KEGG   ORTHOLOGY: K23741
Entry
K23741                      KO                                     
Symbol
MAN1B, MNS3
Name
endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
Pathway
map00510  N-Glycan biosynthesis
map00513  Various types of N-glycan biosynthesis
map01100  Metabolic pathways
map04141  Protein processing in endoplasmic reticulum
Module
M00073  N-glycan precursor trimming
M00074  N-glycan biosynthesis, high-mannose type
Disease
H00768  Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
   00513 Various types of N-glycan biosynthesis
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.209  endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
     K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Membrane trafficking [BR:ko04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Other DBs
RN: R06722
CAZy: GH47
Genes
HSA: 11253(MAN1B1)
PTR: 473099(MAN1B1)
PPS: 100987343(MAN1B1)
GGO: 101134859(MAN1B1)
PON: 100432279(MAN1B1)
NLE: 100594686(MAN1B1)
MCC: 706918(MAN1B1)
MCF: 101867098(MAN1B1)
CSAB: 103239582(MAN1B1)
CATY: 105580607(MAN1B1)
PANU: 101010071
TGE: 112607962(MAN1B1)
RRO: 104669636(MAN1B1)
RBB: 108542887(MAN1B1)
TFN: 117099113(MAN1B1)
PTEH: 111553018(MAN1B1)
CJC: 100392624(MAN1B1)
SBQ: 101032054(MAN1B1)
CSYR: 103269499(MAN1B1)
MMUR: 105882249(MAN1B1)
OGA: 100964793(MAN1B1)
MMU: 227619(Man1b1)
MCAL: 110289782(Man1b1)
MPAH: 110317719(Man1b1)
RNO: 499751(Man1b1)
MCOC: 116089811(Man1b1)
MUN: 110556996(Man1b1)
CGE: 100756512
PLEU: 114692781(Man1b1)
NGI: 103732606 103741172(Man1b1)
HGL: 101724891(Man1b1)
CPOC: 100715996(Man1b1)
CCAN: 109697987(Man1b1)
DORD: 105995572(Man1b1)
DSP: 122099726(Man1b1)
OPI: 101527587(MAN1B1)
TUP: 102470543(MAN1B1)
CFA: 480667
VVP: 112911405(MAN1B1)
AML: 100478118
UMR: 103675308(MAN1B1)
UAR: 123796283 123796320(MAN1B1)
MPUF: 106003295(MAN1B1)
EJU: 114203748(MAN1B1)
MLX: 118000541(MAN1B1)
PYU: 121020233(MAN1B1) 121024619
PTG: 102948947(MAN1B1)
PPAD: 109260237(MAN1B1)
AJU: 106989099(MAN1B1) 113597246
BTA: 100336900(MAN1B1) 107131137(MAN1B1)
CHX: 102182048(MAN1B1) 106501835
OAS: 105605821 105605822(MAN1B1)
ODA: 120852329(MAN1B1)
CCAD: 122442403 122442546(MAN1B1)
SSC: 100627465(MAN1B1)
CFR: 102513732(MAN1B1)
CBAI: 105073372(MAN1B1)
CDK: 105106772(MAN1B1) 105106783
VPC: 102542693(MAN1B1)
BACU: 103003282 103008754(MAN1B1)
LVE: 103086557(MAN1B1)
OOR: 101275150(MAN1B1)
DLE: 111176994(MAN1B1)
PSIU: 116755439(MAN1B1)
ECB: 100147103(MAN1B1) 100147680
EPZ: 103568009(MAN1B1)
MYB: 102240083(MAN1B1)
MYD: 102775495(MAN1B1)
MMYO: 118655271(MAN1B1)
MLF: 102439240(MAN1B1)
MNA: 107536151(MAN1B1)
PKL: 118707019(MAN1B1)
HAI: 109381800(MAN1B1)
DRO: 112306395(MAN1B1)
SHON: 118980096(MAN1B1)
AJM: 119036097(MAN1B1)
PDIC: 114507914(MAN1B1) 118499400
PHAS: 123823586(MAN1B1)
MMF: 118629766
RFQ: 117032113(MAN1B1)
PALE: 102890593(MAN1B1)
PGIG: 120599824(MAN1B1)
PVP: 105298604(MAN1B1)
RAY: 107503110(MAN1B1)
MJV: 108406826(MAN1B1)
TOD: 119231168(MAN1B1)
SARA: 105943175(MAN1B1)
LAV: 100664627(MAN1B1) 100670902
TMU: 101354994
DNM: 101438190(MAN1B1)
MDO: 100022731(MAN1B1)
GAS: 123237192(MAN1B1)
SHR: 100918683(MAN1B1)
PCW: 110205295(MAN1B1)
OAA: 100080650(MAN1B1)
GGA: 417296(MAN1B1)
PCOC: 116234097(MAN1B1)
MGP: 100543997(MAN1B1)
CJO: 107321628(MAN1B1)
NMEL: 110407012(MAN1B1)
APLA: 101803362(MAN1B1)
ACYG: 106037118(MAN1B1)
AFUL: 116497078(MAN1B1)
TGU: 100223461(MAN1B1)
LSR: 110472180(MAN1B1)
SCAN: 103819092(MAN1B1)
PMOA: 120507335(MAN1B1)
OTC: 121336947(MAN1B1)
PRUF: 121357496(MAN1B1)
GFR: 102031555(MAN1B1)
FAB: 101816081(MAN1B1)
PHI: 102103624(MAN1B1)
PMAJ: 107212037(MAN1B1)
CCAE: 111936881(MAN1B1)
CCW: 104688195(UAP1L1)
ETL: 114064126(MAN1B1)
ZAB: 102067672(MAN1B1)
FPG: 101914433(MAN1B1)
FCH: 102045806(MAN1B1)
