KEGG ORTHOLOGY: K25228

ORTHOLOGY: K25228

Entry

K25228                      KO

Symbol

APC15, ANAPC15

Name

anaphase-promoting complex subunit 15

Pathway

map04110

Cell cycle

map04114

Oocyte meiosis

map04120

Ubiquitin mediated proteolysis

map04914

Progesterone-mediated oocyte maturation

map05166

Human T-cell leukemia virus 1 infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
   04114 Oocyte meiosis
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
   03036 Chromosome and associated proteins
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   APC/C
    Other subunits
     K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Sister chromatid separation proteins
   APC/C complex
    K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15

Genes

HSA:	25906(ANAPC15)

PTR:	101058140(ANAPC15) 101059660

PPS:	100967890(ANAPC15) 100989277

GGO:	101137381 101150039(ANAPC15)

PON:	100440736(ANAPC15) 100441788

PPYG:

129008182

NLE:	100591565(ANAPC15)

HMH:	116476630(ANAPC15) 116810477

SSYN:

129475255 129484580(ANAPC15)

MCC:	718333(ANAPC15)

MCF:	102133437(ANAPC15)

MTHB:

126932969 126935270

MNI:	105468690(ANAPC15)

CSAB:

103247989(ANAPC15)

CATY:

105578802(ANAPC15)

PANU:

100999272(ANAPC15)

TGE:	112606440(ANAPC15)

MLEU:

105549239(ANAPC15)

RRO:	104665156(ANAPC15)

RBB:	108543744(ANAPC15)

TFN:	117081484(ANAPC15)

PTEH:

111540902(ANAPC15)

CANG:

105522308(ANAPC15)

CJC:	100412175(ANAPC15)

SBQ:	101053798(ANAPC15)

CIMI:

108290120 108290174 108307522(ANAPC15) 108314143

ANAN:

105704648 105709587 105720384

CSYR:

103268498(ANAPC15)

MMUR:

105860330(ANAPC15)

LCAT:

123641082(ANAPC15)

ERUF:

138385184(ANAPC15)

PCOQ:

105811495(ANAPC15)

OGA:	100944335(ANAPC15)

MMU:	75430(Anapc15)

MCAL:

110297469(Anapc15)

MPAH:

110316534(Anapc15) 110338331

RNO:	293155(Anapc15)

MCOC:

116102686(Anapc15)

ANU:	117704986(Anapc15)

ASYL:

127664541(Anapc15)

MUN:	110556831 110557542(Anapc15)

CGE:

100752128

MAUA:

101842616(Anapc15)

PROB:

127227997(Anapc15)

PLEU:

114706596(Anapc15)

PMAV:

102912938(Anapc15)

MORG:

121463686(Anapc15)

MFOT:

126488837

AAMP:

119808187(Anapc15)

CNL:	130879203(Anapc15)

NGI:	103750807(Anapc15)

HGL:	101699532(Anapc15)

CPOC:

100726252(Anapc15)

CCAN:

109693011(Anapc15)

DORD:

105983962(Anapc15)

DSP:	122114345(Anapc15)

DMER:

138836441(Anapc15)

PLOP:

125361197(Anapc15)

NCAR:

124958183

MMMA:

107135556(Anapc15)

ITI:	101965526(Anapc15)

OCU:	100338921 100340312 100342681 127483727

OPI:	101521330(ANAPC15) 101521938

OCZ:	121145243(ANAPC15)

TUP:	102500626(ANAPC15)

GVR:	103585876(ANAPC15)

CFA:	476817(ANAPC15)

CLUD:

112667477(ANAPC15) 118352615

VVP:	112928693(ANAPC15)

VLG:	121476289(ANAPC15)

NPO:	129506683(ANAPC15)

AML:	100473315(ANAPC15)

UMR:	103678018(ANAPC15)

UAH:	113269268(ANAPC15)

UAR:	123782551(ANAPC15)

ELK:

111159437

LLV:

125078306

MPUF:

101692406(ANAPC15)

MNP:	132023911(ANAPC15)

MLK:	131807969(ANAPC15)

NVS:	122912635(ANAPC15)

ORO:	101364831(ANAPC15)

EJU:	114218644(ANAPC15)

