KEGG   NETWORK: N00100
Entry
N00100                      Network                                
Name
BCL2-overexpression to intrinsic apoptotic pathway
Definition
BCL2* -| BAX -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
596v1 -| 581 -> 54205 == 317 -> 842 -> (836,840)
Class
nt06267 Small cell lung cancer
nt06231 Apoptosis (cancer)
Type
Variant
Pathway
hsa05222  Small cell lung cancer
Disease
H00013  Small cell lung cancer
Gene
596  BCL2; BCL2, apoptosis regulator
581  BAX; BCL2 associated X, apoptosis regulator
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Variant
596v1 (BCL2*)  BCL2 overepression
Reference
PMID:12616528
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
PMID:23070004
  Authors
Weyhenmeyer B, Murphy AC, Prehn JH, Murphy BM
  Title
Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer.
  Journal
Exp Oncol 34:192-9 (2012)
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