Homo sapiens (human): 1147
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Entry
1147 CDS
T01001
Symbol
CHUK, BPS2, IKBKA, IKK-1, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Name
(RefSeq) component of inhibitor of nuclear factor kappa B kinase complex
KO
K04467
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:
2.7.11.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01523
Antifolate resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04062
Chemokine signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04068
FoxO signaling pathway
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04668
TNF signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05212
Pancreatic cancer
hsa05215
Prostate cancer
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06214
PI3K signaling (cancer)
nt06223
TNF signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06516
TNF signaling
nt06517
TLR signaling
nt06519
RLR signaling
nt06521
NLR signaling
Element
N00151
TNF-NFKB signaling pathway
N00171
KSHV vFLIP to NFKB signaling pathway
N00173
KSHV K15 to TNF-NFKB signaling pathway
N00174
KSHV vFLIP to TNF-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00265
EBV LMP1 to NFKB signaling pathway
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00397
HCMV UL26 to NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00441
HIV gp120 to TNF-NFKB signaling pathway
N00442
HIV Nef to TNF-NFKB signaling pathway
N00467
EBV BPLF1 to TLR2/4-NFKB signaling pathway
N00504
HTLV-1 Tax to NFKB signaling pathway
N00505
CD40-NFKB signaling pathway
N00506
HTLV-1 Tax to CD40-NFKB signaling pathway
N00559
LIGHT-HVEM-NFKB signaling pathway
N00560
HSV gD to HVEM-NFKB signaling pathway
N00563
TLR3-NFKB signaling pathway
N00688
RIG-I-NFKB signaling pathway
N00940
NOD-NFKB signaling pathway
N01112
Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01410
Metals to NFKB signaling pathway
N01411
Metals to NFKB signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H00882
Cocoon syndrome
H01931
Lethal-type popliteal pterygium syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
1147 (CHUK)
04064 NF-kappa B signaling pathway
1147 (CHUK)
04668 TNF signaling pathway
1147 (CHUK)
04068 FoxO signaling pathway
1147 (CHUK)
04151 PI3K-Akt signaling pathway
1147 (CHUK)
04150 mTOR signaling pathway
1147 (CHUK)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
1147 (CHUK)
04660 T cell receptor signaling pathway
1147 (CHUK)
04658 Th1 and Th2 cell differentiation
1147 (CHUK)
04659 Th17 cell differentiation
1147 (CHUK)
04657 IL-17 signaling pathway
1147 (CHUK)
04662 B cell receptor signaling pathway
1147 (CHUK)
04062 Chemokine signaling pathway
1147 (CHUK)
09158 Development and regeneration
04380 Osteoclast differentiation
1147 (CHUK)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1147 (CHUK)
05208 Chemical carcinogenesis - reactive oxygen species
1147 (CHUK)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
1147 (CHUK)
09162 Cancer: specific types
05212 Pancreatic cancer
1147 (CHUK)
05221 Acute myeloid leukemia
1147 (CHUK)
05220 Chronic myeloid leukemia
1147 (CHUK)
05215 Prostate cancer
1147 (CHUK)
05222 Small cell lung cancer
1147 (CHUK)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
1147 (CHUK)
05170 Human immunodeficiency virus 1 infection
1147 (CHUK)
05161 Hepatitis B
1147 (CHUK)
05160 Hepatitis C
1147 (CHUK)
05171 Coronavirus disease - COVID-19
1147 (CHUK)
05164 Influenza A
1147 (CHUK)
05162 Measles
1147 (CHUK)
05163 Human cytomegalovirus infection
1147 (CHUK)
05167 Kaposi sarcoma-associated herpesvirus infection
1147 (CHUK)
05169 Epstein-Barr virus infection
1147 (CHUK)
