Homo sapiens (human): 7849
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Entry
7849 CDS
T01001
Gene name
PAX8
Definition
(RefSeq) paired box 8
KO
K09293
paired box protein 8
Organism
hsa
Homo sapiens (human)
Pathway
hsa04918
Thyroid hormone synthesis
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05216
Thyroid cancer
Network
nt06240
Transcription
nt06274
Thyroid cancer
nt06322
TRH-TSH-TH signaling
Element
N00126
PAX8-PPARG fusion to PPARG-mediated transcription
N00782
TSH-TG signaling pathway
N00783
Mutation-inactivated TSH to TSH-TG signaling pathway
N00784
Mutation-inactivated TSHR to TSH-TG signaling pathway
N00785
Mutation-inactivated PAX8 to TSH-TG signaling pathway
N00797
Mutation-activated TSHR to TSH-TG signaling pathway
Disease
H00032
Thyroid cancer
H00250
Congenital nongoitrous hypothyroidism (CHNG)
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04918 Thyroid hormone synthesis
7849 (PAX8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7849 (PAX8)
05202 Transcriptional misregulation in cancer
7849 (PAX8)
09162 Cancer: specific types
05216 Thyroid cancer
7849 (PAX8)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
7849 (PAX8)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Helix-turn-helix
Homeo domain Paired-related
7849 (PAX8)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PAX
Pax2_C
HTH_23
HTH_32
HTH_38
HTH_Tnp_IS1
HTH_28
Motif
Other DBs
NCBI-GeneID:
7849
NCBI-ProteinID:
NP_003457
OMIM:
167415
HGNC:
8622
Ensembl:
ENSG00000125618
Vega:
OTTHUMG00000128529
Pharos:
Q06710
(Tbio)
UniProt:
Q06710
R9W7C9
LinkDB
All DBs
Structure
PDB:
2K27
Thumbnails
Position
2q14.1
AA seq
450 aa
AA seq
DB search
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK
ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND
TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY
SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF
ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD
PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL
LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP
NSSLLSSPYYYSSTSRPSAPPTTATAFDHL
NT seq
1353 nt
NT seq
+upstream
nt +downstream
nt
atgcctcacaactccatcagatctggccatggagggctgaaccagctgggaggggccttt
gtgaatggcagacctctgccggaagtggtccgccagcgcatcgtagacctggcccaccag
ggtgtaaggccctgcgacatctctcgccagctccgcgtcagccatggctgcgtcagcaag
atccttggcaggtactacgagactggcagcatccggcctggagtgatagggggctccaag
cccaaggtggccacccccaaggtggtggagaagattggggactacaaacgccagaaccct
accatgtttgcctgggagatccgagaccggctcctggctgagggcgtctgtgacaatgac
actgtgcccagtgtcagctccattaatagaatcatccggaccaaagtgcagcaaccattc
aacctccctatggacagctgcgtggccaccaagtccctgagtcccggacacacgctgatc
cccagctcagctgtaactcccccggagtcaccccagtcggattccctgggctccacctac
tccatcaatgggctcctgggcatcgctcagcctggcagcgacaagaggaaaatggatgac
agtgatcaggatagctgccgactaagcattgactcacagagcagcagcagcggaccccga
aagcaccttcgcacggatgccttcagccagcaccacctcgagccgctcgagtgcccattt
gagcggcagcactacccagaggcctatgcctcccccagccacaccaaaggcgagcagggc
ctctacccgctgcccttgctcaacagcaccctggacgacgggaaggccaccctgacccct
tccaacacgccactggggcgcaacctctcgactcaccagacctaccccgtggtggcagat
cctcactcacccttcgccataaagcaggaaacccccgaggtgtccagttctagctccacc
ccttcctctttatctagctccgcctttttggatctgcagcaagtcggctccggggtcccg
cccttcaatgcctttccccatgctgcctccgtgtacgggcagttcacgggccaggccctc
ctctcagggcgagagatggtggggcccacgctgcccggatacccaccccacatccccacc
agcggacagggcagctatgcctcctctgccatcgcaggcatggtggcaggaagtgaatac
tctggcaatgcctatggccacaccccctactcctcctacagcgaggcctggcgcttcccc
aactccagcttgctgagttccccatattattacagttccacatcaaggccgagtgcaccg
cccaccactgccacggcctttgaccatctgtag
DBGET
integrated database retrieval system
