KEGG   ORTHOLOGY: K18072
Entry
K18072                      KO                                     
Symbol
parS
Name
two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
Pathway
map01501  beta-Lactam resistance
map01503  Cationic antimicrobial peptide (CAMP) resistance
map02020  Two-component system
Module
M00745  Imipenem resistance, repression of porin OprD
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
   01503 Cationic antimicrobial peptide (CAMP) resistance
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
   01504 Antimicrobial resistance genes
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.13  Protein-histidine kinases
    2.7.13.3  histidine kinase
     K18072  parS; two-component system, OmpR family, sensor kinase ParS
Protein kinases [BR:ko01001]
 Histidine kinases
  OmpR family
   K18072  parS; two-component system, OmpR family, sensor kinase ParS
Two-component system [BR:ko02022]
 OmpR family
  ParS-ParR (polymyxin-adaptive resistance)
   K18072  parS; two-component system, OmpR family, sensor kinase ParS
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
Other DBs
COG: COG0642
GO: 0000155
Genes
SML: Smlt3730
SMT: Smal_3143
BUJ: BurJV3_3177
SMZ: SMD_3333
SFOE: K5L94_17425
STEN: CCR98_16365
STEM: CLM74_16690
STES: MG068_16225
SINC: DAIF1_32810(sasA_14)
SPAQ: STNY_R33610
SGEN: RKE57_16400
STEJ: FQS62_017465
STEO: PEM_13330
STEZ: ACEPA4_15610
SLAB: AB9L18_04520
LCP: LC55x_3348
LYT: DWG18_07690
VHR: AL538_25580
PAE: PA1798(parS)
PAEV: N297_1852
PAEI: N296_1852
PAU: PA14_41270
PAG: PLES_35301
PAF: PAM18_3246
PNC: NCGM2_2708
PAEB: NCGM1900_4702
PDK: PADK2_16675
PSG: G655_16165
PRP: M062_09405
PAEP: PA1S_16975
PAER: PA1R_gp5421
PAEM: U769_16690
PAEL: T223_18030
PAES: SCV20265_3606
PAEU: BN889_01932
PAEG: AI22_17015
PAEC: M802_1850
PAEO: M801_1851
SECH: B18_20850
PAP: PSPA7_3499
PPAA: B7D75_16020
PFL: PFL_2638
PPRC: PFLCHA0_c27050(rstB1)
PPRO: PPC_2687
PFE: PSF113_2430
PZA: HU749_017750
PFN: HZ99_01210
PFO: Pfl01_3390
PFS: PFLU_3483
PFC: PflA506_2548
PFB: VO64_0594
PMAN: OU5_0718
PTV: AA957_27695
PVR: PverR02_17250
PAZO: AYR47_23880
POI: BOP93_13980
PRX: HRH33_15105
PKR: AYO71_18695
PTOL: I7845_12915
PMAB: U0037_17415
PBRE: QDY63_13665
PFW: PF1751_v1c29120
PFF: PFLUOLIPICF721625
PFX: A7318_12015
PBA: PSEBR_a3303
PSK: U771_18585
PCH: EY04_12105
PCZ: PCL1606_35440
PCP: JM49_17760
PCHP: C4K32_2590
PSEM: TO66_12910
PSOS: POS17_2645
PFK: PFAS1_27180
PANR: A7J50_3186
PYM: AK972_2784
PKE: DLD99_17105
PGY: AWU82_09750
PATA: JWU58_11565
PDW: BV82_1799
PZE: HU754_018310
PMOE: HV782_012060
PSEP: C4K39_2657
PPII: QL104_17580
PVW: HU752_021365
PTRT: HU722_0016460
PSAM: HU731_001120
PTZ: HU718_012220
PSHH: HU773_012015
PASG: KSS96_13685
PMUY: KSS95_18775
PTW: TUM18999_20200(parS)
PIE: HU724_017085
PGF: J0G10_12655
PPEG: KUA23_16550
PSII: NF676_15995
PFIT: KJY40_17740
PNB: NK667_13855
PSOA: PSm6_01730(parS)
PKJ: Q1W70_20625
PHYG: JTY93_10855
PHOM: KJF94_12580
PCUC: PSH97_12605
PPAE: LDL65_26690
PSHS: JJN09_08130
PLIS: NN484_23645
PSNC: C0058_15930
PBEJ: PSH84_20680
PKV: QYQ93_16260
PQE: OSC50_10660
PSDT: NH234_18255
PCAA: V6L78_17455
SDN: Sden_0558
SBL: Sbal_0750
SBP: Sbal223_3500
SBS: Sbal117_0886
SLO: Shew_0803
SWD: Swoo_3977
SPSW: Sps_04160
SHEW: CKQ84_03510
SPSH: FM037_07210
SEUR: FM038_006735
SAEG: K0H80_04075
SHAO: K0H81_16055
SSPA: K0I31_04090
SHNS: K0J45_04095
SRHS: K0I63_04160
SOG: RA178_18015
SHEL: JM642_16550
CPS: CPS_0680
COM: CMT41_02685
COV: EKO29_03700
TPSY: RGQ13_07250
TNN: RI845_11515
TFT: RI844_05480
TACT: SG35_025145
TVD: SG34_003380
PSJS: GZH31_10785
HARO: R50071_32750
MVS: MVIS_3106
RHEI: ATY27_16715
THIP: N838_02940
GAP: GAPWK_0245
GAQ: RAM11_11865
AMAH: DLM_3613
JEU: BJP62_16570
CHIC: N8I74_07785
MAER: DAI18_00070 DAI18_08415
AXY: AXYL_03210 AXYL_03323
AXO: NH44784_028521 NH44784_045751 NH44784_046591 NH44784_052491
AXN: AX27061_2752 AX27061_2832 AX27061_3374 AX27061_5464
AXX: ERS451415_02732(rstB_1) ERS451415_02814(rstB_2) ERS451415_03355(rstB_3) ERS451415_05490(rstB_4)
ADT: APT56_14225 APT56_14645 APT56_25140
AIS: BUW96_05950 BUW96_06500 BUW96_12520
ASW: CVS48_11405
ACHR: C2U31_11540 C2U31_20555 C2U31_20700 C2U31_25185
ACHB: DVB37_23420
ACHO: H4P35_14655
AMUI: PE062_11390
APES: FOC84_28810 FOC84_29330
AAEG: RA224_16525 RA224_17090
ASEL: RAS12_06195 RAS12_06685
ACHM: V6V88_15170
ACHA: KYT87_24595
ACHH: ABFG95_11540 ABFG95_28685 ABFG95_29115
KIA: G8A07_04880
TIN: Tint_0822
THI: THI_1066
URU: DSM104443_00247(rstB_1) DSM104443_01370(rstB_2)
UPL: DSM104440_00257(rstB_1) DSM104440_03492(rstB_2)
OTR: OTERR_23400(ragB)
DEY: HYN24_04295
DECH: GBK02_06530
DAJ: VX159_11915
AHV: AADV58_14250
BEBA: BWI17_03985 BWI17_20150
BAPI: BBC0122_004440
DTO: TOL2_C04000
DVR: Dvar_34360
PAUU: E8A73_009735
MRM: A7982_13202
SCOR: J3U87_20475
 » show all
Reference
PMID:21149619
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
  Sequence
[pae:PA1798]
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
PMID:19258280
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08
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