KEGG   ORTHOLOGY: K24336
Entry
K24336                      KO                                     
Symbol
elg1, pglF, lea1
Name
UDP-N-acetylglucosamine 4,6-dehydratase [EC:4.2.1.115 4.2.1.135]
Pathway
map00541  Biosynthesis of various nucleotide sugars
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Module
M01008  CMP-8eLeg5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-8eLeg5Ac7Ac
M01012  CMP-Leg5Ac7Ala biosynthesis, UDP-GlcNAc => CMP-Leg5Ac7Ala
Reaction
R09697  UDP-N-acetylglucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose-forming)
R10266  UDP-N-acetyl-alpha-D-glucosamine hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 Biosynthesis of various nucleotide sugars
    K24336  elg1, pglF, lea1; UDP-N-acetylglucosamine 4,6-dehydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.115  UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
     K24336  elg1, pglF, lea1; UDP-N-acetylglucosamine 4,6-dehydratase
    4.2.1.135  UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
     K24336  elg1, pglF, lea1; UDP-N-acetylglucosamine 4,6-dehydratase
Other DBs
COG: COG0451
Genes
ECAN: CWI88_07845
CIR: C2U53_26235
CENS: P2W74_17960
KCA: AAEY27_08215
SCOL: KFZ77_12725
EPI: Q3V30_07400
PHAG: PZ638_20285
PXH: ACE2AL_19905
VCZ: VAB027_3605
VVU: VV1_0811
VVY: VV0309
VPA: VP0197
VTA: A3015
VAQ: FIV01_00025(pglF1)
VFI: VF_0140
MARJ: MARI_04430
SPL: Spea_0046
SPSW: Sps_03744
SKH: STH12_02028(pglF_2)
PSAZ: PA25_03940
AVR: B565_2795
ACAV: VI35_13890
OCE: GU3_13395
SULR: B649_08575
HCJ: HCR_18750
AG: ADJ19193(lea1) ADJ19205(elg1) AJR19446
 » show all
Reference
  Authors
Perepelov AV, Liu B, Senchenkova SN, Shashkov AS, Shevelev SD, Feng L, Wang L, Knirel YA
  Title
Structure of the O-antigen and characterization of the O-antigen gene cluster of Escherichia coli O108 containing 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonic (8-epilegionaminic) acid.
  Journal
Biochemistry (Mosc) 75:19-24 (2010)
DOI:10.1134/s0006297910010037
Reference
  Authors
DebRoy C, Fratamico PM, Yan X, Baranzoni G, Liu Y, Needleman DS, Tebbs R, O'Connell CD, Allred A, Swimley M, Mwangi M, Kapur V, Raygoza Garay JA, Roberts EL, Katani R
  Title
Comparison of O-Antigen Gene Clusters of All O-Serogroups of Escherichia coli and Proposal for Adopting a New Nomenclature for O-Typing.
  Journal
PLoS One 11:e0147434 (2016)
DOI:10.1371/journal.pone.0147434
  Sequence
Reference
  Authors
Li X, Perepelov AV, Wang Q, Senchenkova SN, Liu B, Shevelev SD, Guo X, Shashkov AS, Chen W, Wang L, Knirel YA
  Title
Structural and genetic characterization of the O-antigen of Escherichia coli O161 containing a derivative of a higher acidic diamino sugar, legionaminic acid.
  Journal
Carbohydr Res 345:1581-7 (2010)
DOI:10.1016/j.carres.2010.04.008
  Sequence
Reference
  Authors
McDonald ND, DeMeester KE, Lewis AL, Grimes CL, Boyd EF
  Title
Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide.
  Journal
J Biol Chem 293:19113-19126 (2018)
DOI:10.1074/jbc.RA118.004966
  Sequence
[vvu:VV1_0811]
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