KEGG   ORTHOLOGY: K22890
Entry
K22890            Tight     KO                                     

Symbol
vpu
Name
HIV-1 protein Vpu
Pathway
map03230  Viral genome structure
map05170  Human immunodeficiency virus 1 infection
Network
nt06121  TLR signaling (viruses and bacteria)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
  Element
N00437  HIV Vpu to TLR2/4-NFKB signaling pathway
N00440  HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22890  vpu; HIV-1 protein Vpu
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K22890  vpu; HIV-1 protein Vpu
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22890  vpu; HIV-1 protein Vpu
Viral proteins [BR:ko03200]
 ssRNA-RT viruses
  Human immunodeficiency virus
   K22890  vpu; HIV-1 protein Vpu
Genes
VG: 155945(vpu)
Reference
PMID:3043230
  Authors
Cohen EA, Terwilliger EF, Sodroski JG, Haseltine WA
  Title
Identification of a protein encoded by the vpu gene of HIV-1.
  Journal
Nature 334:532-4 (1988)
DOI:10.1038/334532a0
  Sequence
[vg:155945]
LinkDB

KEGG   ORTHOLOGY: K22892
Entry
K22892                      KO                                     

Symbol
vif
Name
HIV-1 virion infectivity factor
Pathway
map03230  Viral genome structure
map05170  Human immunodeficiency virus 1 infection
Network
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
  Element
N00440  HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22892  vif; HIV-1 virion infectivity factor
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K22892  vif; HIV-1 virion infectivity factor
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22892  vif; HIV-1 virion infectivity factor
Viral proteins [BR:ko03200]
 ssRNA-RT viruses
  Human immunodeficiency virus
   K22892  vif; HIV-1 virion infectivity factor
Genes
VG: 1490005(vif) 155459(vif) 1724712(HIV2gp2) 956111(vif)
Reference
  Authors
Andrew A, Strebel K
  Title
HIV-1 accessory proteins: Vpu and Vif.
  Journal
Methods Mol Biol 1087:135-58 (2014)
DOI:10.1007/978-1-62703-670-2_12
  Sequence
[vg:155459]
LinkDB

KEGG   ORTHOLOGY: K22202
Entry
K22202                      KO                                     

Symbol
vpr
Name
HIV-1 virus protein R
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05170  Human immunodeficiency virus 1 infection
Network
nt06123  TNF signaling (viruses and bacteria)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
  Element
N00440  HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
N00443  HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00453  HIV Vpr to intrinsic apoptotic pathway
N00454  HIV Vpr to intrinsic apoptotic pathway
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00458  HIV Vpr to CDC25-cell cycle G2M
N00460  HIV Vpr to WEE1-cell cycle G2M
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22202  vpr; HIV-1 virus protein R
   03240 Viral replication
    K22202  vpr; HIV-1 virus protein R
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K22202  vpr; HIV-1 virus protein R
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22202  vpr; HIV-1 virus protein R
Viral proteins [BR:ko03200]
 ssRNA-RT viruses
  Human immunodeficiency virus
   K22202  vpr; HIV-1 virus protein R
Other DBs
TC: 1.A.42.1
Genes
VG: 155807(vpr) 956112(vpr)
Reference
PMID:8552585
  Authors
Piller SC, Ewart GD, Premkumar A, Cox GB, Gage PW
  Title
Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.
  Journal
Proc Natl Acad Sci U S A 93:111-5 (1996)
DOI:10.1073/pnas.93.1.111
  Sequence
[vg:155807]
Reference
  Authors
Yan Y, Huang F, Yuan T, Sun B, Yang R
  Title
HIV-1 Vpr increases HCV replication through VprBP in cell culture.
  Journal
Virus Res 223:153-60 (2016)
DOI:10.1016/j.virusres.2016.07.007
  Sequence
[vg:155807]
LinkDB

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