CLV: 102083787(MAN1B1)
EGZ: 104124017(MAN1B1)
NNI: 104018375(MAN1B1)
ACUN: 113486627(MAN1B1)
TALA: 104359832(MAN1B1)
PADL: 103915501(MAN1B1)
ACHC: 115334793(MAN1B1)
AAM: 106494264(MAN1B1)
AROW: 112969739(MAN1B1)
NPD: 112955862(MAN1B1)
DNE: 112986766(MAN1B1)
ASN: 102387590(MAN1B1)
AMJ: 102567138(MAN1B1)
CPOO: 109313770(MAN1B1)
GGN: 109292847(MAN1B1)
PSS: 102455673(MAN1B1)
CMY: 102942408(MAN1B1)
CPIC: 101947106(MAN1B1)
TST: 117889404(MAN1B1)
CABI: 116823284(MAN1B1)
MRV: 120386610(MAN1B1)
ACS: 100562395(man1b1)
PVT: 110078803(MAN1B1)
SUND: 121937293(MAN1B1)
PBI: 103052908(MAN1B1)
PMUR: 107295058(MAN1B1)
TSR: 106542597(MAN1B1)
PGUT: 117676613(MAN1B1)
VKO: 123028264(MAN1B1)
PMUA: 114589499(MAN1B1)
ZVI: 118083881(MAN1B1)
GJA: 107123282(MAN1B1)
XLA: 447291(man1b1.L)
XTR: 100145194(man1b1)
NPR: 108797130(MAN1B1)
RTEM: 120914028(MAN1B1)
BBUF: 120977844(MAN1B1)
DRE: 556237(man1b1b) 562592(man1b1a)
IPU: 108255760(man1b1b) 108279088(man1b1a)
SMEO: 124380546(man1b1b) 124398172(man1b1a)
AMEX: 103022471(man1b1) 103024141
EEE: 113573453 113577930(man1b1)
LCO: 104923806 104930877(man1b1)
NCC: 104944586(man1b1)
CGOB: 115013303(man1b1) 115016675
ELY: 117251930(man1b1b) 117270132(man1b1a)
PLEP: 121944325 121959882(man1b1a)
SLUC: 116034794(man1b1a) 116050665(man1b1b)
ECRA: 117944690(man1b1b) 117959386(man1b1a)
PFLV: 114555183(man1b1) 114571584
GAT: 120830398(man1b1b) 120831937(man1b1a)
PPUG: 119226654(man1b1a)
CUD: 121509526 121524878(man1b1a)
MZE: 101475381(man1b1)
OAU: 116319660(man1b1a) 116332782(man1b1b)
OLA: 101156826(man1b1) 101168136
OML: 112137701(man1b1b) 112162853(man1b1a)
XMA: 102232900(man1b1) 102236792
GAF: 122819517(man1b1a) 122827851(man1b1b)
CTUL: 119771995(man1b1a) 119789284(man1b1b)
GMU: 124872048(man1b1a) 124878115(man1b1b)
NFU: 107375119
KMR: 108241416(man1b1a) 108245625(man1b1b)
NWH: 119424279(man1b1a)
POV: 109639093(man1b1) 109641232
SSEN: 122758578(man1b1a) 122769261
HHIP: 117767827(man1b1b) 117772246(man1b1a)
LCF: 108878392(man1b1) 108889011
SDU: 111221245 111226918(man1b1)
SLAL: 111647914(man1b1) 111650117
XGL: 120805701(man1b1b) 120806846(man1b1a)
HCQ: 109527092(man1b1)
BPEC: 110154656(man1b1) 110164288
OMY: 110509710(man1b1a) 110522854 110525472(man1b1b) 110535854
SFM: 108922690 108938629(man1b1)
PKI: 111854001 111857531(man1b1)
AANG: 118213031(man1b1a) 118237521(man1b1b)
LOC: 102690638(man1b1)
PSPA: 121306681
LCM: 102347754(MAN1B1)
CMK: 103180403
RTP: 109927301(man1b1)
BFO: 118420800
BBEL: 109466152
CIN: 100180827
SCLV: 120344397
APLC: 110984825
SKO: 100378677
DME: Dmel_CG11874(alpha-Man-Ib)
DER: 6555014
DSE: 6612651
DSI: Dsimw501_GD17996(Dsim_GD17996)
DAN: 6501495
DSR: 110177400
DPE: 6587772
DMN: 108155025
DGR: 6564284
DAZ: 108609054
DNV: 108656217
DHE: 111599442
DVI: 6632758
CCAT: 101453662
BOD: 106616058
MDE: 101889535
SCAC: 106095719
LCQ: 111690671
ACOZ: 120961362
AARA: 120895336
AALB: 109415549
CPII: 120420766
CNS: 116345876
AME: 413579
ACER: 108003139
ALAB: 122719410
BIM: 100746318
BBIF: 117217221
BVK: 117242501
BVAN: 117155078
BTER: 100651817
BPYO: 122575283
CCAL: 108622226
OBB: 114874226
MGEN: 117226426
NMEA: 116432770
CGIG: 122402115
SOC: 105204046
MPHA: 105832593
AEC: 105149600
ACEP: 105622350
PBAR: 105426911
VEM: 105568559
HST: 105184363
DQU: 106749327
CFO: 105248014
FEX: 115239828
LHU: 105669682
PGC: 109855950
OBO: 105284082
PCF: 106784288
PFUC: 122520610
VPS: 122627052
NVI: 100119267
CSOL: 105360197
TPRE: 106656965
MDL: 103575736
CGLO: 123267022
FAS: 105274150
DAM: 107044372
AGIF: 122856784
CCIN: 107269210
TCA: 659709
DPA: 109541778
SOY: 115890163
ATD: 109598739
CSET: 123318587
AGB: 108910434
LDC: 111502095
NVL: 108565052
APLN: 108740733
PPYR: 116173235
OTU: 111428171
BMOR: 101746534
BMAN: 114244560
MSEX: 115441177
