ORTHOLOGY: K16195
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Entry
K16195 KO
Symbol
EIF2AK2
Name
eukaryotic translation initiation factor 2-alpha kinase 2 [EC:
2.7.11.1
]
Pathway
map04217
Necroptosis
map05010
Alzheimer disease
map05160
Hepatitis C
map05162
Measles
map05164
Influenza A
map05165
Human papillomavirus infection
map05167
Kaposi sarcoma-associated herpesvirus infection
map05168
Herpes simplex virus 1 infection
map05169
Epstein-Barr virus infection
map05171
Coronavirus disease - COVID-19
map05203
Viral carcinogenesis
Disease
H00831
Primary dystonia
H02457
Developmental delay, leukoencephalopathy, and neurologic decompensation
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
09172 Infectious disease: viral
05160 Hepatitis C
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
05171 Coronavirus disease - COVID-19
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
05164 Influenza A
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
05162 Measles
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
05168 Herpes simplex virus 1 infection
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
05167 Kaposi sarcoma-associated herpesvirus infection
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
05169 Epstein-Barr virus infection
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
05165 Human papillomavirus infection
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
09164 Neurodegenerative disease
05010 Alzheimer disease
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
01009 Protein phosphatases and associated proteins
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Enzymes [BR:
ko01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein kinases [BR:
ko01001
]
Serine/threonine kinases: Other
PEK family [OT]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein phosphatases and associated proteins [BR:
ko01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Messenger RNA biogenesis [BR:
ko03019
]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
P-body specific factors
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
BRITE hierarchy
Other DBs
GO:
0004694
Genes
HSA:
5610
(EIF2AK2)
PTR:
459155
(EIF2AK2)
PPS:
100982543
(EIF2AK2)
GGO:
101133221
(EIF2AK2)
PON:
100173054
(EIF2AK2)
PPYG:
129025668
(EIF2AK2)
NLE:
100579484
(EIF2AK2)
HMH:
116484273
SSYN:
129461573
(EIF2AK2)
MCC:
708912
(EIF2AK2)
MCF:
102124745
(EIF2AK2)
MTHB:
126933547
MNI:
105464848
(EIF2AK2)
CSAB:
103220482
(EIF2AK2)
CATY:
105597175
(EIF2AK2)
PANU:
101011480
(EIF2AK2)
TGE:
112605212
(EIF2AK2)
MLEU:
105530227
(EIF2AK2)
RRO:
104669977
(EIF2AK2)
RBB:
108520352
(EIF2AK2)
TFN:
117062468
(EIF2AK2)
PTEH:
111545386
(EIF2AK2)
CANG:
105507534
(EIF2AK2)
CJC:
100399251
(EIF2AK2)
SBQ:
101053943
(EIF2AK2)
CIMI:
108308872
(EIF2AK2)
ANAN:
105733098
