Entry
Name
IL1-IL1R-p38 signaling pathway
Definition
IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK3/6 -> MAPK14 -> MK2 -| TTP
Expanded
(3552,3553) -> (3554+3556) -> 4615 -> (3654,51135) -> 7189 -> (10454,23118,257397) -> 6885 -> (5606,5608) -> 1432 -> 9261 -| 7538
Class
nt06526 MAPK signaling
nt06211 Other MAPK signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
Gene
3552 IL1A; interleukin 1 alpha
3553 IL1B; interleukin 1 beta
3554 IL1R1; interleukin 1 receptor type 1
3556 IL1RAP; interleukin 1 receptor accessory protein
4615 MYD88; myeloid differentiation primary response 88
3654 IRAK1; interleukin 1 receptor associated kinase 1
51135 IRAK4; interleukin 1 receptor associated kinase 4
7189 TRAF6; TNF receptor associated factor 6
10454 TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
257397 TAB3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3
6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7
5606 MAP2K3; mitogen-activated protein kinase kinase 3
5608 MAP2K6; mitogen-activated protein kinase kinase 6
1432 MAPK14; mitogen-activated protein kinase 14
9261 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
7538 ZFP36; ZFP36 ring finger protein
Reference
Authors
Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmuller U, Haussinger D, Timmer J, Bode JG
Title
IL-1beta-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.
Journal
Reference
Authors
Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H
Title
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
de Nadal E, Ammerer G, Posas F
Title
Controlling gene expression in response to stress.
Journal
Reference
Authors
Thapar R, Denmon AP
Title
Signaling pathways that control mRNA turnover.
Journal
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