| Entry |
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| Name |
EGF-EGFR-RAS-RASSF1 signaling pathway
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| Definition |
EGF -> EGFR -> GRB2 -> SOS -> RAS -> (RASSF1+RASSF5) -> STK4 |
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| Expanded |
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (11186+83593) -> 6789 |
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| Class |
nt06266 Non-small cell lung cancer
nt06213 Other RAS signaling (cancer)
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| Type |
Reference
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| Pathway |
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| Gene |
| 1950 | EGF; epidermal growth factor |
| 1956 | EGFR; epidermal growth factor receptor |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 11186 | RASSF1; Ras association domain family member 1 |
| 83593 | RASSF5; Ras association domain family member 5 |
| 6789 | STK4; serine/threonine kinase 4 |
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| Reference |
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| Authors |
Donninger H, Vos MD, Clark GJ |
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| Title |
The RASSF1A tumor suppressor. |
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| Journal |
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| Reference |
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| Authors |
Cox AD, Der CJ |
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| Title |
The dark side of Ras: regulation of apoptosis. |
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| Journal |
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| Reference |
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| Authors |
Wong CM, Ng IO |
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| Title |
Molecular pathogenesis of hepatocellular carcinoma. |
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| Journal |
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| LinkDB |
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