KEGG   ORTHOLOGY: K15760
Entry
K15760                      KO                                     
Symbol
tmoA, tbuA1, touA
Name
toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Reaction
R02550  toluene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R03562  toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)
R05666  toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15760  tmoA, tbuA1, touA; toluene monooxygenase system protein A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15760  tmoA, tbuA1, touA; toluene monooxygenase system protein A
Genes
PSD: DSC_04405
MSR: AU15_20735
CZA: CYCME_2098
THIS: HZT40_03325
TBN: TBH_C0915
SINI: GT972_13790
VFF: VITFI_CDS2830
RPI: Rpic_4632
RPF: Rpic12D_3556
CNC: CNE_BB1p12360(tmoA)
RME: Rmet_1316(tmoA)
CTI: pRALTA_0461(tmoA)
BCON: NL30_24535
BUG: BC1001_PA6410(tmoA)
BPX: BUPH_08274(tmoA)
BHO: D560_1531(tmoA)
BHM: D558_1522(tmoA)
HPSE: HPF_01805(tmoA1)
MPT: Mpe_A0814(tbuA1)
DAR: Daro_3820
THAU: C4PIVTH_0966(tmoA)
BBT: BBta_1598
AOL: S58_10670
HMC: HYPMC_2245(tmoA)
ACIB: ACBT_0273(tmoA)
BTS: Btus_2069
SAY: TPY_0635
MSHG: MSG_02600(mphN)
MSTO: MSTO_08260
MSAK: MSAS_06380
MPHL: MPHLCCUG_04541(tmoA)
MHAS: MHAS_04833(tmoA)
MMAG: MMAD_01710
MMOR: MMOR_05370
MANY: MANY_23670
MTER: 4434518_03550(tmoA)
MHIB: MHIB_29700
CCYC: SCMU_04700
NFR: ERS450000_00312(tmoA)
SBAE: DSM104329_03635(tmoA)
TRO: trd_A0919
SSO: SSO1227(tmoA) SSO1228(tmoA)
SOL: Ssol_2196
SSOA: SULA_2229
SSOL: SULB_2230
SSOF: SULC_2227
POG: Pogu_1801
AG: AAA25999(tmoA)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15761
Entry
K15761                      KO                                     
Symbol
tmoB, tbuU, touB
Name
toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Reaction
R02550  toluene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R03562  toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)
R05666  toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15761  tmoB, tbuU, touB; toluene monooxygenase system protein B
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15761  tmoB, tbuU, touB; toluene monooxygenase system protein B
Genes
PSD: DSC_04400
MSR: AU15_20740
CZA: CYCME_2097
THIS: HZT40_03320
TBN: TBH_C0916
SINI: GT972_13795
VFF: VITFI_CDS2831
RPI: Rpic_4633
RPF: Rpic12D_3557
CNC: CNE_BB1p12350(tmoB)
RME: Rmet_1315(tmoB)
CTI: pRALTA_0462(tmoB)
BCON: NL30_24540
BUG: BC1001_PA6409(tmoB)
BHO: D560_1530
BHM: D558_1521
HPSE: HPF_01800(tmoB)
MPT: Mpe_A0815(tbuU) Mpe_A2540(tbuU)
DAR: Daro_3819
THAU: C4PIVTH_0965(tmoB)
BBT: BBta_1597
AOL: S58_10660
ACIB: ACBT_0272(tmoB)
BTS: Btus_2068
SAY: TPY_0636
MSHG: MSG_02601(tmoB)
MSTO: MSTO_08250
MSAK: MSAS_06390
MPHL: MPHLCCUG_04540(tmoB)
MHAS: MHAS_04834(tmoB)
MMOR: MMOR_05360
MANY: MANY_23680
MTER: 4434518_03549(tmoB)
MHIB: MHIB_29690
CCYC: SCMU_04690
NFR: ERS450000_00313(tmoB)
TRO: trd_A0920
AG: AAA26000(tmoB)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15762
Entry
K15762                      KO                                     
Symbol
tmoC, tbuB, touC
Name
toluene monooxygenase system ferredoxin subunit
Pathway
map00623  Toluene degradation
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Reaction
R02550  toluene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R03562  toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)
R05666  toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
