KEGG   NETWORK: N00126
Entry
N00126                      Network                                
Name
PAX8-PPARG fusion to PPARG-mediated transcription
Definition
PAX8-PPARG -| (RXR+PPARG)
  Expanded
7849v1 -| ((6256,6257,6258)+5468)
Class
nt06274 Thyroid cancer
nt06240 Transcription (cancer)
Type
Variant
Pathway
hsa05216  Thyroid cancer
Disease
H00032  Thyroid cancer
Gene
7849  PAX8; paired box 8
6256  RXRA; retinoid X receptor alpha
6257  RXRB; retinoid X receptor beta
6258  RXRG; retinoid X receptor gamma
5468  PPARG; peroxisome proliferator activated receptor gamma
Variant
7849v1 (PAX8-PPARG)  PAX8-PPARG fusion
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:16179407
  Authors
Au AY, McBride C, Wilhelm KG Jr, Koenig RJ, Speller B, Cheung L, Messina M, Wentworth J, Tasevski V, Learoyd D, Robinson BG, Clifton-Bligh RJ
  Title
PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) disrupts normal PAX8 or PPARgamma transcriptional function and stimulates follicular thyroid cell growth.
  Journal
Endocrinology 147:367-76 (2006)
DOI:10.1210/en.2005-0147
Reference
PMID:19883731
  Authors
Eberhardt NL, Grebe SK, McIver B, Reddi HV
  Title
The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.
  Journal
Mol Cell Endocrinol 321:50-6 (2010)
DOI:10.1016/j.mce.2009.10.013
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