(EIF2AK2)
CSYR:
103255383
103271654
(EIF2AK2)
103271660
103271661
MMUR:
105884498
(EIF2AK2)
LCAT:
123636797
(EIF2AK2)
PCOQ:
105818017
(EIF2AK2)
OGA:
100959776
(EIF2AK2)
MMU:
19106
(Eif2ak2)
MCAL:
110312307
(Eif2ak2)
MPAH:
110335815
(Eif2ak2)
RNO:
54287
(Eif2ak2)
MCOC:
116080069
(Eif2ak2)
ANU:
117701826
117717229
(Eif2ak2)
ASYL:
127687616
(Eif2ak2)
CGE:
100757909
(Eif2ak2)
MAUA:
101836026
(Eif2ak2)
PROB:
127217035
(Eif2ak2)
PLEU:
114695816
(Eif2ak2)
MORG:
121432938
121433086
MFOT:
126514559
AAMP:
119808127
(Eif2ak2)
NGI:
103725269
(Eif2ak2)
HGL:
101724844
(Eif2ak2)
CPOC:
100717384
(Eif2ak2)
CCAN:
109688641
(Eif2ak2)
DORD:
105983707
(Eif2ak2)
DSP:
122104582
(Eif2ak2)
PLOP:
125356561
(Eif2ak2)
NCAR:
124963590
MMMA:
107137355
(Eif2ak2)
ITI:
101973569
(Eif2ak2)
OCU:
100009013
(EIF2AK2)
OPI:
105941681
(EIF2AK2)
TUP:
102469861
(EIF2AK2)
GVR:
103605127
(EIF2AK2)
CFA:
611397
(EIF2AK2)
CLUD:
112664523
(EIF2AK2)
VVP:
112935312
(EIF2AK2)
VLG:
121492020
(EIF2AK2)
NPO:
129510944
(EIF2AK2)
AML:
100469151
(EIF2AK2)
UMR:
103671577
(EIF2AK2)
UAH:
113241346
(EIF2AK2)
UAR:
123799832
(EIF2AK2)
ELK:
111158436
LLV:
125092389
125108791
MPUF:
101687078
(EIF2AK2)
MNP:
132021273
(EIF2AK2)
MLK:
131840546
(EIF2AK2)
NVS:
122915170
(EIF2AK2)
ORO:
101373670
(EIF2AK2)
EJU:
114219582
(EIF2AK2)
ZCA:
113937743
(EIF2AK2)
MLX:
118007769
(EIF2AK2)
NSU:
110587259
(EIF2AK2)
LWW:
102731171
(EIF2AK2)
FCA:
101082744
(EIF2AK2)
PYU:
121044344
(EIF2AK2)
PCOO:
112864251
(EIF2AK2)
PBG:
122497263
(EIF2AK2)
PVIV:
125163061
(EIF2AK2)
LRUF:
124503410
LGF:
123581236
(EIF2AK2)
AJU:
106978970
PTG:
102951575
(EIF2AK2)
PPAD:
109265829
(EIF2AK2)
PUC:
125937286
PLEZ:
122216421
(EIF2AK2)
HHV:
120248750
(EIF2AK2)
BTA:
347700
(EIF2AK2)
BOM:
102281444
(EIF2AK2)
BIU:
109565977
(EIF2AK2)
BBUB:
102391649
(EIF2AK2)
BBIS:
104987589
(EIF2AK2)
CHX:
102171521
(EIF2AK2)
OAS:
101121673
(EIF2AK2)
BTAX:
128056687
(EIF2AK2)
CSUM:
138080063
(EIF2AK2)
ODA:
120851671
(EIF2AK2)
CCAD:
122441567
(EIF2AK2)
MREE:
136164462
(EIF2AK2)
OVR:
110135141
(EIF2AK2)
MBEZ:
129539119
(EIF2AK2)
SSC:
397588
(EIF2AK2)
CFR:
102517994
(EIF2AK2)
CBAI:
105078966
(EIF2AK2)
CDK:
105105818
(EIF2AK2)
VPC:
102532064
(EIF2AK2)
BACU:
103006520
(EIF2AK2)
BMUS:
118905730
(EIF2AK2)
LVE:
103075964
(EIF2AK2)
OOR:
101270256
(EIF2AK2)
LALB:
132531755
(EIF2AK2)
DLE:
111174878
(EIF2AK2)
PCAD:
102977777
(EIF2AK2)
PSIU:
116764650
(EIF2AK2)
NASI:
112405182
(EIF2AK2)
ECB:
100147679
(EIF2AK2)
EPZ:
103548399
(EIF2AK2)
EAI:
106825858
(EIF2AK2)
MYB:
102242739
(EIF2AK2)
MMYO:
118669450
(EIF2AK2)
MLF:
102418614
(EIF2AK2)
MDT:
132213473
(EIF2AK2)
MYUM:
139019822
(EIF2AK2)
PKL:
118717741
(EIF2AK2)
EFUS:
103305673
(EIF2AK2)
MNA:
107541819
(EIF2AK2)
DRO:
112298045
(EIF2AK2)
SHON:
119001265
(EIF2AK2)
AJM:
119063844
(EIF2AK2)
PDIC:
114500200
(EIF2AK2)
PHAS:
123811472
(EIF2AK2)
