KEGG   ORTHOLOGY: K21721
Entry
K21721                      KO                                     
Symbol
sbnB
Name
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase [EC:1.5.1.51]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Reaction
R11655  N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K21721  sbnB; N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
   00997 Biosynthesis of various other secondary metabolites
    K21721  sbnB; N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.51  N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
     K21721  sbnB; N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
Other DBs
COG: COG2423
Genes
ACC: BDGL_001498(ocd2)
ANO: RR32_07480
ACAL: BUM88_11500
ASEI: I8T81_07365(sbnB)
ACD: AOLE_07115
ACW: A0J50_07100
AGU: AS4_16160
SDN: Sden_0589
TACT: SG35_003595(sbnB)
CEK: D0B88_14055(sbnB)
CEG: D0C16_05385(sbnB)
RSO: RSp0418
RSE: F504_3906
RPU: CDC45_19720
RNC: GO999_24060(sbnB)
RSL: RPSI07_mp0379
RSN: RSPO_m01410
RSM: CMR15_mp10431
RSY: RSUY_34860(rapL_2)
RSG: JK151_14180(sbnB)
CNC: CNE_2c14840(ocd)
CUH: BJN34_08320
RME: Rmet_1116(ocd)
CUK: KB879_12560(sbnB)
BPLA: bpln_2g05020
NLC: EBAPG3_006455
NIZ: NNRS527_01549
ALEG: CFBP4996_27385(sbnB)
MNO: Mnod_6949
MAQU: Maq22A_c25430
MIWA: SS37A_35540(ocd2_1) SS37A_39060(ocd2_2)
SBD: ATN00_04615
DBK: DGMP_24730
BTHT: H175_328p223
BBAD: K7T73_21445(sbnB)
BARD: QRY57_11940(sbnB)
PCAL: BV455_03923
LMAC: I6G82_02105(sbnB)
SCIA: HUG15_04755
SAU: SA0113(sbnB)
SAV: SAV0117
SAW: SAHV_0116
SAH: SaurJH1_0108
SAJ: SaurJH9_0104
SAM: MW0090(sbnB)
SAS: SAS0091
SAR: SAR0120
SAC: SACOL0101
SAX: USA300HOU_0128(ocd)
SAA: SAUSA300_0119
SAO: SAOUHSC_00076
SAE: NWMN_0061(sbnB)
SAD: SAAV_0085
SUU: M013TW_0107(sbnB)
SUV: SAVC_00325
SUE: SAOV_0064
SUJ: SAA6159_00100(sbnB)
SUK: SAA6008_00095
SUC: ECTR2_73
SUT: SAT0131_00103
SUQ: HMPREF0772_10380
SUZ: MS7_0109
SUD: ST398NM01_0128
SUX: SAEMRSA15_00830(sbnB)
SUW: SATW20_01290(sbnB)
SUG: SAPIG0128
SUF: SARLGA251_00920(sbnB)
SAUA: SAAG_00601
SAUE: RSAU_000071
SAUN: SAKOR_00091
SAUS: SA40_0084(sbnB)
SAUU: SA957_0099(sbnB)
SAUG: SA268_0096(sbnB)
SAUZ: SAZ172_0128(sbnB)
SAUT: SAI1T1_2000730
SAUJ: SAI2T2_1000730
SAUK: SAI3T3_1000730
SAUQ: SAI4T8_1000730
SAUV: SAI7S6_1000730
SAUW: SAI5S5_1000730
SAUX: SAI6T6_1000730
SAUY: SAI8T7_1000730
SAUF: X998_0096
SAB: SAB0056
SUY: SA2981_0118(sbnB)
SAUB: C248_0105
SAUM: BN843_1190
SAUC: CA347_128
SAUR: SABB_01723(sbnB)
SAUI: AZ30_00610
SAUD: CH52_05135
SAMS: NI36_00505
SUH: SAMSHR1132_00930
SSD: SPSINT_0335
SDT: SPSE_2123(sbnB)
SDP: NCTC12225_02340(sbnB)
SHU: SHYC_00360(sbnB)
SSCH: LH95_00360
SSCZ: RN70_00580
SAGQ: EP23_09765(sbnB)
SEQO: SE1039_25100
SLZ: B5P37_07595
SARL: SAP2_02040
SSH: NCTC13712_00070
SRAI: LN051_00235(sbnB)
SROT: ML435_00405(sbnB)
STAP: AOB58_1874
SFF: FOB90_07430(sbnB)
BLR: BRLA_c008320
BAGR: BA6348_15350
BRW: GOP56_19910(sbnB)
BBOR: RFB14_00530(sbnB)
PMAH: PTQ21_17790(sbnB)
PPAB: KET34_14030(sbnB)
ANX: ACH33_02520
ATHE: K3F53_05635 K3F53_16430(sbnB)
SACA: FFV09_03655(sbnB)
TUM: CBW65_11390
TAB: CIG75_16790
SOW: QWT69_03230
LFB: C1X05_04235
KPUL: GXN76_14220(sbnB)
PABS: JIR001_05100(sbnB)
BACG: D2962_02975
SHAU: K9S39_08615(sbnB)
SACG: FDZ84_26435(sbnB)
PMAD: BAY61_28575
UME: RM788_51380
DOT: EZY12_24665(sbnB)
AFLO: HEQ12_15470(sbnB)
AMIZ: RBH88_00230
PPIO: CE91St28_22640(ocd2)
PYY: RAH42_12000
 » show all
Reference
PMID:24485762
  Authors
Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME
  Title
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.
