Homo sapiens (human): 2885
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Entry
2885 CDS
T01001
Symbol
GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
Name
(RefSeq) growth factor receptor bound protein 2
KO
K04364
growth factor receptor-bound protein 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04014
Ras signaling pathway
hsa04062
Chemokine signaling pathway
hsa04068
FoxO signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04540
Gap junction
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04630
JAK-STAT signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04714
Thermogenesis
hsa04722
Neurotrophin signaling pathway
hsa04910
Insulin signaling pathway
hsa04912
GnRH signaling pathway
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04926
Relaxin signaling pathway
hsa04935
Growth hormone synthesis, secretion and action
hsa05034
Alcoholism
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05231
Choline metabolism in cancer
Network
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06170
Influenza A virus (IAV)
nt06210
ERK signaling (cancer)
nt06213
Other RAS signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06273
Glioma
nt06274
Thyroid cancer
nt06275
Acute myeloid leukemia
nt06276
Chronic myeloid leukemia
nt06324
GHRH-GH-IGF signaling
nt06526
MAPK signaling
nt06530
PI3K signaling
Element
N00001
EGF-EGFR-RAS-ERK signaling pathway
N00002
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003
Mutation-activated KIT to RAS-ERK signaling pathway
N00004
Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005
Mutation-activated MET to RAS-ERK signaling pathway
N00006
Amplified EGFR to RAS-ERK signaling pathway
N00011
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00014
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015
PDGF-PDGFR-RAS-ERK signaling pathway
N00016
PDGF-overexpression to RAS-ERK signaling pathway
N00018
Amplified PDGFR to RAS-ERK signaling pathway
N00019
FGF-FGFR-RAS-ERK signaling pathway
N00020
Amplified FGFR to RAS-ERK signaling pathway
N00021
EGF-ERBB2-RAS-ERK signaling pathway
N00022
ERBB2-overexpression to RAS-ERK signaling pathway
N00030
EGF-EGFR-RAS-PI3K signaling pathway
N00031
Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00041
EGFR-overexpression to RAS-ERK signaling pathway
N00096
EGF-EGFR-RAS-RASSF1 signaling pathway
N00103
EGF-EGFR-RAS-RalGDS signaling pathway
N00215
KITLG-KIT-RAS-ERK signaling pathway
N00216
HGF-MET-RAS-ERK signaling pathway
N00217
FLT3LG-FLT3-RAS-ERK signaling pathway
N00218
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00229
TGFA-EGFR-RAS-ERK signaling pathway
N00230
TGFA-overexpression to RAS-ERK signaling pathway
N00233
IGF-IGF1R-RAS-ERK signaling pathway
N00235
IGF2-overexpression to RAS-ERK signaling pathway
N00237
IGF1R-overexpression to RAS-ERK signaling pathway
N00246
HGF-overexpression to RAS-ERK signaling pathway
N00248
MET-overexpression to RAS-ERK signaling pathway
N00252
Amplified ERBB2 to RAS-ERK signaling pathway
N00259
Amplified MET to RAS-ERK signaling pathway
N00274
HCV NS5A to RAS-ERK signaling pathway
N00276
EGF-overexpression to RAS-ERK signaling pathway
N00277
EREG-EGFR-RAS-ERK signaling pathway
N00278
EREG-overexpression to RAS-ERK signaling pathway
N00279
AREG-EGFR-RAS-ERK signaling pathway
N00280
AREG-overexpression to RAS-ERK signaling pathway
N00367
HPV E5 to EGFR-RAS-ERK signaling pathway
N00386
HCMV gB to PDGFR-RAS-ERK signaling pathway
N00513
Mutation-activated EGFR to RAS-ERK signaling pathway
N00538
Ca2+-PYK2-RAS-ERK signaling pathway
N00540
HBV HBx to RAS-ERK signaling pathway
N00542
EGF-EGFR-RAS-JNK signaling pathway
N01062
Mutation-activated MET to RAS-ERK signaling pathway
N01354
BPA to RAS-ERK signaling pathway
N01360
P4-PR-RAS-ERK signaling pathway
N01361
