| Entry |
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| Name |
BCR-ABL fusion kinase to PI3K signaling pathway
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| Definition |
BCR-ABL -> (CRKL+CBL+CRK) -> PI3K -> PIP3 -> AKT -| BAD |
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| Expanded |
(25v1,25v2) -> (1399+867+1398) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00004 | Chronic myeloid leukemia |
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| Gene |
| 25 | ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase |
| 1399 | CRKL; CRK proto-oncogene, adaptor protein |
| 867 | CBL; Cbl proto-oncogene |
| 1398 | CRK; CRK proto-oncogene, adaptor protein |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
|
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| Variant |
25v1 (BCR-ABL) BCR-ABL1 fusion
25v2 (BCR-ABL) First generation TKI-resistant ABL1 mutation
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
|
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| Authors |
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. |
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| Title |
The biology of chronic myeloid leukemia. |
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| Journal |
|
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| Reference |
|
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| Authors |
Deininger MW, Goldman JM, Melo JV. |
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| Title |
The molecular biology of chronic myeloid leukemia. |
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| Journal |
Blood 96:3343-56 (2000) |
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| Reference |
|
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| Authors |
Calabretta B, Perrotti D. |
|---|
| Title |
The biology of CML blast crisis. |
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| Journal |
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| LinkDB |
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