KEGG   NETWORK: N00447
Entry
N00447                      Network                                
Name
HIV Vpr/Tat to TNF-JNK signaling pathway
Definition
(Vpr,Tat) -> JNK -> AP1
  Expanded
(K22202,K19258) -> (5599,5601,5602) -> (2353,3725)
Class
nt06516 TNF signaling
nt06161 Human immunodeficiency virus 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Perturbant
K22202 (Vpr)  vpr; HIV-1 virus protein R
K19258 (Tat)  tat; HIV-1 protein Tat
Reference
PMID:28358311
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:64 (2017)
DOI:10.3390/v9040064
Reference
PMID:18178131
  Authors
Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
  Journal
Trends Immunol 29:61-7 (2008)
DOI:10.1016/j.it.2007.10.008
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