BANY: 112049746
PMAC: 106717133
PPOT: 106104501
PXU: 106126459
PRAP: 110997563
ZCE: 119835478
HAW: 110377795
TNL: 113493937
OFU: 114361194
PXY: 105381786
API: 100158868
DNX: 107171166
AGS: 114130037
RMD: 113553488
BTAB: 109029927
CLEC: 106662400
HHAL: 106684496
NLU: 111052078
FOC: 113217995
ZNE: 110838192
CSEC: 111873921
FCD: 110856238
DMK: 116932879
PVM: 113818476
PJA: 122264293
PCLA: 123755455
PTRU: 123511212
HAZT: 108676336
EAF: 111713012
DSV: 119432855
RSAN: 119380999
RMP: 119187535
VDE: 111245990
VJA: 111259442
TUT: 107368943
DPTE: 113792907
DFR: 124493645
PTEP: 107453367
SDM: 118197594
CEL: CELE_T03G11.4(mans-3)
CBR: CBG_14624
BMY: BM_BM5524(Bma-mans-3)
TSP: Tsp_04164
PCAN: 112575110
BGT: 106053864
HRF: 124152763
HRJ: 124275180
CRG: 105334865
MYI: 110447565
PMAX: 117322084
MMER: 123554918
OBI: 106884360
OSN: 115227945
EGL: EGR_00365
EPA: 110237771
ATEN: 116294530
ADF: 107335017
AMIL: 114946959
SPIS: 111332673
DGT: 114519075
XEN: 124438093
HMG: 100198486
ATH: AT1G30000(MNS3)
ALY: 9326907
CRB: 17898338
RSZ: 108806417
THJ: 104812670
CPAP: 110807600
CIT: 102616435
PVY: 116114769
TCC: 18596509
EGR: 104440790
VRA: 106775885
VAR: 108343148
VUN: 114187820
CCAJ: 109789197
APRC: 113871446
CAM: 101515695
LJA: Lj6g3v1934090.1(Lj6g3v1934090.1)
ADU: 107468140
AIP: 107622562
LANG: 109345269
FVE: 101313190
RCN: 112164535
PPER: 18780386
PMUM: 103325119
PAVI: 110773985
PDUL: 117623865
PXB: 103951272
ZJU: 107413762
MNT: 21404524
CSV: 101216212
CMO: 103484372
BHJ: 120073818
MCHA: 111015717
RCU: 8264122
JCU: 105633984
HBR: 110651587
POP: 7472574
PEU: 105118639
PALZ: 118050747
JRE: 108988627
QLO: 115988411
TWL: 120015206
VVI: 100243430
VRI: 117923521
SLY: 101246787
SPEN: 107011307
SOT: 102583221
CANN: 107859093
NSY: 104249918
NTO: 104097810
NAU: 109216453
INI: 109192025
ITR: 116025989
SIND: 105175706
OEU: 111402240
EGT: 105962464
SSPL: 121758773
HAN: 110911812
ECAD: 122592643
LSV: 111880716
CCAV: 112526325
CSIN: 114301034
BVG: 104883805
SOE: 110794113
NNU: 104613507
MING: 122059792
TSS: 122652168
NCOL: 116247349
OSA: 4338088
DOSA: Os05t0209100-01(Os05g0209100)
OBR: 102699961
BDI: 100820902
ATS: 109759492
SBI: 8055739
ZMA: 100282405
SITA: 101773458
SVS: 117850070
PHAI: 112888039
DCT: 110116511
PEQ: 110022272
AOF: 109828813
ATR: 18435237
PPP: 112287912
VCN: VOLCADRAFT_119746(amd1)
APRO: F751_6268
MIS: MICPUN_112689(MANA)
SCE: YJR131W(MNS1)
ERC: Ecym_5170
KMX: KLMA_40509(MNS1)
NCS: NCAS_0J02160(NCAS0J02160)
NDI: NDAI_0J02870(NDAI0J02870)
TPF: TPHA_0L00320(TPHA0L00320)
TBL: TBLA_0B06140(TBLA0B06140)
TDL: TDEL_0D00600(TDEL0D00600)
KAF: KAFR_0E04290(KAFR0E04290)
PIC: PICST_84949(MNS1)
SPAA: SPAPADRAFT_57837(MNS1.1)
CAL: CAALFM_C103730CA(MNS1)
CTEN: CANTEDRAFT_110685(MNS1)
SLB: AWJ20_4611(MNS1)
NCR: NCU02778(gh47-1)
NTE: NEUTE1DRAFT74512(NEUTE1DRAFT_74512)
MGR: MGG_11408
SSCK: SPSK_05990
MAW: MAC_03073
MAJ: MAA_04109
CMT: CCM_08185
BFU: BCIN_01g06120(Bcmns1)
MBE: MBM_06132
ANG: ANI_1_1456164(An18g06220)
ALUC: AKAW2_31015S(MNS1)
ACHE: ACHE_11175A(MNS1)
APUU: APUU_41130S(MNS1)
ABE: ARB_01040
TVE: TRV_02790
PTE: PTT_19626
ZTR: MYCGRDRAFT_45066(MgAMN9)
SPO: SPAC2E1P5.01c(mns1)
CNE: CNE04550
CNB: CNBE4550
TASA: A1Q1_06697
ABP: AGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315)
ABV: AGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)
MRT: MRET_4039
SMIN: v1.2.009441.t1(symbB.v1.2.009441.t1) v1.2.009441.t2(symbB.v1.2.009441.t2) v1.2.025226.t1(symbB.v1.2.025226.t1) v1.2.032603.t1(symbB.v1.2.032603.t1)
FCY: FRACYDRAFT_261302(MNS2_1)
 » show all
Reference
  Authors
Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW
  Title
Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose  trimming step in mammalian Asn-linked oligosaccharide biosynthesis.
