KEGG   NETWORK: N00155
Entry
N00155                      Network                                
Name
Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
Definition
mTORC1 -> ULK1_complex -> PI3KC3-C1
  Expanded
(2475+57521+84335+64798+64223+9894+9675) -> (8408+9821+60673+9776) -> (8678+5289+30849+22863+29982)
Class
nt06532 Autophagy
nt06461 Huntington disease
nt06462 Spinocerebellar ataxia
nt06466 Pathways of neurodegeneration
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04140  Autophagy - animal
Gene
2475  MTOR; mechanistic target of rapamycin kinase
57521  RPTOR; regulatory associated protein of MTOR complex 1
84335  AKT1S1; AKT1 substrate 1
64798  DEPTOR; DEP domain containing MTOR interacting protein
64223  MLST8; MTOR associated protein, LST8 homolog
9894  TELO2; telomere maintenance 2
9675  TTI1; TELO2 interacting protein 1
8408  ULK1; unc-51 like autophagy activating kinase 1
9821  RB1CC1; RB1 inducible coiled-coil 1
60673  ATG101; autophagy related 101
9776  ATG13; autophagy related 13
8678  BECN1; beclin 1
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3
30849  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4
22863  ATG14; autophagy related 14
29982  NRBF2; nuclear receptor binding factor 2
Reference
  Authors
Kim KH, Lee MS
  Title
Autophagy--a key player in cellular and body metabolism.
  Journal
Nat Rev Endocrinol 10:322-37 (2014)
DOI:10.1038/nrendo.2014.35
Reference
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
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