KEGG ORTHOLOGY: K23741

ORTHOLOGY: K23741

Entry

K23741                      KO

Symbol

MAN1B, MNS3

Name

endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]

Pathway

map00510

N-Glycan biosynthesis

map00513

Various types of N-glycan biosynthesis

map01100

Metabolic pathways

map04141

Protein processing in endoplasmic reticulum

Module

M00073

N-glycan precursor trimming

M00074

N-glycan biosynthesis, high-mannose type

Disease

H00768

Autosomal recessive intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
   00513 Various types of N-glycan biosynthesis
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Enzymes [BR:ko01000]
3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.209  endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
     K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Membrane trafficking [BR:ko04131]
Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase

Other DBs

RN:

R06722

CAZy:

GH47

Genes

HSA:	11253(MAN1B1)

PTR:	473099(MAN1B1)

PPS:	100987343(MAN1B1)

GGO:	101134859(MAN1B1)

PON:	100432279(MAN1B1)

NLE:	100594686(MAN1B1)

MCC:	706918(MAN1B1)

MCF:	101867098(MAN1B1)

CSAB:

103239582(MAN1B1)

CATY:

105580607(MAN1B1)

PANU:

101010071

TGE:	112607962(MAN1B1)

RRO:	104669636(MAN1B1)

RBB:	108542887(MAN1B1)

TFN:	117099113(MAN1B1)

PTEH:

111553018(MAN1B1)

CJC:	100392624(MAN1B1)

SBQ:	101032054(MAN1B1)

CSYR:

103269499(MAN1B1)

MMUR:

105882249(MAN1B1)

OGA:	100964793(MAN1B1)

MMU:	227619(Man1b1)

MCAL:

110289782(Man1b1)

MPAH:

110317719(Man1b1)

RNO:	499751(Man1b1)

MCOC:

116089811(Man1b1)

MUN:	110556996(Man1b1)

CGE:

100756512

PLEU:

114692781(Man1b1)

NGI:	103732606 103741172(Man1b1)

HGL:	101724891(Man1b1)

CPOC:

100715996(Man1b1)

CCAN:

109697987(Man1b1)

DORD:

105995572(Man1b1)

DSP:	122099726(Man1b1)

OPI:	101527587(MAN1B1)

TUP:	102470543(MAN1B1)

CFA:

480667

VVP:	112911405(MAN1B1)

VLG:	121473188 121473189

AML:

100478118

UMR:	103675308(MAN1B1)

UAH:	113248412 113248447 113248587 113248656 113250061

UAR:	123796283 123796320(MAN1B1)

ELK:	111145781 111145782

LLV:	125083756 125083757

MPUF:

106003295(MAN1B1)

ORO:	101377733 101380090 101380385

EJU:	114203748(MAN1B1)

ZCA:	113934586 113934587

MLX:	118000541(MAN1B1)

FCA:	105261146 111557571

PYU:	121020233(MAN1B1) 121024619

PBG:	122474766 122475133

PTG:	102948947(MAN1B1)

PPAD:

109260237(MAN1B1)

AJU:	106989099(MAN1B1) 113597246

HHV:	120222776 120226452 120227604

BTA:	100336900(MAN1B1) 107131137(MAN1B1)

BOM:	102277240 102277814

BBUB:

102392446 102401107

CHX:	102182048(MAN1B1) 106501835

OAS:	105605821 105605822(MAN1B1)

ODA:	120852329(MAN1B1)

CCAD:

122442403 122442546(MAN1B1)

SSC:	100627465(MAN1B1)

CFR:	102513732(MAN1B1)

CBAI:

105073372(MAN1B1)

CDK:	105106772(MAN1B1) 105106783

VPC:	102542693(MAN1B1)

BACU:

103003282 103008754(MAN1B1)

LVE:	103086557(MAN1B1)

OOR:	101275150(MAN1B1)

DLE:	111176994(MAN1B1)

PCAD:

102987847 112065486

PSIU:

116755439(MAN1B1)

ECB:	100147103(MAN1B1) 100147680

EPZ:	103568009(MAN1B1)

EAI:	106845522 123289508

MYB:	102240083(MAN1B1)

MYD:	102775495(MAN1B1)

MMYO:

118655271(MAN1B1)

MLF:	102439240(MAN1B1)

MNA:	107536151(MAN1B1)

PKL:	118707019(MAN1B1)

HAI:	109381800(MAN1B1)

DRO:	112306395(MAN1B1)

SHON:

118980096(MAN1B1)

AJM:	119036097(MAN1B1)

PDIC:

114507914(MAN1B1) 118499400

PHAS:

123823586(MAN1B1)

MMF:

118629766

RFQ:	117032113(MAN1B1)

PALE:

102890593(MAN1B1)

PGIG:

120599824(MAN1B1)

PVP:	105298604(MAN1B1)

RAY:	107503110(MAN1B1)

MJV:	108406826(MAN1B1)

TOD:	119231168(MAN1B1)

SARA:

105943175(MAN1B1)

LAV:	100664627(MAN1B1) 100670902

TMU:

101354994

DNM:	101438190(MAN1B1)

MDO:	100022731(MAN1B1)

GAS:	123237192(MAN1B1)

SHR:	100918683(MAN1B1)

PCW:	110205295(MAN1B1)

OAA:	100080650(MAN1B1)

GGA:	417296(MAN1B1)

PCOC:

116234097(MAN1B1)

MGP:	100543997(MAN1B1)

CJO:	107321628(MAN1B1)

NMEL:

110407012(MAN1B1)

APLA:

101803362(MAN1B1)

ACYG:

106037118(MAN1B1)

AFUL:

116497078(MAN1B1)

TGU:	100223461(MAN1B1)

LSR:	110472180(MAN1B1)

SCAN:

103819092(MAN1B1)

PMOA:

120507335(MAN1B1)

OTC:	121336947(MAN1B1)

PRUF:

121357496(MAN1B1)

GFR:	102031555(MAN1B1)

FAB:	101816081(MAN1B1)

PHI:	102103624(MAN1B1)

PMAJ:

107212037(MAN1B1)

CCAE:

111936881(MAN1B1)

CCW:	104688195(UAP1L1)

ETL:	114064126(MAN1B1)

ZAB:	102067672(MAN1B1)

FPG:	101914433(MAN1B1)

FCH:	102045806(MAN1B1)

CLV:	102083787(MAN1B1)

EGZ:	104124017(MAN1B1)

NNI:	104018375(MAN1B1)

ACUN:

113486627(MAN1B1)

TALA:

104359832(MAN1B1)

PADL:

103915501(MAN1B1)

ACHC:

115334793(MAN1B1)

AAM:	106494264(MAN1B1)

AROW:

112969739(MAN1B1)