MMF:
118630454
(EIF2AK2)
PPAM:
129066240
(EIF2AK2)
HAI:
109385455
(EIF2AK2)
RFQ:
117032767
(EIF2AK2)
PALE:
102890643
(EIF2AK2)
PGIG:
120621778
(EIF2AK2)
PVP:
105292967
(EIF2AK2)
RAY:
107519635
(EIF2AK2)
MJV:
108392233
(EIF2AK2)
TOD:
119259396
(EIF2AK2)
SARA:
101542873
(EIF2AK2)
SFUM:
130019026
130034140
130035508
130035805
SETR:
126024318
(EIF2AK2)
LAV:
100665908
(EIF2AK2)
TMU:
101359071
ETF:
101640829
(EIF2AK2)
DNM:
101427484
(EIF2AK2)
MDO:
103106286
(EIF2AK2)
GAS:
123237046
(EIF2AK2)
SHR:
100931721
(EIF2AK2)
AFZ:
127548654
PCW:
110212711
(EIF2AK2)
TVP:
118843195
(EIF2AK2)
PBRV:
138149196
(EIF2AK2)
OAA:
100077821
(EIF2AK2)
TACU:
119950319
(EIF2AK2)
GGA:
395147
(EIF2AK2)
PCOC:
116229008
(EIF2AK2)
MGP:
100543196
104909671
CJO:
107311230
(EIF2AK2)
TPAI:
128080226
(EIF2AK2)
LMUT:
125689920
(EIF2AK2)
NMEL:
110397137
(EIF2AK2)
APLA:
110353866
(EIF2AK2)
ACYG:
106029410
(EIF2AK2)
CATA:
118256378
(EIF2AK2)
AFUL:
116488044
(EIF2AK2)
TGU:
100223594
(EIF2AK2)
LSR:
110469407
(EIF2AK2)
SCAN:
103817583
(EIF2AK2)
PMOA:
120506926
(EIF2AK2)
OTC:
121335840
(EIF2AK2)
PRUF:
121358740
(EIF2AK2)
ATRC:
139591242
(EIF2AK2)
GFR:
102039637
(EIF2AK2)
FAB:
101807308
(EIF2AK2)
OMA:
130250636
(EIF2AK2)
PHI:
102111278
(EIF2AK2)
PMAJ:
107201738
(EIF2AK2)
CCAE:
111926977
(EIF2AK2)
CCW:
104684377
(EIF2AK2)
CBRC:
103624142
(EIF2AK2)
ACOE:
138108004
(EIF2AK2)
ETL:
114065176
(EIF2AK2)
ZAB:
102065214
(EIF2AK2)
ZLE:
135445758
(EIF2AK2)
ACHL:
103805533
(EIF2AK2)
SVG:
106853384
(EIF2AK2)
MMEA:
130588839
(EIF2AK2)
HRT:
120749969
(EIF2AK2)
SATI:
136359348
(EIF2AK2)
CCIC:
134042624
(EIF2AK2)
FPG:
101910588
(EIF2AK2)
FCH:
102051537
(EIF2AK2)
CCRI:
104169258
(EIF2AK2)
NNT:
104408561
(EIF2AK2)
SHAB:
115613970
(EIF2AK2)
ACUN:
113478166
(EIF2AK2)
TALA:
104367635
(EIF2AK2)
ACHC:
115350100
(EIF2AK2)
HALD:
104322018
(EIF2AK2)
HLE:
104840340
(EIF2AK2)
AGEN:
126051772
HHAR:
128149871
(EIF2AK2)
GCL:
127015326
CSTI:
104551621
(EIF2AK2)
LDI:
104350057
(EIF2AK2)
MNB:
103769145
(EIF2AK2)
DPUB:
104310308
(EIF2AK2)
PPUS:
135183574
(EIF2AK2)
AVIT:
104277283
(EIF2AK2)
BRHI:
104502187
(EIF2AK2)
EGZ:
104124114
(EIF2AK2)
NNI:
104018710
(EIF2AK2)
PCRI:
104024784
(EIF2AK2)
PCAO:
104044269
(EIF2AK2)
PADL:
103922839
(EIF2AK2)
AFOR:
103902697
(EIF2AK2)
FGA:
104070250
(EIF2AK2)
GSTE:
104251029
(EIF2AK2)
CLV:
102085389
(EIF2AK2)
MUI:
104537934
PGUU:
104471549
(EIF2AK2)
PLET:
104619368
(EIF2AK2)
EHS:
104506985
(EIF2AK2)
CMAC:
104473908
(EIF2AK2)
CUCA:
104057918
(EIF2AK2)
TEO:
104372782
BREG:
104630528
(EIF2AK2)
OHA:
104329308
(EIF2AK2)
ACAR:
104520360
(EIF2AK2)
CPEA:
104394947
(EIF2AK2)
CVF:
104282349
(EIF2AK2)
RTD:
128906825
(EIF2AK2)
CRID:
134512927
(EIF2AK2)
AAM:
106485536
(EIF2AK2)
AROW:
112973366
(EIF2AK2)
NPD:
112957570
(EIF2AK2)
TGT:
104576065
(EIF2AK2)
DNE:
112984624
(EIF2AK2)
SCAM:
104151675
(EIF2AK2)
ASN:
102379754
(EIF2AK2)
AMJ:
102558195
(EIF2AK2)
CPOO:
109319895
(EIF2AK2)
GGN:
109304771
(EIF2AK2)
PSS:
102449543
(EIF2AK2)
CMY:
102934103
(EIF2AK2)
CCAY:
125633838
(EIF2AK2)
DCC:
119853864
(EIF2AK2)
CPIC:
101940470
(EIF2AK2)
TST:
117874623
(EIF2AK2)
CABI:
116820141
(EIF2AK2)
MRV:
120401970
(EIF2AK2)
ACS:
100561872
(eif2ak2)
ASAO:
132761260
(EIF2AK2)
PVT:
110083920
(EIF2AK2)
SUND:
121919623
(EIF2AK2)
PBI:
103059200
(EIF2AK2)
PMUR:
107287469
(EIF2AK2)
CTIG:
120312073
(EIF2AK2)
PGUT:
117671374
(EIF2AK2)
APRI:
131188848
(EIF2AK2)
PTEX:
113433060
(EIF2AK2)
NSS:
113413243
(EIF2AK2)
VKO:
123036001
(EIF2AK2)
PMUA:
114594483
(EIF2AK2)
PRAF:
128410927
(EIF2AK2)
ZVI:
118081810
(EIF2AK2)
HCG:
128347927
(EIF2AK2)
STOW:
125438909
(EIF2AK2)
EMC:
129325820
(EIF2AK2)
XLA:
100037060
(eif2ak2.L)
108716648
(pkr2.L)
XTR:
100141483
(pkr3)
779992
(eif2ak2)
NPR:
108792731
RTEM:
120928088
120937509
120937510
BBUF:
120998752
(EIF2AK2)
BGAR:
122934381
122934511
PWL:
138295907
(EIF2AK2)
MUO:
115465714
(EIF2AK2)
GSH:
117356986
(EIF2AK2)
DRE:
100001092
(eif2ak2)
SANH:
107689757
SGH:
107562393
CCAR:
109064588
CAUA:
113056626
113112326
CGIB:
127970062
128025851
PTET:
122356246
(eif2ak2)
LROH:
127174979
(eif2ak2)
OMC:
131551762
131551764
(eif2ak2)
RKG:
130068978
(eif2ak2)
MAMB:
125276480
125276481
CIDE:
127524372
MASI:
127411938
127414369
TROS:
130550154
(eif2ak2)
TDW:
130431996
(eif2ak2)
MANU:
129415477
(eif2ak2)
PDAB:
135786717
(eif2ak2)
IPU:
108263213
IFU:
128605187
(eif2ak2)
PHYP:
113542164
(eif2ak2)
SMEO:
124375860
(eif2ak2)
TFD:
113655344
(eif2ak2)
TVC:
132846943
132846946
CGAR:
128528677
NGRA:
132889104
(eif2ak2)
TRN:
134314939
(eif2ak2)
AMEX:
107197130
(eif2ak2)
CMAO:
118810736
(eif2ak2)
EEE:
113579882
(eif2ak2)
CHAR:
105902253
(eif2ak2)
SPIL:
134063467
TRU:
100144316
(eif2ak2)
TFS:
130534288
(eif2ak2)
LCO:
104918202
NCC:
104951309
TBEN:
117477550
117481967
117499827
117499828
117499829
117499830
CGOB:
115020152
(eif2ak2)
PGEO:
117449934
117453025
117459400
GACU:
117535939
117552924
117553320
117553328
117553339
117553348
117553426
EMAC:
134858649
134858650
ELY:
117248421
117248422
PLEP:
121954255
121954256
121954257
121954451
121954878
SLUC:
116051240
(eif2ak2)
ECRA:
117960114
117960115
117960116
(eif2ak2)
117960117
ESP:
116705407
116705409
PFLV:
114571671
114571672
114572139
GAT:
100190866
(pkr1)
120820497
120820498
PPUG:
119214493
AFB:
129092304
(eif2ak2)
129092306
129092307
CLUM:
117744489
117744490
(eif2ak2)
117744491
PSWI:
130207039
130207400
130207468
CANA:
137779963
137779964
137779965
(eif2ak2)
CVE:
137883530
(eif2ak2)
137883545
137883554
MSAM:
119916938
119916939
119916940
SCHU:
122884720
122884721
122884722
CUD:
121510796
121510797
121510798
121511321
121511402
(eif2ak2)
SPUL:
138588147
138588764
LMIX:
132975092
(eif2ak2)
ALAT:
119033620
119033621
ASTR:
137603583