  Journal
J Biol Chem 274:21375-86 (1999)
DOI:10.1074/jbc.274.30.21375
  Sequence
[hsa:11253]
Reference
  Authors
Liebminger E, Huttner S, Vavra U, Fischl R, Schoberer J, Grass J, Blaukopf C, Seifert GJ, Altmann F, Mach L, Strasser R
  Title
Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana.
  Journal
Plant Cell 21:3850-67 (2009)
DOI:10.1105/tpc.109.072363
  Sequence
[ath:AT1G30000]
LinkDB

KEGG   ENZYME: 3.2.1.209
Entry
EC 3.2.1.209                Enzyme                                 
Name
endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase;
MAN1B1 (gene name);
MNS1 (gene name);
MNS3 (gene name)
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
Man9GlcNAc2-[protein]2-alpha-mannohydrolase (configuration-inverting)
Reaction(IUBMB)
Man9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + D-mannopyranose [RN:R12477]
Reaction(KEGG)
R12477(G);
(other) R06722(G)
Substrate
Man9GlcNAc2-[protein];
H2O [CPD:C00001]
Product
Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3);
D-mannopyranose [CPD:C00159]
Comment
The enzyme, located in the endoplasmic reticulum, primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 isomer 8A1,2,3B1,3 (the names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7]). The removal of the single mannosyl residue occurs in all eukaryotes as part of the processing of N-glycosylated proteins, and is absolutely essential for further elongation of the outer chain of properly-folded N-glycosylated proteins in yeast. In addition, the enzyme is involved in glycoprotein quality control at the ER quality control compartment (ERQC), helping to target misfolded glycoproteins for degradation. When present at very high concentrations in the ERQC, the enzyme can trim the carbohydrate chain further to Man(5-6)GlcNAc2.
History
EC 3.2.1.209 created 2019
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K23741  endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Genes
HSA11253(MAN1B1)
PTR473099(MAN1B1)
PPS100987343(MAN1B1)
GGO101134859(MAN1B1)
PON100432279(MAN1B1)
NLE100594686(MAN1B1)
MCC706918(MAN1B1)
MCF101867098(MAN1B1)
CSAB103239582(MAN1B1)
CATY105580607(MAN1B1)
PANU101010071
TGE112607962(MAN1B1)
RRO104669636(MAN1B1)
RBB108542887(MAN1B1)
TFN117099113(MAN1B1)
PTEH111553018(MAN1B1)
CJC100392624(MAN1B1)
SBQ101032054(MAN1B1)
CSYR103269499(MAN1B1)
MMUR105882249(MAN1B1)
OGA100964793(MAN1B1)
MMU227619(Man1b1)
MCAL110289782(Man1b1)
MPAH110317719(Man1b1)
RNO499751(Man1b1)
MCOC116089811(Man1b1)
MUN110556996(Man1b1)
CGE100756512
PLEU114692781(Man1b1)
NGI103732606 103741172(Man1b1)
HGL101724891(Man1b1)
CPOC100715996(Man1b1)
CCAN109697987(Man1b1)
DORD105995572(Man1b1)
DSP122099726(Man1b1)
OPI101527587(MAN1B1)
TUP102470543(MAN1B1)
CFA480667
VVP112911405(MAN1B1)
VLG121473188 121473189
AML100478118
UMR103675308(MAN1B1)
UAH113248412 113248447 113248587 113248656 113250061
UAR123796283 123796320(MAN1B1)
ELK111145781 111145782
LLV125083756 125083757
MPUF106003295(MAN1B1)
ORO101377733 101380090 101380385
EJU114203748(MAN1B1)
ZCA113934586 113934587
MLX118000541(MAN1B1)
FCA105261146 111557571
PYU121020233(MAN1B1) 121024619
PBG122474766 122475133
PTG102948947(MAN1B1)
PPAD109260237(MAN1B1)
AJU106989099(MAN1B1) 113597246
HHV120222776 120226452 120227604
BTA100336900(MAN1B1) 107131137(MAN1B1)
BOM102277240 102277814
BBUB102392446 102401107
CHX102182048(MAN1B1) 106501835
OAS105605821 105605822(MAN1B1)
ODA120852329(MAN1B1)
CCAD122442403 122442546(MAN1B1)
SSC100627465(MAN1B1)
CFR102513732(MAN1B1)
CBAI105073372(MAN1B1)
CDK105106772(MAN1B1) 105106783
VPC102542693(MAN1B1)
BACU103003282 103008754(MAN1B1)
LVE103086557(MAN1B1)
OOR101275150(MAN1B1)
DLE111176994(MAN1B1)
PCAD102987847 112065486
PSIU116755439(MAN1B1)
ECB100147103(MAN1B1) 100147680
EPZ103568009(MAN1B1)
EAI106845522 123289508
MYB102240083(MAN1B1)
MYD102775495(MAN1B1)