NPD:	112955862(MAN1B1)

DNE:	112986766(MAN1B1)

ASN:	102387590(MAN1B1)

AMJ:	102567138(MAN1B1)

CPOO:

109313770(MAN1B1)

GGN:	109292847(MAN1B1)

PSS:	102455673(MAN1B1)

CMY:	102942408(MAN1B1)

CPIC:

101947106(MAN1B1)

TST:	117889404(MAN1B1)

CABI:

116823284(MAN1B1)

MRV:	120386610(MAN1B1)

ACS:	100562395(man1b1)

PVT:	110078803(MAN1B1)

SUND:

121937293(MAN1B1)

PBI:	103052908(MAN1B1)

PMUR:

107295058(MAN1B1)

TSR:	106542597(MAN1B1)

PGUT:

117676613(MAN1B1)

VKO:	123028264(MAN1B1)

PMUA:

114589499(MAN1B1)

ZVI:	118083881(MAN1B1)

GJA:	107123282(MAN1B1)

XLA:	447291(man1b1.L)

XTR:	100145194(man1b1)

NPR:	108797130(MAN1B1)

RTEM:

120914028(MAN1B1)

BBUF:

120977844(MAN1B1)

BGAR:

122919491 122946129

DRE:	556237(man1b1b) 562592(man1b1a)

SRX:	107709694 107736907 107739703 107757969

SANH:

107661470 107681241 107690671 107692283

SGH:	107548773 107560236 107587425 107595674

CCAR:

109045768 109052759 109081650

CAUA:

113038798 113049299 113064119 113074139

IPU:	108255760(man1b1b) 108279088(man1b1a)

PHYP:

113535490 113536854

SMEO:

124380546(man1b1b) 124398172(man1b1a)

AMEX:

103022471(man1b1) 103024141

EEE:	113573453 113577930(man1b1)

TRU:	101072461 105418968

TNG:	GSTEN00004960G001 GSTEN00009295G001

LCO:	104923806 104930877(man1b1)

NCC:	104944586(man1b1)

CGOB:

115013303(man1b1) 115016675

ELY:	117251930(man1b1b) 117270132(man1b1a)

PLEP:

121944325 121959882(man1b1a)

SLUC:

116034794(man1b1a) 116050665(man1b1b)

ECRA:

117944690(man1b1b) 117959386(man1b1a)

PFLV:

114555183(man1b1) 114571584

GAT:	120830398(man1b1b) 120831937(man1b1a)

PPUG:

119226654(man1b1a)

MSAM:

119883771 119892352 119914215 119917792

CUD:	121509526 121524878(man1b1a)

MZE:	101475381(man1b1)

ONL:	100700979 112841850

OAU:	116319660(man1b1a) 116332782(man1b1b)

OLA:	101156826(man1b1) 101168136

OML:	112137701(man1b1b) 112162853(man1b1a)

XMA:	102232900(man1b1) 102236792

XCO:	114149976 114155129

XHE:	116724506 116729397

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122819517(man1b1a) 122827851(man1b1b)

CVG:	107083730 107088025

CTUL:

119771995(man1b1a) 119789284(man1b1b)

GMU:	124872048(man1b1a) 124878115(man1b1b)

NFU:

107375119

KMR:	108241416(man1b1a) 108245625(man1b1b)

ALIM:

106529420 106535448 106535552

NWH:	119424279(man1b1a)

AOCE:

111578422 111582694

CSEM:

103389019 103397364

POV:	109639093(man1b1) 109641232

SSEN:

122758578(man1b1a) 122769261

HHIP:

117767827(man1b1b) 117772246(man1b1a)

LCF:	108878392(man1b1) 108889011

SDU:	111221245 111226918(man1b1)

SLAL:

111647914(man1b1) 111650117

XGL:	120805701(man1b1b) 120806846(man1b1a)

HCQ:	109527092(man1b1)

BPEC:

110154656(man1b1) 110164288

MALB:

109959672 109968690

SASA:

106563131 106579997 106585427

OTW:	112232797 112234451(man1b1a) 112263106

OMY:	110509710(man1b1a) 110522854 110525472(man1b1b) 110535854

OGO:	124016952(man1b1a) 124033369 124036136

ONE:	115111439 115139862 115147146

SALP:

111960863 111963948 111974854(man1b1) 111974855

SNH:	120021738(man1b1a) 120025509 120054209 120063123

ELS:	105014133 105014927

SFM:	108922690 108938629(man1b1)

PKI:	111854001 111857531(man1b1)

AANG:

118213031(man1b1a) 118237521(man1b1b)

LOC:	102690638(man1b1)

PSPA:

121306681

ARUT:

117397023 117962293

LCM:	102347754(MAN1B1)

CMK:

103180403

RTP:	109927301(man1b1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115919045 592701

APLC:

110984825

SKO:

100378677

DME:	Dmel_CG11874(alpha-Man-Ib)

DER:

6555014

DSE:

6612651

DSI:	Dsimw501_GD17996(Dsim_GD17996)

DYA:	Dyak_GE10478

DAN:

6501495

DSR:

110177400

DPO:	Dpse_GA11250

DPE:

6587772

DMN:

108155025

DWI:	26529661 6649837

DGR:

6564284

DMO:	Dmoj_GI23409

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

AGA:	AgaP_AGAP003884

ACOZ:

120961362

AARA:

120895336

AAG:	110681198 5567412

AALB:

109415549

CQU:	CpipJ_CPIJ003661

CPII:

CNS:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206782

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

TNL:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:	103512631 103521396

CLEC:

106662400

HHAL:

106684496

NLU:

111052078

PHU:	Phum_PHUM530360

FOC:

ZNE:

CSEC:

FCD:

DPX:	DAPPUDRAFT_194674

DMK:

PVM:

PJA:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_T03G11.4(mans-3)

CBR:

CBG_14624

BMY:	BM_BM5524(Bma-mans-3)

LOA:	LOAG_01198

NAI:	NECAME_15419

TSP:

Tsp_04164

HRO:	HELRODRAFT_113976 HELRODRAFT_178867 HELRODRAFT_193110

LGI:	LOTGIDRAFT_120396

PCAN:

112575110

BGT:

106053864

GAE:	121366616 121384018

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:	106161727 106176115

OVI:	T265_03386

EGL:

EGR_00365

NVE:	116607129 5501352

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_53127

AQU:	100638524 100640055

ATH:	AT1G30000(MNS3)

ALY:

9326907

CRB:

17898338

CSAT:

104741591 104757343 104777030

EUS:	EUTSA_v10007084mg

BRP:	103835247 103840441

BNA:	106361602 106367368 106375950 106425028 111212331

BOE:	106295385 106328390

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10014607mg

PVY:

116114769

MINC:

123192943 123218754

TCC:

18596509

GRA:	105768906 105772769

GHI:	107905885 107958416 121230865

GAB:	108453420 108459983

DZI:	111274860 111280996

EGR:

104440790

GMX:	100789211 100806551

GSJ:	114375271 114387749

PVU:	PHAVU_006G164400g

VRA:

VAR:

VUN:

CCAJ:

APRC:

MTR:	MTR_2g019520

CAM:

101515695

LJA:	Lj6g3v1934090.1(Lj6g3v1934090.1)

ADU:

107468140

AIP:

107622562

AHF:	112714314 112785361

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103444000 103446189

PXB:

ZJU:

MNT:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

QSU:	111984426 112002631 112014039 112015529 112021377

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107782104 107783782

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

HAN:

ECAD:

LSV:

CCAV:

DCR:	108206430 108209987

CSIN:

114301034

BVG:

104883805

SOE:

110794113

CQI:	110698318 110728570

NNU:

MING:

TSS:

PSOM:

NCOL:

OSA:

DOSA:

Os05t0209100-01(Os05g0209100)

OBR:

102699961

BDI:

100820902

ATS:

109759492

TDC:	119329569 119368635

TAES:

123041929 123116155 123180779

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:	103702402 103703024

EGU:	105040640 105048159

MUS:	103987808 104000849

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_168485 SELMODRAFT_176646

PPP:

112287912

CRE:	CHLRE_07g336600v5

VCN:	VOLCADRAFT_119746(amd1)

MNG:	MNEG_2789 MNEG_9467

CSL:	COCSUDRAFT_48568

CVR:	CHLNCDRAFT_133855

APRO:

F751_6268

BPG:	Bathy13g00050

MIS:	MICPUN_112689(MANA)

MPP:	MICPUCDRAFT_15822

CME:	CYME_CMF045C

CCP:	CHC_T00008598001 CHC_T00009079001

SCE:	YJR131W(MNS1)

AGO:	AGOS_AER165W

ERC:

Ecym_5170

KLA:	KLLA0_B04356g

KMX:	KLMA_40509(MNS1)

LTH:	KLTH0D17908g

VPO:	Kpol_1028p79

ZRO:	ZYRO0B08360g

CGR:	CAGL0M00528g

NCS:	NCAS_0J02160(NCAS0J02160)

NDI:	NDAI_0J02870(NDAI0J02870)

TPF:	TPHA_0L00320(TPHA0L00320)

TBL:	TBLA_0B06140(TBLA0B06140)

TDL:	TDEL_0D00600(TDEL0D00600)

TGB:	HG536_0C06190

KAF:	KAFR_0E04290(KAFR0E04290)

ZMK:	HG535_0E01530

PPA:	PAS_chr2-1_0753

DHA:	DEHA2D09218g

PIC:	PICST_84949(MNS1)

PGU:	PGUG_04716

SPAA:

SPAPADRAFT_57837(MNS1.1)

LEL:	LELG_01334

CAL:	CAALFM_C103730CA(MNS1)

CTP:	CTRG_04351

COT:	CORT_0B11480

CDU:	CD36_03470

CTEN:

CANTEDRAFT_110685(MNS1)

YLI:	YALI0D17424g

CLU:	CLUG_04485

CLUS:

A9F13_04g00121

CAUR:

CJI97_003303

SLB:	AWJ20_4611(MNS1)

PKZ:	C5L36_0C09850

BNN:	FOA43_002911

BBRX:

BRETT_005208

NCR:	NCU02778(gh47-1)

NTE:	NEUTE1DRAFT74512(NEUTE1DRAFT_74512)

SMP:	SMAC_04842

PAN:	PODANSg09987

TTT:	THITE_2057638 THITE_2085147

MTM:	MYCTH_2294863

CTHR:

CTHT_0054060

MGR:

MGG_11408

TMN:	UCRPA7_1844 UCRPA7_7249

SSCK:

SPSK_05990

FGR:	FGSG_00612

FPU:	FPSE_04518 FPSE_04589

FVR:	FVEG_01076

FOX:	FOXG_00435

NHE:	NECHADRAFT_105814

TRE:	TRIREDRAFT_2662

TRR:	M419DRAFT_6341

MAW:

MAC_03073

MAJ:

MAA_04109

CMT:

CCM_08185

PLJ:	VFPFJ_03711

VAL:	VDBG_06023

VDA:	VDAG_03184

CFJ:	CFIO01_01386 CFIO01_11192

SAPO:

SAPIO_CDS3217

ELA:	UCREL1_10905 UCREL1_115

PFY:	PFICI_00615

SSL:	SS1G_04513

BFU:	BCIN_01g06120(Bcmns1)

MBE:

MBM_06132

PSCO:

LY89DRAFT_295383

GLZ:	GLAREA_11212

ANI:	AN0551.2 AN5748.2

AFM:	AFUA_6G06790

ACT:	ACLA_088570

NFI:	NFIA_052440

AOR:	AO090003000057

ANG:	ANI_1_1456164(An18g06220)

AFV:	AFLA_001640

ALUC:

AKAW2_31015S(MNS1)

ACHE:

ACHE_11175A(MNS1)

APUU:

APUU_41130S(MNS1)

PCS:	Pc14g01760

PDP:	PDIP_68610

TMF:	PMAA_093860

TRG:	TRUGW13939_09818

CIM:	CIMG_07325

CPW:	CPC735_001190

URE:	UREG_07868

PBL:	PAAG_00769

PBN:	PADG_04061

ABE:

ARB_01040

TVE:

TRV_02790

AJE:	HCAG_04182 HCAG_08449

BGH:	BDBG_01802 BDBG_03796

PNO:	SNOG_03652

PTE:

PTT_19626

BZE:	COCCADRAFT_2121

BSC:	COCSADRAFT_38869

BOR:	COCMIDRAFT_8408

AALT:

CC77DRAFT_988245

ZTR:	MYCGRDRAFT_45066(MgAMN9)

PFJ:	MYCFIDRAFT_204581 MYCFIDRAFT_88410

BCOM:

BAUCODRAFT_80378

NPA:	UCRNP2_2127

TML:	GSTUM_00001932001

SPO:	SPAC2E1P5.01c(mns1)

CNE:

CNE04550

CNB:

CNBE4550

CGI:	CGB_E6120W

TMS:	TREMEDRAFT_33664

TASA:

A1Q1_06697

PPL:	POSPLDRAFT_111281 POSPLDRAFT_130143 POSPLDRAFT_49494 POSPLDRAFT_99932

TVS:	TRAVEDRAFT_123722 TRAVEDRAFT_54985

DSQ:	DICSQDRAFT_131718

PCO:	PHACADRAFT_248627 PHACADRAFT_28202

SHS:	STEHIDRAFT_63527 STEHIDRAFT_68181

HIR:	HETIRDRAFT_30389 HETIRDRAFT_64121

PSQ:	PUNSTDRAFT_113060 PUNSTDRAFT_140588

ADL:	AURDEDRAFT_110124 AURDEDRAFT_112600

FME:	FOMMEDRAFT_143158

GTR:	GLOTRDRAFT_105477 GLOTRDRAFT_134936

LBC:	LACBIDRAFT_228999 LACBIDRAFT_255188 LACBIDRAFT_305436

MPR:	MPER_07540 MPER_09462 MPER_10851 MPER_11974

MRR:	Moror_11662 Moror_1765 Moror_9085

CCI:	CC1G_00625 CC1G_12305

SCM:	SCHCODRAFT_50368

ABP:	AGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315)

ABV:	AGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)

CPUT:

CONPUDRAFT_96550

SLA:	SERLADRAFT_480395

WSE:	WALSEDRAFT_35272

WIC:	J056_001603

UMA:	UMAG_02227

PFP:	PFL1_05588

MRT:

MRET_4039

MSYM:

MSY001_0287

PGR:	PGTG_14908

MLR:	MELLADRAFT_32725

MBR:	MONBRDRAFT_13888

SRE:	PTSG_01891

SMIN:

v1.2.009441.t1(symbB.v1.2.009441.t1) v1.2.009441.t2(symbB.v1.2.009441.t2) v1.2.025226.t1(symbB.v1.2.025226.t1) v1.2.032603.t1(symbB.v1.2.032603.t1)

FCY:	FRACYDRAFT_261302(MNS2_1)

TPS:	THAPSDRAFT_34968

NGD:	NGA_2009400(MAN1) NGA_2024900

AAF:	AURANDRAFT_10610 AURANDRAFT_71340

PIF:	PITG_01855 PITG_10149

PSOJ:

PHYSODRAFT_313654 PHYSODRAFT_557352

SPAR:

SPRG_01621 SPRG_08812

EHX:	EMIHUDRAFT_455715 EMIHUDRAFT_464075 EMIHUDRAFT_64898 EMIHUDRAFT_76998

GTT:	GUITHDRAFT_75084

TVA:	TVAG_104870 TVAG_245880 TVAG_379870 TVAG_382860 TVAG_402460 TVAG_447400

» show all

Reference

PMID:10409699

Authors

Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW

Title

Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis.

Journal

J Biol Chem 274:21375-86 (1999)
DOI:10.1074/jbc.274.30.21375

Sequence

[hsa:11253]

Reference

PMID:20023195

Authors

Liebminger E, Huttner S, Vavra U, Fischl R, Schoberer J, Grass J, Blaukopf C, Seifert GJ, Altmann F, Mach L, Strasser R

Title

Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana.

Journal

Plant Cell 21:3850-67 (2009)
DOI:10.1105/tpc.109.072363

Sequence

[ath:AT1G30000]

LinkDB

ENZYME: 3.2.1.209

Entry

EC 3.2.1.209                Enzyme

Name

endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase;
MAN1B1 (gene name);
MNS1 (gene name);
MNS3 (gene name)

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

Man9GlcNAc2-[protein]2-alpha-mannohydrolase (configuration-inverting)

Reaction(IUBMB)

Man9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + D-mannopyranose [RN:R12477]

Reaction(KEGG)

R12477(G);
(other) R06722(G)

Substrate

Man9GlcNAc2-[protein];
H2O [CPD:C00001]

Product

Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3);
D-mannopyranose [CPD:C00159]

Comment

The enzyme, located in the endoplasmic reticulum, primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 isomer 8A1,2,3B1,3 (the names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7]). The removal of the single mannosyl residue occurs in all eukaryotes as part of the processing of N-glycosylated proteins, and is absolutely essential for further elongation of the outer chain of properly-folded N-glycosylated proteins in yeast. In addition, the enzyme is involved in glycoprotein quality control at the ER quality control compartment (ERQC), helping to target misfolded glycoproteins for degradation. When present at very high concentrations in the ERQC, the enzyme can trim the carbohydrate chain further to Man(5-6)GlcNAc2.

History

EC 3.2.1.209 created 2019

Pathway

ec00510

N-Glycan biosynthesis

ec00513

Various types of N-glycan biosynthesis

ec01100

Metabolic pathways

Orthology

K23741

endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase

Genes

HSA:	11253(MAN1B1)

PTR:	473099(MAN1B1)

PPS:	100987343(MAN1B1)

GGO:	101134859(MAN1B1)

PON:	100432279(MAN1B1)

NLE:	100594686(MAN1B1)

MCC:	706918(MAN1B1)

MCF:	101867098(MAN1B1)

CSAB:

103239582(MAN1B1)

CATY:

105580607(MAN1B1)

PANU:

101010071

TGE:	112607962(MAN1B1)

RRO:	104669636(MAN1B1)

RBB:	108542887(MAN1B1)

TFN:	117099113(MAN1B1)

PTEH:

111553018(MAN1B1)

CJC:	100392624(MAN1B1)

SBQ:	101032054(MAN1B1)

CSYR:

103269499(MAN1B1)

MMUR:

105882249(MAN1B1)

OGA:	100964793(MAN1B1)

MMU:	227619(Man1b1)

MCAL:

110289782(Man1b1)

MPAH:

110317719(Man1b1)

RNO:	499751(Man1b1)

MCOC:

116089811(Man1b1)

MUN:	110556996(Man1b1)

CGE:

100756512

PLEU:

114692781(Man1b1)

NGI:	103732606 103741172(Man1b1)

HGL:	101724891(Man1b1)

CPOC:

100715996(Man1b1)

CCAN:

109697987(Man1b1)

DORD:

105995572(Man1b1)

DSP:	122099726(Man1b1)

OPI:	101527587(MAN1B1)

TUP:	102470543(MAN1B1)

CFA:

480667

VVP:	112911405(MAN1B1)

VLG:	121473188 121473189

AML:

100478118

UMR:	103675308(MAN1B1)

UAH:	113248412 113248447 113248587 113248656 113250061

UAR:	123796283 123796320(MAN1B1)

ELK:	111145781 111145782

LLV:	125083756 125083757

MPUF:

106003295(MAN1B1)

ORO:	101377733 101380090 101380385

EJU:	114203748(MAN1B1)

ZCA:	113934586 113934587

MLX:	118000541(MAN1B1)

FCA:	105261146 111557571

PYU:	121020233(MAN1B1) 121024619

PBG:	122474766 122475133

PTG:	102948947(MAN1B1)

PPAD:

109260237(MAN1B1)