  Journal
Chem Biol 21:379-88 (2014)
DOI:10.1016/j.chembiol.2013.12.011
  Sequence
[sae:NWMN_0061]
LinkDB

KEGG   ENZYME: 1.5.1.51
Entry
EC 1.5.1.51                 Enzyme                                 
Name
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase;
SbnB
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming)
Reaction(IUBMB)
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O = 2-oxoglutarate + L-2,3-diaminopropanoate + NADH + H+ [RN:R11655]
Reaction(KEGG)
R11655
Substrate
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate [CPD:C21559];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
2-oxoglutarate [CPD:C00026];
L-2,3-diaminopropanoate [CPD:C03401];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.
History
EC 1.5.1.51 created 2017
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21721  N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
Genes
ACC: BDGL_001498(ocd2)
ANO: RR32_07480
ACAL: BUM88_11500
ASEI: I8T81_07365(sbnB)
ACD: AOLE_07115
ACW: A0J50_07100
AGU: AS4_16160
SDN: Sden_0589
TACT: SG35_003595(sbnB)
CEK: D0B88_14055(sbnB)
CEG: D0C16_05385(sbnB)
RSO: RSp0418
RSE: F504_3906
RPU: CDC45_19720
RNC: GO999_24060(sbnB)
RSL: RPSI07_mp0379
RSN: RSPO_m01410
RSM: CMR15_mp10431
RSY: RSUY_34860(rapL_2)
RSG: JK151_14180(sbnB)
CNC: CNE_2c14840(ocd)
CUH: BJN34_08320
RME: Rmet_1116(ocd)
CUK: KB879_12560(sbnB)
BPLA: bpln_2g05020
NLC: EBAPG3_006455
NIZ: NNRS527_01549
ALEG: CFBP4996_27385(sbnB)
MNO: Mnod_6949
MAQU: Maq22A_c25430
MIWA: SS37A_35540(ocd2_1) SS37A_39060(ocd2_2)
SBD: ATN00_04615
DBK: DGMP_24730
BTHT: H175_328p223
BBAD: K7T73_21445(sbnB)
BARD: QRY57_11940(sbnB)
PCAL: BV455_03923
LMAC: I6G82_02105(sbnB)
SCIA: HUG15_04755
SAU: SA0113(sbnB)
SAV: SAV0117
SAW: SAHV_0116
SAH: SaurJH1_0108
SAJ: SaurJH9_0104
SAM: MW0090(sbnB)
SAS: SAS0091
SAR: SAR0120
SAC: SACOL0101
SAX: USA300HOU_0128(ocd)
SAA: SAUSA300_0119
SAO: SAOUHSC_00076
SAE: NWMN_0061(sbnB)
SAD: SAAV_0085
SUU: M013TW_0107(sbnB)
SUV: SAVC_00325
SUE: SAOV_0064
SUJ: SAA6159_00100(sbnB)
SUK: SAA6008_00095
SUC: ECTR2_73
SUT: SAT0131_00103
SUQ: HMPREF0772_10380
SUZ: MS7_0109
SUD: ST398NM01_0128
SUX: SAEMRSA15_00830(sbnB)
SUW: SATW20_01290(sbnB)
SUG: SAPIG0128
SUF: SARLGA251_00920(sbnB)
SAUA: SAAG_00601
SAUE: RSAU_000071
SAUN: SAKOR_00091
SAUS: SA40_0084(sbnB)
SAUU: SA957_0099(sbnB)
SAUG: SA268_0096(sbnB)
SAUZ: SAZ172_0128(sbnB)
SAUT: SAI1T1_2000730
SAUJ: SAI2T2_1000730
SAUK: SAI3T3_1000730
SAUQ: SAI4T8_1000730
SAUV: SAI7S6_1000730
SAUW: SAI5S5_1000730
SAUX: SAI6T6_1000730
SAUY: SAI8T7_1000730