ZCA:	113915118(ANAPC15)

MLX:	118003900(ANAPC15)

MANO:

123857467(ANAPC15)

NSU:	110593445(ANAPC15)

LWW:	102729680(ANAPC15)

FCA:	101084987(ANAPC15)

PYU:	121039226(ANAPC15)

PCOO:

112865215(ANAPC15)

PBG:	122483394(ANAPC15)

PVIV:

125177096(ANAPC15)

LRUF:

124505329

LGF:	123601227(ANAPC15)

AJU:

106970937

PTG:	102971875(ANAPC15)

PPAD:

109267132(ANAPC15)

PUC:

125937242

PLEZ:

122199363(ANAPC15)

HHV:	120245117(ANAPC15)

CCRU:

144230022(ANAPC15)

BTA:	101905242 505356(ANAPC15)

BOM:	102275413(ANAPC15) 102276528

BIU:	109563481 109569221(ANAPC15)

BBUB:

102392555(ANAPC15)

BKE:	129629165(ANAPC15)

BBIS:

104995560(ANAPC15)

CHX:	102172283(ANAPC15)

OAS:	101120520(ANAPC15) 101120997 114113771

BTAX:

128048135 128060036(ANAPC15)

CSUM:

138092904(ANAPC15)

ODA:	120876725(ANAPC15)

CCAD:

122449551(ANAPC15)

MREE:

136176069(ANAPC15)

OVR:	110131316(ANAPC15)

MBEZ:

129554627(ANAPC15)

SSC:	100520682(ANAPC15)

CFR:	102509409(ANAPC15)

CBAI:

105083284(ANAPC15)

CDK:	105096682(ANAPC15)

VPC:	102535389(ANAPC15)

BACU:

102997861(ANAPC15)

BMUS:

118898717(ANAPC15)

LVE:	103078964(ANAPC15)

OOR:	101282393 101289591(ANAPC15)

LALB:

132526087(ANAPC15)

GMF:	115839479(ANAPC15)

DDP:	132429707(ANAPC15)

DLE:	111170573(ANAPC15)

PCAD:

102977723 102993978(ANAPC15)

PSIU:

116755911 116757470(ANAPC15)

PPHC:

136127177(ANAPC15)

NASI:

112390776(ANAPC15)

ECB:	100066106(ANAPC15)

EPZ:	103549334(ANAPC15)

EAI:	106831654(ANAPC15)

MYB:	102249055 102254780(ANAPC15)

MYD:	102753269 102756465(ANAPC15)

MMYO:

118664707(ANAPC15)

MLF:	102419523(ANAPC15) 102439680

MDT:	132240867(ANAPC15)

MYUM:

139017307(ANAPC15)

PKL:	118713450(ANAPC15)

EFUS:

103293565(ANAPC15) 129148615

MNA:	107541142(ANAPC15)

DRO:	112315981(ANAPC15)

SHON:

119002616(ANAPC15)

AJM:	119042142(ANAPC15)

PDIC:

114498645(ANAPC15)

PHAS:

123805403(ANAPC15)

MMF:	118627612(ANAPC15) 118638149

PPAM:

129072716(ANAPC15)

HAI:	109372421(ANAPC15)

RFQ:	117030242(ANAPC15)

PALE:

102890991(ANAPC15)

PGIG:

120590295(ANAPC15)

PVP:	105303659(ANAPC15)

RAY:	107517377(ANAPC15)

MJV:	108405092(ANAPC15)

TOD:	119255597(ANAPC15)

SARA:

101547183(ANAPC15)

SFUM:

130025096(ANAPC15)

SETR:

126008581 126018337(ANAPC15)

LAV:	100674848(ANAPC15)

TMU:

101350579

ETF:	101646928 101656706(ANAPC15) 101658016 101658135 101663033

DNM:	101416412(ANAPC15)

MDO:	100013043(ANAPC15)

GAS:	123240490(ANAPC15)

SHR:	100930602(ANAPC15)

AFZ:

127555258

PCW:	110195211(ANAPC15)

TVP:	118835332(ANAPC15)

PBRV:

138143451(ANAPC15)

MLAO:

141508577(ANAPC15)

OAA:	114808075(ANAPC15)

TACU:

119949093(ANAPC15)

GGA:	100857405(ANAPC15)

PCOC:

116233916(ANAPC15)

MGP:	100548682(ANAPC15)

CJO:	107308546(ANAPC15)

TPAI:

128074980(ANAPC15)

LMUT:

125696338(ANAPC15)

NMEL:

110391664(ANAPC15)

AACU:

137857257(ANAPC15)

OJA:	118159271(ANAPC15)

AFUL:

116493576(ANAPC15)

TGU:	100232520(ANAPC15)

LSR:	110473114(ANAPC15)

SCAN:

103820694(ANAPC15)

PMOA:

120500069(ANAPC15)

OTC:	121345419(ANAPC15)

PRUF:

121354727(ANAPC15)

ATRC:

139593025(ANAPC15)

GFR:	102032636(ANAPC15)

FAB:	101814781(ANAPC15)

OMA:	130249479(ANAPC15)

PHI:	102104038 102105493(ANAPC15)

PMAJ:

107199792 107212183(ANAPC15)

CCAE:

111943507

CCW:	104687165(ANAPC15)

CBRC:

103613975(ANAPC15)

ACOE:

138114286(ANAPC15)

ETL:	114059634(ANAPC15)

ZAB:	102071768(ANAPC15)

ZLE:	135454107(ANAPC15)

ACHL:

103803990(ANAPC15)

SVG:	106856627(ANAPC15)

MMEA:

130579880(ANAPC15)

HRT:	120747895(ANAPC15) 120749528

SATI:

136375230(ANAPC15)

CFAI:

136305730(ANAPC15) 136305819

CCIC:

134058220(ANAPC15)

FPG:	101912834(ANAPC15)

FCH:	102057326(ANAPC15)

SHAB:

115603635(ANAPC15)

ANOC:

141966594(ANAPC15)

SURA:

141939924(ANAPC15)

TALA:

116965800(ANAPC15)

ACHC:

115353525(ANAPC15)

HLE:	104837564(ANAPC15)

AGEN:

126048412

HHAR:

128153376(ANAPC15)

BBUT:

142041465(ANAPC15)

DPUB:

104298357(ANAPC15)

PPUS:

135175810(ANAPC15)

PARX:

142061814(ANAPC15)

CBOR:

142077996(ANAPC15)

CBOY:

140646684(ANAPC15)

MAME:

142404483(ANAPC15)

CLV:	102097033(ANAPC15)

CNIC:

135988931(ANAPC15)

PLET:

104625554(ANAPC15)

CUCA:

104060257(ANAPC15)

GAME:

129198389(ANAPC15) 129201312

RTD:	128914241(ANAPC15)

CRID:

134514083(ANAPC15)

LMIC:

141737982(ANAPC15)

NARQ:

141467078(ANAPC15)

AAM:

106483918

AROW:

112961379(ANAPC15)

DNE:	112993980(ANAPC15)

ASN:	102387073(ANAPC15)

AMJ:	106737697(ANAPC15)

GGN:	109288732(ANAPC15)

PSS:	102448757(ANAPC15)

CIZ:	142024468(ANAPC15)

CMY:	102944182(ANAPC15)

CCAY:

125631553(ANAPC15)

LKP:	140907488(ANAPC15)

NDS:	141981036(ANAPC15)

DCC:	119861604(ANAPC15)

CPIC:

101949565(ANAPC15)

TST:	117871343(ANAPC15)

EOB:	135887760(ANAPC15)

CABI:

116832125(ANAPC15)

MRV:	120395278(ANAPC15)

ACS:	100565539(anapc15)

ASAO:

132772328(ANAPC15)

PVT:	110078165(ANAPC15)

SUND:

121925685(ANAPC15)

PBI:	103051341(ANAPC15)

PMUR:

107297404 107299756

CTIG:

120320221(ANAPC15)

TSR:	106552178(ANAPC15)

PGUT:

117676434(ANAPC15)

PCAE:

139317169(ANAPC15)

APRI:

131199493(ANAPC15)

PTEX:

113451115(ANAPC15)

VKO:	123017306(ANAPC15)

PMUA:

114595502(ANAPC15)

PRAF:

128412440(ANAPC15)

