KEGG   MODULE: M00934
Entry
M00934            Pathway   Module                                 
Name
Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Definition
(K24528+K24559+K24560+K24561+K24562) K24529 (K24292+K24530) K24531 K21540 K21539 K24390
Diagram
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
M00934

Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Macrolide biosynthesis
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K24528,K24559,K24560,K24561,K24562  
mycA; protomycinolide IV synthase [RN:R12660]
K24529  
mycB; protomycinolide IV desosaminyltransferase [EC:2.4.1.-] [RN:R10876]
K24292  
mycCI; mycinamicin VIII C21 methyl hydroxylase [EC:1.14.-.-] [RN:R10875]
K24530  
mycCII; ferredoxin [RN:R10875]
K24531  
mycD; mycinamicin VII 6-deoxyallosyltransferase [EC:2.4.1.-] [RN:R10874]
K21540  
mycE; mycinamicin VI 2''-O-methyltransferase [EC:2.1.1.238] [RN:R09822]
K21539  
mycF; mycinamicin III 3''-O-methyltransferase [EC:2.1.1.237] [RN:R09823]
K24390  
mycG; mycinamicin IV hydroxylase/epoxidase [EC:1.14.-.-] [RN:R10877 R10878]
Complete
28040  Micromonospora griseorubida
Reaction
R12660  
R10876  
R10875  
R10874  
R09822  
R09823  
R10877  
R10878  
Compound
C00083  Malonyl-CoA
C02557  Methylmalonyl-CoA
C15685  Protomycinolide IV
C15684  Mycinamicin VIII
C15683  Mycinamicin VII
C15682  Mycinamicin VI
C15681  Mycinamicin III
C18846  Mycinamicin IV
C18847  Mycinamicin V
C15680  Mycinamicin II
Reference
PMID:18804032
  Authors
Anzai Y, Li S, Chaulagain MR, Kinoshita K, Kato F, Montgomery J, Sherman DH.
  Title
Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics.
  Journal
Chem Biol 15:950-9 (2008)
DOI:10.1016/j.chembiol.2008.07.014
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