05165 Human papillomavirus infection
1147 (CHUK)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
1147 (CHUK)
05130 Pathogenic Escherichia coli infection
1147 (CHUK)
05131 Shigellosis
1147 (CHUK)
05135 Yersinia infection
1147 (CHUK)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
1147 (CHUK)
05142 Chagas disease
1147 (CHUK)
09164 Neurodegenerative disease
05010 Alzheimer disease
1147 (CHUK)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
1147 (CHUK)
05418 Fluid shear stress and atherosclerosis
1147 (CHUK)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
1147 (CHUK)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
1147 (CHUK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
1147 (CHUK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
1147 (CHUK)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: Other
IKK family [OT]
1147 (CHUK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IKBKB_SDD
Pkinase
PK_Tyr_Ser-Thr
IKKbetaNEMObind
Pkinase_fungal
Kdo
TBK1_ULD
Motif
Other DBs
NCBI-GeneID:
1147
NCBI-ProteinID:
NP_001269
OMIM:
600664
HGNC:
1974
Ensembl:
ENSG00000213341
UniProt:
O15111
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:complement(100186319..100229596)
Genome browser
AA seq
745 aa
AA seq
DB search
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
NT seq
2238 nt
NT seq
+upstream
nt +downstream
nt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ctgggcaccggcggcttcgggaacgtctgtctgtaccagcatcgggaacttgatctcaaa
atagcaattaagtcttgtcgcctagagctaagtaccaaaaacagagaacgatggtgccat
gaaatccagattatgaagaagttgaaccatgccaatgttgtaaaggcctgtgatgttcct
gaagaattgaatattttgattcatgatgtgcctcttctagcaatggaatactgttctgga
ggagatctccgaaagctgctcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttactaagtgatatagggtctgggattcgatatttgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaacatagttcttcaggatgttggtggaaagataata
cataaaataattgatctgggatatgccaaagatgttgatcaaggaagtctgtgtacatct
tttgtgggaacactgcagtatctggccccagagctctttgagaataagccttacacagcc
actgttgattattggagctttgggaccatggtatttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgtgaagagatgtcaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttagtagtagaacccatggaaaactggctacagttgatgttg
aattgggaccctcagcagagaggaggacctgttgaccttactttgaagcagccaagatgt
tttgtattaatggatcacattttgaatttgaagatagtacacatcctaaatatgacttct
gcaaagataatttcttttctgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaatactggttctcaagaacttctttcagagacaggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagttagaggctgtgat
agctatatggtttatttgtttgataaaagtaaaactgtatatgaagggccatttgcttcc
agaagtttatctgattgtgtaaattatattgtacaggacagcaaaatacagcttccaatt
atacagctgcgtaaagtgtgggctgaagcagtgcactatgtgtctggactaaaagaagac
tatagcaggctctttcagggacaaagggcagcaatgttaagtcttcttagatataatgct
aacttaacaaaaatgaagaacactttgatctcagcatcacaacaactgaaagctaaattg
gagttttttcacaaaagcattcagcttgacttggagagatacagcgagcagatgacgtat
gggatatcttcagaaaaaatgctaaaagcatggaaagaaatggaagaaaaggccatccac
tatgctgaggttggtgtcattggatacctggaggatcagattatgtctttgcatgctgaa
atcatggagctacagaagagcccctatggaagacgtcagggagacttgatggaatctctg
gaacagcgtgccattgatctatataagcagttaaaacacagaccttcagatcactcctac
agtgacagcacagagatggtgaaaatcattgtgcacactgtgcagagtcaggaccgtgtg
ctcaaggagctgtttggtcatttgagcaagttgttgggctgtaagcagaagattattgat
ctactccctaaggtggaagtggccctcagtaatatcaaagaagctgacaatactgtcatg
ttcatgcagggaaaaaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgcccggtcccttgtaggatccagtctagaaggtgcagtaacccctcagacatca
gcatggctgcccccgacttcagcagaacatgatcattctctgtcatgtgtggtaactcct
caagatggggagacttcagcacaaatgatagaagaaaatttgaactgccttggccattta
agcactattattcatgaggcaaatgaggaacagggcaatagtatgatgaatcttgattgg
agttggttaacagaatga
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