134001979(msl2b)

GMH:

115537441

SASA:

100380287(msl2) 106590518

STRU:

115151835 115190082 115195438

OTW:	112227676(msl2b) 112236920

OMY:	110490918(msl2b) 110535395

OGO:	123991273 124039513

ONE:	115104988(msl2)

OKI:	109899227 109909904

OKE:	118361694 118376319

OMM:	135517183 135522777

OCLA:

139366940 139420292

SALP:

111953322 111972850

SNH:	120027797 120050938(msl2b)

CCLU:

121549795 121569304(msl2b)

ELS:	105022014(msl2)

OEP:	134026357(msl2a) 134034693(msl2b)

SFM:	108927659 108935140(msl2)

PKI:	111850507(msl2) 111853473

AANG:

118225811(msl2b) 118230892(msl2a)

AROT:

135253405(msl2b) 135256696(msl2a)

CCOG:

133126257(msl2b) 133129766(msl2a)

LOC:	102690496(msl2)

PSPA:

121322969 121326773

ARUT:

117417414 117423652

PSEX:

120534196

LCM:	102365984(MSL2)

CMK:

103174814

RTP:	109927342 109934308

CPLA:

HOC:

LERI:

BFO:

SPU:

AJJ:

APLC:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG3241(msl-2)

DER:

6541512

DSI:	Dsimw501_GD15895(Dsim_GD15895)

DYA:	Dyak_GE14867

DSR:

110176958

DPO:	4816801 6899940

DPE:	6587642 6589062 6601046

DMN:	108153785 108154451 108163249

DWI:	6641706 6645214

DGR:

6561706

DMO:	Dmoj_GI14252

DAZ:

DNV:

DHE:

CCAT:

BOD:

TDA:

MDE:	101894148 131805489

SCAC:

LCQ:

LSQ:

AAG:

ASUA:

CQU:	CpipJ_CPIJ010636 CpipJ_CPIJ012569

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

VEM:

COBS:

139109607(Msl-2)

TLN:	139820494(Msl-2)

HST:

DQU:

CFO:

FEX:

PMEC:

138932975(Msl-2)

LHU:	105667595(msl-2)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

TCA:

TMOL:

DPA:

ESIM:

136414961(msl-2)

EFOR:

136350297(msl-2)

SOY:

ATD:

CSET:

HAXR:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100101214(MSL2)

BMAN:

114250914

MSEX:

115449007

DPL:	KGM_215626

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137926928(msl-2)

PRAP:

110995820

PBX:

123716645

PNAP:

125049178

ZCE:	119829770 119829776

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

API:

DNX:

RMD:

BTAB:

CLEC:

HHAL:

106687892(msl-2)

NLU:

111048617

PHU:	Phum_PHUM348150

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138715280(msl-2)

BROR:

134535498

IEL:

124154031

HAMR:

139687707(msl-2)

DPX:	DAPPUDRAFT_347562(MSL-2)

DMK:

DPZ:

AFRA:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

EAF:

PPOI:

DSV:

RSAN:

RMP:	119160991 119178224

TUT:

107366086

CSCU:

111633235

CVS:	136976725(msl-2)

SDM:

PCAN:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

MYI:

PMAX:

OBI:

OSN:

LAK:	106155731 106179837

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

Reference

PMID:16227571

Authors

Smith ER, Cayrou C, Huang R, Lane WS, Cote J, Lucchesi JC

Title

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.

Journal

Mol Cell Biol 25:9175-88 (2005)
DOI:10.1128/MCB.25.21.9175-9188.2005

Sequence

[hsa:55167]

Reference

PMID:21726816

Authors

Wu L, Zee BM, Wang Y, Garcia BA, Dou Y

Title

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

Journal

Mol Cell 43:132-44 (2011)
DOI:10.1016/j.molcel.2011.05.015

Sequence

[hsa:55167] [dme:Dmel_CG3241]

LinkDB

DBGET integrated database retrieval system