KEGG ORTHOLOGY: K16195

ORTHOLOGY: K16195

Entry

K16195                      KO

Symbol

EIF2AK2

Name

eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]

Pathway

map04217

Necroptosis

map05010

Alzheimer disease

map05160

Hepatitis C

map05162

Measles

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05171

Coronavirus disease - COVID-19

map05203

Viral carcinogenesis

Disease

H00831

Primary dystonia

H02457

Developmental delay, leukoencephalopathy, and neurologic decompensation

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09172 Infectious disease: viral
   05160 Hepatitis C
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05171 Coronavirus disease - COVID-19
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05164 Influenza A
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05162 Measles
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05168 Herpes simplex virus 1 infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05169 Epstein-Barr virus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05165 Human papillomavirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   01009 Protein phosphatases and associated proteins
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  PEK family [OT]
   K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2

Other DBs

GO:

0004694

Genes

HSA:	5610(EIF2AK2)

PTR:	459155(EIF2AK2)

PPS:	100982543(EIF2AK2)

GGO:	101133221(EIF2AK2)

PON:	100173054(EIF2AK2)

PPYG:

129025668(EIF2AK2)

NLE:	100579484(EIF2AK2)

HMH:

116484273

SSYN:

129461573(EIF2AK2)

MCC:	708912(EIF2AK2)

MCF:	102124745(EIF2AK2)

MTHB:

126933547

MNI:	105464848(EIF2AK2)

CSAB:

103220482(EIF2AK2)

CATY:

105597175(EIF2AK2)

PANU:

101011480(EIF2AK2)

TGE:	112605212(EIF2AK2)

MLEU:

105530227(EIF2AK2)

RRO:	104669977(EIF2AK2)

RBB:	108520352(EIF2AK2)

TFN:	117062468(EIF2AK2)

PTEH:

111545386(EIF2AK2)

CANG:

105507534(EIF2AK2)

CJC:	100399251(EIF2AK2)

SBQ:	101053943(EIF2AK2)

CIMI:

108308872(EIF2AK2)

ANAN:

105733098(EIF2AK2)

CSYR:

103255383 103271654(EIF2AK2) 103271660 103271661

MMUR:

105884498(EIF2AK2)

LCAT:

123636797(EIF2AK2)

PCOQ:

105818017(EIF2AK2)

OGA:	100959776(EIF2AK2)

MMU:	19106(Eif2ak2)

MCAL:

110312307(Eif2ak2)

MPAH:

110335815(Eif2ak2)

RNO:	54287(Eif2ak2)

MCOC:

116080069(Eif2ak2)

ANU:	117701826 117717229(Eif2ak2)

ASYL:

127687616(Eif2ak2)

CGE:	100757909(Eif2ak2)

MAUA:

101836026(Eif2ak2)

PROB:

127217035(Eif2ak2)

PLEU:

114695816(Eif2ak2)

MORG:

121432938 121433086

MFOT:

126514559

AAMP:

119808127(Eif2ak2)

NGI:	103725269(Eif2ak2)

HGL:	101724844(Eif2ak2)

CPOC:

100717384(Eif2ak2)

CCAN:

109688641(Eif2ak2)

DORD:

105983707(Eif2ak2)

DSP:	122104582(Eif2ak2)

PLOP:

125356561(Eif2ak2)

NCAR:

124963590

MMMA:

107137355(Eif2ak2)

ITI:	101973569(Eif2ak2)

OCU:	100009013(EIF2AK2)

OPI:	105941681(EIF2AK2)

TUP:	102469861(EIF2AK2)

GVR:	103605127(EIF2AK2)

CFA:	611397(EIF2AK2)

CLUD:

112664523(EIF2AK2)

VVP:	112935312(EIF2AK2)

VLG:	121492020(EIF2AK2)

NPO:	129510944(EIF2AK2)

AML:	100469151(EIF2AK2)

UMR:	103671577(EIF2AK2)

UAH:	113241346(EIF2AK2)

UAR:	123799832(EIF2AK2)

