KEGG ORTHOLOGY: K13899

ORTHOLOGY: K13899

Entry

K13899                      KO

Symbol

CST3

Name

cystatin-C

Pathway

map04970

Salivary secretion

Disease

H00821

Age-related macular degeneration

H01185

Cerebral amyloid angiopathy

H02960

Autosomal dominant adult-onset leukodystrophy without amyloid angiopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09154 Digestive system
   04970 Salivary secretion
    K13899  CST3; cystatin-C
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K13899  CST3; cystatin-C
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K13899  CST3; cystatin-C
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I25: cystatin family
   K13899  CST3; cystatin-C
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K13899  CST3; cystatin-C

Other DBs

GO:

0004869

Genes

HSA:	1471(CST3)

PTR:	743081(CST3)

PPS:	100976872(CST3)

GGO:	101149507(CST3)

PON:	100935686(CST3)

PPYG:

129021777(CST3) 129021945

NLE:	100605640(CST3)

HMH:	116461509(CST3)

SSYN:

129474465(CST3)

MCC:	574313(CST3)

MCF:	135965589(CST3)

MTHB:

126929315

MNI:	105486751(CST3)

CSAB:

103215462(CST3)

CATY:

105581976(CST3)

TGE:	112633578(CST3)

RRO:	104677867(CST3) 115895742

RBB:	108512567(CST3)

TFN:	117068362(CST3)

PTEH:

111535684(CST3)

CANG:

105504292 105519017(CST3)

CJC:	100404389(CST3)

SBQ:	101050202(CST3) 104652104

CIMI:

108313150(CST3)

ANAN:

105707543(CST3)

CSYR:

103263545 103264656

MMUR:

105857083 105857088(CST3) 105860658 105860659 105871240 105871241 105871242

LCAT:

123622604 123622606

ERUF:

138400559(CST3) 138400969

PCOQ:

105817436(CST3)

OGA:	100952792 100960043

MMU:	13010(Cst3)

MCAL:

110288151 110307257

MPAH:

110318027 110318739

RNO:	25307(Cst3)

MCOC:

116091106 116091810 116092426

ANU:

117703797

ASYL:

127686025

MUN:	110542718 110554870 110560600(Cst3)

CGE:	100766583 100771186

MAUA:

PROB:

PLEU:

PMAV:

MORG:

MFOT:

126489107 126496542 126512064

AAMP:

119814752

NGI:	103731643 103731650

HGL:	101720692 101723151 101723501

CPOC:

100721551 100721826 100734096 101788442

CCAN:

DORD:

DSP:

DMER:

PLOP:

NCAR:

124976318 124976319 124976975

MMMA:

107140493 107147408

ITI:	101955705 101962508 120886443

OCU:	100009450(CST3)

OPI:

101523340

OCZ:	121157033(CST3)

TUP:	102481379(CST3)

CFA:

607874

CLUD:

112668861

VVP:

112933280

VLG:	121478587(CST3) 121498857

NPO:

129507377

AML:

100468639

UMR:	103677867(CST3) 103680484

UAH:	113247936 125283121

UAR:	123779050 123791697

ELK:

111141546

LLV:

125109548

MPUF:

101673853

MNP:	132021679(CST3)

MLK:

131808242

NVS:

122916325

ORO:	101382163(CST3)

EJU:

114224518

ZCA:

113937592

MLX:	118011173(CST3)

NSU:	110590009(CST3)

LWW:	102736490(CST3)

FCA:	100462660(CST3) 101088567

PYU:	121012024 121012572

PCOO:

112869406 112869456

PBG:	122466968 122496644

PVIV:

125157556 125162844 125162992

LRUF:

124503248 124503703 124509238

LGF:	123579678 123580579

AJU:	106965604 113592413

PTG:	102965167(CST3) 107181026

PPAD:

109274640 109274819

PUC:	125936311 125936874

PLEZ:

122214985 122215882

HHV:	120222955(CST3) 120227368

BTA:	281102(CST3)

BOM:

BIU:

BBUB:

BKE:

BBIS:

CHX:

OAS:	101104079(CST3)

BTAX:

CSUM:

ODA:

CCAD:

MREE:

OVR:

MBEZ:

SSC:	733672(CST3)

CFR:

CBAI:

CDK:

BMUS:

LVE:	103074395(CST3)

OOR:	101284827(CST3)

LALB:

132505030

GMF:

115861561

DDP:

132438662

DLE:	111185039(CST3)

PCAD:

102994383

PSIU:

116740997(CST3)

PPHC:

136134845

ECB:	100058494(CST3)

EPZ:	103566764(CST3)

EAI:	106841791(CST3)

MYD:

MMYO:

MLF:

MDT:

MYUM:

PKL:

EFUS:

DRO:

SHON:

118975879(CST3)

AJM:	119053323(CST3)

PDIC:

114506466

PHAS:

123815354(CST3)

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

120587005 120587006 120593175 120616918

PVP:	105306926 105311358

RAY:	107498631 118610012 118610013

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:	100675856(CST3)

TMU:

101351675

ETF:	101660007(CST3)

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:	110197272 110208920

TVP:	118842946(CST3)

PBRV:

138151939(CST3)

OAA:

100089139

TACU:

119932497

GGA:	396497(CST3)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

110397101(CST3)

APLA:

AACU:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

GFR:

FAB:

OMA:	130251629(CST3)

PHI:

102099573

PMAJ:

107201629

CCAE:

111926340

CCW:	104685609(CST3)

CBRC:

103612835(CST3)

ACOE:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

130581312(CST3)

HRT:

SATI:

CCIC:

FCH:

SHAB:

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

GCL:

CSTI:

LDI:

DPUB:

PPUS:

BRHI:

EGZ:

NNI:

PCAO:

PARX:

142055110(CST3)

PADL:

FGA:

CBOR:

CBOY:

MAME:

142407306(CST3)

CLV:

CNIC:

MUI:

PLET:

CMAC:

CUCA:

TEO:

OHA:

CVF:

RTD:

CRID:

LMIC:

AROW:

NPD:

TGT:

DNE:	112985549(CST3)

ASN:

102379946

AMJ:	102573658(CST3)

CPOO:

109316163

GGN:

109296665

CIZ:	142010831(CST3)

CMY:	119565875(CST3)

CCAY:

125633350(CST3)

LKP:

140909724

NDS:	141985505(CST3)

DCC:

CPIC:

TST:

CABI:

MRV:	120402036(CST3)

ACS:	100554354(cst11) 103282790

ASAO:

132774207

PVT:

110089602

SUND:

121929766(CST3)

PBI:

PMUR:

CTIG:

TSR:

PGUT:

117662377(CST3) 117671336 132709301

PCAE:

139314857 139322188 139322403

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:	107108829 107110102 107125462

STOW:

125438891 125443804

EMC:	129325300 129334077 129338527

XLA:	108716610 108716611 108716612 108717399 108717539 108717540 108717786 108717964(cst3.S) 733234(cst3.L)

XTR:	100485774 105945141

NPR:	108784996 108788902 108789514

RTEM:

120917506(CST6) 120935372 120937126 120937621 120937622 120937624

ACAT:

141112386(CST6) 141140120 141140587 141140589 141140590

PADS:

140328805(CST3) 140329244 140329245 140329251

BBUF:

120997357 120998203 120998811 120998813

BGAR:

122933811 122934304 122934348 122936359

DTC:	141063430 141063431 141063433 141100846

PWL:	138296158 138296160 138296418 138297057 138297110

MUO:	115464406 115464414 115465634 115465635 115465636 115465637 115465638 115467267

GSH:	117356761 117357670 117357973 117357974 117358034

DRE:	566959(zgc:163030) 791878(cst3)

SRX:	107705402 107724449 107751540 107758160

SANH:

107655000 107671512 107675574 107698537

SGH:	107567281 107571587 107585508

CCAR:

109050100 109064570 109076654 109083736 109087886 109091649 109092110 109106167(cst3) 122138180 122138181 122138182

CAUA:

113056757 113106748 113107348 113108008 113112610

CGIB:

127963000 127964240 127964241 127969837 128026069

PTET:

122356414

LROH:

127175591(cst3)

OMC:	131551895(cst3)

PPRM:

120463939 120464038

RKG:	130086793 130086794

MAMB:

125277144(cst3)

CIDE:

127525186

CERY:

137020690

MASI:

127412394 127414178

TROS:

130552772 130559088(cst3)

TDW:	130431532 130435132

MANU:

129415825(cst3)

PDAB:

135786838

IPU:	100528758(cyt) 108263371 108263374

IFU:	128605229 128605230 128605231

PHYP:

113541930 113542015 113542138

SMEO:

124394504 124401572 124403676

TFD:	113655255 113655302 113655303 113655304 113655305 113655396

TVC:	132846626 132846627 132846628 132846767 132846975 132846976

CGAR:

128529027 128529029 128529533 128529534 128529535

NGRA:

132888584 132888585 132889210

TRN:	134304409 134314379 134314742

AMEX:

103024600(cst3)

CMAO:

118810912 118810913

EEE:	113587093(cst3)

CHAR:

105911811 122131881(cst3)

SPIL:

134063552 134063904 134064086 134064435 134064513 134064514 134071299 134071755

ASAD:

121685795

TRU:

101065878

TFS:	130534372(cst3)

TNG:	GSTEN00030810G001

LCO:

104918270

NCC:	104943161 104963446

TBEN:

117499682(cst3) 117499806

CGOB:

115020098 115020132

PGEO:

117459908(cst3) 117460133

GACU:

117546416 117553159(cst3)

EMAC:

134859198(cst3)

ELY:	117248412(cst3) 117248777

EFO:	125903801(cst3)

PLEP:

121954427(cst3) 121954926

SLUC:

116051542(cst3) 116060945 116061267 116061546

ECRA:

117937198 117960035(cst3)

ESP:

116705712

PFLV:

114547705 114572370

GAT:	120820217 120820605 120820606

PPUG:

119214300(cst3) 119214353

AFB:	129092094(cst3)

CLUM:

117743847(cst3) 117744342

PSWI:

130207071(cst3) 130207625

CANA:

137779692(cst3) 137779794

CVE:	137883161 137883225(cst3)

MSAM:

119907861 119907871 119907878 119907885 119916926(cst3)

SCHU:

122884006(cst3)

EARM:

139294018(cst3)

CUD:	121511340 121511488(cst3) 121511553

SPUL:

138588469(cst3)

LMIX:

132975111 132975126(cst3)

HTC:	141795083 141795190 141795191

ALAT:

119033078 119033168 119033170

ASTR:

137603757

PKLU:

139210727(cst3)

MZE:	101488042 112430052

ONL:

100711094

OAU:	116318549(cst3) 116318603

OLA:	101165252 101165499 101165755 101165999 101166492 101166737 101167477 101170488 101171465 105355827 110013957

OML:	112139708 112161583 112161743 112161744 112161970 112161986 112161987 112162003 112162073 112162191 112162226 112162241 118599706

CSAI:

133442001 133463484(cst3)

XMA:	102228167 102228416 102228679 102228941

XCO:	114137724 114138265 114138266 114138267

XHE:	116712745 116713649 116713650 116713728

PRET:

103477221 103477222 103477223 103477224

PFOR:

103134154 103134156 103134157 103134158 103134159 103134162

PLAI:

106959265 106961699 106961700 106961702 106961703

PMEI:

106930046 106930047 106930048 106930049 106930050 106930053

GAF:	122842944 122842945 122842948 122842949

PPRL:

129359796 129359990 129359991

CVG:	107104908 107104910 107104911

CTUL:

119797682 119797690

GMU:	124859088 124859325 124859365

NFU:	107375463 107375576

KMR:	108233930 108233983 108234053 108234056

ALIM:

106515857 106515908 106515910 106535728

NWH:	119417768(cst3) 119417778

AOCE:

111564394 111585237(cst3)

EJA:	138195519(cst3)

BFRE:

138616086(cst3)

MCEP:

125019162(cst3)

CSEM:

103387550

POV:	109632944(cst3)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108877107(cst3)

SDU:

111220584

SLAL:

111669547(cst3)

XGL:	120796163 120796296(cst3)

HCQ:	109509836 109516178

SSCV:

125978763(cst3)

SBIA:

133509468(cst3)

PEE:	133409714(cst3)

PTAO:

133485565(cst3)

BPEC:

110156780 110156781 110159148

ENY:	140351401 140351535(cst3)

MALB:

109958820

BSPL:

114870584(cst3)

SJO:	128372654(cst3)

SSCO:

133991710(cst3)

GMH:

115559797

SASA:

106589915(CYT) 106611588(CYT)

STRU:

115153549 115201725

OTW:	112224706 112258172

OMY:	100136752 110499484 110499485 110527556 118942071

OGO:	124038502 124040434

ONE:	115112651 115144627

OKI:	109870262 109870263 109887706 109899954

OKE:	118370152 118374066 118402700 118402702

OMM:	135512042 135523374 135536115

OCLA:

139375728 139375729 139382019

SALP:

111978541 112069883 112069885 112069890 112071242 112071243 112071244

SNH:	120029560 120029562 120029563 120029564 120029927 120029928 120029930 120029932 120029933 120029934 120041287 120046729

SFON:

129828473 129828595 129828596 129828597 129828598 129861395

CCLU:

121548047 121576366 121576380

ELS:	105009985 105010005(cyt)

OEP:	134022644(cst3)

SFM:	108920047 108927031 108927044

PKI:	111835671 111835679 111835750 111835751 111835752 111838893

AANG:

118214530 118217960(cst3) 118218385 118222598

AROT:

135241105 135244425(cst3) 135251935

CCOG:

133116224 133117881 133118364 133118477 133118478 133118658 133118742 133118743 133118744 133118745 133125214