AJU:	106989099(MAN1B1) 113597246

HHV:	120222776 120226452 120227604

BTA:	100336900(MAN1B1) 107131137(MAN1B1)

BOM:	102277240 102277814

BBUB:

102392446 102401107

CHX:	102182048(MAN1B1) 106501835

OAS:	105605821 105605822(MAN1B1)

ODA:	120852329(MAN1B1)

CCAD:

122442403 122442546(MAN1B1)

SSC:	100627465(MAN1B1)

CFR:	102513732(MAN1B1)

CBAI:

105073372(MAN1B1)

CDK:	105106772(MAN1B1) 105106783

VPC:	102542693(MAN1B1)

BACU:

103003282 103008754(MAN1B1)

LVE:	103086557(MAN1B1)

OOR:	101275150(MAN1B1)

DLE:	111176994(MAN1B1)

PCAD:

102987847 112065486

PSIU:

116755439(MAN1B1)

ECB:	100147103(MAN1B1) 100147680

EPZ:	103568009(MAN1B1)

EAI:	106845522 123289508

MYB:	102240083(MAN1B1)

MYD:	102775495(MAN1B1)

MMYO:

118655271(MAN1B1)

MLF:	102439240(MAN1B1)

MNA:	107536151(MAN1B1)

PKL:	118707019(MAN1B1)

HAI:	109381800(MAN1B1)

DRO:	112306395(MAN1B1)

SHON:

118980096(MAN1B1)

AJM:	119036097(MAN1B1)

PDIC:

114507914(MAN1B1) 118499400

PHAS:

123823586(MAN1B1)

MMF:

118629766

RFQ:	117032113(MAN1B1)

PALE:

102890593(MAN1B1)

PGIG:

120599824(MAN1B1)

PVP:	105298604(MAN1B1)

RAY:	107503110(MAN1B1)

MJV:	108406826(MAN1B1)

TOD:	119231168(MAN1B1)

SARA:

105943175(MAN1B1)

LAV:	100664627(MAN1B1) 100670902

TMU:

101354994

DNM:	101438190(MAN1B1)

MDO:	100022731(MAN1B1)

GAS:	123237192(MAN1B1)

SHR:	100918683(MAN1B1)

PCW:	110205295(MAN1B1)

OAA:	100080650(MAN1B1)

GGA:	417296(MAN1B1)

PCOC:

116234097(MAN1B1)

MGP:	100543997(MAN1B1)

CJO:	107321628(MAN1B1)

NMEL:

110407012(MAN1B1)

APLA:

101803362(MAN1B1)

ACYG:

106037118(MAN1B1)

AFUL:

116497078(MAN1B1)

TGU:	100223461(MAN1B1)

LSR:	110472180(MAN1B1)

SCAN:

103819092(MAN1B1)

PMOA:

120507335(MAN1B1)

OTC:	121336947(MAN1B1)

PRUF:

121357496(MAN1B1)

GFR:	102031555(MAN1B1)

FAB:	101816081(MAN1B1)

PHI:	102103624(MAN1B1)

PMAJ:

107212037(MAN1B1)

CCAE:

111936881(MAN1B1)

CCW:	104688195(UAP1L1)

ETL:	114064126(MAN1B1)

ZAB:	102067672(MAN1B1)

FPG:	101914433(MAN1B1)

FCH:	102045806(MAN1B1)

CLV:	102083787(MAN1B1)

EGZ:	104124017(MAN1B1)

NNI:	104018375(MAN1B1)

ACUN:

113486627(MAN1B1)

TALA:

104359832(MAN1B1)

PADL:

103915501(MAN1B1)

ACHC:

115334793(MAN1B1)

AAM:	106494264(MAN1B1)

AROW:

112969739(MAN1B1)

NPD:	112955862(MAN1B1)

DNE:	112986766(MAN1B1)

ASN:	102387590(MAN1B1)

AMJ:	102567138(MAN1B1)

CPOO:

109313770(MAN1B1)

GGN:	109292847(MAN1B1)

PSS:	102455673(MAN1B1)

CMY:	102942408(MAN1B1)

CPIC:

101947106(MAN1B1)

TST:	117889404(MAN1B1)

CABI:

116823284(MAN1B1)

MRV:	120386610(MAN1B1)

ACS:	100562395(man1b1)

PVT:	110078803(MAN1B1)

SUND:

121937293(MAN1B1)

PBI:	103052908(MAN1B1)

PMUR:

107295058(MAN1B1)

TSR:	106542597(MAN1B1)

PGUT:

117676613(MAN1B1)

VKO:	123028264(MAN1B1)

PMUA:

114589499(MAN1B1)

ZVI:	118083881(MAN1B1)

GJA:	107123282(MAN1B1)

XLA:	447291(man1b1.L)

XTR:	100145194(man1b1)

NPR:	108797130(MAN1B1)

RTEM:

120914028(MAN1B1)

BBUF:

120977844(MAN1B1)

BGAR:

122919491 122946129

DRE:	556237(man1b1b) 562592(man1b1a)

SRX:	107709694 107736907 107739703 107757969

SANH:

107661470 107681241 107690671 107692283

SGH:	107548773 107560236 107587425 107595674

CCAR:

109045768 109052759 109081650

CAUA:

113038798 113049299 113064119 113074139

IPU:	108255760(man1b1b) 108279088(man1b1a)

PHYP:

113535490 113536854

SMEO:

124380546(man1b1b) 124398172(man1b1a)

AMEX:

103022471(man1b1) 103024141

EEE:	113573453 113577930(man1b1)

TRU:	101072461 105418968

TNG:	GSTEN00004960G001 GSTEN00009295G001

LCO:	104923806 104930877(man1b1)

NCC:	104944586(man1b1)

CGOB:

115013303(man1b1) 115016675

ELY:	117251930(man1b1b) 117270132(man1b1a)

PLEP:

121944325 121959882(man1b1a)

SLUC:

116034794(man1b1a) 116050665(man1b1b)

ECRA:

117944690(man1b1b) 117959386(man1b1a)

PFLV:

114555183(man1b1) 114571584

GAT:	120830398(man1b1b) 120831937(man1b1a)

PPUG:

119226654(man1b1a)

MSAM:

119883771 119892352 119914215 119917792

CUD:	121509526 121524878(man1b1a)

MZE:	101475381(man1b1)

ONL:	100700979 112841850

OAU:	116319660(man1b1a) 116332782(man1b1b)

OLA:	101156826(man1b1) 101168136

OML:	112137701(man1b1b) 112162853(man1b1a)

XMA:	102232900(man1b1) 102236792

XCO:	114149976 114155129

XHE:	116724506 116729397

PRET:

103469620 103473953

PFOR:

103141937 103155541

PLAI:

106936359 106951546

PMEI:

106904614 106906201

GAF:	122819517(man1b1a) 122827851(man1b1b)

