KEGG   MODULE: M00373
Entry
M00373            Pathway   Module                                 
Name
Ethylmalonyl pathway
Definition
K00626 K00023 K17865 K14446 K14447 K14448 K14449 K08691 K14451
K01965+K01966 K05606 K01847
Diagram
M00373  Ethylmalonyl pathway
M00373

Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Orthology
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
K00023  
acetoacetyl-CoA reductase [EC:1.1.1.36] [RN:R01977]
K17865  
3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55] [RN:R03027]
K14446  
crotonyl-CoA carboxylase/reductase [EC:1.3.1.85] [RN:R09291]
K14447  
ethylmalonyl-CoA mutase [EC:5.4.99.63] [RN:R09292]
K14448  
(2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12] [RN:R09293]
K14449  
2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076]
K08691  
malyl-CoA lyase [EC:4.1.3.24] [RN:R00934 R00473]
K14451  
(3S)-malyl-CoA thioesterase [RN:R10612]
K01965+K01966  
propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859]
K05606  
methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765 R09979]
K01847  
methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
Complete
mens  Methylobacterium sp. NMS14P
sil  Ruegeria pomeroyi
sit  Ruegeria sp. TM1040
rua  Ruegeria sp. AD91A
rut  Ruegeria sp. THAF33
rcon  Ruegeria conchae
ruy  Ruegeria sp. YS9
jan  Jannaschia sp. CCS1
rde  Roseobacter denitrificans
rli  Roseobacter litoralis
rpon  Roseobacter ponti
rfu  Roseobacter fucihabitans
dsh  Dinoroseobacter shibae
pga  Phaeobacter inhibens DSM 17395
pgl  Phaeobacter inhibens 2.10
pgd  Phaeobacter gallaeciensis DSM 26640
php  Phaeobacter porticola
ppic  Phaeobacter piscinae
phq  Phaeobacter sp. LSS9
phae  Phaeobacter sp. G2
oat  Octadecabacter antarcticus
oar  Octadecabacter arcticus
otm  Octadecabacter temperatus
oct  Octadecabacter sp. SW4
lmd  Leisingera methylohalidivorans
lej  Leisingera sp. NJS204
laqu  Leisingera aquaemixtae
lcae  Leisingera caerulea
leim  Leisingera sp. M523
cid  Celeribacter indicus
cmar  Celeribacter marinus
ceh  Celeribacter ethanolicus
malg  Marinovum algicola
con  Actibacterium sp. EMB200-NS6
ypac  Alloyangia pacifica
yan  Salipiger sp. CCB-MM3
tpro  Salipiger profundus
paby  Salipiger abyssi
suam  Sulfitobacter alexandrii
sulz  Sulfitobacter sp. SK012
suli  Sulfitobacter sp. JL08
suld  Sulfitobacter sp. D7
spot  Sulfitobacter pontiacus
smed  Sulfitobacter mediterraneus
sinl  Sulfitobacter indolifex
sfav  Sulfitobacter faviae
sdub  Sulfitobacter dubius
sulb  Sulfitobacter sp. CB2047
suly  Sulfitobacter sp. TCYB15
sulp  Sulfitobacter sp. PM12
susq  Sulfitobacter sp. S190
spse  Pseudosulfitobacter pseudonitzschiae
tom  Tateyamaria omphalii
tate  Tateyamaria sp. SN3-11
taty  Tateyamaria sp. SN6-1
rmm  Roseovarius mucosus
rok  Roseovarius sp. AK1035
rid  Roseovarius indicus
rom  Roseovarius faecimaris
roh  Roseovarius sp. THAF27
rpel  Roseovarius pelagicus
rphc  Roseovarius phycicola
aht  Antarctobacter heliothermus
sagu  Sagittula sp. P11
sstl  Sagittula stellata
sagz  Sagittula sp. MA-2
thaa  Thalassococcus sp. S3
ocd  Oceanicola sp. D3
rot  Roseivivax sp. THAF197b
rmh  Roseivivax marinus
malu  Mameliella alba
tgl  Thalassovita gelatinovora
palx  Ponticoccus alexandrii
lsal  Loktanella salsilacus
lalg  Lentibacter algarum
try  Tropicibacter oceani
maru  Palleronia sp. THAF1
