KEGG ORTHOLOGY: K13369

ORTHOLOGY: K13369

Entry

K13369                      KO

Symbol

HSD17B6

Name

17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]

Pathway

map00140

Steroid hormone biosynthesis

map00830

Retinol metabolism

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Module

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R01836

testosterone:NAD+ 17-oxidoreductase

R02124

retinol:NAD+ oxidoreductase

R02352

estradiol-17beta:NAD+ 17-oxidoreductase

R02353

estradiol-17beta:NADP+ 17-oxidoreductase

R02476

androsterone:NAD+ oxidoreductase

R04330

androstan-3alpha,17beta-diol:NAD+ oxidoreductase

R04681

estriol:NAD+ 17-oxidoreductase

R04682

estriol:NADP+ 17-oxidoreductase

R08945

11beta,17beta-dihydroxy-4-androsten-3-one:NAD+ 17-oxidoreductase

R08980

11beta,17beta-dihydroxy-4-androsten-3-one:NADP+ 17-oxidoreductase

R13216

5alpha-pregnane-3alpha,17alpha-diol-20-one:NAD+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
    1.1.1.105  all-trans-retinol dehydrogenase (NAD+)
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

Other DBs

GO:	0004303 0004745 0047035

Genes

HSA:	8630(HSD17B6)

PPS:	100996145(HSD17B6)

GGO:

101153072

PON:	100454653 100458219(HSD17B6)

PPYG:

129010009(HSD17B6)

NLE:

100606923

HMH:

116480891

SSYN:

129465575

MCC:	713549(HSD17B6)

MCF:	101926544(HSD17B6)

MTHB:

126930391

MNI:	105474127(HSD17B6)

CSAB:

103238543(HSD17B6)

CATY:

105587281(HSD17B6)

TGE:

112634424

MLEU:

105545551(HSD17B6)

RRO:	104673659(HSD17B6)

RBB:	108516069(HSD17B6)

TFN:	117089914(HSD17B6)

PTEH:

111541833(HSD17B6)

CANG:

105500532(HSD17B6)

CJC:	100387390(HSD17B6)

SBQ:	101054253(HSD17B6)

CIMI:

108309703(HSD17B6)

ANAN:

105715970(HSD17B6)

CSYR:

103275150(HSD17B6) 103275152

MMUR:

105865568

LCAT:

123639631 123639632(HSD17B6)

PCOQ:

105816028

OGA:

100947460

MMU:	27400(Hsd17b6)

MCAL:

110303948

MPAH:

110326955(Hsd17b6)

RNO:	134479803 286964(Hsd17b6)

MCOC:

116076149

ANU:

117696662

CGE:

100762147

PROB:

127215652(Hsd17b6)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103730224(Hsd17b6)

HGL:	101699287(Hsd17b6)

CPOC:

100717492 100717768 100718054

CCAN:

109686095

DORD:

105986857(Hsd17b6)

DSP:	122124416(Hsd17b6)

PLOP:

125362512(Hsd17b6)

TUP:	102485005(HSD17B6)

CFA:	481118(HSD17B6)

CLUD:

112678001(HSD17B6)

VVP:	112922366(HSD17B6)

VLG:	121491966(HSD17B6)

NPO:

129511964

AML:

100474694

UMR:	103656323(HSD17B6)

UAH:	113256406(HSD17B6)

UAR:	123787236(HSD17B6)

ELK:

111160200

LLV:

125106172

MPUF:

101672306(HSD17B6)

MNP:	132019817(HSD17B6)

MLK:	131838584(HSD17B6)

NVS:	122892252(HSD17B6)

ORO:	101368715(HSD17B6)

EJU:	114215053(HSD17B6)

ZCA:	113921488(HSD17B6)

MLX:

118008692

NSU:

110577830

LWW:	102743313(HSD17B6)

FCA:	101088341(HSD17B6)

PYU:	121040906(HSD17B6)

PCOO:

112863243(HSD17B6)

PBG:	122473787(HSD17B6)

PVIV:

125170822(HSD17B6)

LRUF:

124502205

PTG:	102971783(HSD17B6)

PPAD:

109270351(HSD17B6)

PUC:

125920256

AJU:

106986922

HHV:	120224864(HSD17B6)

BTA:	533086(HSD17B6)

BOM:	102283510(HSD17B6)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:	102527912 102534817 107034922

BACU:

103008169(HSD17B6)

BMUS:

118902700

LVE:	103076064(HSD17B6)

OOR:	101278484(HSD17B6)

DLE:	111173857(HSD17B6)

PCAD:

102988625

PSIU:

116761374

NASI:

112393956(HSD17B6)

ECB:

100052840

EPZ:	103565330(HSD17B6)

EAI:	106832977(HSD17B6)

MMF:

118623751

RFQ:

117028833

PALE:

102883634(HSD17B6)

PGIG:

120604931

PVP:

105302561

RAY:	107521200(HSD17B6)

MJV:

LAV:

TMU:

SHR:

AFZ:

PCW:

TVP:	118850303 118850652 118850653 118851548 118851597

AROW:

112962016

NPD:

112956391

DNE:

112994731

ASN:	102370921 102371169

AMJ:

102567845

CPOO:

109324411 109324469

PSS:	102444001 102454079

CMY:

102944543

CCAY:

125627856

DCC:	119845913(HSD17B6)

CPIC:

103306704

TST:	117888588(HSD17B6)

CABI:

116827724

MRV:

120391156

ACS:	100564174(hsd17b6)

ASAO:

132768358 132768360

PVT:	110071325 110091362

SUND:

PBI:

PMUR:

CTIG:

TSR:	106545328(HSD17B6)

PGUT:

117662721

APRI:

131192991 131193302(HSD17B6)

PTEX:

113445491 113445552

NSS:	113422732 113422749

PMUA:

114592701 114592979 114592981

PRAF:

128405337 128405345 128405364 128405369 128405390

ZVI:	118077226(HSD17B6)

HCG:	128339160 128339162 128344041 128345225 128345226 128346238 128346556 128346634

GJA:	107120904(HSD17B6)

STOW:

125430225 125430298 125430340

EMC:	129328144 129346101 129346224

XTR:

GSH:

BROR:

DSV:

RMP:

LOA:	LOAG_08821

LGI:	LOTGIDRAFT_141736

PCAN:

112563790 112563794 112563795

BGT:

HRJ:

CRG:

CANU:

CVN:	111111885 111114621

MYI:	110451842 110466177

PMAX:

117316732 117316733 117316734 117318303

MCAF:

127719989

MMER:

123531644 123531645 123532231

RPHI:

132715842 132719757 132734128 132736821 132737641 132737771 132738844

DPOL:

127855977

MAEA:

128208576 128236155 128236793 128237301 128244468 128244563

OBI:

106873408

HSY:

130655463

TAD:	TRIADDRAFT_22801

» show all

Reference

PMID:9188497

Authors

Biswas MG, Russell DW

Title

Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate.

Journal

J Biol Chem 272:15959-66 (1997)
DOI:10.1074/jbc.272.25.15959

Sequence

[hsa:8630] [rno:286964]

Reference

PMID:11360992

Authors

Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY

Title

Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase.

Journal

Arch Biochem Biophys 386:1-10 (2001)
DOI:10.1006/abbi.2000.2203

Sequence

[hsa:8630]

LinkDB

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