ELK:

111158436

LLV:	125092389 125108791

MPUF:

101687078(EIF2AK2)

MNP:	132021273(EIF2AK2)

MLK:	131840546(EIF2AK2)

NVS:	122915170(EIF2AK2)

ORO:	101373670(EIF2AK2)

EJU:	114219582(EIF2AK2)

ZCA:	113937743(EIF2AK2)

MLX:	118007769(EIF2AK2)

NSU:	110587259(EIF2AK2)

LWW:	102731171(EIF2AK2)

FCA:	101082744(EIF2AK2)

PYU:	121044344(EIF2AK2)

PCOO:

112864251(EIF2AK2)

PBG:	122497263(EIF2AK2)

PVIV:

125163061(EIF2AK2)

LRUF:

124503410

LGF:	123581236(EIF2AK2)

AJU:

106978970

PTG:	102951575(EIF2AK2)

PPAD:

109265829(EIF2AK2)

PUC:

125937286

PLEZ:

122216421(EIF2AK2)

HHV:	120248750(EIF2AK2)

BTA:	347700(EIF2AK2)

BOM:	102281444(EIF2AK2)

BIU:	109565977(EIF2AK2)

BBUB:

102391649(EIF2AK2)

BBIS:

104987589(EIF2AK2)

CHX:	102171521(EIF2AK2)

OAS:	101121673(EIF2AK2)

BTAX:

128056687(EIF2AK2)

CSUM:

138080063(EIF2AK2)

ODA:	120851671(EIF2AK2)

CCAD:

122441567(EIF2AK2)

MREE:

136164462(EIF2AK2)

OVR:	110135141(EIF2AK2)

MBEZ:

129539119(EIF2AK2)

SSC:	397588(EIF2AK2)

CFR:	102517994(EIF2AK2)

CBAI:

105078966(EIF2AK2)

CDK:	105105818(EIF2AK2)

VPC:	102532064(EIF2AK2)

BACU:

103006520(EIF2AK2)

BMUS:

118905730(EIF2AK2)

LVE:	103075964(EIF2AK2)

OOR:	101270256(EIF2AK2)

LALB:

132531755(EIF2AK2)

DLE:	111174878(EIF2AK2)

PCAD:

102977777(EIF2AK2)

PSIU:

116764650(EIF2AK2)

NASI:

112405182(EIF2AK2)

ECB:	100147679(EIF2AK2)

EPZ:	103548399(EIF2AK2)

EAI:	106825858(EIF2AK2)

MYB:	102242739(EIF2AK2)

MMYO:

118669450(EIF2AK2)

MLF:	102418614(EIF2AK2)

MDT:	132213473(EIF2AK2)

MYUM:

139019822(EIF2AK2)

PKL:	118717741(EIF2AK2)

EFUS:

103305673(EIF2AK2)

MNA:	107541819(EIF2AK2)

DRO:	112298045(EIF2AK2)

SHON:

119001265(EIF2AK2)

AJM:	119063844(EIF2AK2)

PDIC:

114500200(EIF2AK2)

PHAS:

123811472(EIF2AK2)

MMF:	118630454(EIF2AK2)

PPAM:

129066240(EIF2AK2)

HAI:	109385455(EIF2AK2)

RFQ:	117032767(EIF2AK2)

PALE:

102890643(EIF2AK2)

PGIG:

120621778(EIF2AK2)

PVP:	105292967(EIF2AK2)

RAY:	107519635(EIF2AK2)

MJV:	108392233(EIF2AK2)

TOD:	119259396(EIF2AK2)

SARA:

101542873(EIF2AK2)

SFUM:

130019026 130034140 130035508 130035805

SETR:

126024318(EIF2AK2)

LAV:	100665908(EIF2AK2)

TMU:

101359071

ETF:	101640829(EIF2AK2)

DNM:	101427484(EIF2AK2)

MDO:	103106286(EIF2AK2)

GAS:	123237046(EIF2AK2)

SHR:	100931721(EIF2AK2)

