KEGG   MODULE: M00951
Entry
M00951            Pathway   Module                                 
Name
Cremeomycin biosynthesis, aspartate/3,4-AHBA => cremeomycin
Definition
K25562 K25597
K25563 K25594
K25598
Diagram
M00951  Cremeomycin biosynthesis, aspartate/3,4-AHBA => cremeomycin
M00951

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K25562  
creE; L-aspartate N-monooxygenase (nitrosuccinate-forming) [EC:1.14.13.248] [RN:R12907]
K25597  
creD; nitrosuccinate lyase [EC:4.3.99.5] [RN:R12947]
K25563  
creL; 3-amino-4-hydroxybenzoate 2-monooxygenase [EC:1.14.13.249] [RN:R12912]
K25594  
creN; 3-amino-4-hydroxybenzoate 4-O-methyltransferase [EC:2.1.1.380] [RN:R12928]
K25598  
creM; 3-amino-2-hydroxy-4-methoxybenzoate diazotase [EC:6.7.1.1] [RN:R12943]
Complete
66881  Streptomyces cremeus
Reaction
R12907  
R12947  
R12912  
R12928  
R12943  
Compound
C00049  L-Aspartate
C22388  (2S)-2-Nitrobutanedioate
C00088  Nitrite
C12115  3-Amino-4-hydroxybenzoate
C22455  3-Amino-2,4-dihydroxybenzoate
C22425  3-Amino-2-hydroxy-4-methoxybenzoate
C22416  Cremeomycin
Reference
PMID:26278892
  Authors
Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP.
  Title
The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation.
  Journal
Chembiochem 16:2172-5 (2015)
DOI:10.1002/cbic.201500407
LinkDB

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