KEGG   NETWORK: N00078
Entry
N00078                      Network                                
Name
Mutation-activated HRAS to ERK signaling pathway
Definition
HRAS* -> RAF -> MEK -> ERK -> MSK1 -> MYC
  Expanded
3265v2 -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 9252 -> 4609
Class
nt06265 Bladder cancer
nt06210 ERK signaling (cancer)
Type
Variant
Pathway
hsa05219  Bladder cancer
Disease
H00022  Bladder cancer
Gene
3265  HRAS; HRas proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
9252  RPS6KA5; ribosomal protein S6 kinase A5
4609  MYC; MYC proto-oncogene, bHLH transcription factor
Variant
3265v2 (HRAS*)  HRAS mutation
Reference
PMID:17158541
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
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