AFZ:

127548654

PCW:	110212711(EIF2AK2)

TVP:	118843195(EIF2AK2)

PBRV:

138149196(EIF2AK2)

OAA:	100077821(EIF2AK2)

TACU:

119950319(EIF2AK2)

GGA:	395147(EIF2AK2)

PCOC:

116229008(EIF2AK2)

MGP:	100543196 104909671

CJO:	107311230(EIF2AK2)

TPAI:

128080226(EIF2AK2)

LMUT:

125689920(EIF2AK2)

NMEL:

110397137(EIF2AK2)

APLA:

110353866(EIF2AK2)

ACYG:

106029410(EIF2AK2)

CATA:

118256378(EIF2AK2)

AFUL:

116488044(EIF2AK2)

TGU:	100223594(EIF2AK2)

LSR:	110469407(EIF2AK2)

SCAN:

103817583(EIF2AK2)

PMOA:

120506926(EIF2AK2)

OTC:	121335840(EIF2AK2)

PRUF:

121358740(EIF2AK2)

ATRC:

139591242(EIF2AK2)

GFR:	102039637(EIF2AK2)

FAB:	101807308(EIF2AK2)

OMA:	130250636(EIF2AK2)

PHI:	102111278(EIF2AK2)

PMAJ:

107201738(EIF2AK2)

CCAE:

111926977(EIF2AK2)

CCW:	104684377(EIF2AK2)

CBRC:

103624142(EIF2AK2)

ACOE:

138108004(EIF2AK2)

ETL:	114065176(EIF2AK2)

ZAB:	102065214(EIF2AK2)

ZLE:	135445758(EIF2AK2)

ACHL:

103805533(EIF2AK2)

SVG:	106853384(EIF2AK2)

MMEA:

130588839(EIF2AK2)

HRT:	120749969(EIF2AK2)

SATI:

136359348(EIF2AK2)

CCIC:

134042624(EIF2AK2)

FPG:	101910588(EIF2AK2)

FCH:	102051537(EIF2AK2)

CCRI:

104169258(EIF2AK2)

NNT:	104408561(EIF2AK2)

SHAB:

115613970(EIF2AK2)

ACUN:

113478166(EIF2AK2)

TALA:

104367635(EIF2AK2)

ACHC:

115350100(EIF2AK2)

HALD:

104322018(EIF2AK2)

HLE:	104840340(EIF2AK2)

AGEN:

126051772

HHAR:

128149871(EIF2AK2)

GCL:

127015326

CSTI:

104551621(EIF2AK2)

LDI:	104350057(EIF2AK2)

MNB:	103769145(EIF2AK2)

DPUB:

104310308(EIF2AK2)

PPUS:

135183574(EIF2AK2)

AVIT:

104277283(EIF2AK2)

BRHI:

104502187(EIF2AK2)

EGZ:	104124114(EIF2AK2)

NNI:	104018710(EIF2AK2)

PCRI:

104024784(EIF2AK2)

PCAO:

104044269(EIF2AK2)

PADL:

103922839(EIF2AK2)

AFOR:

103902697(EIF2AK2)

FGA:	104070250(EIF2AK2)

GSTE:

104251029(EIF2AK2)

CLV:	102085389(EIF2AK2)

MUI:

104537934

PGUU:

104471549(EIF2AK2)

PLET:

104619368(EIF2AK2)

EHS:	104506985(EIF2AK2)

CMAC:

104473908(EIF2AK2)

CUCA:

104057918(EIF2AK2)

TEO:

104372782

BREG:

104630528(EIF2AK2)

OHA:	104329308(EIF2AK2)

ACAR:

104520360(EIF2AK2)

CPEA:

104394947(EIF2AK2)

CVF:	104282349(EIF2AK2)

RTD:	128906825(EIF2AK2)

CRID:

134512927(EIF2AK2)

AAM:	106485536(EIF2AK2)

AROW:

112973366(EIF2AK2)

NPD:	112957570(EIF2AK2)

