Homo sapiens (human): 4792
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Entry
4792 CDS
T01001
Symbol
NFKBIA, EDAID2, IKBA, MAD-3, NFKBI
Name
(RefSeq) NFKB inhibitor alpha
KO
K04734
NF-kappa-B inhibitor alpha
Organism
hsa
Homo sapiens (human)
Pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04210
Apoptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04926
Relaxin signaling pathway
hsa04931
Insulin resistance
hsa04936
Alcoholic liver disease
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05215
Prostate cancer
hsa05220
Chronic myeloid leukemia
hsa05222
Small cell lung cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06214
PI3K signaling (cancer)
nt06223
TNF signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06516
TNF signaling
nt06517
TLR signaling
nt06519
RLR signaling
nt06521
NLR signaling
Element
N00151
TNF-NFKB signaling pathway
N00171
KSHV vFLIP to NFKB signaling pathway
N00173
KSHV K15 to TNF-NFKB signaling pathway
N00174
KSHV vFLIP to TNF-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00265
EBV LMP1 to NFKB signaling pathway
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00441
HIV gp120 to TNF-NFKB signaling pathway
N00442
HIV Nef to TNF-NFKB signaling pathway
N00468
EBV BPLF1 to TLR2/4-NFKB signaling pathway
N00504
HTLV-1 Tax to NFKB signaling pathway
N00559
LIGHT-HVEM-NFKB signaling pathway
N00560
HSV gD to HVEM-NFKB signaling pathway
N00563
TLR3-NFKB signaling pathway
N00688
RIG-I-NFKB signaling pathway
N00940
NOD-NFKB signaling pathway
N00942
Shigella OspG to TNF-NFKB signaling pathway
N01112
Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01116
Salmonella SseL to TNF-NFKB signaling pathway
N01117
Salmonella GogB to TNF-NFKB signaling pathway
N01123
Salmonella AvrA to TNF-NFKB signaling pathway
N01410
Metals to NFKB signaling pathway
N01411
Metals to NFKB signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H00007
Hodgkin lymphoma
H00095
Ectodermal dysplasia and immunodeficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
4792 (NFKBIA)
04668 TNF signaling pathway
4792 (NFKBIA)
04024 cAMP signaling pathway
4792 (NFKBIA)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
4792 (NFKBIA)
04660 T cell receptor signaling pathway
4792 (NFKBIA)
04658 Th1 and Th2 cell differentiation
4792 (NFKBIA)
04659 Th17 cell differentiation
4792 (NFKBIA)
04657 IL-17 signaling pathway
4792 (NFKBIA)
04662 B cell receptor signaling pathway
4792 (NFKBIA)
04062 Chemokine signaling pathway
4792 (NFKBIA)
09152 Endocrine system
04926 Relaxin signaling pathway
4792 (NFKBIA)
09156 Nervous system
04722 Neurotrophin signaling pathway
4792 (NFKBIA)
09158 Development and regeneration
04380 Osteoclast differentiation
4792 (NFKBIA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4792 (NFKBIA)
05208 Chemical carcinogenesis - reactive oxygen species
4792 (NFKBIA)
05203 Viral carcinogenesis
4792 (NFKBIA)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
4792 (NFKBIA)
09162 Cancer: specific types
05220 Chronic myeloid leukemia
4792 (NFKBIA)
05215 Prostate cancer
4792 (NFKBIA)
05222 Small cell lung cancer
4792 (NFKBIA)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
4792 (NFKBIA)
05170 Human immunodeficiency virus 1 infection
4792 (NFKBIA)
05161 Hepatitis B
4792 (NFKBIA)
05160 Hepatitis C
4792 (NFKBIA)
05171 Coronavirus disease - COVID-19
4792 (NFKBIA)
05164 Influenza A
4792 (NFKBIA)
05162 Measles
4792 (NFKBIA)
05163 Human cytomegalovirus infection
4792 (NFKBIA)
05167 Kaposi sarcoma-associated herpesvirus infection
4792 (NFKBIA)
05169 Epstein-Barr virus infection
4792 (NFKBIA)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
4792 (NFKBIA)
05130 Pathogenic Escherichia coli infection
4792 (NFKBIA)
05131 Shigellosis
4792 (NFKBIA)
05135 Yersinia infection
4792 (NFKBIA)
05134 Legionellosis
4792 (NFKBIA)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
4792 (NFKBIA)
05140 Leishmaniasis
4792 (NFKBIA)
05142 Chagas disease
4792 (NFKBIA)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
4792 (NFKBIA)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
4792 (NFKBIA)
04931 Insulin resistance
4792 (NFKBIA)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
4792 (NFKBIA)
04131 Membrane trafficking [BR:
hsa04131
]
4792 (NFKBIA)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
RHR (Rel homology region) Ankyrin only
4792 (NFKBIA)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Chaperone mediated autophagy (CMA)
Selective cargos
4792 (NFKBIA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ank_2
Ank
Ank_3
Ank_5
Ank_4
ANK_LRRK2
Motif
Other DBs
NCBI-GeneID:
4792
NCBI-ProteinID:
NP_065390
OMIM:
164008
HGNC:
7797
Ensembl:
ENSG00000100906
UniProt:
P25963
Structure
PDB
PDBj
LinkDB
All DBs
Position
14:complement(35401513..35404749)
Genome browser
AA seq
317 aa
AA seq
DB search
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP
RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI
TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN
YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG
ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE
DELPYDDCVFGGQRLTL
NT seq
954 nt
NT seq
+upstream
nt +downstream
nt
atgttccaggcggccgagcgcccccaggagtgggccatggagggcccccgcgacgggctg
aagaaggagcggctactggacgaccgccacgacagcggcctggactccatgaaagacgag
gagtacgagcagatggtcaaggagctgcaggagatccgcctcgagccgcaggaggtgccg
cgcggctcggagccctggaagcagcagctcaccgaggacggggactcgttcctgcacttg
gccatcatccatgaagaaaaggcactgaccatggaagtgatccgccaggtgaagggagac
ctggccttcctcaacttccagaacaacctgcagcagactccactccacttggctgtgatc
accaaccagccagaaattgctgaggcacttctgggagctggctgtgatcctgagctccga
gactttcgaggaaatacccccctacaccttgcctgtgagcagggctgcctggccagcgtg
ggagtcctgactcagtcctgcaccaccccgcacctccactccatcctgaaggctaccaac
tacaatggccacacgtgtctacacttagcctctatccatggctacctgggcatcgtggag
cttttggtgtccttgggtgctgatgtcaatgctcaggagccctgtaatggccggactgcc
cttcacctcgcagtggacctgcaaaatcctgacctggtgtcactcctgttgaagtgtggg
gctgatgtcaacagagttacctaccagggctattctccctaccagctcacctggggccgc
ccaagcacccggatacagcagcagctgggccagctgacactagaaaaccttcagatgctg
ccagagagtgaggatgaggagagctatgacacagagtcagagttcacggagttcacagag
gacgagctgccctatgatgactgtgtgtttggaggccagcgtctgacgttatga
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