MMYO118655271(MAN1B1)
MLF102439240(MAN1B1)
MNA107536151(MAN1B1)
PKL118707019(MAN1B1)
HAI109381800(MAN1B1)
DRO112306395(MAN1B1)
SHON118980096(MAN1B1)
AJM119036097(MAN1B1)
PDIC114507914(MAN1B1) 118499400
PHAS123823586(MAN1B1)
MMF118629766
RFQ117032113(MAN1B1)
PALE102890593(MAN1B1)
PGIG120599824(MAN1B1)
PVP105298604(MAN1B1)
RAY107503110(MAN1B1)
MJV108406826(MAN1B1)
TOD119231168(MAN1B1)
SARA105943175(MAN1B1)
LAV100664627(MAN1B1) 100670902
TMU101354994
DNM101438190(MAN1B1)
MDO100022731(MAN1B1)
GAS123237192(MAN1B1)
SHR100918683(MAN1B1)
PCW110205295(MAN1B1)
OAA100080650(MAN1B1)
GGA417296(MAN1B1)
PCOC116234097(MAN1B1)
MGP100543997(MAN1B1)
CJO107321628(MAN1B1)
NMEL110407012(MAN1B1)
APLA101803362(MAN1B1)
ACYG106037118(MAN1B1)
AFUL116497078(MAN1B1)
TGU100223461(MAN1B1)
LSR110472180(MAN1B1)
SCAN103819092(MAN1B1)
PMOA120507335(MAN1B1)
OTC121336947(MAN1B1)
PRUF121357496(MAN1B1)
GFR102031555(MAN1B1)
FAB101816081(MAN1B1)
PHI102103624(MAN1B1)
PMAJ107212037(MAN1B1)
CCAE111936881(MAN1B1)
CCW104688195(UAP1L1)
ETL114064126(MAN1B1)
ZAB102067672(MAN1B1)
FPG101914433(MAN1B1)
FCH102045806(MAN1B1)
CLV102083787(MAN1B1)
EGZ104124017(MAN1B1)
NNI104018375(MAN1B1)
ACUN113486627(MAN1B1)
TALA104359832(MAN1B1)
PADL103915501(MAN1B1)
ACHC115334793(MAN1B1)
AAM106494264(MAN1B1)
AROW112969739(MAN1B1)
NPD112955862(MAN1B1)
DNE112986766(MAN1B1)
ASN102387590(MAN1B1)
AMJ102567138(MAN1B1)
CPOO109313770(MAN1B1)
GGN109292847(MAN1B1)
PSS102455673(MAN1B1)
CMY102942408(MAN1B1)
CPIC101947106(MAN1B1)
TST117889404(MAN1B1)
CABI116823284(MAN1B1)
MRV120386610(MAN1B1)
ACS100562395(man1b1)
PVT110078803(MAN1B1)
SUND121937293(MAN1B1)
PBI103052908(MAN1B1)
PMUR107295058(MAN1B1)
TSR106542597(MAN1B1)
PGUT117676613(MAN1B1)
VKO123028264(MAN1B1)
PMUA114589499(MAN1B1)
ZVI118083881(MAN1B1)
GJA107123282(MAN1B1)
XLA447291(man1b1.L)
XTR100145194(man1b1)
NPR108797130(MAN1B1)
RTEM120914028(MAN1B1)
BBUF120977844(MAN1B1)
BGAR122919491 122946129
DRE556237(man1b1b) 562592(man1b1a)
SRX107709694 107736907 107739703 107757969
SANH107661470 107681241 107690671 107692283
SGH107548773 107560236 107587425 107595674
CCAR109045768 109052759 109081650
CAUA113038798 113049299 113064119 113074139
IPU108255760(man1b1b) 108279088(man1b1a)
PHYP113535490 113536854
SMEO124380546(man1b1b) 124398172(man1b1a)
AMEX103022471(man1b1) 103024141
EEE113573453 113577930(man1b1)
TRU101072461 105418968
TNGGSTEN00004960G001 GSTEN00009295G001
LCO104923806 104930877(man1b1)
NCC104944586(man1b1)
CGOB115013303(man1b1) 115016675
ELY117251930(man1b1b) 117270132(man1b1a)
PLEP121944325 121959882(man1b1a)
SLUC116034794(man1b1a) 116050665(man1b1b)
ECRA117944690(man1b1b) 117959386(man1b1a)
PFLV114555183(man1b1) 114571584
GAT120830398(man1b1b) 120831937(man1b1a)
PPUG119226654(man1b1a)
MSAM119883771 119892352 119914215 119917792
CUD121509526 121524878(man1b1a)
MZE101475381(man1b1)
ONL100700979 112841850
OAU116319660(man1b1a) 116332782(man1b1b)
OLA101156826(man1b1) 101168136
OML112137701(man1b1b) 112162853(man1b1a)
XMA102232900(man1b1) 102236792
XCO114149976 114155129
XHE116724506 116729397
PRET103469620 103473953
PFOR103141937 103155541
PLAI106936359 106951546
PMEI106904614 106906201
GAF122819517(man1b1a) 122827851(man1b1b)
CVG107083730 107088025
CTUL119771995(man1b1a) 119789284(man1b1b)
GMU124872048(man1b1a) 124878115(man1b1b)
NFU107375119
KMR108241416(man1b1a) 108245625(man1b1b)
ALIM106529420 106535448 106535552
NWH119424279(man1b1a)
AOCE111578422 111582694
CSEM103389019 103397364
POV109639093(man1b1) 109641232
SSEN122758578(man1b1a) 122769261
HHIP117767827(man1b1b) 117772246(man1b1a)
LCF108878392(man1b1) 108889011
SDU111221245 111226918(man1b1)
SLAL111647914(man1b1) 111650117
XGL120805701(man1b1b) 120806846(man1b1a)
HCQ109527092(man1b1)
BPEC110154656(man1b1) 110164288
MALB109959672 109968690
SASA106563131 106579997 106585427
