| Entry |
|
|---|
| Name |
Amplified PDGFR to PI3K signaling pathway
|
|---|
| Definition |
PDGFR* -> PI3K -> PIP3 -> AKT -> MTOR |
|---|
| Expanded |
5156v1 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
|
|---|
| Gene |
| 5156 | PDGFRA; platelet derived growth factor receptor alpha |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2475 | MTOR; mechanistic target of rapamycin |
|
|---|
| Variant |
5156v1 (PDGFR*) PDGFRA amplification
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Westermark B |
|---|
| Title |
Platelet-derived growth factor in glioblastoma-driver or biomarker? |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Soni D, King JA, Kaye AH, Hovens CM. |
|---|
| Title |
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Bansal K, Liang ML, Rutka JT. |
|---|
| Title |
Molecular biology of human gliomas. |
|---|
| Journal |
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|---|
| LinkDB |
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