KEGG   NETWORK: N00155
Entry
N00155                      Network                                

Name
Autophagy-vesicle nucleation
Definition
(ULK1+RB1CC1+ATG101+ATG13) -> (BECN1+PIK3C3+ATG14+PIK3R4+AMBRA1) -> PI3P -> (WIPI1,WIPI2,ZFYVE1)
  Expanded
(8408+9821+60673+9776) -> (8678+5289+22863+30849+55626) -> C04549 -> (55062,26100,53349)
Class
nt06228 Autophagy
nt06413 Autophagy
nt06461 Huntington disease
nt06462 Spinocerebellar ataxia
nt06128 Autophagy (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04140  Autophagy - animal
Gene
8408  ULK1; unc-51 like autophagy activating kinase 1
9821  RB1CC1; RB1 inducible coiled-coil 1
60673  ATG101; autophagy related 101
9776  ATG13; autophagy related 13
8678  BECN1; beclin 1
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3
22863  ATG14; autophagy related 14
30849  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4
55626  AMBRA1; autophagy and beclin 1 regulator 1
55062  WIPI1; WD repeat domain, phosphoinositide interacting 1
26100  WIPI2; WD repeat domain, phosphoinositide interacting 2
53349  ZFYVE1; zinc finger FYVE-type containing 1
Metabolite
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Kim KH, Lee MS
  Title
Autophagy--a key player in cellular and body metabolism.
  Journal
Nat Rev Endocrinol 10:322-37 (2014)
DOI:10.1038/nrendo.2014.35
Reference
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
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