ZVI:	118085767(ANAPC15)

HCG:	128352482(ANAPC15)

GJA:	107115795(ANAPC15)

STOW:

125425536 125431883(ANAPC15)

EMC:	129326005(ANAPC15)

XLA:	432025(anapc15.S) 734832(anapc15.L)

XTR:	100135123(anapc15)

NPR:	108802495(ANAPC15)

RTEM:

120941699(ANAPC15)

BBUF:

121000794(ANAPC15)

BGAR:

122938278(ANAPC15)

DTC:	141054046(ANAPC15)

HSQ:	130272840(ANAPC15)

PCOB:

134928647(ANAPC15)

PWL:	138261671(ANAPC15)

MUO:	115465925(ANAPC15)

GSH:	117354417(ANAPC15)

DRE:	751740(anapc15)

SRX:	107738282(anapc15)

SANH:

107679448 107701603

SGH:	107557664 107568471

CCAR:

122139847(anapc15)

CAUA:

113114684(anapc15)

CGIB:

127972308

PTET:

122332942(anapc15)

LROH:

127177639(anapc15)

GRF:	141284539(anapc15)

OMC:	131554351(anapc15)

PPRM:

120478258(anapc15)

RKG:	130085498(anapc15)

MAMB:

125248112(anapc15)

CIDE:

127494932

CERY:

137004461(anapc15)

MASI:

127421846

TROS:

130565263(anapc15)

TDW:	130428527(anapc15)

MANU:

129438762 141363176

PDAB:

135770640(anapc15)

IPU:

108277659

PHYP:

113544640(anapc15)

SMEO:

124394974(anapc15)

TFD:	113637827(anapc15)

TVC:	132858134(anapc15)

CGAR:

128532763(anapc15)

TRN:	134334748(anapc15)

AMEX:

103026613(anapc15)

CMAO:

118802300(anapc15)

EEE:	113581589(anapc15)

CHAR:

105913025(anapc15)

SPIL:

134100206(anapc15)

ASAD:

121683355(anapc15)

TRU:	101061954(anapc15)

TFS:	130535378(anapc15)

TNG:	GSTEN00005116G001

LCO:	104920127(anapc15)

NCC:	104968279(anapc15)

TBEN:

117470359(anapc15)

CGOB:

115017522(anapc15)

PGEO:

117457416(anapc15)

GACU:

117534910(anapc15)

EMAC:

134879794(anapc15)

ELY:	117259389(anapc15)

EFO:	125889334(anapc15)

PLEP:

121943334(anapc15)

SLUC:

116045600(anapc15)

ECRA:

117942433(anapc15)

ESP:	116687079(anapc15)

PFLV:

114552613(anapc15)

GAT:	120818188(anapc15)

PPUG:

119222367(anapc15)

AFB:	129092856(anapc15)

CLUM:

117741471(anapc15)

PSWI:

130211385(anapc15)

CANA:

137790734(anapc15)

CVE:	137877296(anapc15)

MSAM:

119883578(anapc15)

SCHU:

122879195(anapc15)

EARM:

139285012(anapc15)

CUD:	121515338(anapc15)

SPUL:

138597094(anapc15)

LMIX:

132980307(anapc15)

HTC:	141797591(anapc15)

ALAT:

119033464(anapc15)

ASTR:

137596314(anapc15)

PKLU:

139200590(anapc15)

MZE:	101484616(anapc15)

ONL:	100711215(anapc15)

OAU:	116330384(anapc15)

OLA:	101171686(anapc15)

OML:	112149906(anapc15)

CSAI:

133441675(anapc15)

XMA:	102222102(anapc15)

XCO:	114162013(anapc15)

XHE:	116707772(anapc15)

PRET:

103474472(anapc15)

PFOR:

103146278(anapc15)

PLAI:

106939945(anapc15)

PMEI:

106927837(anapc15)

GAF:	122832946(anapc15)

PPRL:

129358731(anapc15)

CVG:	107091934(anapc15)

CTUL:

119771753(anapc15)

GMU:	124883610(anapc15)

NFU:	107380467(anapc15)

KMR:	108228375(anapc15)

ALIM:

106517264(anapc15)

NWH:	119411112(anapc15) 119414532

AOCE:

111570855(anapc15)

EJA:	138196910(anapc15)

BFRE:

138616755(anapc15)

MCEP:

125013391(anapc15)

CSEM:

103378550(anapc15)

POV:	109634552(anapc15)

SSEN:

122773176(anapc15)

SSOE:

131462193(anapc15)

HHIP:

117772748(anapc15)

HSP:	118105919(anapc15)

PPLT:

128439792(anapc15)

SMAU:

118299702(anapc15)

LCF:

108886610

SDU:	111224132(anapc15)

SLAL:

111655307(anapc15)

XGL:	120791767(anapc15)

HCQ:	109525468(anapc15)

SSCV:

125972762(anapc15)

SBIA:

133505365(anapc15)

PEE:	133405432(anapc15)

PTAO:

133482584(anapc15)

BPEC:

110174330(anapc15)

ENY:	140375440(anapc15)

BSPL:

114867965(anapc15)

SJO:	128361011(anapc15)

SSCO:

133980380(anapc15)

TTY:	137185962(anapc15)

GMH:	115561633(anapc15)

SASA:

100286580(hs020) 106613224(anapc15)

STRU:

115163715 115206593(anapc15)

OTW:	112247994 112267300

OMY:	100301688(hs020) 110503187(anapc15)

OGO:	123993881 124006344

ONE:	115122286 115141999

OKI:	109879386 109909284(anapc15)

OKE:	118389558(anapc15) 118397585

OMM:	135546665 135553152

OCLA:

139382389 139386302

SALP:

112071322(anapc15) 112077198

SNH:	120028586 120036075

SFON:

129821887 129831717(anapc15)

CCLU:

121567818

ELS:	105024054(anapc15)

OEP:	134029202(anapc15)

SFM:	108932359(anapc15)

PKI:	111833890(anapc15)

AANG:

118210394(anapc15)

AROT:

135235817(anapc15)

CCOG:

133107610(anapc15)

LOC:	102698468(anapc15)

PSPA:

121302730(anapc15)

ARUT:

117405883 117973037

PSEX:

120523940(anapc15)

LCM:	102361451(ANAPC15)

CMK:	103171933(anapc15)

RTP:	109925021(anapc15)

CPLA:

122550967(anapc15)

CPUN:

140481093(anapc15)

HOC:	132816577(anapc15)

SCAU:

119977415(anapc15)

STOZ:

140392139(anapc15)

LERI:

129694774(anapc15)

HAKA:

140727097(anapc15)

PMRN:

116948489

LRJ:	133345203(ANAPC15)

BFO:

BBEL:

SCLV:

CLEP:

SPU:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG15237(CG15237)

DER:

6541561

DSE:

6607897

DSI:	Dsimw501_GD10298(Dsim_GD10298)

DYA:	Dyak_GE24443

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI20225

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119670983 119673915

MDE:	101889544 131802096

SCAC:

LCQ:

LSQ:

CVJ:

GFS:	119643321 119644149 119644240

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003073

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

TLN:

TAME:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

RFG:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203333 KGM_213108

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137920493 137921450 137929680

PRAP:

111000215 111002044

PBX:

123706864

PNAP:

125055933

ZCE:	119830009 119835555

CCRC:

LSIN:

HAW:

HZE:

TNL:

SLIU:

OFU:	114359102 114359163

ONU:	135080877 135087214

ATRA:

GMW:

ECLR:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111045530 120351504

LDA:

HVI:

MQU:

FOC:

TPAL:

CSEC:

PAME:

BROR:

IEL:

HAMR:

DPX:	DAPPUDRAFT_226463

DMK:

DPZ:

PVM:

PCHN:

PMOO:

HAME:

PCLA:

MNZ:	135205030 135205034

MRJ:

PORN:

LSM:

DSV:

DALB:

RSAN:

RMP:

OTI:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

HRO:	HELRODRAFT_170437

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

Reference

PMID:21926987

Authors

Mansfeld J, Collin P, Collins MO, Choudhary JS, Pines J

Title

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.

Journal

Nat Cell Biol 13:1234-43 (2011)
DOI:10.1038/ncb2347

Sequence

[hsa:25906]

LinkDB

DBGET integrated database retrieval system