| Entry |
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| Name |
KSHV vFLIP to NFKB signaling pathway
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| Definition |
vFLIP -> IKK -> NFKBIA -> NFKB |
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| Expanded |
K21662 -> (1147+3551+8517) -> 4792 -> (4790+5970) |
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| Class |
nt06516 TNF signaling
nt06223 TNF signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
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| Type |
Pathogen
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| Pathway |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
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| Disease |
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| Gene |
| 1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
| 3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
| 8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
| 4792 | NFKBIA; NFKB inhibitor alpha |
| 4790 | NFKB1; nuclear factor kappa B subunit 1 |
| 5970 | RELA; RELA proto-oncogene, NF-kB subunit |
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| Perturbant |
| K21662 (vFLIP) | vFLIP; KSHV FLICE inhibitory protein |
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| Reference |
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| Authors |
Chaudhary PM, Jasmin A, Eby MT, Hood L |
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| Title |
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. |
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| Journal |
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| Reference |
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| Authors |
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M |
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| Title |
KSHV vFLIP binds to IKK-gamma to activate IKK. |
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| Journal |
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| Reference |
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| Authors |
Liu L, Eby MT, Rathore N, Sinha SK, Kumar A, Chaudhary PM |
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| Title |
The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. |
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| Journal |
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| Reference |
|
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| Authors |
Schulz TF |
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| Title |
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis. |
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| Journal |
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| LinkDB |
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