P4/MPA to PR-RAS-ERK signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01595
Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
N01658
GF-RTK-RAS-PI3K signaling pathway
Drug target
Prexigebersen:
D11165
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
2885 (GRB2)
04630 JAK-STAT signaling pathway
2885 (GRB2)
04068 FoxO signaling pathway
2885 (GRB2)
04072 Phospholipase D signaling pathway
2885 (GRB2)
04151 PI3K-Akt signaling pathway
2885 (GRB2)
04150 mTOR signaling pathway
2885 (GRB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
2885 (GRB2)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
2885 (GRB2)
04660 T cell receptor signaling pathway
2885 (GRB2)
04662 B cell receptor signaling pathway
2885 (GRB2)
04664 Fc epsilon RI signaling pathway
2885 (GRB2)
04062 Chemokine signaling pathway
2885 (GRB2)
09152 Endocrine system
04915 Estrogen signaling pathway
2885 (GRB2)
04917 Prolactin signaling pathway
2885 (GRB2)
04926 Relaxin signaling pathway
2885 (GRB2)
04935 Growth hormone synthesis, secretion and action
2885 (GRB2)
09156 Nervous system
04722 Neurotrophin signaling pathway
2885 (GRB2)
09158 Development and regeneration
04380 Osteoclast differentiation
2885 (GRB2)
09159 Environmental adaptation
04714 Thermogenesis
2885 (GRB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2885 (GRB2)
05206 MicroRNAs in cancer
2885 (GRB2)
05205 Proteoglycans in cancer
2885 (GRB2)
05207 Chemical carcinogenesis - receptor activation
2885 (GRB2)
05208 Chemical carcinogenesis - reactive oxygen species
2885 (GRB2)
05203 Viral carcinogenesis
2885 (GRB2)
05231 Choline metabolism in cancer
2885 (GRB2)
09162 Cancer: specific types
05210 Colorectal cancer
2885 (GRB2)
05225 Hepatocellular carcinoma
2885 (GRB2)
05226 Gastric cancer
2885 (GRB2)
05214 Glioma
2885 (GRB2)
05221 Acute myeloid leukemia
2885 (GRB2)
05220 Chronic myeloid leukemia
2885 (GRB2)
05211 Renal cell carcinoma
2885 (GRB2)
05215 Prostate cancer
2885 (GRB2)
05213 Endometrial cancer
2885 (GRB2)
05224 Breast cancer
2885 (GRB2)
05223 Non-small cell lung cancer
2885 (GRB2)
09172 Infectious disease: viral
05161 Hepatitis B
2885 (GRB2)
05160 Hepatitis C
2885 (GRB2)
05163 Human cytomegalovirus infection
2885 (GRB2)
05165 Human papillomavirus infection
2885 (GRB2)
09165 Substance dependence
05034 Alcoholism
2885 (GRB2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
2885 (GRB2)
01522 Endocrine resistance
2885 (GRB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
2885 (GRB2)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Receptor tyrosine kinase (RTK) adaptor proteins
2885 (GRB2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
SH3_1
SH3_9
SH3_2
SH2
SH3_10
SH3_3
SH2_2
DUF5093
hSH3
SH3_4
Motif
Other DBs
NCBI-GeneID:
2885
NCBI-ProteinID:
NP_002077
OMIM:
108355
HGNC:
4566
Ensembl:
ENSG00000177885
Pharos:
P62993
(Tchem)
UniProt:
P62993
B0LPF3
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:complement(75318076..75405678)
Genome browser
AA seq
217 aa
AA seq
DB search
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq
654 nt
NT seq
+upstream
nt +downstream
nt
atggaagccatcgccaaatatgacttcaaagctactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaacgaagaatgtgatcagaactggtacaaggcagag
cttaatggaaaagacggcttcattcccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagtgagagcgctcctggggacttctccctctctgtcaag
tttggaaacgatgtgcagcacttcaaggtgctccgagatggagccgggaagtacttcctc
tgggtggtgaagttcaattctttgaatgagctggtggattatcacagatctacatctgtc
tccagaaaccagcagatattcctgcgggacatagaacaggtgccacagcagccgacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggcttccgccgggga
gattttatccatgtcatggataactcagaccccaactggtggaaaggagcttgccacggg
cagaccggcatgtttccccgcaattatgtcacccccgtgaaccggaacgtctaa
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integrated database retrieval system