rmai  Roseicyclus marinus
acld  Algirhabdus cladophorae
seoh  Seohaeicola sp. tig00000074
matg  Marivita sp. tig00000067
boo  Rhodophyticola sp. CCM32
rpoh  Rhodophyticola porphyridii
rsp  Cereibacter sphaeroides 2.4.1
rsh  Cereibacter sphaeroides ATCC 17029
rsq  Cereibacter sphaeroides ATCC 17025
rsk  Cereibacter sphaeroides KD131
cazt  Cereibacter azotoformans
rbl  Pseudogemmobacter blasticus
fyt  Fuscovulum ytuae
pde  Paracoccus denitrificans
pami  Paracoccus aminophilus
pye  Paracoccus yeei
pcon  Paracoccus contaminans
pzh  Paracoccus zhejiangensis
paro  Paracoccus tegillarcae
pamn  Paracoccus aminovorans
parr  Paracoccus sp. Arc7-R13
paak  Paracoccus sp. AK26
pkd  Paracoccus kondratievae
ppan  Paracoccus pantotrophus
plia  Paracoccus liaowanqingii
psan  Paracoccus sanguinis
pmau  Paracoccus marcusii
pmeh  Paracoccus methylovorus
psew  Paracoccus seriniphilus
psap  Paracoccus saliphilus
pfis  Paracoccus fistulariae
paex  Paracoccus aestuarii
pstl  Paracoccus stylophorae
palp  Paracoccus alcaliphilus
pver  Paracoccus versutus
pfeo  Paracoccus ferrooxidans
phoi  Paracoccus homiensis
ptp  Planktomarina temperata
rsu  Rhodovulum sulfidophilum
rhm  Rhodovulum sp. MB263
rhc  Rhodovulum sp. P5
rhov  Rhodovulum sp. HP10
tsco  Tritonibacter scottomollicae
daa  Frigidibacter mobilis
don  Marivivens sp. JLT3646
malc  Marivivens sp. LCG002
rbz  Aestuarium zhoushanense
tec  Thioclava electrotropha
tlb  Thioclava litoralis
lvs  Yoonia vestfoldensis
yag  Yoonia algicola
yrh  Yoonia rhodophyticola
geh  Paragemmobacter aquarius
gfu  Gemmobacter fulvus
taw  Tabrizicola piscis
salo  Silicimonas algicola
sedi  Parasedimentitalea marina
ppso  Parasedimentitalea psychrophila
pseb  Pseudorhodobacter turbinis
ppru  Paroceanicella profunda
paed  Pseudohalocynthiibacter aestuariivivens
pamo  Profundibacter amoris
poz  Pontivivens ytuae
mon  Pontivivens nitratireducens
palw  Pseudooceanicola algae
pshq  Pseudooceanicola spongiae
cact  Cognatishimia activa
thas  Pukyongiella litopenaei
hdh  Pikeienuella piscinae
cmag  Pacificitalea manganoxidans
gce  Gymnodinialimonas ceratoperidinii
gyj  Gymnodinialimonas sp. 57CJ19
nsm  Neotabrizicola shimadae
acro  Aliiroseovarius crassostreae
aalk  Abyssibius alkaniclasticus
amyl  Amylibacter sp. IMCC11727
amaq  Algicella marina
pbae  Roseinatronobacter sp. S2
rbg  Roseinatronobacter bogoriensis subsp. barguzinensis
bosg  Boseongicola sp. MH-Pat-all_autometa_1-3
manh  Marinibacterium anthonyi
faq  Rhodobacteraceae bacterium SC52
sinr  Sinirhodobacter sp. HNIBRBA609
rcp  Rhodobacter capsulatus
rhp  Rhodobacter xanthinilyticus
rbx  Rhodobacterales bacterium HKCCA1288
 » show all
Reaction
R00238  
R01977  
R03027  
R09291  
R09979  
R09292  
R09293  
R05076  
R00934  
R00473  
R10612  
R01859  
R02765  
R00833  
Compound
C00024  Acetyl-CoA
C00332  Acetoacetyl-CoA
C03561  (R)-3-Hydroxybutanoyl-CoA
C00877  Crotonoyl-CoA
C18026  (2S)-Ethylmalonyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C06028  2-Methylfumaryl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C00100  Propanoyl-CoA
C00048  Glyoxylate
C04348  L-Malyl-CoA
C00149  (S)-Malate
C00683  (S)-Methylmalonyl-CoA
C01213  (R)-Methylmalonyl-CoA
C00091  Succinyl-CoA
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
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