TGT:	104576065(EIF2AK2)

DNE:	112984624(EIF2AK2)

SCAM:

104151675(EIF2AK2)

ASN:	102379754(EIF2AK2)

AMJ:	102558195(EIF2AK2)

CPOO:

109319895(EIF2AK2)

GGN:	109304771(EIF2AK2)

PSS:	102449543(EIF2AK2)

CMY:	102934103(EIF2AK2)

CCAY:

125633838(EIF2AK2)

DCC:	119853864(EIF2AK2)

CPIC:

101940470(EIF2AK2)

TST:	117874623(EIF2AK2)

CABI:

116820141(EIF2AK2)

MRV:	120401970(EIF2AK2)

ACS:	100561872(eif2ak2)

ASAO:

132761260(EIF2AK2)

PVT:	110083920(EIF2AK2)

SUND:

121919623(EIF2AK2)

PBI:	103059200(EIF2AK2)

PMUR:

107287469(EIF2AK2)

CTIG:

120312073(EIF2AK2)

PGUT:

117671374(EIF2AK2)

APRI:

131188848(EIF2AK2)

PTEX:

113433060(EIF2AK2)

NSS:	113413243(EIF2AK2)

VKO:	123036001(EIF2AK2)

PMUA:

114594483(EIF2AK2)

PRAF:

128410927(EIF2AK2)

ZVI:	118081810(EIF2AK2)

HCG:	128347927(EIF2AK2)

STOW:

125438909(EIF2AK2)

EMC:	129325820(EIF2AK2)

XLA:	100037060(eif2ak2.L) 108716648(pkr2.L)

XTR:	100141483(pkr3) 779992(eif2ak2)

NPR:

108792731

RTEM:

120928088 120937509 120937510

BBUF:

120998752(EIF2AK2)

BGAR:

122934381 122934511

PWL:	138295907(EIF2AK2)

MUO:	115465714(EIF2AK2)

GSH:	117356986(EIF2AK2)

DRE:	100001092(eif2ak2)

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122356246(eif2ak2)

LROH:

127174979(eif2ak2)

OMC:	131551762 131551764(eif2ak2)

RKG:	130068978(eif2ak2)

MAMB:

125276480 125276481

CIDE:

127524372

MASI:

127411938 127414369

TROS:

130550154(eif2ak2)

TDW:	130431996(eif2ak2)

MANU:

129415477(eif2ak2)

PDAB:

135786717(eif2ak2)

IPU:

108263213

IFU:	128605187(eif2ak2)

PHYP:

113542164(eif2ak2)

SMEO:

124375860(eif2ak2)

TFD:	113655344(eif2ak2)

TVC:	132846943 132846946

CGAR:

128528677

NGRA:

132889104(eif2ak2)

TRN:	134314939(eif2ak2)

AMEX:

107197130(eif2ak2)

CMAO:

118810736(eif2ak2)

EEE:	113579882(eif2ak2)

CHAR:

105902253(eif2ak2)

SPIL:

134063467

TRU:	100144316(eif2ak2)

TFS:	130534288(eif2ak2)

LCO:

104918202

NCC:

104951309

TBEN:

117477550 117481967 117499827 117499828 117499829 117499830

CGOB:

115020152(eif2ak2)

PGEO:

117449934 117453025 117459400

GACU:

117535939 117552924 117553320 117553328 117553339 117553348 117553426

EMAC:

134858649 134858650

ELY:	117248421 117248422

PLEP:

121954255 121954256 121954257 121954451 121954878

SLUC:

116051240(eif2ak2)

ECRA:

117960114 117960115 117960116(eif2ak2) 117960117

ESP:	116705407 116705409

PFLV:

114571671 114571672 114572139

GAT:	100190866(pkr1) 120820497 120820498

PPUG:

119214493

AFB:	129092304(eif2ak2) 129092306 129092307

CLUM:

117744489 117744490(eif2ak2) 117744491

PSWI:

130207039 130207400 130207468

CANA:

137779963 137779964 137779965(eif2ak2)