LOC:	102682936 102690146 107079444 107079447 107079448

PSPA:

121315716(cst3) 121316808 121316813 121316814 121316815

ARUT:

117402499 117402599 117402600 117410388 117410765 117972491

LCM:

102349826

CMK:

103181669

RTP:	109910571(si:busm1-57f23.1) 109910573

CPLA:

122552995 122553241

CPUN:

140457081 140482615 140482616 140483196

HOC:	132819488 132819489 132819833 132836259

SCAU:

119969964(si:busm1-57f23.1) 119969974 119969979 119969987 119970055

LERI:

129695044 129699517 129699522 129699523

HAKA:

140729419

PMRN:

116947380 116947795

LRJ:	133341363 133361426

AJJ:	139970953 139971116

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

LBD:	127284976 127286585

CGLO:

123261287

DPL:	KGM_214605

DCI:	103517987 103523964 103523965 113467867 113471845

CLEC:

106666190

LDA:	142324521 142325338 142325734

DPX:	DAPPUDRAFT_40094 DAPPUDRAFT_8489

PPOI:

119104532

DSV:	119458242 119458457 119458458 119458460 119458463 119459193 119459639

DALB:

135896906 135903466 135903467 135903510 135903511

RSAN:

119373693 119373856 119373932 119375504 119375505

RMP:	119167644 119168020 119168121 119168123

VDE:	111251844 111252001

VJA:	111260320 111260444

GOE:

100907198

TUT:	107361217 107362897

DPTE:

DFR:

CSCU:

CVS:

PTEP:

107440888 107440895 122273184

ABRU:

129962747 129962770 129962780

UDV:	129221642 129221643 129222799

SDM:	118184125 118189486 118189490 118202671

LPOL:

106461738 106461748

LOA:	LOAG_09834

HRO:	HELRODRAFT_176339 HELRODRAFT_183936 HELRODRAFT_188988

PCAN:

112570150 112570151 112571317

LSAX:

138953554

BGT:

106060232

HRF:	124132270 124133151

HRJ:

HASI:

HCRA:

RPHI:

DPOL:

MAEA:

128208277 128209097 128216914

EPA:

110250729

ATEN:

116299216

XEN:

124444010

HSY:	130622065 130645125

RES:	135686253 135687854

CPAP:

110807958

CIT:

102619077

CIC:	CICLE_v10006584mg

PVY:	116117909 116139061

MINC:

123210909

TCC:

18602603

GRA:

105794019

GHI:	107888175 107910179

GAB:	108461348 108465038

HSYR:

120135030 120138719 120146286 120160607 120164107 120175183 120175184 120191751 120218182

DZI:

111288392

RARG:

115732569

GMX:	100527919 100809340

GSJ:	114381971 114412854

PVU:	137839075 137839081

VRA:	106767781 106778276

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131607936 131607946

LJA:

130713360

ADU:

107482320

AIP:

107629405

AHF:	112736274 112792619

LANG:

109349421

PCIN:

129297119 129301426

QSA:	O6P43_002572 O6P43_023607

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103434431 103434432

MSYL:

126615764 126620167

PXB:	103943674 103966697

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:	105115781 105125843

JRE:	108996662 109011707

CILL:

CAVE:

QLO:

TWL:

VVI:

VRI:

INI:	109158115 109161767 109175195

ITR:	115998047 115998098 115998282 115998474 115998475 115998476 115998477 115998478 115998479 116007913 116015409

EGT:

105972697

SSPL:

121808360

APAN:

127241612

HAN:	110887241 110887242

ECAD:

122580827

LSV:

111896904

DCR:

108211283

AEW:	130772722 130782273 130783646

BVG:

104889768

ATRI:

130814394

MOF:	131145182 131145183

NNU:	104587305 104587976

MING:

122057615 122089424

TSS:	122659416 122669005

PSOM:

113277846 113277847 113358963

EGU:

ZOF:

MSIN:

ACAK:

NCOL:

116248654 116248655 116248758 116250983

GTT:	GUITHDRAFT_119707

NOZ:	DMB37_36020

» show all

Reference

PMID:3495457

Authors

Abrahamson M, Grubb A, Olafsson I, Lundwall A

Title

Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C.

Journal

FEBS Lett 216:229-33 (1987)
DOI:10.1016/0014-5793(87)80695-6

Sequence

[hsa:1471]

Reference

PMID:1391414

Authors

Bobek LA, Levine MJ

Title

Cystatins--inhibitors of cysteine proteinases.

Journal

Crit Rev Oral Biol Med 3:307-32 (1992)
DOI:10.1177/10454411920030040101

LinkDB

DBGET integrated database retrieval system