OTW112232797 112234451(man1b1a) 112263106
OMY110509710(man1b1a) 110522854 110525472(man1b1b) 110535854
OGO124016952(man1b1a) 124033369 124036136
ONE115111439 115139862 115147146
SALP111960863 111963948 111974854(man1b1) 111974855
SNH120021738(man1b1a) 120025509 120054209 120063123
ELS105014133 105014927
SFM108922690 108938629(man1b1)
PKI111854001 111857531(man1b1)
AANG118213031(man1b1a) 118237521(man1b1b)
LOC102690638(man1b1)
PSPA121306681
ARUT117397023 117962293
LCM102347754(MAN1B1)
CMK103180403
RTP109927301(man1b1)
BFO118420800
BBEL109466152
CIN100180827
SCLV120344397
SPU115919045 592701
APLC110984825
SKO100378677
DMEDmel_CG11874(alpha-Man-Ib)
DER6555014
DSE6612651
DSIDsimw501_GD17996(Dsim_GD17996)
DYADyak_GE10478
DAN6501495
DSR110177400
DPODpse_GA11250
DPE6587772
DMN108155025
DWI26529661 6649837
DGR6564284
DMODmoj_GI23409
DAZ108609054
DNV108656217
DHE111599442
DVI6632758
CCAT101453662
BOD106616058
MDE101889535
SCAC106095719
LCQ111690671
AGAAgaP_AGAP003884
ACOZ120961362
AARA120895336
AAG110681198 5567412
AALB109415549
CQUCpipJ_CPIJ003661
CPII120420766
CNS116345876
AME413579
ACER108003139
ALAB122719410
BIM100746318
BBIF117217221
BVK117242501
BVAN117155078
BTER100651817
BPYO122575283
CCAL108622226
OBB114874226
MGEN117226426
NMEA116432770
CGIG122402115
SOC105204046
MPHA105832593
AEC105149600
ACEP105622350
PBAR105426911
VEM105568559
HST105184363
DQU106749327
CFO105248014
FEX115239828
LHU105669682
PGC109855950
OBO105284082
PCF106784288
PFUC122520610
VPS122627052
NVI100119267
CSOL105360197
TPRE106656965
MDL103575736
CGLO123267022
FAS105274150
DAM107044372
AGIF122856784
CCIN107269210
TCA659709
DPA109541778
SOY115890163
ATD109598739
CSET123318587
AGB108910434
LDC111502095
NVL108565052
APLN108740733
PPYR116173235
OTU111428171
BMOR101746534
BMAN114244560
MSEX115441177
DPLKGM_206782
BANY112049746
PMAC106717133
PPOT106104501
PXU106126459
PRAP110997563
ZCE119835478
HAW110377795
TNL113493937
OFU114361194
PXY105381786
API100158868
DNX107171166
AGS114130037
RMD113553488
BTAB109029927
DCI103512631 103521396
CLEC106662400
HHAL106684496
NLU111052078
PHUPhum_PHUM530360
FOC113217995
ZNE110838192
CSEC111873921
FCD110856238
DPXDAPPUDRAFT_194674
DMK116932879
PVM113818476
PJA122264293
HAME121860164 121875029
PCLA123755455
PTRU123511212
HAZT108676336
EAF111713012
DSV119432855
RSAN119380999
RMP119187535
VDE111245990
VJA111259442
TUT107368943
DPTE113792907
DFR124493645
CSCU111620023 111631894
PTEP107453367
SDM118197594
CELCELE_T03G11.4(mans-3)
CBRCBG_14624
BMYBM_BM5524(Bma-mans-3)
LOALOAG_01198
NAINECAME_15419
TSPTsp_04164
HROHELRODRAFT_113976 HELRODRAFT_178867 HELRODRAFT_193110
LGILOTGIDRAFT_120396
PCAN112575110
BGT106053864
GAE121366616 121384018
HRF124152763
HRJ124275180
CRG105334865
MYI110447565
PMAX117322084
MMER123554918
OBI106884360
OSN115227945
LAK106161727 106176115
OVIT265_03386
EGLEGR_00365
NVE116607129 5501352
EPA110237771
ATEN116294530
ADF107335017
AMIL114946959
PDAM113665639 113673540
SPIS111332673
DGT114519075
XEN124438093
HMG100198486
TADTRIADDRAFT_53127
AQU100638524 100640055
ATHAT1G30000(MNS3)
ALY9326907
CRB17898338
CSAT104741591 104757343 104777030
EUSEUTSA_v10007084mg
BRP103835247 103840441
BNA106361602 106367368 106375950 106425028 111212331
BOE106295385 106328390
RSZ108806417
THJ104812670
CPAP110807600
CIT102616435
CICCICLE_v10014607mg
PVY116114769
MINC123192943 123218754
TCC18596509
GRA105768906 105772769
GHI107905885 107958416 121230865
GAB108453420 108459983
DZI111274860 111280996
EGR104440790
GMX100789211 100806551
GSJ114375271 114387749
PVUPHAVU_006G164400g
VRA106775885
VAR108343148
VUN114187820
CCAJ109789197
APRC113871446
MTRMTR_2g019520
CAM101515695
LJALj6g3v1934090.1(Lj6g3v1934090.1)
ADU107468140
AIP107622562
AHF112714314 112785361
LANG109345269
FVE101313190
RCN112164535
PPER18780386
PMUM103325119
PAVI110773985
PDUL117623865