SAUF: X998_0096
SAB: SAB0056
SUY: SA2981_0118(sbnB)
SAUB: C248_0105
SAUM: BN843_1190
SAUC: CA347_128
SAUR: SABB_01723(sbnB)
SAUI: AZ30_00610
SAUD: CH52_05135
SAMS: NI36_00505
SUH: SAMSHR1132_00930
SSD: SPSINT_0335
SDT: SPSE_2123(sbnB)
SDP: NCTC12225_02340(sbnB)
SHU: SHYC_00360(sbnB)
SSCH: LH95_00360
SSCZ: RN70_00580
SAGQ: EP23_09765(sbnB)
SEQO: SE1039_25100
SLZ: B5P37_07595
SARL: SAP2_02040
SSH: NCTC13712_00070
SRAI: LN051_00235(sbnB)
SROT: ML435_00405(sbnB)
STAP: AOB58_1874
SFF: FOB90_07430(sbnB)
BLR: BRLA_c008320
BAGR: BA6348_15350
BRW: GOP56_19910(sbnB)
BBOR: RFB14_00530(sbnB)
PMAH: PTQ21_17790(sbnB)
PPAB: KET34_14030(sbnB)
ANX: ACH33_02520
ATHE: K3F53_05635 K3F53_16430(sbnB)
SACA: FFV09_03655(sbnB)
TUM: CBW65_11390
TAB: CIG75_16790
SOW: QWT69_03230
LFB: C1X05_04235
KPUL: GXN76_14220(sbnB)
PABS: JIR001_05100(sbnB)
BACG: D2962_02975
SHAU: K9S39_08615(sbnB)
SACG: FDZ84_26435(sbnB)
PMAD: BAY61_28575
UME: RM788_51380
DOT: EZY12_24665(sbnB)
AFLO: HEQ12_15470(sbnB)
AMIZ: RBH88_00230
PPIO: CE91St28_22640(ocd2)
PYY: RAH42_12000
 » show all
Reference
1  [PMID:21906287]
  Authors
Beasley FC, Cheung J, Heinrichs DE
  Title
Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.
  Journal
BMC Microbiol 11:199 (2011)
DOI:10.1186/1471-2180-11-199
Reference
2  [PMID:24485762]
  Authors
Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME
  Title
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.
  Journal
Chem Biol 21:379-88 (2014)
DOI:10.1016/j.chembiol.2013.12.011
  Sequence
[sae:NWMN_0061]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.51
IUBMB Enzyme Nomenclature: 1.5.1.51
ExPASy - ENZYME nomenclature database: 1.5.1.51
BRENDA, the Enzyme Database: 1.5.1.51
LinkDB

KEGG   REACTION: R11655
Entry
R11655                      Reaction                               
Name
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming)
Definition
N-[(2S)-2-Amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O <=> 2-Oxoglutarate + L-2,3-Diaminopropanoate + NADH + H+
Equation
C21559 + C00003 + C00001 <=> C00026 + C03401 + C00004 + C00080
Reaction class
RC00217  C03401_C21559
RC01532  C00026_C21559
Enzyme
1.5.1.51
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.51
     R11655  N-[(2S)-2-Amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O <=> 2-Oxoglutarate + L-2,3-Diaminopropanoate + NADH + H+
Orthology
K21721  N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase [EC:1.5.1.51]
Other DBs
RHEA: 51931
LinkDB

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