MZE:
101480023
101480319
101480895
ONL:
100691607
100700343
OAU:
116318522
116318523
116318560
OLA:
100144382
110016550
CSAI:
133440811
133463806
133464092
133464169
133464170
133464172
133464174
133464175
XMA:
102232776
XCO:
114138280
XHE:
116713488
116713793
PRET:
103477270
PLAI:
106945326
(eif2ak2)
106945327
106949773
PMEI:
106933429
GAF:
122842153
122842154
(eif2ak2)
122842156
PPRL:
129359967
129360146
CVG:
107096530
107096531
CTUL:
119782887
119782888
119782913
GMU:
124858844
NFU:
107375439
KMR:
108248129
(eif2ak2)
ALIM:
106515883
NWH:
119424292
119424390
EJA:
138195533
BFRE:
138616070
MCEP:
125018942
125019065
CSEM:
103387634
(eif2ak2)
POV:
109636756
SSEN:
122781705
(eif2ak2)
122781707
122781708
SSOE:
131473988
131473989
131474532
HHIP:
117775636
117775712
(eif2ak2)
117775713
117775716
HSP:
118118664
(eif2ak2)
PPLT:
128453858
128453859
SMAU:
118283298
118283304
LCF:
108885802
SDU:
111220787
111220788
SLAL:
111658980
XGL:
120796597
120796825
(eif2ak2)
HCQ:
109516199
(eif2ak2)
SSCV:
125978370
SBIA:
133510212
(eif2ak2)
PEE:
133409375
PTAO:
133485684
(eif2ak2)
BPEC:
110156836
ENY:
140350907
140351481
140351484
MALB:
109959079
BSPL:
114842116
114842162
114870757
114870758
SJO:
128372548
128372550
128373087
SSCO:
133992164
133992165
133992166
133992167
133992280
GMH:
115560248
115560249
115560250
115560251
STRU:
115155450
OTW:
112253229
(eif2ak2)
OMY:
100271898
(eif2ak2)
OGO:
124048040
(eif2ak2)
ONE:
115119677
OKI:
109882105
OKE:
118374422
(eif2ak2)
OMM:
135505282
(eif2ak2)
OCLA:
139367863
SALP:
112073823
SNH:
120046046
120046048
CCLU:
121556612
(eif2ak2)
ELS:
105008364
OEP:
134022664
(eif2ak2)
134022666
SFM:
108927142
PKI:
111835715
AANG:
118218399
(eif2ak2)
AROT:
135245349
(eif2ak2)
CCOG:
133118661
(eif2ak2)
LOC:
102692100
(eif2ak2)
PSPA:
121316085
121317678
(eif2ak2)
ARUT:
117399704
117403092
117410404
(eif2ak2)
LCM:
102365233
(EIF2AK2)
CMK:
103187174
RTP:
109918246
(eif2ak2)
CPLA:
122542638
HOC:
132807144
(eif2ak2)
LERI:
129696980
(eif2ak2)
GFS:
119641808
BCOO:
119066182
LLL:
129787152
OTU:
111425650
AFRA:
136030925
CANU:
128182699
128184553
128185293
128185294
128185799
128186122
128186352
CVN:
111104115
111105245
OED:
125674910
XEN:
124454454
124454673
AANS:
126800787
MNT:
112094066
PALZ:
118035442
118045154
ATRI:
130805887
TDC:
119316362
ZTR:
MYCGRDRAFT_30507
DPP:
DICPUDRAFT_9913
PTI:
PHATRDRAFT_bd152
PHATRDRAFT_bd165
TPS:
THAPSDRAFT_16613
GTT:
GUITHDRAFT_84326
» show all
Taxonomy
UniProt
Reference
PMID:
1695551
Authors
Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, Hovanessian AG
Title
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.
Journal
Cell 62:379-90 (1990)
DOI:
10.1016/0092-8674(90)90374-N
Sequence
[hsa:
5610
]
LinkDB
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DBGET
integrated database retrieval system