CVG:	107083730 107088025

CTUL:

119771995(man1b1a) 119789284(man1b1b)

GMU:	124872048(man1b1a) 124878115(man1b1b)

NFU:

107375119

KMR:	108241416(man1b1a) 108245625(man1b1b)

ALIM:

106529420 106535448 106535552

NWH:	119424279(man1b1a)

AOCE:

111578422 111582694

CSEM:

103389019 103397364

POV:	109639093(man1b1) 109641232

SSEN:

122758578(man1b1a) 122769261

HHIP:

117767827(man1b1b) 117772246(man1b1a)

LCF:	108878392(man1b1) 108889011

SDU:	111221245 111226918(man1b1)

SLAL:

111647914(man1b1) 111650117

XGL:	120805701(man1b1b) 120806846(man1b1a)

HCQ:	109527092(man1b1)

BPEC:

110154656(man1b1) 110164288

MALB:

109959672 109968690

SASA:

106563131 106579997 106585427

OTW:	112232797 112234451(man1b1a) 112263106

OMY:	110509710(man1b1a) 110522854 110525472(man1b1b) 110535854

OGO:	124016952(man1b1a) 124033369 124036136

ONE:	115111439 115139862 115147146

SALP:

111960863 111963948 111974854(man1b1) 111974855

SNH:	120021738(man1b1a) 120025509 120054209 120063123

ELS:	105014133 105014927

SFM:	108922690 108938629(man1b1)

PKI:	111854001 111857531(man1b1)

AANG:

118213031(man1b1a) 118237521(man1b1b)

LOC:	102690638(man1b1)

PSPA:

121306681

ARUT:

117397023 117962293

LCM:	102347754(MAN1B1)

CMK:

103180403

RTP:	109927301(man1b1)

BFO:

118420800

BBEL:

109466152

CIN:

100180827

SCLV:

120344397

SPU:	115919045 592701

APLC:

110984825

SKO:

100378677

DME:	Dmel_CG11874(alpha-Man-Ib)

DER:

6555014

DSE:

6612651

DSI:	Dsimw501_GD17996(Dsim_GD17996)

DYA:	Dyak_GE10478

DAN:

6501495

DSR:

110177400

DPO:	Dpse_GA11250

DPE:

6587772

DMN:

108155025

DWI:	26529661 6649837

DGR:

6564284

DMO:	Dmoj_GI23409

DAZ:

108609054

DNV:

108656217

DHE:

111599442

DVI:

6632758

CCAT:

101453662

BOD:

106616058

MDE:

101889535

SCAC:

106095719

LCQ:

111690671

AGA:	AgaP_AGAP003884

ACOZ:

120961362

AARA:

120895336

AAG:	110681198 5567412

AALB:

109415549

CQU:	CpipJ_CPIJ003661

CPII:

120420766

CNS:

116345876

AME:

413579

ACER:

108003139

ALAB:

122719410

BIM:

100746318

BBIF:

117217221

BVK:

117242501

BVAN:

117155078

BTER:

100651817

BPYO:

122575283

CCAL:

108622226

OBB:

114874226

MGEN:

117226426

NMEA:

116432770

CGIG:

122402115

SOC:

105204046

MPHA:

105832593

AEC:

105149600

ACEP:

105622350

PBAR:

105426911

VEM:

105568559

HST:

105184363

DQU:

106749327

CFO:

105248014

FEX:

115239828

LHU:

105669682

PGC:

109855950

OBO:

105284082

PCF:

106784288

PFUC:

122520610

VPS:

122627052

NVI:

100119267

CSOL:

105360197

TPRE:

106656965

MDL:

103575736

CGLO:

123267022

FAS:

105274150

DAM:

107044372

AGIF:

122856784

CCIN:

107269210

TCA:

659709

DPA:

109541778

SOY:

115890163

ATD:

109598739

CSET:

123318587

AGB:

108910434

LDC:

111502095

NVL:

108565052

APLN:

108740733

PPYR:

116173235

OTU:

111428171

BMOR:

101746534

BMAN:

114244560

MSEX:

115441177

DPL:	KGM_206782

BANY:

112049746

PMAC:

106717133

PPOT:

106104501

PXU:

106126459

PRAP:

110997563

ZCE:

119835478

HAW:

110377795

TNL:

113493937

OFU:

114361194

PXY:

105381786

API:

100158868

DNX:

107171166

AGS:

114130037

RMD:

113553488

BTAB:

109029927

DCI:	103512631 103521396

CLEC:

106662400

HHAL:

106684496

NLU:

111052078

PHU:	Phum_PHUM530360

FOC:

113217995

ZNE:

110838192

CSEC:

111873921

FCD:

110856238

DPX:	DAPPUDRAFT_194674

DMK:

116932879

PVM:

113818476

PJA:

122264293

HAME:

121860164 121875029

PCLA:

123755455

PTRU:

123511212

HAZT:

108676336

EAF:

111713012

DSV:

119432855

RSAN:

119380999

RMP:

119187535

VDE:

111245990

VJA:

111259442

TUT:

107368943

DPTE:

113792907

DFR:

124493645

CSCU:

111620023 111631894

PTEP:

107453367

SDM:

118197594

CEL:	CELE_T03G11.4(mans-3)

CBR:

CBG_14624

BMY:	BM_BM5524(Bma-mans-3)

LOA:	LOAG_01198

NAI:	NECAME_15419

TSP:

Tsp_04164

HRO:	HELRODRAFT_113976 HELRODRAFT_178867 HELRODRAFT_193110

LGI:	LOTGIDRAFT_120396

PCAN:

112575110

BGT:

106053864

GAE:	121366616 121384018

HRF:

124152763

HRJ:

124275180

CRG:

105334865

MYI:

110447565

PMAX:

117322084

MMER:

123554918

OBI:

106884360

OSN:

115227945

LAK:	106161727 106176115

OVI:	T265_03386

EGL:

EGR_00365

NVE:	116607129 5501352

EPA:

110237771

ATEN:

116294530

ADF:

107335017

AMIL:

114946959

PDAM:

113665639 113673540

SPIS:

111332673

DGT:

114519075

XEN:

124438093

HMG:

100198486

TAD:	TRIADDRAFT_53127

AQU:	100638524 100640055

ATH:	AT1G30000(MNS3)

ALY:

9326907

CRB:

17898338

CSAT:

104741591 104757343 104777030

EUS:	EUTSA_v10007084mg

BRP:	103835247 103840441

BNA:	106361602 106367368 106375950 106425028 111212331

BOE:	106295385 106328390

RSZ:

108806417

THJ:

104812670

CPAP:

110807600

CIT:

102616435

CIC:	CICLE_v10014607mg

PVY:

116114769

MINC:

123192943 123218754

TCC:

18596509

GRA:	105768906 105772769

GHI:	107905885 107958416 121230865

GAB:	108453420 108459983

DZI:	111274860 111280996

EGR:

104440790

GMX:	100789211 100806551

GSJ:	114375271 114387749

PVU:	PHAVU_006G164400g

VRA:

106775885

VAR:

108343148

VUN:

114187820

CCAJ:

109789197

APRC:

113871446

MTR:	MTR_2g019520

CAM:

101515695

LJA:	Lj6g3v1934090.1(Lj6g3v1934090.1)

ADU:

107468140

AIP:

107622562

AHF:	112714314 112785361

LANG:

109345269

FVE:

101313190

RCN:

112164535

PPER:

18780386

PMUM:

103325119

PAVI:

110773985

PDUL:

117623865

MDM:	103444000 103446189

PXB:

103951272

ZJU:

107413762

MNT:

21404524

CSV:

101216212

CMO:

103484372

BHJ:

120073818

MCHA:

111015717

CMAX:

111478371 111496964

CMOS:

111433252 111433756

CPEP:

111781525 111804180

RCU:

8264122

JCU:

105633984

HBR:

110651587

MESC:

110601605 110605198

POP:

7472574

PEU:

105118639

PALZ:

118050747

JRE:

108988627

QSU:	111984426 112002631 112014039 112015529 112021377

QLO:

115988411

TWL:

120015206

VVI:

100243430

VRI:

117923521

SLY:

101246787

SPEN:

107011307

SOT:

102583221

CANN:

107859093

NTA:	107782104 107783782

NSY:

104249918

NTO:

104097810

NAU:

109216453

INI:

109192025

ITR:

116025989

SIND:

105175706

OEU:

111402240

EGT:

105962464

SSPL:

121758773

HAN:

110911812

ECAD:

122592643

LSV:

111880716

CCAV:

112526325

DCR:	108206430 108209987

CSIN:

114301034

BVG:

104883805

SOE:

110794113

CQI:	110698318 110728570

NNU:

104613507

MING:

122059792

TSS:

122652168

PSOM:

113289725 113299707

NCOL:

116247349

OSA:

4338088

DOSA:

Os05t0209100-01(Os05g0209100)

OBR:

102699961

BDI:

100820902

ATS:

109759492

TDC:	119329569 119368635

TAES:

123041929 123116155 123180779

SBI:

8055739

ZMA:

100282405

SITA:

101773458

SVS:

117850070

PVIR:

120663968 120697123

PHAI:

112888039

PDA:	103702402 103703024

EGU:	105040640 105048159

MUS:	103987808 104000849

DCT:

110116511

PEQ:

110022272

AOF:

109828813

ATR:

18435237

SMO:	SELMODRAFT_168485 SELMODRAFT_176646

PPP:

112287912

CRE:	CHLRE_07g336600v5

VCN:	VOLCADRAFT_119746(amd1)

MNG:	MNEG_2789 MNEG_9467

CSL:	COCSUDRAFT_48568

CVR:	CHLNCDRAFT_133855

APRO:

F751_6268

BPG:	Bathy13g00050

MIS:	MICPUN_112689(MANA)

MPP:	MICPUCDRAFT_15822

CME:	CYME_CMF045C

CCP:	CHC_T00008598001 CHC_T00009079001

SCE:	YJR131W(MNS1)

AGO:	AGOS_AER165W

ERC:

Ecym_5170

KLA:	KLLA0_B04356g

KMX:	KLMA_40509(MNS1)

LTH:	KLTH0D17908g

VPO:	Kpol_1028p79

ZRO:	ZYRO0B08360g

CGR:	CAGL0M00528g

NCS:	NCAS_0J02160(NCAS0J02160)

NDI:	NDAI_0J02870(NDAI0J02870)

TPF:	TPHA_0L00320(TPHA0L00320)

TBL:	TBLA_0B06140(TBLA0B06140)

TDL:	TDEL_0D00600(TDEL0D00600)

TGB:	HG536_0C06190

KAF:	KAFR_0E04290(KAFR0E04290)

ZMK:	HG535_0E01530

PPA:	PAS_chr2-1_0753

DHA:	DEHA2D09218g

PIC:	PICST_84949(MNS1)

PGU:	PGUG_04716

SPAA:

SPAPADRAFT_57837(MNS1.1)

LEL:	LELG_01334

CAL:	CAALFM_C103730CA(MNS1)

CTP:	CTRG_04351

COT:	CORT_0B11480

CDU:	CD36_03470

CTEN:

CANTEDRAFT_110685(MNS1)

YLI:	YALI0D17424g

CLU:	CLUG_04485

CLUS:

A9F13_04g00121

CAUR:

CJI97_003303

SLB:	AWJ20_4611(MNS1)

PKZ:	C5L36_0C09850

BNN:	FOA43_002911

BBRX:

BRETT_005208

NCR:	NCU02778(gh47-1)

NTE:	NEUTE1DRAFT74512(NEUTE1DRAFT_74512)

SMP:	SMAC_04842

PAN:	PODANSg09987

TTT:	THITE_2057638 THITE_2085147

MTM:	MYCTH_2294863

CTHR:

CTHT_0054060

MGR:

MGG_11408

TMN:	UCRPA7_1844 UCRPA7_7249

SSCK:

SPSK_05990

FGR:	FGSG_00612

FPU:	FPSE_04518 FPSE_04589

FVR:	FVEG_01076

FOX:	FOXG_00435

NHE:	NECHADRAFT_105814

TRE:	TRIREDRAFT_2662

TRR:	M419DRAFT_6341

MAW:

MAC_03073

MAJ:

MAA_04109

CMT:

CCM_08185

PLJ:	VFPFJ_03711

VAL:	VDBG_06023

VDA:	VDAG_03184

CFJ:	CFIO01_01386 CFIO01_11192

SAPO:

SAPIO_CDS3217

ELA:	UCREL1_10905 UCREL1_115

PFY:	PFICI_00615

SSL:	SS1G_04513

BFU:	BCIN_01g06120(Bcmns1)

MBE:

MBM_06132

PSCO:

LY89DRAFT_295383

GLZ:	GLAREA_11212

ANI:	AN0551.2 AN5748.2

AFM:	AFUA_6G06790

ACT:	ACLA_088570

NFI:	NFIA_052440

AOR:	AO090003000057

ANG:	ANI_1_1456164(An18g06220)

AFV:	AFLA_001640

ALUC:

AKAW2_31015S(MNS1)

ACHE:

ACHE_11175A(MNS1)

APUU:

APUU_41130S(MNS1)