MDM103444000 103446189
PXB103951272
ZJU107413762
MNT21404524
CSV101216212
CMO103484372
BHJ120073818
MCHA111015717
CMAX111478371 111496964
CMOS111433252 111433756
CPEP111781525 111804180
RCU8264122
JCU105633984
HBR110651587
MESC110601605 110605198
POP7472574
PEU105118639
PALZ118050747
JRE108988627
QSU111984426 112002631 112014039 112015529 112021377
QLO115988411
TWL120015206
VVI100243430
VRI117923521
SLY101246787
SPEN107011307
SOT102583221
CANN107859093
NTA107782104 107783782
NSY104249918
NTO104097810
NAU109216453
INI109192025
ITR116025989
SIND105175706
OEU111402240
EGT105962464
SSPL121758773
HAN110911812
ECAD122592643
LSV111880716
CCAV112526325
DCR108206430 108209987
CSIN114301034
BVG104883805
SOE110794113
CQI110698318 110728570
NNU104613507
MING122059792
TSS122652168
PSOM113289725 113299707
NCOL116247349
OSA4338088
DOSAOs05t0209100-01(Os05g0209100)
OBR102699961
BDI100820902
ATS109759492
TDC119329569 119368635
TAES123041929 123116155 123180779
SBI8055739
ZMA100282405
SITA101773458
SVS117850070
PVIR120663968 120697123
PHAI112888039
PDA103702402 103703024
EGU105040640 105048159
MUS103987808 104000849
DCT110116511
PEQ110022272
AOF109828813
ATR18435237
SMOSELMODRAFT_168485 SELMODRAFT_176646
PPP112287912
CRECHLRE_07g336600v5
VCNVOLCADRAFT_119746(amd1)
MNGMNEG_2789 MNEG_9467
CSLCOCSUDRAFT_48568
CVRCHLNCDRAFT_133855
APROF751_6268
BPGBathy13g00050
MISMICPUN_112689(MANA)
MPPMICPUCDRAFT_15822
CMECYME_CMF045C
CCPCHC_T00008598001 CHC_T00009079001
SCEYJR131W(MNS1)
AGOAGOS_AER165W
ERCEcym_5170
KLAKLLA0_B04356g
KMXKLMA_40509(MNS1)
LTHKLTH0D17908g
VPOKpol_1028p79
ZROZYRO0B08360g
CGRCAGL0M00528g
NCSNCAS_0J02160(NCAS0J02160)
NDINDAI_0J02870(NDAI0J02870)
TPFTPHA_0L00320(TPHA0L00320)
TBLTBLA_0B06140(TBLA0B06140)
TDLTDEL_0D00600(TDEL0D00600)
TGBHG536_0C06190
KAFKAFR_0E04290(KAFR0E04290)
ZMKHG535_0E01530
PPAPAS_chr2-1_0753
DHADEHA2D09218g
PICPICST_84949(MNS1)
PGUPGUG_04716
SPAASPAPADRAFT_57837(MNS1.1)
LELLELG_01334
CALCAALFM_C103730CA(MNS1)
CTPCTRG_04351
COTCORT_0B11480
CDUCD36_03470
CTENCANTEDRAFT_110685(MNS1)
YLIYALI0D17424g
CLUCLUG_04485
CLUSA9F13_04g00121
CAURCJI97_003303
SLBAWJ20_4611(MNS1)
PKZC5L36_0C09850
BNNFOA43_002911
BBRXBRETT_005208
NCRNCU02778(gh47-1)
NTENEUTE1DRAFT74512(NEUTE1DRAFT_74512)
SMPSMAC_04842
PANPODANSg09987
TTTTHITE_2057638 THITE_2085147
MTMMYCTH_2294863
CTHRCTHT_0054060
MGRMGG_11408
TMNUCRPA7_1844 UCRPA7_7249
SSCKSPSK_05990
FGRFGSG_00612
FPUFPSE_04518 FPSE_04589
FVRFVEG_01076
FOXFOXG_00435
NHENECHADRAFT_105814
TRETRIREDRAFT_2662
TRRM419DRAFT_6341
MAWMAC_03073
MAJMAA_04109
CMTCCM_08185
PLJVFPFJ_03711
VALVDBG_06023
VDAVDAG_03184
CFJCFIO01_01386 CFIO01_11192
SAPOSAPIO_CDS3217
ELAUCREL1_10905 UCREL1_115
PFYPFICI_00615
SSLSS1G_04513
BFUBCIN_01g06120(Bcmns1)
MBEMBM_06132
PSCOLY89DRAFT_295383
GLZGLAREA_11212
ANIAN0551.2 AN5748.2
AFMAFUA_6G06790
ACTACLA_088570
NFINFIA_052440
AORAO090003000057
ANGANI_1_1456164(An18g06220)
AFVAFLA_001640
ALUCAKAW2_31015S(MNS1)
ACHEACHE_11175A(MNS1)
APUUAPUU_41130S(MNS1)
PCSPc14g01760
PDPPDIP_68610
TMFPMAA_093860
TRGTRUGW13939_09818
CIMCIMG_07325
CPWCPC735_001190
UREUREG_07868
PBLPAAG_00769
PBNPADG_04061
ABEARB_01040
TVETRV_02790
AJEHCAG_04182 HCAG_08449
BGHBDBG_01802 BDBG_03796
PNOSNOG_03652
PTEPTT_19626
BZECOCCADRAFT_2121
BSCCOCSADRAFT_38869
BORCOCMIDRAFT_8408
AALTCC77DRAFT_988245
ZTRMYCGRDRAFT_45066(MgAMN9)
PFJMYCFIDRAFT_204581 MYCFIDRAFT_88410
BCOMBAUCODRAFT_80378
NPAUCRNP2_2127
TMLGSTUM_00001932001
SPOSPAC2E1P5.01c(mns1)
CNECNE04550
CNBCNBE4550
CGICGB_E6120W
TMSTREMEDRAFT_33664
TASAA1Q1_06697
PPLPOSPLDRAFT_111281 POSPLDRAFT_130143 POSPLDRAFT_49494 POSPLDRAFT_99932
TVSTRAVEDRAFT_123722 TRAVEDRAFT_54985
DSQDICSQDRAFT_131718
PCOPHACADRAFT_248627 PHACADRAFT_28202
SHSSTEHIDRAFT_63527 STEHIDRAFT_68181
HIRHETIRDRAFT_30389 HETIRDRAFT_64121
PSQPUNSTDRAFT_113060 PUNSTDRAFT_140588
ADLAURDEDRAFT_110124 AURDEDRAFT_112600