CVE:	137883530(eif2ak2) 137883545 137883554

MSAM:

119916938 119916939 119916940

SCHU:

122884720 122884721 122884722

CUD:	121510796 121510797 121510798 121511321 121511402(eif2ak2)

SPUL:

138588147 138588764

LMIX:

132975092(eif2ak2)

ALAT:

119033620 119033621

ASTR:

137603583

MZE:	101480023 101480319 101480895

ONL:	100691607 100700343

OAU:	116318522 116318523 116318560

OLA:	100144382 110016550

CSAI:

133440811 133463806 133464092 133464169 133464170 133464172 133464174 133464175

XMA:

102232776

XCO:

114138280

XHE:	116713488 116713793

PRET:

103477270

PLAI:

106945326(eif2ak2) 106945327 106949773

PMEI:

106933429

GAF:	122842153 122842154(eif2ak2) 122842156

PPRL:

129359967 129360146

CVG:	107096530 107096531

CTUL:

119782887 119782888 119782913

GMU:

124858844

NFU:

107375439

KMR:	108248129(eif2ak2)

ALIM:

106515883

NWH:	119424292 119424390

EJA:

138195533

BFRE:

138616070

MCEP:

125018942 125019065

CSEM:

103387634(eif2ak2)

POV:

109636756

SSEN:

122781705(eif2ak2) 122781707 122781708

SSOE:

131473988 131473989 131474532

HHIP:

117775636 117775712(eif2ak2) 117775713 117775716

HSP:	118118664(eif2ak2)

PPLT:

128453858 128453859

SMAU:

118283298 118283304

LCF:

108885802

SDU:	111220787 111220788

SLAL:

111658980

XGL:	120796597 120796825(eif2ak2)

HCQ:	109516199(eif2ak2)

SSCV:

125978370

SBIA:

133510212(eif2ak2)

PEE:

133409375

PTAO:

133485684(eif2ak2)

BPEC:

110156836

MALB:

109959079

BSPL:

114842116 114842162 114870757 114870758

SJO:	128372548 128372550 128373087

SSCO:

133992164 133992165 133992166 133992167 133992280

GMH:	115560248 115560249 115560250 115560251

STRU:

115155450

OTW:	112253229(eif2ak2)

OMY:	100271898(eif2ak2)

OGO:	124048040(eif2ak2)

ONE:

115119677

OKI:

109882105

OKE:	118374422(eif2ak2)

OMM:	135505282(eif2ak2)

OCLA:

139367863

SALP:

112073823

SNH:	120046046 120046048

CCLU:

121556612(eif2ak2)

ELS:

105008364

SFM:

108927142

PKI:

111835715

AANG:

118218399(eif2ak2)

AROT:

135245349(eif2ak2)

CCOG:

133118661(eif2ak2)

LOC:	102692100(eif2ak2)

PSPA:

121316085 121317678(eif2ak2)

ARUT:

117399704 117403092 117410404(eif2ak2)

LCM:	102365233(EIF2AK2)

CMK:

103187174

RTP:	109918246(eif2ak2)

CPLA:

122542638

HOC:	132807144(eif2ak2)

LERI:

129696980(eif2ak2)

GFS:

BCOO:

LLL:

OTU:

AFRA:

CANU:

128182699 128184553 128185293 128185294 128185799 128186122 128186352

CVN:	111104115 111105245

OED:

125674910

XEN:	124454454 124454673

AANS:

MNT:

PALZ:

ATRI:

TDC:

ZTR:	MYCGRDRAFT_30507

DPP:	DICPUDRAFT_9913

PTI:	PHATRDRAFT_bd152 PHATRDRAFT_bd165

TPS:	THAPSDRAFT_16613

GTT:	GUITHDRAFT_84326

» show all

Reference

PMID:1695551

Authors

Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, Hovanessian AG

Title

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.

Journal

Cell 62:379-90 (1990)
DOI:10.1016/0092-8674(90)90374-N

Sequence

[hsa:5610]

LinkDB

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