KEGG   NETWORK: N00046
Entry
N00046                      Network                                
Name
Mutation-activated KIT to PI3K signaling pathway
Definition
KIT* -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
3815v1 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06275 Acute myeloid leukemia
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
Disease
H00003  Acute myeloid leukemia
Gene
3815  KIT; KIT proto-oncogene receptor tyrosine kinase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
3815v1 (KIT*)  KIT kinase domain mutation
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19540337
  Authors
Masson K, Ronnstrand L
  Title
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3.
  Journal
Cell Signal 21:1717-26 (2009)
DOI:10.1016/j.cellsig.2009.06.002
Reference
PMID:15625120
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
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