R09513  methanesulfonate,NADH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K15762  tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15762  tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit
Genes
PSD: DSC_04395
MCA: MCA0225 MCA0586
METU: GNH96_03875 GNH96_15290
MMEO: OOT43_11210 OOT43_16330
MMAI: sS8_4250 sS8_5417 sS8_5458
MSZE: MSZNOR_4676
CZA: CYCME_2096
THIS: HZT40_03315
HAZ: A9404_01470
TBN: TBH_C0917
RPI: Rpic_4634
CNC: CNE_BB1p12340(tbcC)
RME: Rmet_1314(tmoC)
BCON: NL30_24545
BUG: BC1001_PA6408(tmoC)
BHO: D560_1527
BHM: D558_1518
PNA: Pnap_2045
HPSE: HPF_01795(tmoC)
MPT: Mpe_A0816(tbuB) Mpe_A0922(msmC) Mpe_A2541(tbuB)
DAR: Daro_3818
AZO: azo2601
AOA: dqs_2762
THAU: C4PIVTH_0964(tmoC)
BRA: BRADO3598
XAU: Xaut_4301
BID: Bind_2847
HMC: HYPMC_2243(tmoC)
MSC: BN69_2679
ACIB: ACBT_0271(tmoC)
BTS: Btus_2067
SAY: TPY_0637
MSHG: MSG_02602
MSTO: MSTO_08240
MSAK: MSAS_06400
MPHL: MPHLCCUG_04539(tmoC)
MHAS: MHAS_04835(tmoC)
MMAG: MMAD_01690(nirD)
MMOR: MMOR_05350
MANY: MANY_23690
MTER: 4434518_03548(tmoC)
MHIB: MHIB_29680
CCYC: SCMU_04680
NFR: ERS450000_00317(tmoC)
TRO: trd_A0921
SSO: SSO1230(tmoC)
SOL: Ssol_2198
SSOA: SULA_2231
SSOL: SULB_2232
SSOF: SULC_2229
SID: M164_0422
SII: LD85_0413
SIH: SiH_0429
SIR: SiRe_0387
PAS: Pars_0544
AG: AAA26001(tmoC)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15763
Entry
K15763                      KO                                     
Symbol
tmoD, tbuV, touD
Name
toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Reaction
R02550  toluene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R03562  toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)
R05666  toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15763  tmoD, tbuV, touD; toluene monooxygenase system protein D
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15763  tmoD, tbuV, touD; toluene monooxygenase system protein D
Genes
PSD: DSC_04390
MSR: AU15_20750
CZA: CYCME_2095
TBN: TBH_C0918
SINI: GT972_13805
VFF: VITFI_CDS2833
RPI: Rpic_4635
RPF: Rpic12D_3559
CNC: CNE_BB1p12330(tmoD)
REU: Reut_B5676
RME: Rmet_1313(tmoD)
CTI: pRALTA_0465(tmoD)
BCON: NL30_24550
BUG: BC1001_PA6407(tmoD)
BHO: D560_1529
BHM: D558_1520
HPSE: HPF_01790(tmoD)
MPT: Mpe_A0817(tbuV) Mpe_A2542(tbuV)
DAR: Daro_3817
THAU: C4PIVTH_0963(tmoD)
BBT: BBta_1595
AOL: S58_10640
HMC: HYPMC_2242(tmoD)
ACIB: ACBT_0270(tmoD)
BTS: Btus_2066
SAY: TPY_0638
MSHG: MSG_02603(tmoD)
MSTO: MSTO_08230
MSAK: MSAS_06410
MPHL: MPHLCCUG_04538(tmoD)
MHAS: MHAS_04836(tmoD)
MMAG: MMAD_01680
MMOR: MMOR_05340
MANY: MANY_23700
MTER: 4434518_03547(tmoD)
MHIB: MHIB_29670
CCYC: SCMU_04670
NFR: ERS450000_00314(tmoD)
TRO: trd_A0922
SSO: SSO1231(tmoD)
SOL: Ssol_2199
SSOA: SULA_2232
SSOL: SULB_2233
SSOF: SULC_2230
SID: M164_0423
SII: LD85_0414
SIH: SiH_0430
SIR: SiRe_0388
PAS: Pars_0543
AG: AAA26002(tmoD)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15764
Entry
K15764                      KO                                     
Symbol
tmoE, tbuA2, touE
Name
toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Reaction
R02550  toluene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R03562  toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)
R05666  toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15764  tmoE, tbuA2, touE; toluene monooxygenase system protein E
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15764  tmoE, tbuA2, touE; toluene monooxygenase system protein E
Genes
PSD: DSC_04385