FMEFOMMEDRAFT_143158
GTRGLOTRDRAFT_105477 GLOTRDRAFT_134936
LBCLACBIDRAFT_228999 LACBIDRAFT_255188 LACBIDRAFT_305436
MPRMPER_07540 MPER_09462 MPER_10851 MPER_11974
MRRMoror_11662 Moror_1765 Moror_9085
CCICC1G_00625 CC1G_12305
SCMSCHCODRAFT_50368
ABPAGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315)
ABVAGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)
CPUTCONPUDRAFT_96550
SLASERLADRAFT_480395
WSEWALSEDRAFT_35272
WICJ056_001603
UMAUMAG_02227
PFPPFL1_05588
MRTMRET_4039
MSYMMSY001_0287
PGRPGTG_14908
MLRMELLADRAFT_32725
MBRMONBRDRAFT_13888
SREPTSG_01891
SMINv1.2.009441.t1(symbB.v1.2.009441.t1) v1.2.009441.t2(symbB.v1.2.009441.t2) v1.2.025226.t1(symbB.v1.2.025226.t1) v1.2.032603.t1(symbB.v1.2.032603.t1)
FCYFRACYDRAFT_261302(MNS2_1)
TPSTHAPSDRAFT_34968
NGDNGA_2009400(MAN1) NGA_2024900
AAFAURANDRAFT_10610 AURANDRAFT_71340
PIFPITG_01855 PITG_10149
PSOJPHYSODRAFT_313654 PHYSODRAFT_557352
SPARSPRG_01621 SPRG_08812
EHXEMIHUDRAFT_455715 EMIHUDRAFT_464075 EMIHUDRAFT_64898 EMIHUDRAFT_76998
GTTGUITHDRAFT_75084
TVATVAG_104870 TVAG_245880 TVAG_379870 TVAG_382860 TVAG_402460 TVAG_447400
 » show all
Reference
1  [PMID:3049586]
  Authors
Jelinek-Kelly S, Herscovics A
  Title
Glycoprotein biosynthesis in Saccharomyces cerevisiae. Purification of the alpha-mannosidase which removes one specific mannose residue from Man9GlcNAc.
  Journal
J Biol Chem 263:14757-63 (1988)
Reference
2  [PMID:1822240]
  Authors
Ziegler FD, Trimble RB
  Title
Glycoprotein biosynthesis in yeast: purification and characterization of the endoplasmic reticulum Man9 processing alpha-mannosidase.
  Journal
Glycobiology 1:605-14 (1991)
DOI:10.1093/glycob/1.6.605
Reference
3  [PMID:10409699]
  Authors
Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW
  Title
Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose  trimming step in mammalian Asn-linked oligosaccharide biosynthesis.
  Journal
J Biol Chem 274:21375-86 (1999)
DOI:10.1074/jbc.274.30.21375
  Sequence
[hsa:11253]
Reference
4  [PMID:12090241]
  Authors
Herscovics A, Romero PA, Tremblay LO
  Title
The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported.
  Journal
Glycobiology 12:14G-15G (2002)
Reference
5  [PMID:18003979]
  Authors
Avezov E, Frenkel Z, Ehrlich M, Herscovics A, Lederkremer GZ
  Title
Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation.
  Journal
Mol Biol Cell 19:216-25 (2008)
DOI:10.1091/mbc.e07-05-0505
  Sequence
[hsa:11253]
Reference
6  [PMID:20023195]
  Authors
Liebminger E, Huttner S, Vavra U, Fischl R, Schoberer J, Grass J, Blaukopf C, Seifert GJ, Altmann F, Mach L, Strasser R
  Title
Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana.
  Journal
Plant Cell 21:3850-67 (2009)
DOI:10.1105/tpc.109.072363
  Sequence
[ath:AT1G30000]
Reference
7  [PMID:19181540]
  Authors
Prien JM, Ashline DJ, Lapadula AJ, Zhang H, Reinhold VN
  Title
The high mannose glycans from bovine ribonuclease B isomer characterization by ion trap MS.
  Journal
J Am Soc Mass Spectrom 20:539-56 (2009)
DOI:10.1016/j.jasms.2008.11.012
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.209
IUBMB Enzyme Nomenclature: 3.2.1.209
ExPASy - ENZYME nomenclature database: 3.2.1.209
BRENDA, the Enzyme Database: 3.2.1.209
LinkDB

KEGG   REACTION: R06722
Entry
R06722                      Reaction                               
Name
alpha 1,2-mannosyloligosaccharide alpha-D-mannohydrolase
Definition
H2O + G00011 <=> D-Mannose + G10694
Equation
Enzyme
Pathway
rn00510  N-Glycan biosynthesis
rn00513  Various types of N-glycan biosynthesis
rn01100  Metabolic pathways
Module
M00073  N-glycan precursor trimming
M00074  N-glycan biosynthesis, high-mannose type
Orthology
K23741  endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
Other DBs
RHEA: 56007
LinkDB

DBGET integrated database retrieval system