| Entry |
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| Name |
EGF-EGFR-RAS-RalGDS signaling pathway
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| Definition |
EGF -> EGFR -> GRB2 -> SOS -> RAS -> RALGDS -> RAL |
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| Expanded |
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> 5900 -> (5898,5899) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 1950 | EGF; epidermal growth factor |
| 1956 | EGFR; epidermal growth factor receptor |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 5900 | RALGDS; ral guanine nucleotide dissociation stimulator |
| 5898 | RALA; RAS like proto-oncogene A |
| 5899 | RALB; RAS like proto-oncogene B |
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| Reference |
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| Authors |
Karnoub AE, Weinberg RA |
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| Title |
Ras oncogenes: split personalities. |
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| Journal |
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| Reference |
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| Authors |
Schubbert S, Shannon K, Bollag G |
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| Title |
Hyperactive Ras in developmental disorders and cancer. |
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| Journal |
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| Reference |
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| Authors |
Normanno N, Tejpar S, Morgillo F, De Luca A, Van Cutsem E, Ciardiello F |
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| Title |
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. |
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| Journal |
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| Reference |
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| Authors |
Berndt N, Hamilton AD, Sebti SM |
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| Title |
Targeting protein prenylation for cancer therapy. |
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| Journal |
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| LinkDB |
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