KEGG   MODULE: M00789
Entry
M00789            Pathway   Module                                 
Name
Rebeccamycin biosynthesis, tryptophan => rebeccamycin
Definition
K14266 K19884 K19885 K19886+K19887 K19888 K19889
Diagram
M00789

Orthology
K14266  
rebH; tryptophan halogenase [EC:1.14.19.9] [RN:R09570]
K19884  
rebO; 7-chloro-L-tryptophan oxidase [EC:1.4.3.23] [RN:R09560]
K19885  
rebD; dichlorochromopyrrolate synthase / catalase [EC:1.21.98.2 1.11.1.6] [RN:R09566]
K19886  
rebC; flavin-dependent monooxygenase RebC [EC:1.13.12.17] [RN:R09567]
K19887  
rebP; cytochrome P450 RebP [EC:1.13.12.17] [RN:R09567]
K19888  
rebG; 4'-demethylrebeccamycin synthase [EC:4.3.3.5] [RN:R09568]
K19889  
rebM; demethylrebeccamycin-D-glucose O-methyltransferase [EC:2.1.1.164] [RN:R09569]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
Pathway
map00404  Staurosporine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R09570  
R09560  
R09566  
R09567  
R09568  
R09569  
Compound
C00078  L-Tryptophan
C19687  7-Chloro-L-tryptophan
C19688  2-Imino-3-(7-chloroindol-3-yl)propanoate
C19698  3,4-Bis(7-chloroindol-3-yl)pyrrole-2,5-dicarboxylate
C19699  Dichloroarcyriaflavin A
C19700  4'-O-Demethylrebeccamycin
C19701  Rebeccamycin
Reference
PMID:12619684
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
Biosci Biotechnol Biochem 67:127-38 (2003)
DOI:10.1271/bbb.67.127
Reference
PMID:15743957
  Authors
Nishizawa T, Aldrich CC, Sherman DH
  Title
Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
J Bacteriol 187:2084-92 (2005)
DOI:10.1128/JB.187.6.2084-2092.2005
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