MSR: AU15_20755
CZA: CYCME_2094
THIS: HZT40_03305
TBN: TBH_C0919
SINI: GT972_13810
VFF: VITFI_CDS2834
RPI: Rpic_4636
RPF: Rpic12D_3560
CNC: CNE_BB1p12320(tmoE)
RME: Rmet_1312(tmoE)
CTI: pRALTA_0466(tmoE)
BCON: NL30_24555
BUG: BC1001_PA6406(tmoE)
BHO: D560_1528(touE)
BHM: D558_1519(touE)
HPSE: HPF_01785(tmoE)
MPT: Mpe_A0818(tbuA2) Mpe_A2543(tbuA2)
DAR: Daro_3816
THAU: C4PIVTH_0962(tmoE)
BBT: BBta_1594
AOL: S58_10630
HMC: HYPMC_2241(tmoE)
ACIB: ACBT_0269(tmoE)
BTS: Btus_2065
SAY: TPY_0639
MSHG: MSG_02604
MSTO: MSTO_08220
MSAK: MSAS_06420
MPHL: MPHLCCUG_04537(tmoE)
MHAS: MHAS_04837(tmoE)
MMAG: MMAD_01670
MMOR: MMOR_05330
MANY: MANY_23710
MTER: 4434518_03546(tmoE)
MHIB: MHIB_29660
CCYC: SCMU_04660
NFR: ERS450000_00315(tmoE)
TRO: trd_A0923
SSO: SSO1233(tmoE)
SOL: Ssol_2200
SSOA: SULA_2233
SSOL: SULB_2234
SSOF: SULC_2231
SID: M164_0424
SII: LD85_0415
SIH: SiH_0431
SIR: SiRe_0389
SIC: SiL_0415
PAS: Pars_0542
AG: AAA26003(tmoE)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15765
Entry
K15765                      KO                                     
Symbol
tmoF, tbuC, touF
Name
toluene monooxygenase electron transfer component [EC:1.18.1.3]
Pathway
map00623  Toluene degradation
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Reaction
R02550  toluene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)
R03562  toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)
R05666  toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
R09513  methanesulfonate,NADH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.3  ferredoxin---NAD+ reductase
     K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
Genes
PSD: DSC_04380
PPSE: BN5_3604
MBS: MRBBS_1308(tmoF)
MSR: AU15_20760
CYQ: Q91_2220
CZA: CYCME_2538
CYY: CPC19_01700
THIS: HZT40_03300
TBN: TBH_C0920
APAC: S7S_13335
RPI: Rpic_4637
CNC: CNE_BB1p12310(tmoF)
RME: Rmet_1311
BCT: GEM_5810
BCON: NL30_24560
BUG: BC1001_PA6405(tmoF)
PPNO: DA70_22375
BPE: BP0066
BPC: BPTD_0064
BPER: BN118_3398
BPET: B1917_0069
BPEU: Q425_690
BPA: BPP0517
BBR: BB0522
BTRM: SAMEA390648701722(dmpP_1)
PUT: PT7_2459
LIM: L103DPR2_00189(carAd)
HPSE: HPF_01780(tmoF)
MPT: Mpe_A0819(tbuC) Mpe_A0921(msmD)
DAR: Daro_3815
BBT: BBta_1593
AOL: S58_10620
OCA: OCAR_6789
FIL: BN1229_v1_3546(msmD)
FIY: BN1229_v1_2377(msmD)
HDI: HDIA_4247(carAd)
SGI: SGRAN_2803(thnA4)
BTS: Btus_2064
NFR: ERS450000_00316(tmoF)
TRO: trd_A0924
AG: AAA26004(tmoF)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
  Sequence
LinkDB

KEGG   REACTION: R03562
Entry
R03562                      Reaction                               
Name
toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)
Definition
Toluene + Oxygen + NADPH + H+ <=> 3-Cresol + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC00490  C01455_C01467
Enzyme
1.14.13.-
Pathway
rn00623  Toluene degradation
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R03562  Toluene + Oxygen + NADPH + H+ <=> 3-Cresol + NADP+ + H2O
Orthology
K15760  toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-]
K15761  toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-]
K15762  toluene monooxygenase system ferredoxin subunit
K15763  toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-]
K15764  toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-]
K15765  toluene monooxygenase electron transfer component [EC:1.18.1.3]
LinkDB

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