KEGG   MODULE: M00608
Entry
M00608            Pathway   Module                                 
Name
2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Definition
K10977 K16792+K16793 K10978
Diagram
M00608

Orthology
K10977  
methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] [RN:R00271 R08331 R08332]
K16792+K16793  
methanogen homoaconitase large subunit [EC:4.2.1.114] [RN:R03444 R04371 R09720 R10392 R10393 R10391 R10395 R10396 R10394]
K10978  
methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-] [RN:R01934 R08214 R08215]
Class
Pathway modules; Energy metabolism; Methane metabolism
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R00271  
R03444  
R04371  
R09720  
R01934  
R08331  
R10392  
R10393  
R10391  
R08214  
R08332  
R10395  
R10396  
R10394  
R08215  
Compound
C00026  2-Oxoglutarate
C00024  Acetyl-CoA
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C04002  (Z)-But-1-ene-1,2,4-tricarboxylate
C05662  Homoisocitrate
C00322  2-Oxoadipate
C16583  (R)-(Homo)2-citrate
C20581  cis-(Homo)2-aconitate
C16597  (-)-threo-Iso(homo)2-citrate
C16588  2-Oxopimelate
C16598  (R)-(Homo)3-citrate
C20582  cis-(Homo)3-aconitate
C16600  (-)-threo-Iso(homo)3-citrate
C16589  2-Oxosuberate
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Comment
Organism group: methanogenic archaea
Reference
PMID:9665716
  Authors
Howell DM, Harich K, Xu H, White RH
  Title
Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.
  Journal
Biochemistry 37:10108-17 (1998)
DOI:10.1021/bi980662p
Reference
PMID:18765671
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
Reference
PMID:10940051
  Authors
Howell DM, Graupner M, Xu H, White RH
  Title
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:5013-6 (2000)
DOI:10.1128/JB.182.17.5013-5016.2000
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