PCS:	Pc14g01760

PDP:	PDIP_68610

TMF:	PMAA_093860

TRG:	TRUGW13939_09818

CIM:	CIMG_07325

CPW:	CPC735_001190

URE:	UREG_07868

PBL:	PAAG_00769

PBN:	PADG_04061

ABE:

ARB_01040

TVE:

TRV_02790

AJE:	HCAG_04182 HCAG_08449

BGH:	BDBG_01802 BDBG_03796

PNO:	SNOG_03652

PTE:

PTT_19626

BZE:	COCCADRAFT_2121

BSC:	COCSADRAFT_38869

BOR:	COCMIDRAFT_8408

AALT:

CC77DRAFT_988245

ZTR:	MYCGRDRAFT_45066(MgAMN9)

PFJ:	MYCFIDRAFT_204581 MYCFIDRAFT_88410

BCOM:

BAUCODRAFT_80378

NPA:	UCRNP2_2127

TML:	GSTUM_00001932001

SPO:	SPAC2E1P5.01c(mns1)

CNE:

CNE04550

CNB:

CNBE4550

CGI:	CGB_E6120W

TMS:	TREMEDRAFT_33664

TASA:

A1Q1_06697

PPL:	POSPLDRAFT_111281 POSPLDRAFT_130143 POSPLDRAFT_49494 POSPLDRAFT_99932

TVS:	TRAVEDRAFT_123722 TRAVEDRAFT_54985

DSQ:	DICSQDRAFT_131718

PCO:	PHACADRAFT_248627 PHACADRAFT_28202

SHS:	STEHIDRAFT_63527 STEHIDRAFT_68181

HIR:	HETIRDRAFT_30389 HETIRDRAFT_64121

PSQ:	PUNSTDRAFT_113060 PUNSTDRAFT_140588

ADL:	AURDEDRAFT_110124 AURDEDRAFT_112600

FME:	FOMMEDRAFT_143158

GTR:	GLOTRDRAFT_105477 GLOTRDRAFT_134936

LBC:	LACBIDRAFT_228999 LACBIDRAFT_255188 LACBIDRAFT_305436

MPR:	MPER_07540 MPER_09462 MPER_10851 MPER_11974

MRR:	Moror_11662 Moror_1765 Moror_9085

CCI:	CC1G_00625 CC1G_12305

SCM:	SCHCODRAFT_50368

ABP:	AGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315)

ABV:	AGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)

CPUT:

CONPUDRAFT_96550

SLA:	SERLADRAFT_480395

WSE:	WALSEDRAFT_35272

WIC:	J056_001603

UMA:	UMAG_02227

PFP:	PFL1_05588

MRT:

MRET_4039

MSYM:

MSY001_0287

PGR:	PGTG_14908

MLR:	MELLADRAFT_32725

MBR:	MONBRDRAFT_13888

SRE:	PTSG_01891

SMIN:

v1.2.009441.t1(symbB.v1.2.009441.t1) v1.2.009441.t2(symbB.v1.2.009441.t2) v1.2.025226.t1(symbB.v1.2.025226.t1) v1.2.032603.t1(symbB.v1.2.032603.t1)

FCY:	FRACYDRAFT_261302(MNS2_1)

TPS:	THAPSDRAFT_34968

NGD:	NGA_2009400(MAN1) NGA_2024900

AAF:	AURANDRAFT_10610 AURANDRAFT_71340

PIF:	PITG_01855 PITG_10149

PSOJ:

PHYSODRAFT_313654 PHYSODRAFT_557352

SPAR:

SPRG_01621 SPRG_08812

EHX:	EMIHUDRAFT_455715 EMIHUDRAFT_464075 EMIHUDRAFT_64898 EMIHUDRAFT_76998

GTT:	GUITHDRAFT_75084

TVA:	TVAG_104870 TVAG_245880 TVAG_379870 TVAG_382860 TVAG_402460 TVAG_447400

» show all

Reference

1 [PMID:3049586]

Authors

Jelinek-Kelly S, Herscovics A

Title

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Purification of the alpha-mannosidase which removes one specific mannose residue from Man9GlcNAc.

Journal

J Biol Chem 263:14757-63 (1988)

Reference

2 [PMID:1822240]

Authors

Ziegler FD, Trimble RB

Title

Glycoprotein biosynthesis in yeast: purification and characterization of the endoplasmic reticulum Man9 processing alpha-mannosidase.

Journal

Glycobiology 1:605-14 (1991)
DOI:10.1093/glycob/1.6.605

Reference

3 [PMID:10409699]

Authors

Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW

Title

Journal

J Biol Chem 274:21375-86 (1999)
DOI:10.1074/jbc.274.30.21375

Sequence

[hsa:11253]

Reference

4 [PMID:12090241]

Authors

Herscovics A, Romero PA, Tremblay LO

Title

The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported.

Journal

Glycobiology 12:14G-15G (2002)

Reference

5 [PMID:18003979]

Authors

Avezov E, Frenkel Z, Ehrlich M, Herscovics A, Lederkremer GZ

Title

Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation.

Journal

Mol Biol Cell 19:216-25 (2008)
DOI:10.1091/mbc.e07-05-0505

Sequence

[hsa:11253]

Reference

6 [PMID:20023195]

Authors

Liebminger E, Huttner S, Vavra U, Fischl R, Schoberer J, Grass J, Blaukopf C, Seifert GJ, Altmann F, Mach L, Strasser R

Title

Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana.

Journal

Plant Cell 21:3850-67 (2009)
DOI:10.1105/tpc.109.072363

Sequence

[ath:AT1G30000]

Reference

7 [PMID:19181540]

Authors

Prien JM, Ashline DJ, Lapadula AJ, Zhang H, Reinhold VN

Title

The high mannose glycans from bovine ribonuclease B isomer characterization by ion trap MS.

Journal

J Am Soc Mass Spectrom 20:539-56 (2009)
DOI:10.1016/j.jasms.2008.11.012

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.209

IUBMB Enzyme Nomenclature:

3.2.1.209

ExPASy - ENZYME nomenclature database:

3.2.1.209

BRENDA, the Enzyme Database:

3.2.1.209

LinkDB

REACTION: R06722

Entry

R06722                      Reaction

Name

alpha 1,2-mannosyloligosaccharide alpha-D-mannohydrolase

Definition

H2O + G00011 <=> D-Mannose + G10694

Equation

C00001 + G00011 <=> C00159 + G10694

Enzyme

3.2.1.209

Pathway

rn00510

N-Glycan biosynthesis

rn00513

Various types of N-glycan biosynthesis

rn01100

Metabolic pathways

Module

M00073

N-glycan precursor trimming

M00074

N-glycan biosynthesis, high-mannose type

Orthology

K23741

endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]

Other DBs

RHEA:

56007

LinkDB

DBGET integrated database retrieval system